R Clarke

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    PLoS Med 9:e1001177. 2012
  2. ncbi A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]
    Alan D Dangour
    Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Nutr J 10:22. 2011
  3. ncbi Variability and determinants of total homocysteine concentrations in plasma in an elderly population
    R Clarke
    Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, UK
    Clin Chem 44:102-7. 1998
  4. ncbi Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia
    Robert Clarke
    J Intern Med 254:67-75. 2003
  5. ncbi Plasma phospholipid fatty acids and CHD in older men: Whitehall study of London civil servants
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX37LF, UK
    Br J Nutr 102:279-84. 2009
  6. ncbi Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Br J Nutr 100:1054-9. 2008
  7. ncbi Biomarkers of inflammation predict both vascular and non-vascular mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Eur Heart J 29:800-9. 2008
  8. ncbi Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis
    R Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Clin Chem Lab Med 45:1575-81. 2007
  9. ncbi Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
  10. ncbi Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, England
    Arch Intern Med 167:1373-8. 2007

Collaborators

Detail Information

Publications73

  1. ncbi Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Oxford, UK
    PLoS Med 9:e1001177. 2012
    ....
  2. ncbi A randomised controlled trial investigating the effect of vitamin B12 supplementation on neurological function in healthy older people: the Older People and Enhanced Neurological function (OPEN) study protocol [ISRCTN54195799]
    Alan D Dangour
    Department of Nutrition and Public Health Intervention Research, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Nutr J 10:22. 2011
    ....
  3. ncbi Variability and determinants of total homocysteine concentrations in plasma in an elderly population
    R Clarke
    Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, UK
    Clin Chem 44:102-7. 1998
    ..7 and 10.6 vs 9.6 micromol/L). Epidemiological studies based on single tHcy measurements may underestimate the magnitude of any risk associations with disease by 10-15%...
  4. ncbi Effect of vitamins and aspirin on markers of platelet activation, oxidative stress and homocysteine in people at high risk of dementia
    Robert Clarke
    J Intern Med 254:67-75. 2003
    ....
  5. ncbi Plasma phospholipid fatty acids and CHD in older men: Whitehall study of London civil servants
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX37LF, UK
    Br J Nutr 102:279-84. 2009
    ....
  6. ncbi Folate and vitamin B12 status in relation to cognitive impairment and anaemia in the setting of voluntary fortification in the UK
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Br J Nutr 100:1054-9. 2008
    ..88)). There was no evidence of modification by high folate status of the associations of low B12 with anaemia or cognitive impairment in the setting of voluntary fortification, but periodic surveys are needed to monitor fortification...
  7. ncbi Biomarkers of inflammation predict both vascular and non-vascular mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Eur Heart J 29:800-9. 2008
    ..To compare the predictive value of inflammatory biomarkers and lipids for vascular and non-vascular mortality in older men...
  8. ncbi Homocysteine-lowering trials for prevention of vascular disease: protocol for a collaborative meta-analysis
    R Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Clin Chem Lab Med 45:1575-81. 2007
    ....
  9. ncbi Low vitamin B-12 status and risk of cognitive decline in older adults
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 86:1384-91. 2007
    ..Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline...
  10. ncbi Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, England
    Arch Intern Med 167:1373-8. 2007
    ..The relevance of blood lipid levels as risk factors for ischemic heart disease (IHD) in older people is uncertain; hence, cholesterol-lowering therapy is not routinely prescribed in older populations...
  11. ncbi Survival in relation to angina symptoms and diagnosis among men aged 70-90 years: the Whitehall Study
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    Eur J Cardiovasc Prev Rehabil 14:280-6. 2007
    ....
  12. ncbi Homocysteine and coronary heart disease
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, University of Oxford, Oxford, United Kingdom
    Semin Vasc Med 2:391-9. 2002
    ..Large-scale clinical trials of folic acid-based vitamin supplements are currently in progress to test whether lowering blood homocysteine levels can reduce the risks of CHD and stroke...
  13. ncbi Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Clin Chem 53:963-70. 2007
    ..Concentrations of this active component, carried on holotranscobalamin (holoTC), may be of greater relevance than total vitamin B(12)...
  14. ncbi Lymphotoxin-alpha gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study
    Robert Clarke
    Clinical Trial Service Unit, Old Road Campus, Oxford, United Kingdom
    PLoS Genet 2:e107. 2006
    ..Overall, these studies provide reliable evidence that these common polymorphisms for the LTA gene are not strongly associated with susceptibility to coronary disease...
