L Clark

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Disordered gambling: a behavioral addiction
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge, UK
    Curr Opin Neurobiol 23:655-9. 2013
  2. doi request reprint Risk-avoidant decision making increased by threat of electric shock
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge, UK
    Psychophysiology 49:1436-43. 2012
  3. pmc Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuroimage 63:40-6. 2012
  4. doi request reprint Physiological responses to near-miss outcomes and personal control during simulated gambling
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    J Gambl Stud 28:123-37. 2012
  5. pmc Impulsivity and response inhibition in alcohol dependence and problem gambling
    Andrew J Lawrence
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 207:163-72. 2009
  6. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
  7. ncbi request reprint Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005
  8. ncbi request reprint Association between response inhibition and working memory in adult ADHD: a link to right frontal cortex pathology?
    Luke Clark
    Department of Experimental Psychology, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 61:1395-401. 2007
  9. pmc Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
    L Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Brain 131:1311-22. 2008
  10. ncbi request reprint Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, U K
    Am J Psychiatry 162:1980-2. 2005

Collaborators

Detail Information

Publications78

  1. doi request reprint Disordered gambling: a behavioral addiction
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge, UK
    Curr Opin Neurobiol 23:655-9. 2013
    ..Behavioral addictions can also provide experimental traction on distinguishing vulnerability markers for addictions from the active detrimental effects of chronic drug use. ..
  2. doi request reprint Risk-avoidant decision making increased by threat of electric shock
    Luke Clark
    Department of Psychology, University of Cambridge, Cambridge, UK
    Psychophysiology 49:1436-43. 2012
    ..Threat exerts immediate effects on decision making and physiological arousal, biasing subjects towards safer alternatives, potentially through a magnified processing of loss information...
  3. pmc Striatal dopamine D₂/D₃ receptor binding in pathological gambling is correlated with mood-related impulsivity
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuroimage 63:40-6. 2012
    ..Nevertheless, our data indicate heterogeneity in dopamine receptor availability in disordered gambling, such that individuals with high mood-related impulsivity may show differential benefits from dopamine-based medications...
  4. doi request reprint Physiological responses to near-miss outcomes and personal control during simulated gambling
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing St, Cambridge, CB2 3EB, UK
    J Gambl Stud 28:123-37. 2012
    ..Near-miss outcomes are capable of eliciting phasic changes in physiological arousal consistent with a state of subjective excitement, despite their objective non-win status...
  5. pmc Impulsivity and response inhibition in alcohol dependence and problem gambling
    Andrew J Lawrence
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, UK
    Psychopharmacology (Berl) 207:163-72. 2009
    ..The extent to which inhibitory deficits arise as a consequence of drug exposure or relate to pre-existing addiction vulnerability is unknown...
  6. pmc Incentive motivation in first-episode psychosis: a behavioural study
    Graham K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    BMC Psychiatry 8:34. 2008
    ..It has been proposed that there are abnormalities in incentive motivational processing in psychosis, possibly secondary to subcortical dopamine abnormalities, but few empirical studies have addressed this issue...
  7. ncbi request reprint Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity
    L Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, and Department of Medical Genetics, Addenbrooke s Hospital, Cambridge, UK
    Psychopharmacology (Berl) 182:570-8. 2005
    ..Reduced serotonin neurotransmission is implicated in disorders of impulse control, but the involvement of serotonin in inhibitory processes in healthy human subjects remains unclear...
  8. ncbi request reprint Association between response inhibition and working memory in adult ADHD: a link to right frontal cortex pathology?
    Luke Clark
    Department of Experimental Psychology, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 61:1395-401. 2007
    ..We sought to assess the relationship between response inhibition and working memory in adult patients with attention-deficit/hyperactivity disorder (ADHD) and neurosurgical patients with frontal lobe damage...
  9. pmc Differential effects of insular and ventromedial prefrontal cortex lesions on risky decision-making
    L Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Brain 131:1311-22. 2008
    ..Poor decision-making in clinical populations can arise via multiple routes, with functionally dissociable effects of vmPFC and insular cortex damage...
