J G Cleland

Summary

Affiliation: University of Hull
Country: UK

Publications

  1. pmc An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure
    John G Cleland
    National Heart and Lung Institute, Imperial College London Royal Brompton and Harefield Hospitals and Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Eur Heart J 34:3547-56. 2013
  2. ncbi request reprint Case selection for cardiac resynchronization in atrial fibrillation
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull, Kingston upon Hull HU6 5JQ, UK Electronic address
    Heart Fail Clin 9:461-74, ix. 2013
  3. doi request reprint The determinants of clinical outcome and clinical response to CRT are not the same
    John G F Cleland
    Department of Cardiology, Hull York Medical School, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Heart Fail Rev 17:755-66. 2012
  4. doi request reprint Long-term mortality with cardiac resynchronization therapy in the Cardiac Resynchronization-Heart Failure (CARE-HF) trial
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 14:628-34. 2012
  5. doi request reprint Relationship between plasma concentrations of N-terminal pro brain natriuretic peptide and the characteristics and outcome of patients with a clinical diagnosis of diastolic heart failure: a report from the PEP-CHF study
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 14:487-94. 2012
  6. ncbi request reprint Role of antithrombotic agents in heart failure
    John G F Cleland
    Department of Cardiology, Hull York Medical School University of Hull, Castle Hill Hospital, Kingston upon Hull, East Riding of Yorkshire, England, UK
    Curr Cardiol Rep 14:314-25. 2012
  7. doi request reprint Renal dysfunction in acute and chronic heart failure: prevalence, incidence and prognosis
    John G F Cleland
    Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital, Kingston upon Hull, HU16 5JQ, UK
    Heart Fail Rev 17:133-49. 2012
  8. pmc Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: a cardiovascular magnetic resonance study
    Christos V Bourantas
    Department of Cardiology, Academic Unit, University of Hull, Postgraduate Medical Institute, Kingston upon Hull, UK
    J Cardiovasc Magn Reson 13:53. 2011
  9. pmc Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF
    Magnus Edner
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
    Cardiovasc Ultrasound 7:1. 2009
  10. pmc Patients with treatable malignant diseases--including heart failure--are entitled to specialist care
    John G F Cleland
    University of Hull, Kingston upon Hull, UK
    CMAJ 172:207-9. 2005

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. pmc An individual patient meta-analysis of five randomized trials assessing the effects of cardiac resynchronization therapy on morbidity and mortality in patients with symptomatic heart failure
    John G Cleland
    National Heart and Lung Institute, Imperial College London Royal Brompton and Harefield Hospitals and Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Eur Heart J 34:3547-56. 2013
    ..We sought to identify pre-implantation variables that predict the response to CRT in a meta-analysis using individual patient-data...
  2. ncbi request reprint Case selection for cardiac resynchronization in atrial fibrillation
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull, Kingston upon Hull HU6 5JQ, UK Electronic address
    Heart Fail Clin 9:461-74, ix. 2013
    ..Evidence is lacking that biventricular rather than AV resynchronization is an important mechanism for delivering the benefits of CRT. ..
  3. doi request reprint The determinants of clinical outcome and clinical response to CRT are not the same
    John G F Cleland
    Department of Cardiology, Hull York Medical School, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Heart Fail Rev 17:755-66. 2012
    ..Clinicians should follow the criteria for patient selection in the landmark trials when selecting patients for CRT, should extrapolate with caution from these and should be extremely cautious in the interpretation of observational data...
  4. doi request reprint Long-term mortality with cardiac resynchronization therapy in the Cardiac Resynchronization-Heart Failure (CARE-HF) trial
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 14:628-34. 2012
    ..We now report the long-term outcome during and subsequent to the randomized trial...
  5. doi request reprint Relationship between plasma concentrations of N-terminal pro brain natriuretic peptide and the characteristics and outcome of patients with a clinical diagnosis of diastolic heart failure: a report from the PEP-CHF study
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 14:487-94. 2012
    ..The lack of a simple, objective test to identify patients with HFPEF at increased risk of cardiovascular events would be valuable...
  6. ncbi request reprint Role of antithrombotic agents in heart failure
    John G F Cleland
    Department of Cardiology, Hull York Medical School University of Hull, Castle Hill Hospital, Kingston upon Hull, East Riding of Yorkshire, England, UK
    Curr Cardiol Rep 14:314-25. 2012
    ..For those with the opportunity, engaging with a randomized trial is clinically and scientifically appropriate. The dilemma for such studies is the comparator. Should it be against or in addition to "standard of care" or both?..
  7. doi request reprint Renal dysfunction in acute and chronic heart failure: prevalence, incidence and prognosis
    John G F Cleland
    Department of Cardiology, Hull York Medical School, University of Hull, Castle Hill Hospital, Kingston upon Hull, HU16 5JQ, UK
    Heart Fail Rev 17:133-49. 2012
    ..Reversing renal dysfunction and stopping its progression remain important targets for treatment of heart failure...