  15. ncbi Life expectancy in relation to cardiovascular risk factors: 38 year follow-up of 19,000 men in the Whitehall study
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Richard Doll Building, University of Oxford, Oxford OX3 7LF
    BMJ 339:b3513. 2009
    ..To assess life expectancy in relation to cardiovascular risk factors recorded in middle age...
  16. ncbi Screening for vitamin B-12 and folate deficiency in older persons
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 77:1241-7. 2003
    ..Folate deficiency also results in elevated tHcy. Measurement of these metabolites can be used to screen for functional vitamin B-12 or folate deficiency...
  17. ncbi Assessment of homocysteine as a cardiovascular risk factor in clinical practice
    R Clarke
    Clinical Trial Service Unit, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK
    Ann Clin Biochem 38:624-32. 2001
    ....
  18. ncbi Commentary: an updated review of the published studies of homocysteine and cardiovascular disease
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, Radcliffe Infirmary, Oxford, England
    Int J Epidemiol 31:70-1. 2002
  19. ncbi Vitamin supplements and cardiovascular risk: review of the randomized trials of homocysteine-lowering vitamin supplements
    R Clarke
    Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, England
    Semin Thromb Hemost 26:341-8. 2000
    ..Large-scale randomized trials of such regimens are now required to determine whether lowering homocysteine levels by folic acid and vitamin B12, with or without added vitamin B6, reduces the risk of vascular disease...
  20. ncbi Vitamin B12 and folate deficiency in later life
    Robert Clarke
    Clinical Trial Service Unit Division of Clinical Geratology University Department of Pharmacology, University of Oxford, Oxford, UK
    Age Ageing 33:34-41. 2004
    ..to examine the prevalence of vitamin B12 deficiency and folate deficiency in later life in representative samples of the elderly population in the United Kingdom...
  21. ncbi Homocysteine and vascular disease: review of published results of the homocysteine-lowering trials
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Richard Doll Building, Oxford, UK
    J Inherit Metab Dis 34:83-91. 2011
    ..However, available evidence does not support the routine use of B vitamins to prevent cardiovascular disease...
  22. ncbi Antioxidant vitamins and risk of cardiovascular disease. Review of large-scale randomised trials
    Robert Clarke
    Clinical Trial Service Unit, Radcliffe Infirmary, Oxford OX2 6HE, UK
    Cardiovasc Drugs Ther 16:411-5. 2002
    ..The results of these trials have been disappointing and failed to confirm any protective effect of these vitamins for either cancer or for cardiovascular disease...
  23. ncbi Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals
    Robert Clarke
    University of Oxford, England
    Arch Intern Med 170:1622-31. 2010
    ..Dietary supplementation with folic acid to lower homocysteine levels had no significant effects within 5 years on cardiovascular events or on overall cancer or mortality in the populations studied...
  24. ncbi Genetic variants associated with Lp(a) lipoprotein level and coronary disease
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
    N Engl J Med 361:2518-28. 2009
    ..The genetic determinants of the Lp(a) lipoprotein level and their relevance for the risk of coronary disease are incompletely understood...
  25. ncbi Effects of B-vitamins on plasma homocysteine concentrations and on risk of cardiovascular disease and dementia
    Robert Clarke
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Curr Opin Clin Nutr Metab Care 10:32-9. 2007
    ..Dietary supplementation with folic acid and vitamin B12 lowers blood homocysteine concentrations, but it is not known if this reduces the risk of coronary heart disease and stroke...
  26. ncbi Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies
    R Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU, Nuffield Department of Clinical Medicine, University of Oxford, UK
    J Cardiovasc Risk 8:363-9. 2001
    ..Failure to correct for increasing regression dilution using lower RDRs for longer follow-up may underestimate the relative risks of cardiovascular disease associated with tHcy by about one-fifth after 2 years and one-half after 10 years...
  27. ncbi Underestimation of the importance of blood pressure and cholesterol for coronary heart disease mortality in old age
    R Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, UK
    Eur Heart J 23:286-93. 2002
    ....
  28. ncbi B-vitamins and prevention of dementia
    Robert Clarke
    Clinical Trial Service Unit, Richard Doll Building, University of Oxford, Oxford OX3 7LF, UK
    Proc Nutr Soc 67:75-81. 2008
    ..The principal investigators of such trials have agreed to combine individual-participant data from their trials after their separate publication...