  10. ncbi request reprint Impairment of executive function but not memory in first-degree relatives of patients with bipolar I disorder and in euthymic patients with unipolar depression
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, U K
    Am J Psychiatry 162:1980-2. 2005
    ..The authors' goal was to characterize cognitive flexibility and verbal learning in relatives of patients with bipolar disorder and in euthymic patients with recurrent major depression...
  11. pmc Cognitive neuroscience and brain imaging in bipolar disorder
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Dialogues Clin Neurosci 10:153-63. 2008
    ....
  12. pmc Gambling near-misses enhance motivation to gamble and recruit win-related brain circuitry
    Luke Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, CB2 3EB Cambridge, UK
    Neuron 61:481-90. 2009
    ..These data indicate that near-misses invigorate gambling through the anomalous recruitment of reward circuitry, despite the objective lack of monetary reinforcement on these trials...
  13. doi request reprint Neurocognitive mechanisms in depression: implications for treatment
    Luke Clark
    Behavioural and Clinical Neuroscience Institute BCNI, Department of Experimental Psychology, University of Cambridge, Cambridge CB23EB, United Kingdom
    Annu Rev Neurosci 32:57-74. 2009
    ....
  14. ncbi request reprint Sustained attention-deficit confirmed in euthymic bipolar disorder but not in first-degree relatives of bipolar patients or euthymic unipolar depression
    Luke Clark
    University Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, United Kingdom
    Biol Psychiatry 57:183-7. 2005
    ..This study aimed to replicate a deficit in sustained attention in euthymic bipolar patients and investigate sustained attention in first-degree relatives of bipolar probands and in remitted patients with major depressive disorder...
  15. pmc Disrupted 'reflection' impulsivity in cannabis users but not current or former ecstasy users
    L Clark
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, School of Clinical Medicine, University of Cambridge, and Addenbrooke s Hospital, Cambridge, UK
    J Psychopharmacol 23:14-22. 2009
    ..However, the lack of effects in the two ecstasy groups suggests that the relationship between serotonin function, ecstasy use and impulsivity is more complex...
  16. ncbi request reprint The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning
    L Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Brain Cogn 55:41-53. 2004
    ..Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning...
  17. pmc Decision-making during gambling: an integration of cognitive and psychobiological approaches
    Luke Clark
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Philos Trans R Soc Lond B Biol Sci 365:319-30. 2010
    ..These manipulations appear to harness a reward system that evolved to learn skill-oriented behaviours, and by modulating activity in this system, these cognitive distortions may promote continued, and potentially excessive, gambling...
  18. pmc Impairment in risk-sensitive decision-making in older suicide attempters with depression
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom
    Psychol Aging 26:321-30. 2011
    ..These impairments may precipitate and perpetuate suicidal crisis in depressed elders. Identification of decision-making impairment in suicidal elders may help with designing effective interventions...
  19. ncbi request reprint The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Neuropsychologia 41:1474-83. 2003
    ..The Cambridge Gamble Task and Risk Task were less sensitive to the effects of unilateral frontal lobe lesions, and may be more selectively associated with ventral prefrontal damage...
  20. ncbi request reprint Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Cambridge, United Kingdom
    Biol Psychiatry 55:1031-40. 2004
    ..We examined whether modafinil induced similar improvements in adults with attention-deficit/hyperactivity disorder...
  21. pmc The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention
    Jonathan P Roiser
    Department of Psychiatry, Box 189, Addenbrooke s Hospital, Cambridge, UKInstitute of Neurology, Queen Square House, London, UK
    Int J Neuropsychopharmacol 10:449-61. 2007
    ....
  22. ncbi request reprint Tyrosine depletion attenuates dopamine function in healthy volunteers
    C J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Psychopharmacology (Berl) 154:105-11. 2001
    ..Such information could establish tyrosine depletion as an effective probe of dopamine function in healthy volunteers and would also have relevance for future therapeutic applications of this manipulation...
  23. pmc Methylphenidate ('Ritalin') can ameliorate abnormal risk-taking behavior in the frontal variant of frontotemporal dementia
    Shibley Rahman
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
    Neuropsychopharmacology 31:651-8. 2006
    ..The results are discussed in terms of the 'somatic marker' hypothesis of impaired decision-making following orbitofrontal dysfunction...
