Karl P Claxton

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi request reprint Exploring uncertainty in cost-effectiveness analysis
    Karl Claxton
    Centre for Health Economics, Department of Economics and NICE Decision Support Unit, University of York, Heslington, York, UK
    Pharmacoeconomics 26:781-98. 2008
  2. pmc Value based pricing for NHS drugs: an opportunity not to be missed?
    Karl Claxton
    Centre for Health Economics, University of York, York
    BMJ 336:251-4. 2008
  3. ncbi request reprint A dynamic programming approach to the efficient design of clinical trials
    K Claxton
    Department of Economics, University of York, Heslington, UK
    J Health Econ 20:797-822. 2001
  4. doi request reprint Identifying research priorities: the value of information associated with repeat screening for age-related macular degeneration
    Laura Bojke
    Centre for Health Economics, University of York, York, United Kingdom
    Med Decis Making 28:33-43. 2008
  5. doi request reprint Discounting and decision making in the economic evaluation of health-care technologies
    Karl Claxton
    Centre for Health Economics, University of York, UK
    Health Econ 20:2-15. 2011
  6. ncbi request reprint Using value of information analysis to prioritise health research: some lessons from recent UK experience
    Karl P Claxton
    Centre for Health Economics, University of York, York, England
    Pharmacoeconomics 24:1055-68. 2006
  7. ncbi request reprint A rational framework for decision making by the National Institute For Clinical Excellence (NICE)
    Karl Claxton
    Department of Economics and Related Studies, University of York, Heslington, York, UK
    Lancet 360:711-5. 2002
  8. pmc Rights, responsibilities and NICE: a rejoinder to Harris
    Karl Claxton
    Centre for Health Economics, University of York, Heslington, York, UK
    J Med Ethics 33:462-4. 2007
  9. doi request reprint Cost-effectiveness of enhanced external counterpulsation (EECP) for the treatment of stable angina in the United Kingdom
    Claire McKenna
    Centre for Health Economics, University of York, Heslington, York, United Kingdom
    Int J Technol Assess Health Care 26:175-82. 2010
  10. ncbi request reprint Using value of information analysis to inform publicly funded research priorities
    Laura Ginnelly
    Centre for Health Economics, University of York, York, UK
    Appl Health Econ Health Policy 4:37-46. 2005

Detail Information

Publications33

  1. ncbi request reprint Exploring uncertainty in cost-effectiveness analysis
    Karl Claxton
    Centre for Health Economics, Department of Economics and NICE Decision Support Unit, University of York, Heslington, York, UK
    Pharmacoeconomics 26:781-98. 2008
    ..measures of uncertainty should be used to present the results to decision makers; and (v) should formal methods be recommended to inform the assessment of the need for evidence and the consequences of an uncertain decision for the UK NHS?..
  2. pmc Value based pricing for NHS drugs: an opportunity not to be missed?
    Karl Claxton
    Centre for Health Economics, University of York, York
    BMJ 336:251-4. 2008
  3. ncbi request reprint A dynamic programming approach to the efficient design of clinical trials
    K Claxton
    Department of Economics, University of York, Heslington, UK
    J Health Econ 20:797-822. 2001
    ..Bayesian decision theory can provide a general methodological framework that can ensure consistency in decision making between service provision, research and development, and the design, conduct and interpretation clinical research...
  4. doi request reprint Identifying research priorities: the value of information associated with repeat screening for age-related macular degeneration
    Laura Bojke
    Centre for Health Economics, University of York, York, United Kingdom
    Med Decis Making 28:33-43. 2008
    ..This case study also illustrates the need to account for any structural uncertainties appropriately...
  5. doi request reprint Discounting and decision making in the economic evaluation of health-care technologies
    Karl Claxton
    Centre for Health Economics, University of York, UK
    Health Econ 20:2-15. 2011
    ....
  6. ncbi request reprint Using value of information analysis to prioritise health research: some lessons from recent UK experience
    Karl P Claxton
    Centre for Health Economics, University of York, York, England
    Pharmacoeconomics 24:1055-68. 2006
    ....
  7. ncbi request reprint A rational framework for decision making by the National Institute For Clinical Excellence (NICE)
    Karl Claxton
    Department of Economics and Related Studies, University of York, Heslington, York, UK
    Lancet 360:711-5. 2002
    ..Additionally, the analysis can be used to aid the efficient design of research. We discuss the implications of adoption of this new framework for regulatory and reimbursement decisions...