  8. pmc Prevalence of scarred and dysfunctional myocardium in patients with heart failure of ischaemic origin: a cardiovascular magnetic resonance study
    Christos V Bourantas
    Department of Cardiology, Academic Unit, University of Hull, Postgraduate Medical Institute, Kingston upon Hull, UK
    J Cardiovasc Magn Reson 13:53. 2011
    ....
  9. pmc Prevalence and inter-relationship of different Doppler measures of dyssynchrony in patients with heart failure and prolonged QRS: a report from CARE-HF
    Magnus Edner
    Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden
    Cardiovasc Ultrasound 7:1. 2009
    ..Observational studies suggest that patients having more left ventricular dyssynchrony pre-implantation obtain greater benefit on ventricular function and symptoms with CRT...
  10. pmc Patients with treatable malignant diseases--including heart failure--are entitled to specialist care
    John G F Cleland
    University of Hull, Kingston upon Hull, UK
    CMAJ 172:207-9. 2005
  11. ncbi request reprint Prevalence of markers of heart failure in patients with atrial fibrillation and the effects of ximelagatran compared to warfarin on the incidence of morbid and fatal events: a report from the SPORTIF III and V trials
    John G F Cleland
    Department of Cardiology, Kingston upon Hull, UK
    Eur J Heart Fail 9:730-9. 2007
    ..Patients with atrial fibrillation (AF) who also have heart failure have a worse outcome but the diagnosis of heart failure is often missed...
  12. ncbi request reprint Fighting against sudden death: a single or multidisciplinary approach
    John G F Cleland
    Department of Cardiology, University of Hull Castle Hill Hospital, Kingston upon Hull, East Riding of Yorkshire, UK
    J Interv Card Electrophysiol 17:205-10. 2006
    ..Implantable defibrillators confer a small but definite additional survival advantage by treating arrhythmias that have not been prevented...
  13. ncbi request reprint Thiazolidinediones, deadly sins, surrogates, and elephants
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Hull HU16 5JQ, UK
    Lancet 370:1103-4. 2007
  14. ncbi request reprint Should patients who have persistent severe symptoms receive a left ventricular assist device or cardiac resynchronization therapy as the next step?
    John Cleland
    University of Hull, Castle Hill Hospital, Kingston upon Hull, UK
    Heart Fail Clin 3:267-73. 2007
    ..In the longer-term future, it is possible that the development of less expensive, small, and safe left ventricular assist devices will supplant the role of both CRT and CRT-defibrillator devices...
  15. ncbi request reprint Levosimendan: first in a new class of inodilator for acute and chronic severe heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Cottingham, Kington upon Hull, UK
    Expert Rev Cardiovasc Ther 2:9-19. 2004
    ..If these studies confirm the benefits of levosimendan, then it may become routine therapy for the management of severe heart failure...
  16. ncbi request reprint Predicting the long-term effects of cardiac resynchronization therapy on mortality from baseline variables and the early response a report from the CARE-HF (Cardiac Resynchronization in Heart Failure) Trial
    John Cleland
    Department of Cardiology, University of Hull, Hull, United Kingdom
    J Am Coll Cardiol 52:438-45. 2008
    ..This study was designed to investigate whether selected baseline variables and early response markers predict the effects of cardiac resynchronization therapy (CRT) on long-term mortality...
  17. ncbi request reprint The Warfarin/Aspirin Study in Heart failure (WASH): a randomized trial comparing antithrombotic strategies for patients with heart failure
    J G F Cleland
    Academic Unit, Department of Cardiology, Castlehill Hospital, University of Hull, Kingston upon Hull, United Kingdom
    Am Heart J 148:157-64. 2004
    ..Heart failure is commonly associated with vascular disease and a high rate of athero-thrombotic events, but the risks and benefits of antithrombotic therapy are unknown...
  18. ncbi request reprint Baseline characteristics of patients recruited into the CARE-HF study
    J G F Cleland
    Department of Cardiology, Castle Hill Hospital, Castle Road, Cottingham, University of Hull, Kingston upon Hull, UK HU16 5JQ
    Eur J Heart Fail 7:205-14. 2005
    ..The CARE-HF study is a morbidity/mortality trial designed to provide conclusive evidence of the effects of CRT in patients with moderate to severe heart failure...
  19. ncbi request reprint Cardiac resynchronization therapy or atrio-biventricular pacing-what should it be called?
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull HU16 5TX, UK
    Nat Clin Pract Cardiovasc Med 4:90-101. 2007
    ..Here, we examine the evidence that cardiac resynchronization is indeed the mechanism by which atrio-biventricular pacing exerts its effects...
  20. ncbi request reprint The effect of cardiac resynchronization on morbidity and mortality in heart failure
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    N Engl J Med 352:1539-49. 2005
    ..We evaluated its effects on morbidity and mortality...
  21. ncbi request reprint Can cardiac-resynchronization therapy reduce mortality in patients suffering from advanced chronic heart failure?
    John G F Cleland
    Academic Cardiology Unit, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Nat Clin Pract Cardiovasc Med 1:10-1. 2004
  22. ncbi request reprint A comparison of the effects of carvedilol and metoprolol on well-being, morbidity, and mortality (the "patient journey") in patients with heart failure: a report from the Carvedilol Or Metoprolol European Trial (COMET)
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    J Am Coll Cardiol 47:1603-11. 2006
    ..This study was designed to investigate the loss of well-being, in terms of life-years, overall and in patients randomized to metoprolol versus carvedilol in the Carvedilol Or Metoprolol European Trial (COMET)...