  24. ncbi request reprint Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Biol Psychiatry 62:977-84. 2007
    ..Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD...
  25. pmc Reinforcement and reversal learning in first-episode psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Schizophr Bull 34:848-55. 2008
    ..Abnormalities in reinforcement learning and reversal learning have been reported in psychosis, possibly secondary to subcortical dopamine abnormalities...
  26. ncbi request reprint Sustained attention deficit in bipolar disorder
    Luke Clark
    University Department of Psychiatry, Warneford Hospital, Oxford
    Br J Psychiatry 180:313-9. 2002
    ..Previous work has suggested that neuropsychological impairment persists during the euthymic state but has been confounded partly by mild affective symptoms in remitted patients...
  27. ncbi request reprint Differential responses in human striatum and prefrontal cortex to changes in object and rule relevance
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 24:1129-35. 2004
    ....
  28. ncbi request reprint Cognitive enhancing effects of modafinil in healthy volunteers
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Psychopharmacology (Berl) 165:260-9. 2003
    ....
  29. doi request reprint Neuropsychological testing of cognitive impairment in euthymic bipolar disorder: an individual patient data meta-analysis
    C Bourne
    Department of Psychiatry, University of Oxford, Oxford, UK
    Acta Psychiatr Scand 128:149-62. 2013
    ..Findings are inconsistent both across primary studies and previous meta-analyses. This study reanalysed 31 primary data sets as a single large sample (N = 2876) to provide a more definitive view...
  30. pmc The effects of acute tryptophan depletion on costly information sampling: impulsivity or aversive processing?
    M J Crockett
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, England, UK
    Psychopharmacology (Berl) 219:587-97. 2012
    ..These studies focused on situations where actions lead directly to punishments. However, decision-making often involves making tradeoffs between small 'local' costs and larger 'global' losses...
  31. pmc Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
    G K Murray
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Mol Psychiatry 13:239, 267-76. 2008
    ..This study provides the first evidence linking abnormal mesolimbic activity, reward learning and psychosis...
  32. ncbi request reprint Antidopaminergic effects of dietary tyrosine depletion in healthy subjects and patients with manic illness
    S F McTavish
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    Br J Psychiatry 179:356-60. 2001
    ..In rats, amino acid mixtures lacking tyrosine and its precursor phenylalanine decrease the release of dopamine produced by the psychostimulant drug amphetamine. Amphetamine has been proposed as a model for clinical mania...
  33. pmc Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
    K D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 180:612-23. 2005
    ..We sought to investigate this possibility using functional neuroimaging...
  34. doi request reprint Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory
    Philip L Clatworthy
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 29:4690-6. 2009
    ....
  35. ncbi request reprint Tryptophan depletion disrupts the motivational guidance of goal-directed behavior as a function of trait impulsivity
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:1362-73. 2005
    ..By contrast, ATD left unaltered the ability to inhibit prepotent responses. Our findings may have implications for a variety of neuropsychiatric disorders including impulsive aggressive disorders and depression...
  36. ncbi request reprint Decision-making processes following damage to the prefrontal cortex
    Facundo Manes
    University of Cambridge Psychiatry Department, Addenbrooke s Hospital, Cambridge, UK
    Brain 125:624-39. 2002
    ..Ventral and dorsal aspects of prefrontal cortex must interact in the maintenance of rational and 'non-risky' decision making...
  37. pmc Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion
    Jonathan P Roiser
    Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Neuropsychopharmacology 31:2264-72. 2006
    ....
  38. pmc Impulsivity and cognitive distortions in pathological gamblers attending the UK National Problem Gambling Clinic: a preliminary report
    R Michalczuk
    Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, UK
    Psychol Med 41:2625-35. 2011
    ..We sought to assess the relationship between the level of cognitive distortions and state and trait measures of impulsivity in treatment-seeking pathological gamblers...
  39. ncbi request reprint The influence of positive and negative mood states on risk taking, verbal fluency, and salivary cortisol
    L Clark
    University Department of Psychiatry, Neurosciences Building, Warneford Hospital, Oxford OX3 7JX, UK
    J Affect Disord 63:179-87. 2001
    ..Performance on frontal lobe tests appears to be insensitive to normal mood fluctuations, which supports the argument that the deficits in mood disorder patient groups may instead reflect core disturbances of neurobiological processes...
