H Clark

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice
    Lars Knudsen
    Department of Anatomy, Division of Electron Microscopy, University of Gottingen, Gottingen, Germany
    Respir Res 8:70. 2007
  2. ncbi request reprint Surfactant protein D reduces alveolar macrophage apoptosis in vivo
    Howard Clark
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    J Immunol 169:2892-9. 2002
  3. ncbi request reprint Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D
    Howard Clark
    Department of Biochemistry, Oxford, United Kingdom
    Immunobiology 205:619-31. 2002
  4. ncbi request reprint The genetics of neonatal respiratory disease
    Howard Clark
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Headington, Oxford OX1 3QU, UK
    Semin Fetal Neonatal Med 10:271-82. 2005
  5. pmc The potential of recombinant surfactant protein D therapy to reduce inflammation in neonatal chronic lung disease, cystic fibrosis, and emphysema
    H Clark
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK
    Arch Dis Child 88:981-4. 2003
  6. ncbi request reprint A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema
    Howard Clark
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Ann N Y Acad Sci 1010:113-6. 2003
  7. ncbi request reprint Intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy
    P Strong
    Medical Research Council Immunochemistry Unit, University of Oxford, Oxford UK
    Clin Exp Allergy 32:1794-800. 2002
  8. ncbi request reprint Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation
    Nades Palaniyar
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK
    J Immunol 174:7352-8. 2005
  9. doi request reprint The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms
    Anne Jäkel
    Department of Biochemistry, University of Oxford, Oxford, UK
    Immunobiology 215:551-8. 2010
  10. pmc The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
    R Jounblat
    MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Respir Res 6:126. 2005

