Dylan N Clements

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi request reprint Assessment of the use of RNA quality metrics for the screening of articular cartilage specimens from clinically normal dogs and dogs with osteoarthritis
    Dylan N Clements
    Connective Tissue Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
    Am J Vet Res 67:1438-44. 2006
  2. pmc Expression stability of commonly used reference genes in canine articular connective tissues
    Duncan Ayers
    Centre for Integrated Genomic Medical Research, The Manchester Interdisciplinary Biocentre, University of Manchester, UK
    BMC Vet Res 3:7. 2007
  3. doi request reprint The effectiveness of 3D animations to enhance understanding of cranial cruciate ligament rupture
    Dylan N Clements
    The University of Edinburgh, Roslin, UK
    J Vet Med Educ 40:29-34. 2013
  4. pmc Dogslife: a web-based longitudinal study of Labrador Retriever health in the UK
    Dylan N Clements
    Royal Dick School of Veterinary Studies, University of Edinburgh, Rosli, Scotland
    BMC Vet Res 9:13. 2013
  5. doi request reprint A candidate gene study of canine joint diseases
    Dylan N Clements
    Division of Veterinary Clinical Sciences, The Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, UK
    J Hered 101:54-60. 2010
  6. doi request reprint Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complex
    D N Clements
    Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland
    Vet Comp Orthop Traumatol 24:262-5. 2011
  7. ncbi request reprint Assessment of the quality and quantity of genomic DNA recovered from canine blood samples by three different extraction methods
    Dylan N Clements
    Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    Res Vet Sci 85:74-9. 2008
  8. ncbi request reprint Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis
    Dylan N Clements
    Department of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX, UK
    Vet J 179:211-8. 2009
  9. pmc Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
    Dylan N Clements
    The Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
    Arthritis Res Ther 8:R158. 2006
  10. doi request reprint Reference genes for canine skin when using quantitative real-time PCR
    Shona H Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    Vet Immunol Immunopathol 126:392-5. 2008

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Assessment of the use of RNA quality metrics for the screening of articular cartilage specimens from clinically normal dogs and dogs with osteoarthritis
    Dylan N Clements
    Connective Tissue Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
    Am J Vet Res 67:1438-44. 2006
    ..To assess 2 methods of RNA purification by use of different quality metrics and identify the most useful metric for quality assessment of RNA extracted from articular cartilage from dogs with osteoarthritis...
  2. pmc Expression stability of commonly used reference genes in canine articular connective tissues
    Duncan Ayers
    Centre for Integrated Genomic Medical Research, The Manchester Interdisciplinary Biocentre, University of Manchester, UK
    BMC Vet Res 3:7. 2007
    ....
  3. doi request reprint The effectiveness of 3D animations to enhance understanding of cranial cruciate ligament rupture
    Dylan N Clements
    The University of Edinburgh, Roslin, UK
    J Vet Med Educ 40:29-34. 2013
    ..Multiple peer-review testing is required to maximize the usefulness of 3D animations during development. Free and open access to such tools should improve student learning and client understanding through wide-spread uptake and use...
  4. pmc Dogslife: a web-based longitudinal study of Labrador Retriever health in the UK
    Dylan N Clements
    Royal Dick School of Veterinary Studies, University of Edinburgh, Rosli, Scotland
    BMC Vet Res 9:13. 2013
    ..The study has been designed to examine how environmental and genetic factors influence the health and development of a birth cohort of UK-based pedigree Labrador Retrievers...
  5. doi request reprint A candidate gene study of canine joint diseases
    Dylan N Clements
    Division of Veterinary Clinical Sciences, The Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, UK
    J Hered 101:54-60. 2010
    ..The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation...
  6. doi request reprint Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complex
    D N Clements
    Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland
    Vet Comp Orthop Traumatol 24:262-5. 2011
    ..To investigate the association of the major histocompatability (MHC) class II allele haplotype frequencies with the diagnosis of cranial cruciate ligament (CCL) rupture in two breeds of dog...
  7. ncbi request reprint Assessment of the quality and quantity of genomic DNA recovered from canine blood samples by three different extraction methods
    Dylan N Clements
    Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
    Res Vet Sci 85:74-9. 2008
    ..The silica column method recovered gDNA with equal efficiency, purity and integrity irrespective of the sample type or method of quantification...
