C E Clarke

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. ncbi request reprint Rasagiline for motor complications in Parkinson's disease
    Carl E Clarke
    University of Birmingham and Department of Neurology, City Hospital, Birmingham B18 7QH, UK
    Lancet 365:914-6. 2005
  2. doi request reprint Comparison of speech and language therapy techniques for speech problems in Parkinson's disease
    Clare P Herd
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Birmingham, UK
    Cochrane Database Syst Rev 8:CD002814. 2012
  3. doi request reprint Speech and language therapy versus placebo or no intervention for speech problems in Parkinson's disease
    Clare P Herd
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Birmingham, UK
    Cochrane Database Syst Rev 8:CD002812. 2012
  4. ncbi request reprint Neuroprotection and pharmacotherapy for motor symptoms in Parkinson's disease
    Carl E Clarke
    University of Birmingham, UK
    Lancet Neurol 3:466-74. 2004
  5. pmc Ability of a nurse specialist to diagnose simple headache disorders compared with consultant neurologists
    C E Clarke
    Academic Department of Neurology, University of Birmingham and Department of Neurology, Sandwell, UK
    J Neurol Neurosurg Psychiatry 76:1170-2. 2005
  6. pmc Systematic review of acute levodopa and apomorphine challenge tests in the diagnosis of idiopathic Parkinson's disease
    C E Clarke
    Department of Neurology, City Hospital NHS Trust, Birmingham B18 7QH, UK
    J Neurol Neurosurg Psychiatry 69:590-4. 2000
  7. doi request reprint Are delayed-start design trials to show neuroprotection in Parkinson's disease fundamentally flawed?
    Carl E Clarke
    Department of Neurology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom
    Mov Disord 23:784-9. 2008
  8. doi request reprint Pilot randomised controlled trial of occupational therapy to optimise independence in Parkinson's disease: the PD OT trial
    C E Clarke
    Department of Neurology, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    J Neurol Neurosurg Psychiatry 80:976-8. 2009
  9. doi request reprint Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease
    Carl E Clarke
    Department of Neurology, City Hospital, Birmingham, UK
    Parkinsonism Relat Disord 15:728-41. 2009
  10. doi request reprint Imaging results in a consecutive series of 530 new patients in the Birmingham Headache Service
    C E Clarke
    School of Clinical and Experimental Medicine, College of Medicine and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Neurol 257:1274-8. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Rasagiline for motor complications in Parkinson's disease
    Carl E Clarke
    University of Birmingham and Department of Neurology, City Hospital, Birmingham B18 7QH, UK
    Lancet 365:914-6. 2005
  2. doi request reprint Comparison of speech and language therapy techniques for speech problems in Parkinson's disease
    Clare P Herd
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Birmingham, UK
    Cochrane Database Syst Rev 8:CD002814. 2012
    ..Speech and language therapy (SLT) aims to improve the intelligibility of speech with behavioural treatment techniques or instrumental aids...
  3. doi request reprint Speech and language therapy versus placebo or no intervention for speech problems in Parkinson's disease
    Clare P Herd
    School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, Birmingham, UK
    Cochrane Database Syst Rev 8:CD002812. 2012
    ..These symptoms increase in frequency and intensity with progression of the disease). Speech and language therapy (SLT) aims to improve the intelligibility of speech with behavioural treatment techniques or instrumental aids...
  4. ncbi request reprint Neuroprotection and pharmacotherapy for motor symptoms in Parkinson's disease
    Carl E Clarke
    University of Birmingham, UK
    Lancet Neurol 3:466-74. 2004
    ..Severe fluctuations that are not controlled by oral combination therapy can be controlled with subcutaneous apomorphine injections or infusions...
  5. pmc Ability of a nurse specialist to diagnose simple headache disorders compared with consultant neurologists
    C E Clarke
    Academic Department of Neurology, University of Birmingham and Department of Neurology, Sandwell, UK
    J Neurol Neurosurg Psychiatry 76:1170-2. 2005
    ..To compare the ability of a headache nurse specialist and consultant neurologists in diagnosing tension-type headache and migraine...