  40. ncbi request reprint Sustained attention deficit in bipolar disorder is not a working memory impairment in disguise
    Catherine J Harmer
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Neuropsychologia 40:1586-90. 2002
    ..Deficits in sustaining attention may help explain the difficulties in psychological and occupational functioning in bipolar disorder patients during remission...
  41. pmc Problem gamblers share deficits in impulsive decision-making with alcohol-dependent individuals
    Andrew J Lawrence
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Addiction 104:1006-15. 2009
    ..We reasoned that shared deficits across the two conditions may reflect underlying vulnerability mechanisms, whereas impairments specific to alcohol dependence may reflect cumulative effects of alcohol consumption...
  42. ncbi request reprint Defining the neural mechanisms of probabilistic reversal learning using event-related functional magnetic resonance imaging
    Roshan Cools
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 22:4563-7. 2002
    ..Overall, these data concur with findings in rodents and nonhuman primates of reversal-learning deficits after damage to ventral frontostriatal circuitry, and also support recent clinical findings using this task...
  43. ncbi request reprint Social and emotional decision-making following frontal lobe injury
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neurocase 10:398-403. 2004
    ..The extent to which disrupted decision-making can be separated from the broader domain of executive function is discussed...
  44. ncbi request reprint A neuropsychological investigation of prefrontal cortex involvement in acute mania
    L Clark
    Department of Psychiatry, University of Oxford, UK
    Am J Psychiatry 158:1605-11. 2001
    ..The data do not implicate ventral prefrontal cortex disruption as a locus of pathology in acute mania. Verbal memory and sustained attention deficits may relate differentially to the state and trait characteristics of bipolar disorder...
  45. ncbi request reprint Relative lack of cognitive effects of methylphenidate in elderly male volunteers
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Psychopharmacology (Berl) 168:455-64. 2003
    ....
  46. pmc Punishment induces risky decision-making in methadone-maintained opiate users but not in heroin users or healthy volunteers
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 30:2115-24. 2005
    ..These findings are discussed with respect to the different mechanisms of action of heroin and methadone. Neuropsychopharmacology (2005) 30, 2115-2124. doi:10.1038/sj.npp.1300812; published online 6 July 2005...
  47. pmc Place your bets: psychophysiological correlates of decision-making under risk
    Bettina Studer
    Department of Experimental Psychology, University of Cambridge, CB2 3EB, Cambridge, England, UK
    Cogn Affect Behav Neurosci 11:144-58. 2011
    ..Our results further highlight the differential sensitivities of EDA and HR to psychological features of the decision scenario...
  48. pmc Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans
    Molly J Crockett
    Behavioral and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom
    J Neurosci 29:11993-9. 2009
    ..These findings extend and clarify previous research on the role of serotonin in aversive processing and behavioral inhibition and fit with current theorizing on the involvement of serotonin in predicting aversive outcomes...
  49. pmc The dopamine D2 receptor antagonist sulpiride modulates striatal BOLD signal during the manipulation of information in working memory
    Chris M Dodds
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Psychopharmacology (Berl) 207:35-45. 2009
    ..Dopamine (DA) plays an important role in working memory. However, the precise functions supported by different DA receptor subtypes in different neural regions remain unclear...
  50. doi request reprint Methylphenidate has differential effects on blood oxygenation level-dependent signal related to cognitive subprocesses of reversal learning
    Chris M Dodds
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 28:5976-82. 2008
    ..The results show that the precise neural site of modulation by methylphenidate depends on the nature of the cognitive subprocess recruited...
  51. ncbi request reprint Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Neuropsychopharmacology 29:1363-73. 2004
    ..Modafinil may have potential as an important therapy for cognitive impairment in patients with schizophrenia, particularly because of its beneficial effects on attentional set shifting...
  52. pmc Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD)
    Elise E DeVito
    Department of Psychiatry, University of Cambridge, P O Box 189, Addenbrooke s Hospital, Cambridge CB22QQ, UK
    Psychopharmacology (Berl) 202:531-9. 2009
    ..However, impulsivity is a multi-factorial construct and the degree to which different forms of impulsivity contribute to impairments in ADHD or respond to pharmacological treatments remains unclear...