Detail Information

Publications17

  1. pmc Truncated recombinant human SP-D attenuates emphysema and type II cell changes in SP-D deficient mice
    Lars Knudsen
    Department of Anatomy, Division of Electron Microscopy, University of Gottingen, Gottingen, Germany
    Respir Res 8:70. 2007
    ..The aim of this study was to investigate if rfhSP-D treatment reduces the structural abnormalities in parenchymal architecture and type II cells characteristic of SP-D deficiency...
  2. ncbi request reprint Surfactant protein D reduces alveolar macrophage apoptosis in vivo
    Howard Clark
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    J Immunol 169:2892-9. 2002
    ..The same SP-D fragment binds preferentially to apoptotic and necrotic alveolar macrophages in vitro, suggesting that SP-D contributes to immune homeostasis in the lung by recognizing and promoting removal of necrotic and apoptotic cells...
  3. ncbi request reprint Structural requirements for SP-D function in vitro and in vivo: therapeutic potential of recombinant SP-D
    Howard Clark
    Department of Biochemistry, Oxford, United Kingdom
    Immunobiology 205:619-31. 2002
    ..The potential of truncated recombinant forms of surfactant protein D as novel therapy for infectious and inflammatory disease is discussed...
  4. ncbi request reprint The genetics of neonatal respiratory disease
    Howard Clark
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Headington, Oxford OX1 3QU, UK
    Semin Fetal Neonatal Med 10:271-82. 2005
    ..The evidence that known variability in the expression of surfactant protein genes may contribute to the risk of development of neonatal chronic lung disease or bronchopulmonary dysplasia is examined...
  5. pmc The potential of recombinant surfactant protein D therapy to reduce inflammation in neonatal chronic lung disease, cystic fibrosis, and emphysema
    H Clark
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK
    Arch Dis Child 88:981-4. 2003
    ..This review addresses the possibility that recently developed recombinant forms of SP-D could be useful therapeutically in attenuating inflammatory processes in neonatal chronic lung disease, cystic fibrosis, and emphysema...
  6. ncbi request reprint A recombinant fragment of human surfactant protein D reduces alveolar macrophage apoptosis and pro-inflammatory cytokines in mice developing pulmonary emphysema
    Howard Clark
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Ann N Y Acad Sci 1010:113-6. 2003
    ....
  7. ncbi request reprint Intranasal application of chitin microparticles down-regulates symptoms of allergic hypersensitivity to Dermatophagoides pteronyssinus and Aspergillus fumigatus in murine models of allergy
    P Strong
    Medical Research Council Immunochemistry Unit, University of Oxford, Oxford UK
    Clin Exp Allergy 32:1794-800. 2002
    ..To date there have been no studies on the effectivness of directly applying chitin microparticles to the respiratory tract as a treatment for allergic symptoms...
  8. ncbi request reprint Innate immune collectin surfactant protein D enhances the clearance of DNA by macrophages and minimizes anti-DNA antibody generation
    Nades Palaniyar
    Medical Research Council Immunochemistry Unit, Department of Biochemistry, University of Oxford, UK
    J Immunol 174:7352-8. 2005
    ..Our findings establish two new roles for these innate immune proteins and that SP-D enhances efficient pinocytosis and phagocytosis of DNA by macrophages and minimizes anti-DNA Ab generation...
  9. doi request reprint The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms
    Anne Jäkel
    Department of Biochemistry, University of Oxford, Oxford, UK
    Immunobiology 215:551-8. 2010
    ..The mechanisms of these interactions appear to involve preferential recognition of different ligands on the apoptotic cell surface, which may include nucleic acid, phospholipid, protein and glycan structures...
  10. pmc The role of surfactant protein D in the colonisation of the respiratory tract and onset of bacteraemia during pneumococcal pneumonia
    R Jounblat
    MRC Immunochemistry Unit, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
    Respir Res 6:126. 2005
    ..Our data provides evidence that SP-D has a significant role to play in the clearance of pneumococci during the early stages of infection in both pulmonary sites and blood...
  11. ncbi request reprint Collectins and host defence
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK
    Novartis Found Symp 279:170-81; discussion 181-6, 216-9. 2006
    ..Mice deficient in SP-A or SP-D are susceptible to lung infections, and SP-D-deficient mice develop an emphysema-like condition...
  12. pmc Intranasal delivery of a truncated recombinant human SP-D is effective at down-regulating allergic hypersensitivity in mice sensitized to allergens of Aspergillus fumigatus
    P Strong
    Medical Research Council Immunochemistry Unit, University of Oxford, UK
    Clin Exp Immunol 130:19-24. 2002
    ..fumigatus culture filtrate, the present results show that rfhSP-D can suppress the development of allergic symptoms in sensitized mice independent of genetic background and using a different preparation of A. fumigatus allergens...
  13. ncbi request reprint Surfactant protein D binds genomic DNA and apoptotic cells, and enhances their clearance, in vivo
    Nades Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford, OX1 3QU, United Kingdom
    Ann N Y Acad Sci 1010:471-5. 2003
    ..Our results also suggest that carbohydrate recognition domains of SP-D may recognize DNA present on the apoptotic cells. Therefore, cell-surface DNA could be a ligand for recognition of apoptotic cells by collectins...
  14. ncbi request reprint Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D
    Roona Deb
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    J Biol Chem 282:36808-19. 2007
    ..Thus, the degradation and consequent inactivation of SP-A and SP-D may be a novel mechanism to account for the potent allergenicity of these common dust mite allergens...
  15. ncbi request reprint Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin
    Nades Palaniyar
    MRC Immunochemistry Unit, Department of Biochemistry, The University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 279:32728-36. 2004
    ..Collectins may therefore play an important role in decreasing the inflammation caused by DNA in lungs and other tissues...
  16. ncbi request reprint Collectins and their role in lung immunity
    T P Hickling
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK
    J Leukoc Biol 75:27-33. 2004
    ..Recent work has shown that collectins have roles in resistance to allergy and in the control of apoptosis and clearance of apoptotic macrophage in the lung...
  17. pmc Pulmonary collectins modulate strain-specific influenza a virus infection and host responses
    Samuel Hawgood
    University of California San Francisco, Laurel Heights Campus, 3333 California St, Suite 150, San Francisco, CA 94118 1944, USA
    J Virol 78:8565-72. 2004
    ..Mice deficient in both SP-A and SP-D responded to IAV similarly to mice deficient in SP-D alone. Since most strains of IAV currently circulating are glycosylated at N165, SP-D may play a role in protection from IAV infection...