  8. pmc Rights, responsibilities and NICE: a rejoinder to Harris
    Karl Claxton
    Centre for Health Economics, University of York, Heslington, York, UK
    J Med Ethics 33:462-4. 2007
    ..Such comparisons do indeed have to be made, but this is not a consequence of the choice of any particular outcome measure, be it the QALY or anything else...
  9. doi request reprint Cost-effectiveness of enhanced external counterpulsation (EECP) for the treatment of stable angina in the United Kingdom
    Claire McKenna
    Centre for Health Economics, University of York, Heslington, York, United Kingdom
    Int J Technol Assess Health Care 26:175-82. 2010
    ....
  10. ncbi request reprint Using value of information analysis to inform publicly funded research priorities
    Laura Ginnelly
    Centre for Health Economics, University of York, York, UK
    Appl Health Econ Health Policy 4:37-46. 2005
    ..The case study presented considers whether long-term, low-dose antibacterial treatment of recurrent urinary tract infections (UTIs) in children is effective and cost effective compared with short-term antibacterial therapy...
  11. doi request reprint The half-life of truth: what are appropriate time horizons for research decisions?
    Zoe Philips
    Centre for Health Economics, University of York, York, YO10 5DD corrected UK corrected
    Med Decis Making 28:287-99. 2008
    ..To evaluate alternative approaches taken to estimate the population that could benefit from research and to demonstrate that explicitly modeling future change leads to more appropriate estimates of the expected value of information (EVI)...
  12. ncbi request reprint Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis
    Elisabeth Fenwick
    Centre for Health Economics, IRISS, University of York, Heslington, York, YO10 5DD, UK
    Intensive Care Med 28:599-608. 2002
    ..To compare the cost and cost-effectiveness of a policy of pre-operative optimisation of oxygen delivery (using either adrenaline or dopexamine) to reduce the risk associated with major elective surgery, in high-risk patients...
  13. doi request reprint Decision analysis for resource allocation in health care
    Susan Griffin
    Centre for Health Economics, University of York, York, UK
    J Health Serv Res Policy 13:23-30. 2008
    ..The paper concludes by describing ongoing methodological work designed to meet the challenges of undertaking decision analysis for resource allocation in health care...
  14. doi request reprint Characterizing structural uncertainty in decision analytic models: a review and application of methods
    Laura Bojke
    Centre for Health Economics, University of York, York, UK
    Value Health 12:739-49. 2009
    ..These have been classified in a number of different ways but can be referred to collectively as structural uncertainties...
  15. pmc Value for money and the Quality and Outcomes Framework in primary care in the UK NHS
    Simon Walker
    Centre for Health Economics, University of York, Heslington, York, UK
    Br J Gen Pract 60:e213-20. 2010
    ..Despite its achievements, there are concerns that the QOF may offer poor value for money...
  16. doi request reprint Budgetary policies and available actions: a generalisation of decision rules for allocation and research decisions
    Claire McKenna
    Centre for Health Economics, University of York, Heslington, York YO10 5DD, United Kingdom
    J Health Econ 29:170-81. 2010
    ....
  17. doi request reprint Exploring the research decision space: the expected value of information for sequential research designs
    Susan Griffin
    Centre for Health Economics, University of York, York, United Kingdom
    Med Decis Making 30:155-62. 2010
    ..To investigate the expected value of partial perfect information (EVPPI) and the research decisions it can address...
  18. doi request reprint Eliciting distributions to populate decision analytic models
    Laura Bojke
    Centre for Health Economics, University of York, York, UK
    Value Health 13:557-64. 2010
    ..Elicitation can be used to characterize structural uncertainty within a decision analytic model. This allows the value of acquiring further evidence to resolve these uncertainties to be established...
  19. doi request reprint Methods for assessing the cost-effectiveness of public health interventions: key challenges and recommendations
    Helen Weatherly
    Centre for Health Economics, University of York, United Kingdom
    Health Policy 93:85-92. 2009
    ..In contrast, the economic evaluation of public health interventions raises additional methodological challenges. The paper identifies these challenges and provides suggestions for overcoming them...
  20. ncbi request reprint OFT, VBP: QED?
    Karl Claxton
    Department of Economics and Related Studies and Centre for Health Economics, University of York, York, UK
    Health Econ 16:545-58. 2007
    ..Whatever view is taken, the OFT report will inevitably shape the scope of future policy debates about value, guidance, price and innovation...
