Steven J Clapcote

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e60141. 2013
  2. pmc Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
    Steven J Clapcote
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:14085-90. 2009
  3. ncbi request reprint Effects of the rd1 mutation and host strain on hippocampal learning in mice
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Room 860, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Behav Genet 35:591-601. 2005
  4. doi request reprint Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5
    Pharmacol Biochem Behav 91:610-20. 2009
  5. ncbi request reprint Behavioral phenotypes of Disc1 missense mutations in mice
    Steven J Clapcote
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Neuron 54:387-402. 2007
  6. pmc Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genetics 173:2407-10. 2006
  7. pmc Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 108:18144-9. 2011
  8. ncbi request reprint NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Toronto, Ontario, M5G 1X5, Canada
    Comp Med 55:310-6. 2005
  9. doi request reprint Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3
    Tatiana V Lipina
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Synapse 65:234-48. 2011
  10. doi request reprint Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice
    Noah L Lazar
    Department of Psychology, University of Western Ontario, London, ON, Canada
    Behav Brain Res 224:73-9. 2011

Collaborators

Detail Information

Publications15

  1. pmc Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e60141. 2013
    ..Our results thus provide validation for missense mutations in Na(+),K(+)-ATPase α3 as a cause of AHC, and highlight Myshkin mice as a starting point for the exploration of disease mechanisms and novel treatments in AHC...
  2. pmc Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
    Steven J Clapcote
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:14085-90. 2009
    ..Our findings reveal the functional significance of the Na(+),K(+)-ATPase alpha3 isoform in the control of epileptiform activity and seizure behavior...
  3. ncbi request reprint Effects of the rd1 mutation and host strain on hippocampal learning in mice
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Room 860, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Behav Genet 35:591-601. 2005
    ..The study thus demonstrates how retinal degeneration and genetic background have different effects in these two tests of hippocampus-dependent learning and memory...
  4. doi request reprint Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors
    Viviane Labrie
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Ave, Toronto, ON, Canada M5G 1X5
    Pharmacol Biochem Behav 91:610-20. 2009
    ..Consequently, application of these treatments for amelioration of schizophrenic symptoms necessitates caution as an enhancement of comorbid anxiety disorders may result...
  5. ncbi request reprint Behavioral phenotypes of Disc1 missense mutations in mice
    Steven J Clapcote
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Neuron 54:387-402. 2007
    ..This study demonstrates that Disc1 missense mutations in mice give rise to phenotypes related to depression and schizophrenia, thus supporting the role of DISC1 in major mental illness...
  6. pmc Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genetics 173:2407-10. 2006
    ..This finding has implications for the study of knockout mice generated from 129-derived embryonic stem cells...
  7. pmc Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 108:18144-9. 2011
    ....
  8. ncbi request reprint NIH Swiss and Black Swiss mice have retinal degeneration and performance deficits in cognitive tests
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Toronto, Ontario, M5G 1X5, Canada
    Comp Med 55:310-6. 2005
    ..These findings indicate that NIH Swiss and Black Swiss mice are visually im paired and thus may be unsuitable for use in some experiments...
  9. doi request reprint Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3
    Tatiana V Lipina
    Samuel Lunenfeld Research Institute at Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Synapse 65:234-48. 2011
    ....
  10. doi request reprint Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice
    Noah L Lazar
    Department of Psychology, University of Western Ontario, London, ON, Canada
    Behav Brain Res 224:73-9. 2011
    ..Given the mild effect of the R189H mutation of Rtn4r on behavioural phenotypes relevant to schizophrenia, our results do not support missense mutation of RTN4R as a strong risk factor in the pathogenesis of schizophrenia...
  11. pmc Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning
    David Ng
    Program in Developmental Biology, The Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS Biol 7:e41. 2009
    ....
  12. doi request reprint Disc1 point mutations in mice affect development of the cerebral cortex
    Frankie H F Lee
    Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    J Neurosci 31:3197-206. 2011
    ..Overall, the histology of Disc1 mutant mouse cortex is reminiscent of the findings in schizophrenia. These results provide further evidence that Disc1 participates in cortical development, including neurogenesis and neuron migration...
  13. ncbi request reprint Survey of embryonic stem cell line source strains in the water maze reveals superior reversal learning of 129S6/SvEvTac mice
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
    Behav Brain Res 152:35-48. 2004
    ....
  14. ncbi request reprint Novel strategies for the development of animal models of refractory epilepsy
    O Carter Snead
    Program in Brain and Behavior, The Hospital for Sick Children, Toronto, Ontario, Canada
    Adv Neurol 97:155-71. 2006
  15. ncbi request reprint Simplex PCR assay for sex determination in mice
    Steven J Clapcote
    Mount Sinai Hospital Research Institute, Toronto, ON, Canada
    Biotechniques 38:702, 704, 706. 2005