  23. ncbi request reprint Once-monthly administration of darbepoetin alfa for the treatment of patients with chronic heart failure and anemia: a pharmacokinetic and pharmacodynamic investigation
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, UK
    J Cardiovasc Pharmacol 46:155-61. 2005
    ..No severe, drug-related adverse events occurred. Darbepoetin alfa administered once monthly elevates and maintains the hemoglobin concentration in patients with CHF and anemia...
  24. ncbi request reprint Chronic aspirin therapy for the prevention of cardiovascular events: a waste of time, or worse?
    John G F Cleland
    Department of Academic Cardiology, University of Hull, Hull, UK
    Nat Clin Pract Cardiovasc Med 3:234-5. 2006
  25. ncbi request reprint Longer-term effects of cardiac resynchronization therapy on mortality in heart failure [the CArdiac REsynchronization-Heart Failure (CARE-HF) trial extension phase]
    John G F Cleland
    Academic Unit of Cardiology, Department of Cardiology, Castle Hill Hospital, University of Hull, Castle Road, Cottingham, Kingston upon Hull, East Yorkshire, UK
    Eur Heart J 27:1928-32. 2006
    ..4 months [median 29.6, interquartile range (IQR) 23.6-34.6]. Prior to study closure, an extension phase lasting a further 8 months (allowing time for data analysis and presentation) was declared during which cross-over was discouraged...
  26. ncbi request reprint Noninvasive home telemonitoring for patients with heart failure at high risk of recurrent admission and death: the Trans-European Network-Home-Care Management System (TEN-HMS) study
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    J Am Coll Cardiol 45:1654-64. 2005
    ..We sought to identify whether home telemonitoring (HTM) improves outcomes compared with nurse telephone support (NTS) and usual care (UC) for patients with heart failure who are at high risk of hospitalization or death...
  27. ncbi request reprint The perindopril in elderly people with chronic heart failure (PEP-CHF) study
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur Heart J 27:2338-45. 2006
    ..Few substantial randomized controlled trials have been conducted in this population, none has focussed on patients with evidence of diastolic dysfunction and none has shown clear benefit on symptoms, morbidity, or mortality...
  28. pmc Epidemiology and management of heart failure and left ventricular systolic dysfunction in the aftermath of a myocardial infarction
    J G F Cleland
    Department of Academic Cardiology, University of Hull, UK
    Heart 91:ii7-13; discussion ii31, ii43-8. 2005
    ..It is important to organise care structures to ensure that patients with post-MI heart failure and LVSD are identified and managed appropriately...
  29. ncbi request reprint Practical applications of intravenous diuretic therapy in decompensated heart failure
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    Am J Med 119:S26-36. 2006
    ....
  30. doi request reprint Cardiac resynchronization therapy: dyssynchrony imaging from a heart failure perspective
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, East Riding of Yorkshire, UK
    Curr Opin Cardiol 23:634-45. 2008
    ..To review the evidence for and against imaging as a means of selecting patients for cardiac resynchronization therapy (CRT)...
  31. doi request reprint Applying evidence-based device care in cardiovascular patients: which patient with heart failure and what device?
    J G Cleland
    Hull and York Medical School, Kingston upon Hull, UK
    J R Coll Physicians Edinb 40:229-39. 2010
    ..For most patients this should be CRT or a combination of CRT and an ICD (CRT-D)...
  32. doi request reprint Plasma concentration of amino-terminal pro-brain natriuretic peptide in chronic heart failure: prediction of cardiovascular events and interaction with the effects of rosuvastatin: a report from CORONA (Controlled Rosuvastatin Multinational Trial in Heart
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    J Am Coll Cardiol 54:1850-9. 2009
    ....
  33. doi request reprint The national heart failure audit for England and Wales 2008-2009
    John G F Cleland
    Department of Cardiology, Castle Hill Hospital, Hull York Medical School, University of Hull, Cottingham, Kingston upon Hull, UK
    Heart 97:876-86. 2011
    ..To obtain national data on the clinical characteristics, investigation, management and outcome of patients hospitalised with a diagnosis of heart failure...
  34. pmc Contemporary management of heart failure in clinical practice
    J G F Cleland
    Department of Cardiology, Castle Hill Hospital, Castle Road, Cottingham, University of Hull, Kingston upon Hull, UK
    Heart 88:ii5-8. 2002
  35. ncbi request reprint Effects of cardiac resynchronization therapy on long-term quality of life: an analysis from the CArdiac Resynchronisation-Heart Failure (CARE-HF) study
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    Am Heart J 157:457-66. 2009
    ..The CArdiac Resynchronisation-Heart Failure study is the only long-term randomized trial of CRT with repeated measures of QoL...