  8. ncbi request reprint Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritis
    Dylan N Clements
    Department of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX, UK
    Vet J 179:211-8. 2009
    ..Levels of expression of COL1A2, MMP2, MMP9, MMP13 and TIMP1 were increased, whereas expression of TIMP2 was decreased in OA bone relative to normal bone. Cartilage gene expression may be correlated with the radiographic severity of OA...
  9. pmc Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
    Dylan N Clements
    The Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
    Arthritis Res Ther 8:R158. 2006
    ..We conclude that the expression profiles of matrix-associated molecules in end-stage mammalian OA may be comparable but that the precise aetiologies of OA affecting specific joints in different species are presently unknown...
  10. doi request reprint Reference genes for canine skin when using quantitative real-time PCR
    Shona H Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    Vet Immunol Immunopathol 126:392-5. 2008
    ..RPL13A and CG14980 were found to be the most stably expressed genes in canine whole skin and would be more suitable as reference genes in future studies...
  11. ncbi request reprint Genetic basis of secondary osteoarthritis in dogs with joint dysplasia
    Dylan N Clements
    Connective Tissue Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
    Am J Vet Res 67:909-18. 2006
  12. pmc Gene expression markers of tendon fibroblasts in normal and diseased tissue compared to monolayer and three dimensional culture systems
    Sarah E Taylor
    Department of Veterinary Clinical Science, University of Liverpool, Neston, South Wirral, UK
    BMC Musculoskelet Disord 10:27. 2009
    ..This study aims to quantify gene expression markers that distinguish between tendon fibroblasts and other mesenchymal cells which may be used to investigate tenogenesis...
  13. doi request reprint Gene expression in canine atopic dermatitis and correlation with clinical severity scores
    Shona H Wood
    Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
    J Dermatol Sci 55:27-33. 2009
    ..Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD...
  14. doi request reprint Population structure and genetic heterogeneity in popular dog breeds in the UK
    Richard J Mellanby
    Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
    Vet J 196:92-7. 2013
    ..The least distinct group contained crossbred dogs. The results show that the registered breeds are subject to a 'breed barrier' which promotes reduction in genetic diversity...
  15. pmc Histological and molecular characterisation of feline humeral condylar osteoarthritis
    John M Ryan
    Royal Dick School of Veterinary Studies and Roslin Institute, Division of Veterinary Clinical Sciences, Hospital for Small Animals, Easter Bush Veterinary Centre, The University of Edinburgh, Roslin, Midlothian EH25 9RG, Scotland
    BMC Vet Res 9:110. 2013
    ..In this study we evaluated selected histological and transcriptomic measures in the articular cartilage and subchondral bone (SCB) of the humeral condyle of cats with or without OA...
  16. ncbi request reprint Type I immune-mediated polyarthritis in dogs: 39 cases (1997-2002)
    Dylan N Clements
    Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow, Scotland, G61 1QH, UK
    J Am Vet Med Assoc 224:1323-7. 2004
    ..To determine clinical signs, laboratory findings, relationship to vaccination, and response to treatment for type I immune-mediated polyarthritis (IMPA) in dogs...
  17. pmc Identification of new reference genes for the normalisation of canine osteoarthritic joint tissue transcripts from microarray data
    Lindsey J Maccoux
    Centre for Integrated Genomic Medical Research, University of Manchester, The Stopford Building, Manchester, UK
    BMC Mol Biol 8:62. 2007
    ..RT-qPCR assays were designed and applied to each different articular tissue. Reference gene expression stability and ranking was compared using three different mathematical algorithms...
  18. ncbi request reprint Expression profiling of select cytokines in canine osteoarthritis tissues
    Lindsey J Maccoux
    Centre for Integrated Genomic Medical Research, University of Manchester, The Stopford Building, Oxford Road, Manchester, UK
    Vet Immunol Immunopathol 118:59-67. 2007
    ..Cytokine expression was detected in multiple tissues within the articular joint, but differential expression in OA was detected primarily in the synovial membrane and cranial cruciate ligament...
  19. doi request reprint Gene (mRNA) expression in canine atopic dermatitis: microarray analysis
    Annemarie E Merryman-Simpson
    Waltham Centre for Pet Nutrition, Melton Mowbray, Leicestershire, UK
    Vet Dermatol 19:59-66. 2008
    ..Investigating gene polymorphisms in the targets identified in this study will help improve our understanding of the genetic basis of this disease...