Steven J Clapcote

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. pmc Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
    Steven J Clapcote
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:14085-90. 2009
  2. pmc Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 108:18144-9. 2011
  3. pmc Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e60141. 2013

Collaborators

  • Neil Dawson
  • Jason P Lerch
  • Laleh Sinai
  • Steven Duffy
  • Greer S Kirshenbaum
  • John C Roder
  • Judith A Pratt
  • Tom H Johnston
  • Mark J Drinkhill
  • Jonathan M Brotchie
  • Susan H Fox
  • Jonathan G L Mullins
  • Ian J Edwards
  • Martin R Ralph
  • Christian R Burgess
  • Bente Vilsen
  • Yeni H Yucel
  • O Carter Snead
  • Miguel A Cortez
  • John H Peever
  • Karolina J Jarowek
  • Janne Petersen

Detail Information

Publications3

  1. pmc Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS
    Steven J Clapcote
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 106:14085-90. 2009
    ..Our findings reveal the functional significance of the Na(+),K(+)-ATPase alpha3 isoform in the control of epileptiform activity and seizure behavior...
  2. pmc Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada M5G 1X5
    Proc Natl Acad Sci U S A 108:18144-9. 2011
    ....
  3. pmc Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice
    Greer S Kirshenbaum
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    PLoS ONE 8:e60141. 2013
    ..Our results thus provide validation for missense mutations in Na(+),K(+)-ATPase α3 as a cause of AHC, and highlight Myshkin mice as a starting point for the exploration of disease mechanisms and novel treatments in AHC...