  36. doi request reprint The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial
    John G F Cleland
    Department of Cardiology, Hull York Medical School, University of Hull, Hull, UK
    Lancet 378:676-83. 2011
    ..We report the first study of the cardiac myosin activator, omecamtiv mecarbil, in patients with systolic heart failure...
  37. ncbi request reprint Prevalence and incidence of arrhythmias and sudden death in heart failure
    John G F Cleland
    University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ
    Heart Fail Rev 7:229-42. 2002
    ..The role of various investigations in risk stratification of sudden death has also been discussed...
  38. ncbi request reprint The CARE-HF study (CArdiac REsynchronisation in Heart Failure study): rationale, design and end-points
    J G Cleland
    Department of Cardiology, Castle Hill Hospital, Castle Road, Cottingham, University of Hull, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 3:481-9. 2001
    ..Cardiac resynchronisation is a promising new intervention for patients with heart failure, left ventricular systolic dysfunction and ventricular dyssynchrony...
  39. ncbi request reprint The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis
    J G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Kingston upon Hull HU16 5JQ UK
    Eur Heart J 24:442-63. 2003
    ..Accordingly, the EuroHeart Failure survey was conducted to ascertain if appropriate tests were being performed with which to confirm or refute a diagnosis of heart failure and how this influenced subsequent management...
  40. ncbi request reprint Management of heart failure in primary care (the IMPROVEMENT of Heart Failure Programme): an international survey
    J G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, UK
    Lancet 360:1631-9. 2002
    ..The aim of this study was to assess how primary-care physicians think that heart failure should be managed, how they implement their knowledge, and whether differences exist in practice between countries...
  41. ncbi request reprint Intravenous levosimendan treatment is cost-effective compared with dobutamine in severe low-output heart failure: an analysis based on the international LIDO trial
    J G F Cleland
    Department of Cardiology, Castle Hill Hospital, Castle Road, Cottingham, University of Hull, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 5:101-8. 2003
    ..Levosimendan, a novel calcium sensitiser, improves cardiac performance and symptoms without increasing oxygen consumption, and decreases the mortality of patients with low-output heart failure...
  42. ncbi request reprint The Euro Heart Failure Survey of the EUROHEART survey programme. A survey on the quality of care among patients with heart failure in Europe. The Study Group on Diagnosis of the Working Group on Heart Failure of the European Society of Cardiology. The Med
    J G Cleland
    Kingston upon Hull, UK
    Eur J Heart Fail 2:123-32. 2000
    ..These surveys will provide information on the nature of cardiovascular disease and its management. This manuscript describes a survey into the nature and management of heart failure...
  43. ncbi request reprint Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD
    Krishna Lalukota
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 6:953-5. 2004
    ....
  44. ncbi request reprint Clinical Trials Update: CAPRICORN, COPERNICUS, MIRACLE, STAF, RITZ-2, RECOVER and RENAISSANCE and cachexia and cholesterol in heart failure. Highlights of the Scientific Sessions of the American College of Cardiology, 2001
    A Louis
    Academic Unit of Cardiology, University of Hull, School of Medicine, Castle Hill Hospital, HU 16 5JQ, Kingston upon Hull, UK
    Eur J Heart Fail 3:381-7. 2001
    ..The RENAISSANCE and RECOVER outcome studies of etanercept, a tumour necrosis factor (TNF) receptor analogue that blocks the effect of TNF, were stopped because of lack of evidence of benefit shortly after the ACC...
  45. ncbi request reprint Clinical trials update: IMPROVEMENT-HF, COPERNICUS, MUSTIC, ASPECT-II, APRICOT and HEART
    K Witte
    Academic Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 2:455-60. 2000
    ..In summary, the annual congress of the ESC provided important new information for clinical practice and, to date, was, by far, the most important cardiology congress in the world this year...
  46. ncbi request reprint Clinical trials update from the European Society of Cardiology meeting 2005: CARE-HF extension study, ESSENTIAL, CIBIS-III, S-ICD, ISSUE-2, STRIDE-2, SOFA, IMAGINE, PREAMI, SIRIUS-II and ACTIVE
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, UK
    Eur J Heart Fail 7:1070-5. 2005
    ..The ACTIVE W study of warfarin versus aspirin plus clopidogrel in atrial fibrillation has been stopped due to superiority of warfarin...
  47. ncbi request reprint The atrial fibrillation paradox of heart failure
    Rhidian J Shelton
    Department of Cardiology, Castle Hill Hospital, Hull York Medical School, Kingston upon Hull, UK
    Congest Heart Fail 16:3-9. 2010
    ..This is predominantly due to AF coinciding with or preceding the development of HF. The annual risk of persistent AF developing can be estimated from clinical variables...
  48. ncbi request reprint Metabolic gas kinetics depend upon the level of exercise performed
    Klaus K A Witte
    Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, United Kingdom
    Eur J Heart Fail 7:991-6. 2005
    ..The aim of the present study was to establish whether the kinetics of O2 are influenced by the work rate...
  49. ncbi request reprint Clinical trials update from the American College of Cardiology: Darbepoetin alfa, ASTEROID, UNIVERSE, paediatric carvedilol, UNLOAD and ICELAND
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 8:326-9. 2006
    ..The ICELAND MI study showed that CMR imaging was more sensitive than ECG or clinical criteria for detecting myocardial infarction...