  29. ncbi Absence of relationship between MTTP haplotypes and longevity
    Matt J Neville
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, UK
    J Gerontol A Biol Sci Med Sci 62:202-5. 2007
    ..However, the association of MTTP with longevity has been contested in a large German collection of nonagenarians and centenarians...
  30. ncbi Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial
    Jane Armitage
    SEARCH Study, Clinical Trial Service Unit and Epidemiological Studies Unit, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford OX3 7LF, UK
    Lancet 376:1658-69. 2010
    ..We aimed to establish efficacy and safety of more intensive statin treatment in patients at high cardiovascular risk...
  31. ncbi Homocysteine-lowering trials for prevention of heart disease and stroke
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Radcliffe Infirmary, Oxford, England
    Semin Vasc Med 5:215-22. 2005
    ..A metaanalysis of these trials should have adequate power to determine whether homocysteine-lowering vitamin supplements can reduce the risk of cardiovascular disease...
  32. ncbi The exon 1-8C/G SNP in the PSMA6 gene contributes only a small amount to the burden of myocardial infarction in 6946 cases and 2720 controls from a United Kingdom population
    Derrick A Bennett
    Clinical Trial Service Unit, University of Oxford, Oxford, UK
    Eur J Hum Genet 16:480-6. 2008
    ..However, given the rarity of this variant in Caucasians, the attributable risk of rs1048990 for MI is unlikely to be great in western populations...
  33. ncbi Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study
    Jemma C Hopewell
    Clinical Trial Service Unit, University of Oxford, Oxford, England
    Circ Cardiovasc Genet 4:68-73. 2011
    ....
  34. ncbi The joint effects of apolipoprotein B, apolipoprotein A1, LDL cholesterol, and HDL cholesterol on risk: 3510 cases of acute myocardial infarction and 9805 controls
    Sarah Parish
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford OX3 7LF, UK
    Eur Heart J 30:2137-46. 2009
    ..The interdependence of these four risk factors is unclear...
  35. ncbi Utility of TICS-M for the assessment of cognitive function in older adults
    Celeste A de Jager
    Oxford Project to Investigate Memory and Ageing and University Department of Pharmacology, Oxford, UK
    Int J Geriatr Psychiatry 18:318-24. 2003
    ..The Telephone Interview of Cognitive Status is a novel instrument for assessment of cognitive function that can be administered in person or by telephone...
  36. ncbi Cystatin C and risk of vascular and nonvascular mortality: a prospective cohort study of older men
    J R Emberson
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK
    J Intern Med 268:145-54. 2010
    ..To assess the relevance of cystatin C, as a marker of mild-to-moderate renal impairment, for vascular and nonvascular mortality in older people...
  37. ncbi Facts and recommendations about total homocysteine determinations: an expert opinion
    Helga Refsum
    Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
    Clin Chem 50:3-32. 2004
    ....
  38. ncbi Homocysteine, B-vitamins, and the risk of cardiovascular disease
    Robert Clarke
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Radcliffe Infirmary, Oxford, England
    Semin Vasc Med 5:75-6. 2005
  39. ncbi Regression dilution bias in blood total and high-density lipoprotein cholesterol and blood pressure in the Glostrup and Framingham prospective studies
    Sarah Lewington
    Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, UK
    J Cardiovasc Risk 10:143-8. 2003
    ....
  40. ncbi Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p
    Helen M Broadbent
    Department of Cardiovascular Medicine, University of Oxford, UK
    Hum Mol Genet 17:806-14. 2008
    ..A large antisense non-coding RNA gene (ANRIL) collocates with the high-risk haplotype, is expressed in tissues and cell types that are affected by atherosclerosis and is a prime candidate gene for the chromosome 9p CAD locus...
  41. ncbi Cholesterol, coronary heart disease and stroke: a review of published evidence from observational studies and randomized controlled trials
    Rachel Huxley
    Department of Public Health Sciences, University of Oxford, Oxford, England
    Semin Vasc Med 2:315-23. 2002
    ..8 mmol/l (that is by 10 to 15%), with four fifths of this reduction being in LDL cholesterol...
  42. ncbi Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
    Sarah Lewington
    CTSU, University of Oxford, Oxford OX3 7LF, UK
    Lancet 370:1829-39. 2007
    ..This meta-analysis combined prospective studies of vascular mortality that recorded both blood pressure and total cholesterol at baseline, to determine the joint relevance of these two risk factors...