  53. pmc Serotonin selectively influences moral judgment and behavior through effects on harm aversion
    Molly J Crockett
    Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    Proc Natl Acad Sci U S A 107:17433-8. 2010
    ..Together, these findings provide unique evidence that serotonin could promote prosocial behavior by enhancing harm aversion, a prosocial sentiment that directly affects both moral judgment and moral behavior...
  54. pmc Neurochemical modulation of response inhibition and probabilistic learning in humans
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge CB2 2QQ, UK
    Science 311:861-3. 2006
    ....
  55. doi request reprint The role of the orbitofrontal cortex in human discrimination learning
    Henry W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, UK
    Neuropsychologia 46:1326-37. 2008
    ..g. anterior cingulate cortex). These data support the notion that the OFC play a role in normal discrimination learning, and suggest qualitative similarities in learning performance of patients with OFC damage and medicated PD patients...
  56. ncbi request reprint Predictors of punding in Parkinson's disease: results from a questionnaire survey
    Andrew J Lawrence
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Mov Disord 22:2339-45. 2007
    ..These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT-related nonmotor behavioral problems in PD...
  57. ncbi request reprint Distinct profiles of neurocognitive function in unmedicated unipolar depression and bipolar II depression
    Joana V Taylor Tavares
    Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, United Kingdom
    Biol Psychiatry 62:917-24. 2007
    ..In this study, we compared the performance of unmedicated currently depressed MDD and BD groups on a battery of neuropsychological tests that included measures of risk taking and reflection impulsivity...
  58. pmc Profile of executive and memory function associated with amphetamine and opiate dependence
    Karen D Ersche
    Department of Psychiatry, School of Clinical Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychopharmacology 31:1036-47. 2006
    ..Impairment persists after several years of drug abstinence and may reflect neuropathology in frontal and temporal cortices...
  59. ncbi request reprint A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychologia 45:654-62. 2007
    ..However, the extent to which these disorders share a common cognitive phenotype has yet to be elucidated using patients without confounding co-morbidities...
  60. ncbi request reprint Impulsivity, reward sensitivity, and decision-making in subarachnoid hemorrhage survivors
    Claire H Salmond
    Wolfson Brain Imaging Centre, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Int Neuropsychol Soc 12:697-706. 2006
    ..These complex deficits may contribute to difficulties in daily living resulting from apathy, poor judgment, or inhibition in SAH survivors...
  61. pmc The effects of methylphenidate on decision making in attention-deficit/hyperactivity disorder
    Elise E DeVito
    Department of Psychiatry, University of Cambridge, Cambridge, UK
    Biol Psychiatry 64:636-9. 2008
    ..The objectives of the study were to assess the effects of stimulant medication on decision making in ADHD and compare performance on the Cambridge Gamble Task between boys with and without ADHD...
  62. ncbi request reprint L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    Roshan Cools
    Department of Experimental Psychology, Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 32:180-9. 2007
    ..These data concur with evidence from studies with experimental animals and indicate an important role for the human nucleus accumbens in the dopaminergic modulation of reversal learning...
  63. ncbi request reprint Lack of effects of guanfacine on executive and memory functions in healthy male volunteers
    Ulrich Muller
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Psychopharmacology (Berl) 182:205-13. 2005
    ..Guanfacine is an alpha2-adrenergic receptor agonist that has been shown to have beneficial effects on working memory and attentional functions in monkeys and in patients with attention deficit hyperactivity disorder...
  64. pmc Serotonin modulates behavioral reactions to unfairness
    Molly J Crockett
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Science 320:1739. 2008
    ..Our results suggest that 5-HT plays a critical role in regulating emotion during social decision-making...
  65. doi request reprint Dissociable roles of prefrontal subregions in self-ordered working memory performance
    Henry W Chase
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
    Neuropsychologia 46:2650-61. 2008
    ..Moreover, we provide evidence for the first time that such functions are dependent on dissociable brain regions within the prefrontal cortex...