  50. ncbi request reprint The prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in a typical regional pacemaker population
    Simon D R Thackray
    Castle Hill Hospital, University of Hull, Cottingham, Hull, UK
    Eur Heart J 24:1143-52. 2003
    ..To assess the prevalence of heart failure and asymptomatic left ventricular systolic dysfunction in the chronically paced population...
  51. ncbi request reprint Clinical trials update and cumulative meta-analyses from the American College of Cardiology: WATCH, SCD-HeFT, DINAMIT, CASINO, INSPIRE, STRATUS-US, RIO-Lipids and cardiac resynchronisation therapy in heart failure
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 6:501-8. 2004
    ..Rimonabant was shown to be safe and effective in treating the combined cardiovascular risk factors of smoking and obesity. An overview of new developments in cardiac resynchronisation therapy (CRT) in heart failure is also reported...
  52. ncbi request reprint Clinical trials update from the American Heart Association meeting: ACORN-CSD, primary care trial of chronic disease management, PEACE, CREATE, SHIELD, A-HeFT, GEMINI, vitamin E meta-analysis, ESCAPE, CARP, and SCD-HeFT cost-effectiveness study
    Rhidian J Shelton
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 7:127-35. 2005
    ..Analysis of data from SCD-HeFT supports the cost-effectiveness of ICDs in heart failure, although overall cost implications may be prohibitive...
  53. ncbi request reprint Update of clinical trials from the American College of Cardiology 2003. EPHESUS, SPORTIF-III, ASCOT, COMPANION, UK-PACE and T-wave alternans
    John G F Cleland
    Department of Academic Cardiology, Castle Hill Hospital, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 5:391-8. 2003
    ..T-wave alternans is an interesting experimental technique that may be useful in selecting which patients need an implantable defibrillator, although the technology needs testing in an appropriate patient population...
  54. doi request reprint The prognostic value of repeated measurement of N-terminal pro-B-type natriuretic peptide in patients with chronic heart failure due to left ventricular systolic dysfunction
    Milos Kubanek
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, UK
    Eur J Heart Fail 11:367-77. 2009
    ..We hypothesized that plasma levels of NT-proBNP, measured after optimization of pharmacotherapy in patients with CHF, may provide independent prognostic information when compared with baseline values and conventional prognostic markers...
  55. ncbi request reprint Poor relationship between exercise capacity and spirometric measurements in patients with more symptomatic heart failure
    Lee Ingle
    Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, Hull, United Kingdom
    J Card Fail 11:619-23. 2005
    ..The aim of the current study was to determine the extent to which spirometric indices predict peak exercise capacity in patients with differing severity of symptoms...
  56. ncbi request reprint Prevalence of ECG abnormalities in an international survey of patients with suspected or confirmed heart failure at death or discharge
    Nasrin K Khan
    University of Hull, Kingston upon Hull, United Kingdom
    Eur J Heart Fail 9:491-501. 2007
    ..Most patients suspected of having heart failure (HF) will get a 12-lead electrocardiogram (ECG) but its utility for excluding HF or assisting in its management has rarely been investigated...
  57. ncbi request reprint What is the optimal medical management of ischemic heart failure?
    J G Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Cottingham, Kingston upon Hull, United Kingdom
    Prog Cardiovasc Dis 43:433-55. 2001
    ..Only once the outcomes to these and other planned trials are known can the medical community know how best to treat their patients...
  58. ncbi request reprint Clinical trials update from the European Society of Cardiology: SENIORS, ACES, PROVE-IT, ACTION, and the HF-ACTION trial
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 6:787-91. 2004
    ..The primary outcome measure is death or hospitalisation for any reason...
  59. ncbi request reprint Clinical trials update from the American College of Cardiology 2007: ALPHA, EVEREST, FUSION II, VALIDD, PARR-2, REMODEL, SPICE, COURAGE, COACH, REMADHE, pro-BNP for the evaluation of dyspnoea and THIS-diet
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 9:740-5. 2007
    ..A large study of BNP provided additional information on its ability to distinguish cardiac and pulmonary breathlessness. The importance of dietary intervention in post-MI patients was highlighted by the findings of THIS-diet study...
  60. ncbi request reprint The effects of long-term beta-blockade on the ventilatory responses to exercise in chronic heart failure
    Klaus K A Witte
    Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham Hull HU16 5JQ, UK
    Eur J Heart Fail 7:612-7. 2005
    ..The aim of this study was to describe the effects of long-term beta-blocker therapy on metabolic gas exchange variables and ventilation during exercise in CHF patients...
  61. doi request reprint Predictors of short term mortality in heart failure - insights from the Euro Heart Failure survey
    Periaswamy Velavan
    Department of Academic Cardiology, University of Hull, UK
    Int J Cardiol 138:63-9. 2010
    ..To identify factors associated with short term mortality in hospitalised patients with heart failure...