  43. ncbi Genome-wide mapping of susceptibility to coronary artery disease identifies a novel replicated locus on chromosome 17
    Martin Farrall
    Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
    PLoS Genet 2:e72. 2006
    ..The region on Chromosome 17 provides a compelling target within which to identify novel genes underlying CAD. Understanding the genetic aetiology of CAD may lead to novel preventative and/or therapeutic strategies...
  44. ncbi Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  45. ncbi Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial
    Simone J P M Eussen
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Arch Intern Med 165:1167-72. 2005
    ..CONCLUSION: The lowest dose of oral cyanocobalamin required to normalize mild vitamin B(12) deficiency is more than 200 times greater than the recommended dietary allowance, which is approximately 3 mug daily...
  46. ncbi Plasma homocysteine, but not folate or vitamin B-12, predicts mortality in older people in the United Kingdom
    Alan D Dangour
    Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    J Nutr 138:1121-8. 2008
    ..Our results extend previously reported associations of homocysteine with mortality, and the absence of associations of folate and vitamin B-12 with mortality, to the older population...
  47. ncbi Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial
    Renate M Winkels
    Top Institute of Food and Nutrition, Wageningen, Netherlands
    Am J Clin Nutr 88:348-55. 2008
    ..Cofortification of flour with folic acid and vitamin B-12 could simultaneously improve folate and vitamin B-12 status...
  48. ncbi Vitamin B12, folic acid, and the prevention of dementia
    Robert Clarke
    N Engl J Med 354:2817-9. 2006
  49. ncbi MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis
    Mariska Klerk
    Division of Human Nutrition and Epidemiology, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    JAMA 288:2023-31. 2002
    ..The MTHFR 677C-->T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain...
  50. ncbi Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study
    Sarah E Vermeer
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Neurol 51:285-9. 2002
    ..16-1.58). We concluded that total homocysteine levels are associated with silent brain infarcts and white matter lesions independent of each other and of other cardiovascular risk factors...
  51. ncbi Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study
    Harold Hin
    Hightown Surgery, Hightown Gardens, Banbury, UK
    Age Ageing 35:416-22. 2006
    ..Large-scale trials of vitamin B12 supplementation are required to assess the clinical significance of these associations...
  52. ncbi B vitamins for the prevention of vascular disease: insufficient evidence to justify treatment
    Colin Baigent
    JAMA 298:1212-4. 2007
  53. ncbi Effect of oral vitamin B-12 with or without folic acid on cognitive function in older people with mild vitamin B-12 deficiency: a randomized, placebo-controlled trial
    Simone J Eussen
    Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 84:361-70. 2006
    ..CONCLUSION: Oral supplementation with vitamin B-12 alone or in combination with folic acid for 24 wk does not improve cognitive function...
  54. ncbi Cause-specific mortality in old age in relation to body mass index in middle age and in old age: follow-up of the Whitehall cohort of male civil servants
    Elizabeth Breeze
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    Int J Epidemiol 35:169-78. 2006
    ..The relevance of body mass index (BMI) to cause-specific mortality in old age is uncertain...
  55. ncbi Homocysteine and cardiovascular risk: considering the evidence in the context of study design, folate fortification, and statistical power
    Per Magne Ueland
    Clin Chem 53:807-9. 2007
  56. ncbi Homocysteine, B vitamins, and the risk of dementia
    Robert Clarke
    Am J Clin Nutr 85:329-30. 2007
  57. ncbi The A4396G polymorphism in interferon regulatory factor 1 is frequently expressed in breast cancer cell lines
    Kerrie B Bouker
    Lombardi Comprehensive Cancer Center and Department of Oncology, Georgetown University School of Medicine, Washington, DC 20057, USA
    Cancer Genet Cytogenet 175:61-4. 2007
    ..001), leading to a significant difference in genotype distribution between these populations (P = 0.002)...
  58. ncbi Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population
    Angela M Devlin
    Department of Internal Medicine, University of California, Davis, Davis, CA, USA
    Am J Clin Nutr 83:708-13. 2006
    ..Homocysteine concentrations are influenced by vitamin status and genetics, especially several polymorphisms in folate-metabolizing genes...
  59. ncbi The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people
    Simone J P M Eussen
    Division of Human Nutrition, Wageningen University, P O Box 8129 6700 EV Wageningen, The Netherlands
    Br J Nutr 98:960-8. 2007
    ..There was a tendency of participants with the largest increases in betaine concentrations to show the greatest improvement in memory function...
