L A Clarke

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction
    L A Clarke
    Department of Rheumatology, Institute of Child Health UCL and Great Ormond Street Hospital NHS Trust, London, UK
    J Thromb Haemost 6:1025-32. 2008
  2. doi request reprint Endothelial injury and repair in systemic vasculitis of the young
    L A Clarke
    Institute of Child Health, University College London and Great Ormond Street Hospital National Health Service Trust, London, UK
    Arthritis Rheum 62:1770-80. 2010
  3. pmc T cell activation profiles in Kawasaki syndrome
    P A Brogan
    Department of Rheumatology, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Clin Exp Immunol 151:267-74. 2008
  4. doi request reprint Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the antiphospholipid syndrome
    Charis Pericleous
    Centre for Rheumatology, Division of Medicine University College London, Rayne Institute, 4 th Floor, Room 422, 5 University Street, London
    Thromb Haemost 109:72-8. 2013
  5. ncbi request reprint Mutation analysis of 19 North American mucopolysaccharidosis type I patients: identification of two additional frequent mutations
    L A Clarke
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Hum Mutat 3:275-82. 1994
  6. ncbi request reprint Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications
    H S Scott
    Department of Chemical Pathology, Women s and Children s Hospital, North Adelaide, Ausralia
    Hum Mutat 6:288-302. 1995
  7. ncbi request reprint Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene
    L A Clarke
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Hum Mol Genet 6:503-11. 1997

Collaborators

  • P A Brogan
  • M J Dillon
  • Charis Pericleous
  • Anisur Rahman
  • David S Latchman
  • David A Isenberg
  • Yiannis Ioannou
  • Ian P Giles
  • H S Scott
  • J J Hopwood
  • C P Morris
  • A Gal
  • S Bunge

Detail Information

Publications7

  1. doi request reprint Quantitative detection of circulating endothelial cells in vasculitis: comparison of flow cytometry and immunomagnetic bead extraction
    L A Clarke
    Department of Rheumatology, Institute of Child Health UCL and Great Ormond Street Hospital NHS Trust, London, UK
    J Thromb Haemost 6:1025-32. 2008
    ..Reports suggest that there is good agreement between these methods for CEC quantification...
  2. doi request reprint Endothelial injury and repair in systemic vasculitis of the young
    L A Clarke
    Institute of Child Health, University College London and Great Ormond Street Hospital National Health Service Trust, London, UK
    Arthritis Rheum 62:1770-80. 2010
    ..The purpose of this study was to assess how indices of endothelial injury and repair change during different stages of disease activity in children with primary systemic vasculitis (PSV)...
  3. pmc T cell activation profiles in Kawasaki syndrome
    P A Brogan
    Department of Rheumatology, Institute of Child Health and Great Ormond St Hospital for Children, London, UK
    Clin Exp Immunol 151:267-74. 2008
    ....
  4. doi request reprint Endothelial microparticle release is stimulated in vitro by purified IgG from patients with the antiphospholipid syndrome
    Charis Pericleous
    Centre for Rheumatology, Division of Medicine University College London, Rayne Institute, 4 th Floor, Room 422, 5 University Street, London
    Thromb Haemost 109:72-8. 2013
    ..3.4% ± 2.0 for HC IgG, p=0.0172). This study therefore demonstrates that purified polyclonal APS-IgG can drive EMP release. We propose that EMP generation may be a useful measure of aPL-mediated pathogenic effects upon EC...
  5. ncbi request reprint Mutation analysis of 19 North American mucopolysaccharidosis type I patients: identification of two additional frequent mutations
    L A Clarke
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Hum Mutat 3:275-82. 1994
    ..These mutations are the most frequent MPS I mutations detected so far after W402X and Q70X. With the definition of these two mutations, a clear picture of the molecular heterogeneity of MPS I is emerging...
  6. ncbi request reprint Molecular genetics of mucopolysaccharidosis type I: diagnostic, clinical, and biological implications
    H S Scott
    Department of Chemical Pathology, Women s and Children s Hospital, North Adelaide, Ausralia
    Hum Mutat 6:288-302. 1995
    ..A complex picture of molecular heterogeneity is emerging, building a valuable database for genotype/phenotype correlation. Mutation analysis is also providing some of the first clues into the structure and function of IDUA...
  7. ncbi request reprint Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene
    L A Clarke
    Department of Medical Genetics, University of British Columbia, Vancouver, Canada
    Hum Mol Genet 6:503-11. 1997
    ..This model should permit detailed evaluation of the pathophysiology of lysosomal storage disorders and provide a small animal model for the testing and development of enzyme replacement and gene therapy regimes...