  62. ncbi request reprint Airway resistance in chronic heart failure measured by impulse oscillometry
    Klaus K A Witte
    Department of Academic Cardiology, Castle Hill Hospital, Cottingham, Hull, UK
    J Card Fail 8:225-31. 2002
    ..Increased airway resistance by increasing the work of breathing might contribute to exercise intolerance in CHF...
  63. ncbi request reprint Does aspirin attenuate the effect of angiotensin-converting enzyme inhibitors in hypertension or heart failure?
    J G Cleland
    Department of Cardiology, Castle Hill Hospital, University of Hull, Kingston upon Hull, UK
    Curr Opin Nephrol Hypertens 10:625-31. 2001
    ..The combination of aspirin and angiotensin-converting enzyme inhibitors is warranted during this period, after which discontinuation or substitution of aspirin with another agent should be considered...
  64. ncbi request reprint Clinical trials update: highlights of the scientific sessions of the XXIII Congress of the European Society of Cardiology--WARIS II, ESCAMI, PAFAC, RITZ-1 and TIME
    A P Coletta
    Department of Academic Cardiology, Castle Hill Hospital, Cottingham, HU16 5JQ, Kingston upon Hull, UK
    Eur J Heart Fail 3:747-50. 2001
    ..Summaries of the following clinical studies are included: WARIS-II, ESCAMI, PAFAC, RITZ-I and TIME...
  65. doi request reprint Clinical trials update from the American Heart Association 2007: CORONA, RethinQ, MASCOT, AF-CHF, HART, MASTER, POISE and stem cell therapy
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 10:102-8. 2008
    ..Three trials of stem cell therapy in post-MI patients gave conflicting results...
  66. doi request reprint Ruling out heart failure in primary-care: the cost-benefit of pre-screening using NT-proBNP and QRS width
    Kevin M Goode
    Department of Cardiology, Hull Royal Infirmary, Kingston upon Hull, United Kingdom
    Int J Cardiol 130:426-37. 2008
    ....
  67. doi request reprint The effect of pharmacological stress on intraventricular dyssynchrony in left ventricular systolic dysfunction
    Sudipta Chattopadhyay
    Department of Cardiology, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 10:412-20. 2008
    ..LV dyssynchrony is conventionally measured at rest but the symptoms of heart failure occur predominantly on exercise. Induction or exacerbation of dyssynchrony during stress might identify additional patients who could benefit from CRT...
  68. ncbi request reprint N-terminal brain natriuretic peptide as a screening tool for heart failure in the pacemaker population
    Simon D R Thackray
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, Cottingham, East Yorkshire, UK
    Eur Heart J 27:447-53. 2006
    ..Assessment of N-terminal brain natriuretic peptide (NT-BNP) as a screening tool for heart failure in patients with a permanent pacemaker...
  69. ncbi request reprint Anemia, renal dysfunction, and their interaction in patients with chronic heart failure
    Ramesh de Silva
    Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, United Kingdom
    Am J Cardiol 98:391-8. 2006
    ..In conclusion, in outpatients with chronic HF, anemia and RD are common and co-exist but confer independent prognostic information. A deficiency of conventional hematinic factors may cause about 1/3 of anemia in this clinical setting...
  70. ncbi request reprint The effect of altering heart rate on ventricular function in patients with heart failure treated with beta-blockers
    Simon D R Thackray
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    Am Heart J 152:713.e9-13. 2006
    ..Beta-blockers are effective for the treatment of heart failure, but their mechanism of action is unresolved. Heart rate reduction may be a central mechanism or a troublesome side effect...
  71. ncbi request reprint The diagnostic utility of N-terminal pro-B-type natriuretic peptide for the detection of major structural heart disease in patients with atrial fibrillation
    Rhidian J Shelton
    Department of Cardiology, Castle Hill Hospital, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur Heart J 27:2353-61. 2006
    ..NT-proBNP is elevated in MSHD and heart failure (HF). AF, a common finding in HF and MSHD, is also associated with raised plasma NT-proBNP. As a result, the utility of NT-proBNP for predicting MSHD may be reduced...
  72. ncbi request reprint Carvedilol alone or in combination with digoxin for the management of atrial fibrillation in patients with heart failure?
    Aleem U Khand
    Academic Unit of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    J Am Coll Cardiol 42:1944-51. 2003
    ..This study examined the relative merits of digoxin, carvedilol, and their combination for the management of patients with atrial fibrillation (AF) and heart failure (HF)...
  73. ncbi request reprint A systematic review of telemonitoring for the management of heart failure
    Amala A Louis
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, UK
    Eur J Heart Fail 5:583-90. 2003
    ..This provides a means to keep patients with heart failure under close supervision, which could reduce the rate of admission to hospital and accelerate discharge...
  74. ncbi request reprint Progression from hypertension to heart failure. Mechanisms and management
    J G Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, UK
    Cardiology 92:10-9; discussion 20-1. 1999
    ..This is reinforced by the salutary benefits of carvedilol for the reduction in the morbidity and mortality of HF itself...
  75. ncbi request reprint What is the optimal medical management of ischaemic heart failure?
    J G Cleland
    Department of Cardiology, Castle Hill Hospital and Hull Royal Infirmary, Kingston upon Hull, UK
    Br Med Bull 59:135-58. 2001
    ....