  60. ncbi Meta-analysis of soy intake and breast cancer risk
    Bruce J Trock
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    J Natl Cancer Inst 98:459-71. 2006
    ..Thus, rigorous evaluation of available epidemiologic data is necessary before appropriate recommendations can be made, especially for women at high risk of breast cancer or those who have survived the disease...
  61. ncbi Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies
    Sarah Lewington
    Lancet 360:1903-13. 2002
    ..INTERPRETATION: Throughout middle and old age, usual blood pressure is strongly and directly related to vascular (and overall) mortality, without any evidence of a threshold down to at least 115/75 mm Hg...
  62. ncbi Trans fatty acids and coronary heart disease
    Robert Clarke
    BMJ 333:214. 2006
  63. ncbi A psychosocial risk assessment and management framework to enhance response to CBRN terrorism threats and attacks
    Louise Lemyre
    School of Psychology, Institute of Population Health, McLaughlin Centre, University of Ottawa, Ontario, Canada
    Biosecur Bioterror 3:316-30. 2005
    ....
  64. ncbi Identification of a putative intestinal stem cell and early lineage marker; musashi-1
    Christopher S Potten
    Epithelial Biology Department, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    Differentiation 71:28-41. 2003
    ..These observations suggest that Musashi-1 is a marker of stem and early lineage progenitor cells in murine intestinal tissue...
  65. ncbi Folic acid and reduction of plasma homocysteine concentrations in older adults: a dose-response study
    Floor V A van Oort
    Wageningen Centre for Food Sciences, Wageningen, Netherlands
    Am J Clin Nutr 77:1318-23. 2003
    ..CONCLUSION: In older adults, daily supplementation with folic acid effectively lowers plasma homocysteine concentrations, and a daily dose of approximately 400 micro g is the minimum dose required for adequate homocysteine reduction...
  66. ncbi Dietary modulation of pregnancy estrogen levels and breast cancer risk among female rat offspring
    Leena Hilakivi-Clarke
    Department of Oncology, Lombardi Cancer Center, Washington, DC 20007, USA
    Clin Cancer Res 8:3601-10. 2002
    ....
  67. ncbi Combined effects of systolic blood pressure and total cholesterol on cardiovascular disease risk
    Sarah Lewington
    Circulation 112:3373-4. 2005
  68. ncbi Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial
    Ruth Peters
    Care of the Elderly, Imperial College London, London, UK
    Lancet Neurol 7:683-9. 2008
    ..The Hypertension in the Very Elderly trial (HYVET) was designed to assess the risks and benefits of treatment of hypertension in elderly patients and included an assessment of cognitive function...
  69. ncbi Expression of an estrogen receptor variant lacking exon 3 in derivatives of MCF-7 cells with acquired estrogen independence or tamoxifen resistance
    Feng Han
    Department of Microbiology and Molecular Genetics, 2209 BPS, Michigan State University, East Lansing, Michigan 48824, USA
    J Mol Endocrinol 32:935-45. 2004
    ..They further suggest that the alteration that leads to estrogen independence in LCC1 cells allows for sustained expression of ERDeltaE3, and that additional changes are required to confer tamoxifen resistance to these cells...
  70. ncbi Role of Toll-like receptor-4 in genetic susceptibility to lung injury induced by residual oil fly ash
    Hye Youn Cho
    Department of Environmental Health Sciences, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA
    Physiol Genomics 22:108-17. 2005
    ..Results support an important contribution of genetic background to particle-mediated lung injury, and Tlr4 is a candidate susceptibility gene...
  71. ncbi Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations
    Alida Melse-Boonstra
    Wageningen Centre for Food Sciences and the Division of Human Nutrition, Wageningen University, Wageningen, Netherlands
    Am J Clin Nutr 81:1378-82. 2005
    ..Folic acid supplementation increases the betaine concentration, which indicates that the 2 remethylation pathways are interrelated...
  72. ncbi Evaluation of the technical performance of novel holotranscobalamin (holoTC) assays in a multicenter European demonstration project
    Anne L Morkbak
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem Lab Med 43:1058-64. 2005
    ..The results obtained using the holoTC RIA were similar to those obtained using the holoTC ELISA assay...
  73. ncbi Functionally active estrogen receptor isoform profiles in the breast tumors of African American women are different from the profiles in breast tumors of Caucasian women
    Indra Poola
    Department of Anatomy, Howard University School of Medicine, Washington, DC 20059, USA
    Cancer 94:615-23. 2002
    ..The molecular factors responsible for these tumor characteristics are mostly unknown...