  66. pmc Impulsive choice and altruistic punishment are correlated and increase in tandem with serotonin depletion
    Molly J Crockett
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, England
    Emotion 10:855-62. 2010
    ..These findings imply that altruistic punishment reflects the absence rather than the presence of self control, and suggest that impulsive choice and altruistic punishment share common neural mechanisms...
  67. pmc Neural basis of abnormal response to negative feedback in unmedicated mood disorders
    Joana V Taylor Tavares
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroimage 42:1118-26. 2008
    ..Disrupted top-down control by the prefrontal cortex of the amygdala may underlie this abnormal response to negative feedback in unipolar depression...
  68. ncbi request reprint State- and trait-related deficits in sustained attention in bipolar disorder
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, UK
    Eur Arch Psychiatry Clin Neurosci 254:61-8. 2004
    ..The state- and trait-related impairments may be differentially associated with the ascending dopamine and noradrenaline projections...
  69. ncbi request reprint Reflection impulsivity in current and former substance users
    Luke Clark
    Department of Experimental Psychology, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 60:515-22. 2006
    ..We investigated impulsive responding in the context of decision making, using a novel behavioral measure of reflection impulsivity: the tendency to gather and evaluate information before making a decision...
  70. doi request reprint 5-HT(1A) receptor binding in euthymic bipolar patients using positron emission tomography with [carbonyl-(11)C]WAY-100635
    Peter A Sargent
    University Department of Psychiatry, Warneford Hospital, Oxford OX3 7JX, UK
    J Affect Disord 123:77-80. 2010
    ..This study was undertaken to examine whether brain 5-HT(1A) receptor binding is reduced in euthymic bipolar patients...
  71. ncbi request reprint Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bipolar Disord 6:233-44. 2004
    ....
  72. ncbi request reprint Individual differences in threat sensitivity predict serotonergic modulation of amygdala response to fearful faces
    Roshan Cools
    MRC Behavioural and Clinical Neuroscience Centre
    Psychopharmacology (Berl) 180:670-9. 2005
    ....
  73. ncbi request reprint The relationship between affective decision-making and theory of mind in the frontal variant of fronto-temporal dementia
    Teresa Torralva
    Cognitive Neurology and Neuropsychiatry Section, Raul Carrea Institute for Neurological Research, Buenos Aires, Argentina
    Neuropsychologia 45:342-9. 2007
    ..Deficits in decision-making and ToM observed in this study have distinct but additive effects upon the development of social behaviour in patients with prefrontal dysfunction...
  74. ncbi request reprint Serotonergic modulation of prefrontal cortex during negative feedback in probabilistic reversal learning
    Elizabeth A T Evers
    Brain and Behavior Institute, University of Maastricht, Maastricht, The Netherlands
    Neuropsychopharmacology 30:1138-47. 2005
    ..These data suggest that ATD affects reversal learning and the processing of aversive signals by modulation of the dorsomedial PFC...
  75. ncbi request reprint Mood-congruent bias in affective go/no-go performance of unmedicated patients with major depressive disorder
    Kristine Erickson
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MD 20814 9692, USA
    Am J Psychiatry 162:2171-3. 2005
    ..This study investigated performance of unmedicated depressed patients on the Affective Go/No-Go Task...
  76. pmc Cognitive performance in suicidal depressed elderly: preliminary report
    Alexandre Y Dombrovski
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:109-15. 2008
    ..This study examined cognitive function in general and executive functioning specifically in depressed elderly with and without suicidal ideation and attempts...
  77. doi request reprint Executive functions in pathologic gamblers selected in an ecologic setting
    Maria Roca
    Department of Cognitive Neurology, Institute of Cognitive Neurology INECO, Favaloro University, Buenos Aires, Argentina
    Cogn Behav Neurol 21:1-4. 2008
    ....
  78. doi request reprint Impulsivity as a vulnerability marker for substance-use disorders: review of findings from high-risk research, problem gamblers and genetic association studies
    Antonio Verdejo-Garcia
    Pharmacology Research Unit, Institut Municipal d Investigacio Medica, Barcelona Biomedical Research Park, Dr Aiguader 88, 08003 Barcelona, Spain
    Neurosci Biobehav Rev 32:777-810. 2008
    ..Within each of these three lines of enquiry, there is accumulating evidence that impulsivity is a pre-existing vulnerability marker for SUDs...