  6. pmc Systematic review of acute levodopa and apomorphine challenge tests in the diagnosis of idiopathic Parkinson's disease
    C E Clarke
    Department of Neurology, City Hospital NHS Trust, Birmingham B18 7QH, UK
    J Neurol Neurosurg Psychiatry 69:590-4. 2000
    ..To perform a systematic review of studies examining the diagnostic accuracy of acute challenge tests with levodopa and/or apomorphine in parkinsonian syndromes to assess their value in the diagnosis of idiopathic Parkinson's disease...
  7. doi request reprint Are delayed-start design trials to show neuroprotection in Parkinson's disease fundamentally flawed?
    Carl E Clarke
    Department of Neurology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, United Kingdom
    Mov Disord 23:784-9. 2008
    ..These arguments add to the growing tide of opinion for a fundamental rethink of our policy toward neuroprotection research in PD...
  8. doi request reprint Pilot randomised controlled trial of occupational therapy to optimise independence in Parkinson's disease: the PD OT trial
    C E Clarke
    Department of Neurology, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    J Neurol Neurosurg Psychiatry 80:976-8. 2009
    ..To perform a pilot trial of occupational therapy (OT) to optimise functional independence in Parkinson disease (PD) to assess accrual/withdrawal rates, acceptability, outcome measures, and inform sample-size calculation...
  9. doi request reprint Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease
    Carl E Clarke
    Department of Neurology, City Hospital, Birmingham, UK
    Parkinsonism Relat Disord 15:728-41. 2009
    ..There is an urgent need for well-designed clinical trials to generate reliable data to inform the clinical management of this difficult-to-treat subgroup of PD patients...
  10. doi request reprint Imaging results in a consecutive series of 530 new patients in the Birmingham Headache Service
    C E Clarke
    School of Clinical and Experimental Medicine, College of Medicine and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Neurol 257:1274-8. 2010
    ..Significant abnormalities in those suspected to have an intracranial abnormality occurred in 5.5%. This supports the practice of selecting patients with suspicious findings for imaging, rather than imaging all patients...
  11. doi request reprint Has drug therapy changed the natural history of Parkinson's disease?
    C E Clarke
    School of Clinical and Experimental Medicine, College of Medicine and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, UK
    J Neurol 257:S262-7. 2010
    ..The mainstay of these therapies continues to be levodopa, although it is now used at lower doses than in the past and in combination with other drug classes...
  12. doi request reprint Should treatment for Parkinson's disease start immediately on diagnosis or delayed until functional disability develops?
    Carl E Clarke
    Department of Neurology, City Hospital, Sandwell and West Birmingham NHS Trust, Dudley Road, Birmingham, United Kingdom
    Mov Disord 26:1187-93. 2011
    ....
  13. ncbi request reprint Tremor and deep white matter changes in alpha-methylacyl-CoA racemase deficiency
    C E Clarke
    Department of Neurology, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Neurology 63:188-9. 2004
  14. ncbi request reprint Systematic review of proton magnetic resonance spectroscopy of the striatum in parkinsonian syndromes
    C E Clarke
    Department of Neurology, City Hospital NHS Trust and University of Birmingham, Birmingham, UK
    Eur J Neurol 8:573-7. 2001
    ..Any discriminatory abnormality must be tested in a large prospective study of newly presenting parkinsonian patients with long-term clinical follow up and ultimate pathological confirmation of the diagnosis as far as possible...
  15. ncbi request reprint Dopamine agonist monotherapy in Parkinson's disease
    C E Clarke
    Department of Neurology, University of Birmingham, Birmingham, UK
    Lancet 360:1767-9. 2002
    ..In addition, preclinical evidence suggests that levodopa is toxic to dopaminergic neurons. These problems have led to a move away from levodopa towards initial monotherapy with a dopamine agonist...
  16. ncbi request reprint A "cure" for Parkinson's disease: can neuroprotection be proven with current trial designs?
    Carl E Clarke
    Reader in Clinical Neurology, Division of Neuroscience, University of Birmingham and City Hospital, Birmingham, United Kingdom
    Mov Disord 19:491-8. 2004
    ..g., UPDRS) has been reported in an interim analysis, the trial could be continued for a further 5 to 10 years to report on quality of life and health economics outcomes...