  21. ncbi request reprint Establishing the cost-effectiveness of new pharmaceuticals under conditions of uncertainty--when is there sufficient evidence?
    Mark Sculpher
    Centre for Health Economics, University of York, York, UK
    Value Health 8:433-46. 2005
    ....
  22. ncbi request reprint Discounting and cost-effectiveness in NICE - stepping back to sort out a confusion
    Karl Claxton
    NICE Task Group on Economics, UK
    Health Econ 15:1-4. 2006
    ..Nor does it reflect the debate that underpinned the guidance. We therefore welcome the opportunity to explain more completely the rationale in the minds of the principal authors of the current guidance...
  23. ncbi request reprint Evidence synthesis, parameter correlation and probabilistic sensitivity analysis
    A E Ades
    MRC Health Services Collaboration, Canynge Hall, England, UK
    Health Econ 15:373-81. 2006
    ..It follows that, if health technology assessments are to be based on a correct analysis of all available data, then probabilistic methods must be used both for sensitivity analysis and for estimation of expected costs and benefits...
  24. ncbi request reprint Whither trial-based economic evaluation for health care decision making?
    Mark J Sculpher
    Centre for Health Economics, University of York, UK
    Health Econ 15:677-87. 2006
    ..It is argued that RCT evidence, with or without economic content, should be viewed as simply one of the sources of evidence, which must be placed in a broader framework of evidence synthesis and decision analysis...
  25. ncbi request reprint Comprehensive decision-analytic model and Bayesian value-of-information analysis: pentoxifylline in the treatment of chronic venous leg ulcers
    Cynthia P Iglesias
    Department of Health Sciences, University of York, York, UK
    Pharmacoeconomics 24:465-78. 2006
    ..To conduct a Bayesian value-of-information analysis of the cost effectiveness of pentoxifylline (vs placebo) as an adjunct to compression for venous leg ulcers...
  26. ncbi request reprint Probabilistic analysis and computationally expensive models: Necessary and required?
    Susan Griffin
    Center for Health Economics, University of York, York, UK
    Value Health 9:244-52. 2006
    ....
  27. ncbi request reprint An iterative Bayesian approach to health technology assessment: application to a policy of preoperative optimization for patients undergoing major elective surgery
    Elisabeth Fenwick
    Department of Economics and Related Studies, University of York, York, United Kingdom
    Med Decis Making 26:480-96. 2006
    ..Within the article, the framework is applied to a policy decision regarding preoperative patient management before major elective surgery, for which trial data are available...
  28. ncbi request reprint Probabilistic sensitivity analysis for NICE technology assessment: not an optional extra
    Karl Claxton
    Centre for Health Economics, Department of Economics and Related Studies, University of York, UK
    Health Econ 14:339-47. 2005
    ..Finally, some of the methodological challenges posed by the need fully to characterise decision uncertainty and to inform the research agenda will be identified and discussed...
  29. ncbi request reprint Efficiency, equity, and budgetary policies: informing decisions using mathematical programming
    David M Epstein
    Centre for Health Economics, University of York, York, UK
    Med Decis Making 27:128-37. 2007
    ..They apply this framework of analysis to a realistic and policy-relevant problem...
  30. doi request reprint Dangerous omissions: the consequences of ignoring decision uncertainty
    Susan C Griffin
    Centre for Health Economics, University of York, UK
    Health Econ 20:212-24. 2011
    ..However, decisions based solely on expected net benefit provide no such incentives, may undermine the evidence base for future clinical practice and reduce expected net health benefits for the patient population...
  31. doi request reprint Dimensions of design space: a decision-theoretic approach to optimal research design
    Stefano Conti
    Centre for Health Economics, University of York, York, UK
    Med Decis Making 29:643-60. 2009
    ..The computational challenges are addressed by implementing optimization algorithms to search the ENBS surface more efficiently over such large dimensions...
  32. ncbi request reprint Searching for a threshold, not setting one: the role of the National Institute for Health and Clinical Excellence
    Anthony Culyer
    Department of Economics and Related Studies, University of York, York, UK
    J Health Serv Res Policy 12:56-8. 2007
    ....
  33. ncbi request reprint When is evidence sufficient?
    Karl Claxton
    University of York, United Kingdom
    Health Aff (Millwood) 24:93-101. 2005
    ..Value-of-information analysis, a related methodology, helps to determine whether it is worthwhile to collect additional information as well as the type of research that would be most helpful...