  76. ncbi request reprint The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis
    Simon Thackray
    Department of Academic Cardiology, University of Hull, Kingston upon Hull, UK
    Eur J Heart Fail 4:515-29. 2002
    ..To review systematically the use of intravenous (IV) inotropic agents acting through the adrenergic signalling pathway, compared with placebo or an active agent, in patients with heart failure...
  77. ncbi request reprint Clinical trials update from the European Society of Cardiology Heart Failure meeting 2009: CHANCE, B-Convinced, CHAT, CIBIS-ELD, and Signal-HF
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, UK
    Eur J Heart Fail 11:802-5. 2009
    ..Signal-HF randomized elderly heart failure patients to treatment guided by NT-proBNP levels or usual care, and showed no effect of NT-proBNP-guided treatment on outcomes...
  78. ncbi request reprint Are hematinic deficiencies the cause of anemia in chronic heart failure?
    Klaus K A Witte
    Division of Academic Cardiology, Castle Hill Hospital, Cottingham, United Kingdom
    Am Heart J 147:924-30. 2004
    ..We explored the relation between hematinic levels and hemoglobin (Hb) levels and exercise tolerance in a group of patients with CHF...
  79. ncbi request reprint Diastolic heart failure. Paroxysmal or chronic?
    Prithwish Banerjee
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 6:427-31. 2004
    ....
  80. ncbi request reprint Screening for left ventricular systolic dysfunction in high-risk patients in primary-care: a cost-benefit analysis
    Kevin M Goode
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, UK
    Eur J Heart Fail 9:1186-95. 2007
    ..Appropriate screening strategies are needed to cost effectively identify patients with undiagnosed and untreated left ventricular systolic dysfunction (LVSD)...
  81. ncbi request reprint Cardiovascular critical event pathways for the progression of heart failure; a report from the ATLAS study
    J G Cleland
    Department of Cardiology, Castle Hill Hospital, Castle Road, University of Hull, Kingston upon Hull, HU16 5JQ
    Eur Heart J 22:1601-12. 2001
    ..A reduction in vascular events, as well as benefits on ventricular remodelling, could account for the decrease in death or hospitalization with high-dose lisinopril...
  82. ncbi request reprint Heart failure update
    U C Gomes
    Cardio net Editorial Office, Macclesfield, Cheshire, UK
    Eur J Heart Fail 1:301-2. 1999
    ..If these results can be confirmed it would render it unique among intravenous inotropic agents...
  83. ncbi request reprint Clinical trials update from the European Society of Cardiology Heart Failure meeting: SHAPE, BRING-UP 2 VAS, COLA II, FOSIDIAL, BETACAR, CASINO and meta-analysis of cardiac resynchronisation therapy
    Alison P Coletta
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 6:673-6. 2004
    ..1% and +12.0%, respectively). Revised mortality data for the CASINO study and a meta-analysis of the effects of cardiac resynchronisation therapy on mortality in the light of the recently published COMPANION study are reported...
  84. ncbi request reprint Relationship of high-sensitivity C-reactive protein to prognosis and other prognostic markers in outpatients with heart failure
    Jonathan D Windram
    Academic Cardiology Department, University of Hull, Hull Royal Infirmary Castle Hill Hospital, Hull, United Kingdom
    Am Heart J 153:1048-55. 2007
    ..We aimed to investigate the relationship between hsCRP and prognosis in patients with CHF and left ventricular systolic dysfunction (LVSD)...
  85. ncbi request reprint A description of the clinical characteristics at baseline of patients recruited into the Carvedilol or Metoprolol European Trial (COMET)
    John G F Cleland
    University of Hull, Kingston upon Hull, UK
    Cardiovasc Drugs Ther 18:139-52. 2004
    ..The purpose of this report is to describe in greater detail the heterogeneity of this population at baseline with particular reference to the impact of symptomatic severity, age and gender on patient characteristics...
  86. doi request reprint The prevalence and incidence of left bundle branch block in ambulant patients with chronic heart failure
    Andrew L Clark
    Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, Hull, UK HU16 5JQ, UK
    Eur J Heart Fail 10:696-702. 2008
    ..Approximately one third of patients with chronic heart failure have left bundle branch block (LBBB) on their 12-lead ECG...
  87. ncbi request reprint A comparison of patient and physician-rated New York Heart Association class in a community-based heart failure clinic
    Kevin M Goode
    Department of Cardiology, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    J Card Fail 14:379-87. 2008
    ..Patient-rated NYHA (Pa-NYHA) and physician-rated NYHA (Dr-NYHA) class have never been compared directly, and it is unknown whether they carry similar prognostic significance...
  88. ncbi request reprint The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure
    Lee Ingle
    Department of Academic Cardiology, Castle Hill Hospital, Castle Road, Cottingham, Hull HU16 5JQ, UK
    Eur Heart J 26:1742-51. 2005
    ....
  89. ncbi request reprint Prognostic value of the VE/VCO2 slope calculated from different time intervals in patients with suspected heart failure
    Lee Ingle
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, United Kingdom
    Int J Cardiol 118:350-5. 2007
    ..The prognostic usefulness of submaximal exercise testing is not clear. The aim of the present study was to assess the prognostic value of the V(E)/V(CO(2)) slope when derived from data acquired from submaximal exercise...
