- Epigenetics and miRNA emerge as key regulators of smooth muscle cell phenotype and functionRachel L Clifford
University of Nottingham, Division of Respiratory Medicine and Nottingham Respiratory Research Unit, Clinical Sciences Building, City Hospital, Hucknall Road, Nottingham NG5 1PB, England, UK
Pulm Pharmacol Ther 26:75-85. 2013....
- Abnormal histone methylation is responsible for increased vascular endothelial growth factor 165a secretion from airway smooth muscle cells in asthmaRachel L Clifford
University of Nottingham, City Hospital, Nottingham, UK
J Immunol 189:819-31. 2012..This is the first study, to our knowledge, to show that airway cells in asthma have altered epigenetic regulation of remodeling gene(s). Histone methylation at genes such as VEGF may be an important new therapeutic target...
- Transcriptional regulation of inflammatory genes associated with severe asthmaRachel L Clifford
Division of Respiratory Medicine and Nottingham Biomedical Research Unit, City Hospital, England, UK
Curr Pharm Des 17:653-66. 2011..An overview is shown in figure 1...
- Future bronchodilator therapy: a bitter pill to swallow?Rachel L Clifford
Division of Respir Med and Nottingham Respiratory Research Unit, Univ of Nottingham, Clinical Sciences Bldg, City Hospital, Nottingham, UK
Am J Physiol Lung Cell Mol Physiol 303:L953-5. 2012..This editorial focus discusses these studies within the context of existing literature and raises questions and challenges for the future development of bitter (better?) therapies for asthma...