Research Topics
Genomes and Genes | Robert B ClarkeSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosisRobert B Clarke
Breast Biology Group, Clinical Research Department, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK
Breast Cancer Res 5:162-3. 2003
The devil is in the methods: lineage tracing, functional screens and sequencing, hormones, tumour-stroma interactions, and expansion of human breast tumours as xenograftsMaría del Mar Vivanco
CIC bioGUNECell Biology and Stem Cells UnitParque Tecnológico de Bizkaia, Ed 801A48160 Derio Bizkaia, Spain
Breast Cancer Res 13:316. 2011..The third meeting in this series, held in April-May 2011 in Weggis, Switzerland, focussed on functional screens and sequencing, hormones, lineage tracing, tumor-stroma interactions and the expansion of human breast tumours as xenografts...- It's all in the details: methods in breast development and cancerMohamed Bentires-Alj
Friedrich Miescher Institute for Biomedical Research FMI, Maulbeerstr, 66 CH 4058 Basel, Switzerland
Breast Cancer Res 11:305. 2009.... - Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cellsZvia Agur
Institute for Medical Biomathematics, 10 Hate ena St, Bene Ataroth, Israel
Biol Direct 5:20. 2010..Theory, predicting that homeostasis is maintained by a negative feedback on stem cell proliferation, implies a Quorum Sensing mechanism in higher vertebrates... 
Stem cells and tissue homeostasis in mammary glandsRobert B Clarke
Breast Biology Group, University of Manchester, Christie Hospital, Manchester, M20 4BX UK
J Mammary Gland Biol Neoplasia 10:1-3. 2005- Ovarian steroids and the human breast: regulation of stem cells and cell proliferationRobert B Clarke
Breast Biology Group, CR UK Department of Medical Oncology, University of Manchester, Christie Hospital, Manchester, M20 4BX, UK
Maturitas 54:327-34. 2006.... - A putative human breast stem cell population is enriched for steroid receptor-positive cellsRobert B Clarke
Breast Biology Group, Cancer Research UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK
Dev Biol 277:443-56. 2005..The data suggest a model where scattered steroid receptor-positive cells are stem cells that self-renew through asymmetric cell division and generate patches of transit amplifying and differentiated cells... - Steroid receptors in human breast cancerRobert B Clarke
CR UK Department of Medical Oncology, Christie Hospital, Manchester, UK
Trends Endocrinol Metab 15:316-23. 2004..These interactions might explain resistance to endocrine treatments and offer solutions in terms of novel therapeutic targets... - Steroid receptors and proliferation in the human breastRobert B Clarke
Breast Biology Group, Clinical Research Department, Christie Hospital, Manchester M20 4BX, UK
Steroids 68:789-94. 2003..Such hormone sensor cells might secrete positive or negative paracrine/juxtacrine factors dependent on the prevailing E or P concentration to influence the proliferative activity of adjacent ERalpha/PR-negative epithelial cells... - Regulation of human breast epithelial stem cellsRobert B Clarke
Breast Biology Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, UK
Cell Prolif 36:45-58. 2003..ERalpha/PR+ breast cancers exhibit loss of the two key regulators of asymmetric cell division, Musashi-1 and Notch-1 and thus may arise from symmetric division of the ERalpha/PR+ stem cell... - The oestrogen receptor (ER) in normal and abnormal uterine tissueK J Neis
Department of Obstetrics and Gynecology Caritasklinik St Theresia Saarbrücken, Academic Hospital Universität des Saarlandes Rheinstrasse 2, D 66113, Saarbrucken, Germany
Eur J Cancer 36:S30-1. 2000..The ER only disappears when nuclear irregularities occur in cases of adenomatous hyperplasia. In cases of invasive carcinoma, a heterogenous picture is seen which closely correlates with the degree of differentiation... 
Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogenRognvald N Blance
Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom
Cancer Prev Res (Phila) 2:257-64. 2009....- Regulation of breast cancer stem cell activity by signaling through the Notch4 receptorHannah Harrison
Breast Biology Group, School of Cancer, Enabling Sciences and Technology, Paterson Institute for Cancer Research, University of Manchester, Manchester Academic Health Sciences Centre, The Christie NHS Foundation Trust Department of Medical Oncology, the Christie NHS Foundation Trust, Manchester M20 4BX, United Kingdom
Cancer Res 70:709-18. 2010..Our findings suggest that Notch4-targeted therapies will be more effective than targeting Notch1 in suppressing breast cancer recurrence, as it is initiated by breast cancer stem cells... - Breast cancer stem cells: something out of notching?Hannah Harrison
Breast Biology Group, School of Cancer and enabling Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, United Kingdom
Cancer Res 70:8973-6. 2010.... - Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicitySacha J Howell
Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Breast Cancer Res 10:R68. 2008..We examined the effects of the 'pure' prolactin receptor antagonist Delta1-9-G129R-hPrl (Delta1-9) on the breast cancer cell number and clonogenicity, alone and in combination with chemotherapy... - Human breast epithelial stem cells and their regulationHelen Kalirai
Breast Biology Group, Division of Cancer Studies, University of Manchester, Christie Hospital, Wilmslow Road, Manchester, M20 4BX, UK
J Pathol 208:7-16. 2006..By understanding the molecular pathways that regulate self-renewal of normal mammary stem cells, it may be possible to target the activation of these pathways in breast tumours... - Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancerFiona M Foster
Faculty of Life Sciences, University of Manchester, Manchester, UK
Breast Cancer Res 11:R41. 2009..Here we examine the levels of IAPs in breast cancer and evaluate whether targeting IAPs can enhance apoptosis in response to growth factor receptor antagonists and TRAIL... - Estrogen deprivation for breast cancer preventionAnthony Howell
CRUK Department of Medical Oncology, Christie Hospital, University of Manchester, UK
Recent Results Cancer Res 174:151-67. 2007..It may be possible to increase effectiveness of ED by additional preventive agents or by lifestyle alterations... - Origins of breast cancer subtypes and therapeutic implicationsAndrew H Sims
Breast Biology Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
Nat Clin Pract Oncol 4:516-25. 2007..Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies... - Mammary stem cells and breast cancer--role of Notch signallingGillian Farnie
Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK
Stem Cell Rev 3:169-75. 2007.... - Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivoFredrik Warnberg
Breast Biology Group, Christie Hospital NHS Trust, Manchester, UK
Breast Cancer Res 8:R21. 2006..Effects on tumour xenografts and human ductal carcinoma in situ (DCIS) of the breast in a xenograft mouse model were also tested... - Biomarkers of dietary energy restriction in women at increased risk of breast cancerKai Ren Ong
Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom
Cancer Prev Res (Phila) 2:720-31. 2009..We conclude that reduced expressions of genes in the lipid metabolism and glycolytic pathways are detectable in breast tissue following DER, and these may represent targets for DER mimetics as effective chemoprophylactic agents... - Breast cancer stem cells and their role in resistance to endocrine therapyCiara S O'Brien
School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, M20 4BX, UK
Horm Cancer 2:91-103. 2011.... - Resistance to endocrine therapy: are breast cancer stem cells the culprits?Ciara S O'Brien
Breast Biology Group, School of Cancer and Imaging Sciences, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK
J Mammary Gland Biol Neoplasia 14:45-54. 2009.... - Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathwaysGillian Farnie
Department of Surgery and Breast Biology Group, Division of Cancer Studies, Faculty of Medicine and Human Sciences, University of Manchester, Christie Hospital NHS Trust, Wilmslow Road, M20 9BX, Manchester, UK
J Natl Cancer Inst 99:616-27. 2007..We investigated the involvement of these signaling pathways in ductal carcinoma in situ (DCIS) of the breast... - Steroid receptors and cell cycle in normal mammary epitheliumElizabeth Anderson
Christie Hospital NHS Trust, Manchester, UK
J Mammary Gland Biol Neoplasia 9:3-13. 2004..Answering these questions could greatly increase our understanding of the factors controlling mammary gland development and the processes leading to cancer formation... - Stem cells in breast tumours: are they ready for the clinic?Matthew P Ablett
Breast Biology Group, School of Cancer and enabling Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK
Eur J Cancer 48:2104-16. 2012..This is likely to be demanding but feasible in the near future. Thus, we asked if CSCs are ready for the clinic, however, the emerging question becomes: is the clinic ready for cancer stem cells?.. - A detailed mammosphere assay protocol for the quantification of breast stem cell activityFrances L Shaw
Breast Biology Group, School of Cancer and enabling Sciences, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow Road, Manchester, UK
J Mammary Gland Biol Neoplasia 17:111-7. 2012..We describe here a detailed mammosphere assay protocol for the assessment of stem cell activity and self-renewal, and discuss how data generated by the assay can be analysed and interpreted... - High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?Andrew H Sims
Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK
Breast Cancer Res 8:214. 2006..Gene expression profiling is beginning to appear in the breast cancer clinic but it is not yet fully evaluated. This review explores the questions that must be addressed before this technology can become an everyday clinical tool... - The origin of estrogen receptor alpha-positive and alpha-negative breast cancerRobert B Clarke
Breast Biology Group, Division of Cancer Studies, University of Manchester Christie Hospital (NHS) Trust, Manchester, UK
Adv Exp Med Biol 617:79-86. 2008 - Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactionsAnthony Howell
Dept of Medical Oncology, University of Manchester, Christie Hospital, Withington, UK
Nat Clin Pract Oncol 2:635-46. 2005..New approaches are required, however, not only to prevent the disease but to devise methods for their assessment that do not require very large and expensive clinical trials... - Do early premalignant changes in normal breast epithelial cells predict cancer development?Robert B Clarke
CR UK Department of Medical Oncology, University of Manchester, Christie Hospital NHS Trust, Manchester, UK
Breast Cancer Res 7:18-20. 2005.... - The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancerDaniel G Hayward
Department of Biochemistry, University of Leicester, Leicester, USA
Cancer Res 64:7370-6. 2004..These data highlight the Nek2 kinase as novel potential target for chemotherapeutic intervention in breast cancer... - The mammary gland "side population": a putative stem/progenitor cell marker?Matthew J Smalley
The Breakthrough Breast Cancer Centre, The Institute of Cancer Research, London, United Kingdom
J Mammary Gland Biol Neoplasia 10:37-47. 2005..However, evidence that the SP is enriched for stem cells is, at the moment, only correlative, and there are potentially confounding technical issues. We still await formal proof that the SP contains a stem cell population...