  90. ncbi request reprint New generation 3-dimensional echocardiography for left ventricular volumetric and functional measurements: comparison with cardiac magnetic resonance
    Nikolay P Nikitin
    Department of Cardiology, Academic Unit, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur J Echocardiogr 7:365-72. 2006
    ....
  91. ncbi request reprint Left ventricular morphology, global and longitudinal function in normal older individuals: a cardiac magnetic resonance study
    Nikolay P Nikitin
    Academic Department of Cardiology, The University of Hull, Castle Hill Hospital, Castle Road, Cottingham, Kingston upon Hull, HU16 5JQ United Kingdom
    Int J Cardiol 108:76-83. 2006
    ..This study was designed to assess left ventricular (LV) morphology, global and longitudinal function in healthy older men and women using cardiac magnetic resonance (CMR)...
  92. ncbi request reprint Clinical trials update from the European Society of Cardiology heart failure meeting: TNT subgroup analysis, darbepoetin alfa, FERRIC-HF and KW-3902
    Alison P Coletta
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 8:547-9. 2006
    ..In a combined analysis of two studies (n=186), the adenosine A(1) receptor antagonist KW-3902 showed diuretic properties and appeared to enhance response to loop diuretics in heart failure patients hospitalised with fluid overload...
  93. ncbi request reprint Comprehensive adrenergic receptor blockade with carvedilol is superior to beta-1-selective blockade with metoprolol in patients with heart failure: COMET
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Kingston upon Hull, United Kingdom
    Curr Heart Fail Rep 1:82-8. 2004
    ..The result of COMET is entirely consistent with the results of previous placebo-controlled trials of beta-1-selective blockers and carvedilol...
  94. ncbi request reprint The effect of ventricular pacing on measurements of left ventricular function: a comparison between echocardiographic methods and with radionuclide ventriculography
    Simon D R Thackray
    Department of Academic Cardiology, University of Hull, Castle Hill Hospital, Cottingham, East Yorkshire, UK
    Eur J Echocardiogr 7:284-92. 2006
    ..Different methods exist for measuring left ventricular function echocardiographically; each may be error prone due to the abnormal pattern of ventricular activation during pacing...
  95. ncbi request reprint A method to reduce loss to follow-up in clinical trials: informed, withdrawal of consent
    John G F Cleland
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU15 5JQ, UK
    Eur J Heart Fail 6:1-2. 2004
  96. pmc Clinical trials update from the Heart Failure Society of America and the American Heart Association meetings in 2008: SADHART-CHF, COMPARE, MOMENTUM, thyroid hormone analogue study, HF-ACTION, I-PRESERVE, beta-interferon study, BACH, and ATHENA
    Alison P Coletta
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull HU16 5JQ, UK
    Eur J Heart Fail 11:214-9. 2009
    ..ix) A secondary analysis from ATHENA showed a reduction in cardiovascular hospitalizations and strokes for patients with atrial fibrillation receiving dronedarone compared with placebo...
  97. ncbi request reprint Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM
    Alison P Coletta
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull HU15 5JQ, UK
    Eur J Heart Fail 5:697-704. 2003
    ..The ESTEEM study showed that the oral thrombin inhibitor ximelagatran plus aspirin was more effective than aspirin alone in the prophylaxis of major cardiovascular events following MI...
  98. ncbi request reprint Color tissue Doppler-derived long-axis left ventricular function in heart failure with preserved global systolic function
    Nikolay P Nikitin
    Department of Cardiology, Academic Unit, University of Hull School of Medicine, Castle Hill Hospital, Kingston upon Hull HU16 5JQ, UK
    Am J Cardiol 90:1174-7. 2002
  99. ncbi request reprint Longitudinal ventricular function: normal values of atrioventricular annular and myocardial velocities measured with quantitative two-dimensional color Doppler tissue imaging
    Nikolay P Nikitin
    Department of Cardiology, University of Hull School of Medicine, Cottingham, Kingston upon Hull, United Kingdom
    J Am Soc Echocardiogr 16:906-21. 2003
    ..The aim of this study was to obtain normal values for atrioventricular annular and regional myocardial velocities using this method...
  100. doi request reprint Clinical trials update from Heart Rhythm 2008 and Heart Failure 2008: ATHENA, URGENT, INH study, HEART and CK-1827452
    Alison P Coletta
    Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston upon Hull, HU16 5JQ, UK
    Eur J Heart Fail 10:917-20. 2008
    ..The selective myosin activator CK-1827452 produced a concentration dependent increase in systolic ejection time, stroke volume and fractional shortening in patients with heart failure compared to placebo...
  101. ncbi request reprint Beta-blockers for heart failure: why, which, when, and where
    John G F Cleland
    Department of Cardiology, University of Hull, Kingston upon Hull, United Kingdom
    Med Clin North Am 87:339-71. 2003
    ..It is unclear whether the target doses of beta-blockers currently recommended are optimal...