  17. pmc Medical management of Parkinson's disease
    C E Clarke
    Department of Neurology, City Hospital NHS Trust, Birmingham, UK
    J Neurol Neurosurg Psychiatry 72:I22-I27. 2002
  18. pmc Parkinson's disease
    C E Clarke
    Department of Neurology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham B18 7QH
    BMJ 335:441-5. 2007
  19. ncbi request reprint Basal ganglia metabolite concentrations in idiopathic Parkinson's disease and multiple system atrophy measured by proton magnetic resonance spectroscopy
    C E Clarke
    Department of Neurology, City Hospital NHS Trust and University of Birmingham, Birmingham, UK
    Eur J Neurol 7:661-5. 2000
    ..The results of the present pilot study, combined with the conflicting findings from previous work, suggest that further, much larger, studies are required to evaluate the diagnostic capability of proton MRS...
  20. ncbi request reprint The inpatient neurology consultation service: value and cost
    M R Douglas
    Department of Neurology, Russells Hall Hospital, Dudley Group of Hospitals NHS Trust, Dudley
    Clin Med 11:215-7. 2011
    ..This audit highlights the importance of neurological input in the diagnosis and management of hospital inpatients. The time taken for this process should be resourced appropriately...
  21. doi request reprint Systematic review of levodopa dose equivalency reporting in Parkinson's disease
    Claire L Tomlinson
    Birmingham Clinical Trials Unit, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Mov Disord 25:2649-53. 2010
    ..Using these conversion formulae to report LEDs would improve the consistency of reporting and assist the interpretation of clinical trials comparing different PD medications...
  22. doi request reprint Meta-analysis of the comparative efficacy and safety of adjuvant treatment to levodopa in later Parkinson's disease
    Rebecca Stowe
    Birmingham Clinical Trials Unit, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Mov Disord 26:587-98. 2011
    ..It is unclear whether one class of drug is more effective than another. This meta-analysis evaluates the comparative benefits and risks of these agents as adjuvant treatment in Parkinson's disease patients with motor complications...
  23. pmc Evaluating drug treatments for Parkinson's disease: how good are the trials?
    Keith Wheatley
    Birmingham Clinical Trials Unit, University of Birmingham, Birmingham B15 2RR, UK
    BMJ 324:1508-11. 2002
  24. doi request reprint Exploring the pathogenesis of IIH: an inflammatory perspective
    Alexandra J Sinclair
    Academic Unit of Ophthalmology, School of Immunology, Infection and Inflammation, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom
    J Neuroimmunol 201:212-20. 2008
    ..Obesity is also related to dysregulation of cortisol production by the pre-receptor enzyme, 11beta-hydroxysteroid dehydrogenase, and we speculate that this may have a role in the pathogenesis of obesity and raised ICP seen in IIH...
  25. pmc Monoamine oxidase type B inhibitors in early Parkinson's disease: meta-analysis of 17 randomised trials involving 3525 patients
    Natalie J Ives
    Birmingham Clinical Trials Unit, University of Birmingham, Birmingham B15 2RR
    BMJ 329:593. 2004
    ..To quantify more reliably the benefits and risks of monoamine oxidase type B inhibitors (MAOBIs) in early Parkinson's disease...
  26. ncbi request reprint An English kindred with a novel recessive tauopathy and respiratory failure
    David J Nicholl
    Department of Neurology, City Hospital, University of Birmingham, Birmingham B18 7QH, UK
    Ann Neurol 54:682-6. 2003
    ..This disorder showed extensive tau neuropathology, and both had a novel homozygous S352L tau gene mutation. This is the first description of a pathologically proved young-onset tauopathy with apparent recessive inheritance...
  27. pmc Surgery for Parkinson's disease: lack of reliable clinical trial evidence
    R L Stowe
    Clinical Trials Unit, University of Birmingham, Park Grange, 1 Somerset Road, Edgbaston, Birmingham B15 2RR, UK
    J Neurol Neurosurg Psychiatry 74:519-21. 2003
    ..Much larger, randomised, controlled trials are needed to assess the longer term effects of surgery on patient rated quality of life and cost effectiveness...
  28. doi request reprint The use of complementary and alternative medicine by patients attending a UK headache clinic
    Thomas D Lambert
    Division of Neuroscience, University of Birmingham, Birmingham, B15 2TT, UK
    Complement Ther Med 18:128-34. 2010
    ..This study was undertaken in order to determine the extent of the use of CAM in a UK headache clinic...
