Research Topics
| Dylan N ClementsSummaryAffiliation: University of Edinburgh Country: UK Publications
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Detail Information
Publications
Assessment of the use of RNA quality metrics for the screening of articular cartilage specimens from clinically normal dogs and dogs with osteoarthritisDylan N Clements
Connective Tissue Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
Am J Vet Res 67:1438-44. 2006..CONCLUSIONS AND CLINICAL RELEVANCE: No single metric provided a completely sensitive and specific assessment of the quality of RNA recovered from articular cartilage...
Expression stability of commonly used reference genes in canine articular connective tissuesDuncan Ayers
Centre for Integrated Genomic Medical Research, The Manchester Interdisciplinary Biocentre, University of Manchester, UK
BMC Vet Res 3:7. 2007....
The effectiveness of 3D animations to enhance understanding of cranial cruciate ligament ruptureDylan N Clements
The University of Edinburgh, Roslin, UK
J Vet Med Educ 40:29-34. 2013..Multiple peer-review testing is required to maximize the usefulness of 3D animations during development. Free and open access to such tools should improve student learning and client understanding through wide-spread uptake and use...- Dogslife: a web-based longitudinal study of Labrador Retriever health in the UKDylan N Clements
Royal Dick School of Veterinary Studies, University of Edinburgh, Rosli, Scotland
BMC Vet Res 9:13. 2013..The study has been designed to examine how environmental and genetic factors influence the health and development of a birth cohort of UK-based pedigree Labrador Retrievers... - A candidate gene study of canine joint diseasesDylan N Clements
Division of Veterinary Clinical Sciences, The Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, UK
J Hered 101:54-60. 2010..The candidate gene approach for the study of genetic association is unlikely to be successful for complex canine diseases such as OA without prior trait mapping evaluation... - Assessment of the quality and quantity of genomic DNA recovered from canine blood samples by three different extraction methodsDylan N Clements
Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool L69 3BX, UK
Res Vet Sci 85:74-9. 2008..The silica column method recovered gDNA with equal efficiency, purity and integrity irrespective of the sample type or method of quantification... - Cartilage gene expression correlates with radiographic severity of canine elbow osteoarthritisDylan N Clements
Department of Veterinary Pathology, University of Liverpool, Liverpool L69 3BX, UK
Vet J 179:211-8. 2009..Levels of expression of COL1A2, MMP2, MMP9, MMP13 and TIMP1 were increased, whereas expression of TIMP2 was decreased in OA bone relative to normal bone. Cartilage gene expression may be correlated with the radiographic severity of OA... - Risk of canine cranial cruciate ligament rupture is not associated with the major histocompatibility complexD N Clements
Royal Dick School of Veterinary Studies, Division of Veterinary Clinical Sciences, The Roslin Institute, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian, EH25 9RG, Scotland
Vet Comp Orthop Traumatol 24:262-5. 2011..To investigate the association of the major histocompatability (MHC) class II allele haplotype frequencies with the diagnosis of cranial cruciate ligament (CCL) rupture in two breeds of dog... - Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reactionDylan N Clements
The Musculoskeletal Research Group, c o Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
Arthritis Res Ther 8:R158. 2006..We conclude that the expression profiles of matrix-associated molecules in end-stage mammalian OA may be comparable but that the precise aetiologies of OA affecting specific joints in different species are presently unknown... - Reference genes for canine skin when using quantitative real-time PCRShona H Wood
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
Vet Immunol Immunopathol 126:392-5. 2008..RPL13A and CG14980 were found to be the most stably expressed genes in canine whole skin and would be more suitable as reference genes in future studies... - Genetic basis of secondary osteoarthritis in dogs with joint dysplasiaDylan N Clements
Connective Tissue Research Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, L69 3BX, UK
Am J Vet Res 67:909-18. 2006 - Gene expression markers of tendon fibroblasts in normal and diseased tissue compared to monolayer and three dimensional culture systemsSarah E Taylor
Department of Veterinary Clinical Science, University of Liverpool, Neston, South Wirral, UK
BMC Musculoskelet Disord 10:27. 2009..This study aims to quantify gene expression markers that distinguish between tendon fibroblasts and other mesenchymal cells which may be used to investigate tenogenesis... - Gene expression in canine atopic dermatitis and correlation with clinical severity scoresShona H Wood
Department of Veterinary Pathology, Faculty of Veterinary Science, University of Liverpool, Liverpool, UK
J Dermatol Sci 55:27-33. 2009..Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD... - Population structure and genetic heterogeneity in popular dog breeds in the UKRichard J Mellanby
Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK
Vet J 196:92-7. 2013..The least distinct group contained crossbred dogs. The results show that the registered breeds are subject to a 'breed barrier' which promotes reduction in genetic diversity... - Type I immune-mediated polyarthritis in dogs: 39 cases (1997-2002)Dylan N Clements
Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, Bearsden, Glasgow, Scotland, G61 1QH, UK
J Am Vet Med Assoc 224:1323-7. 2004..Most dogs with type I IMPA responded to initial immunosuppressive treatment, but 31% (12/39) of dogs relapsed, required further treatment, or both... - Identification of new reference genes for the normalisation of canine osteoarthritic joint tissue transcripts from microarray dataLindsey J Maccoux
Centre for Integrated Genomic Medical Research, University of Manchester, The Stopford Building, Manchester, UK
BMC Mol Biol 8:62. 2007..RT-qPCR assays were designed and applied to each different articular tissue. Reference gene expression stability and ranking was compared using three different mathematical algorithms... - Expression profiling of select cytokines in canine osteoarthritis tissuesLindsey J Maccoux
Centre for Integrated Genomic Medical Research, University of Manchester, The Stopford Building, Oxford Road, Manchester, UK
Vet Immunol Immunopathol 118:59-67. 2007..Cytokine expression was detected in multiple tissues within the articular joint, but differential expression in OA was detected primarily in the synovial membrane and cranial cruciate ligament... - Gene (mRNA) expression in canine atopic dermatitis: microarray analysisAnnemarie E Merryman-Simpson
Waltham Centre for Pet Nutrition, Melton Mowbray, Leicestershire, UK
Vet Dermatol 19:59-66. 2008..Investigating gene polymorphisms in the targets identified in this study will help improve our understanding of the genetic basis of this disease...