  29. doi request reprint Idiopathic intracranial hypertension associated with iron deficiency anaemia: a lesson for management
    S P Mollan
    The Birmingham Neuro Ophthalmology Unit, Birmingham and Midland Eye Centre, City Hospital, Birmingham, UK
    Eur Neurol 62:105-8. 2009
    ..To document the causal association of iron deficiency anaemia (IDA) and intracranial hypertension (IH)...
  30. ncbi request reprint A randomized, double-blind, placebo-controlled, ascending-dose tolerability and safety study of remacemide as adjuvant therapy in Parkinson's disease with response fluctuations
    C E Clarke
    Department of Neurology, City Hospital, Birmingham, UK
    Clin Neuropharmacol 24:133-8. 2001
    ..There was a trend suggesting that remacemide was effective in improving symptoms at patients' individual maximum tolerated doses. These improvements occurred without exacerbating levodopa-induced dyskinesias...
  31. ncbi request reprint Systematic review of paramedical therapies for Parkinson's disease
    Katherine H O Deane
    Department of Neurology, City Hospital NHS Trust, and The University of Birmingham, Birmingham, United Kingdom
    Mov Disord 17:984-91. 2002
    ..However, this lack of evidence is not proof of a lack of effect. Further large pragmatic randomised controlled trials are required to determine the effectiveness of paramedical therapies in Parkinson's disease...
  32. ncbi request reprint Parkinson's disease
    Carl E Clarke
    University of Birmingham, Birmingham, United Kingdom
    Am Fam Physician 75:1045-8. 2007
  33. doi request reprint Elevated cerebrospinal fluid (CSF) leptin in idiopathic intracranial hypertension (IIH): evidence for hypothalamic leptin resistance?
    A K Ball
    Department of Neurology, School of Experimental Medicine, University of Birmingham, Birmingham, UK
    Clin Endocrinol (Oxf) 70:863-9. 2009
    ..Recent studies have linked obesity with abnormalities in circulating inflammatory and adiposity related cytokines. The aim of this study was to characterize adipokine and inflammatory cytokine profiles in IIH...
  34. ncbi request reprint Dopamine agonist monotherapy in early Parkinson's disease
    C E Clarke
    Department of Neurology, City Hospital and University of Birmingham, Birmingham B18 7QH
    Hosp Med 64:8-11. 2003
    ..Monotherapy with dopamine agonists may present an alternative approach with a reduced likelihood of developing dyskinesias. Further studies are required before a definitive judgment can be made...
  35. ncbi request reprint Idiopathic intracranial hypertension
    Alex K Ball
    University of Birmingham, Department of Neurology, City Hospital, Birmingham B18 7QH, UK
    Lancet Neurol 5:433-42. 2006
    ..The importance of weight loss needs clarification, the role of diuretics is uncertain, and which surgical intervention is the most effective and safe is unknown. Prospective trials to examine these issues are urgently needed...
  36. ncbi request reprint Pregnancy in stiff-limb syndrome
    Stuart J M Weatherby
    Department of Neurology, City Hospital, Birmingham, United Kingdom
    Mov Disord 19:852-4. 2004
    ..We present the case of a woman with SLS who improved during pregnancy, delivered a normal healthy baby by forceps-assisted vaginal delivery, and suffered a mild postpartum "relapse."..
  37. ncbi request reprint Rotigotine transdermal patch in early Parkinson's disease: a randomized, double-blind, controlled study versus placebo and ropinirole
    Nir Giladi
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Mov Disord 22:2398-404. 2007
    ..Application-site reactions were predominantly mild or moderate in intensity. In conclusion, the rotigotine transdermal patch represents an effective and safe option for the treatment of patients with early Parkinson's disease...
  38. ncbi request reprint Development of dyskinesias in a 5-year trial of ropinirole and L-dopa
    Olivier Rascol
    Clinical Investigation Centre, Department of Pharmacology and INSERM U455, Toulouse Hospital, Toulouse, France
    Mov Disord 21:1844-50. 2006
    ..Early use of ropinirole postpones the onset of dyskinesias, but these benefits decline when levodopa therapy is started, with no evidence of a subsequent rapid "catch-up" or a persisting preventive effect...
  39. ncbi request reprint Cabergoline versus levodopa monotherapy
    Keith Wheatley
    Mov Disord 19:733-4; author reply 734-5. 2004