O Ciccarelli

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis
    B Bodini
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:72-7. 2011
  2. pmc Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity
    Patrick Freund
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London, UK
    Mult Scler 16:1193-202. 2010
  3. pmc Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis
    Nikos Gorgoraptis
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 16:555-65. 2010
  4. doi request reprint Diffusion-based tractography in neurological disorders: concepts, applications, and future developments
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 7:715-27. 2008
  5. pmc Spinal cord repair in MS: does mitochondrial metabolism play a role?
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neurology 74:721-7. 2010
  6. doi request reprint Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London
    Hum Brain Mapp 30:615-24. 2009
  7. ncbi request reprint Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    Brain 130:2220-31. 2007
  8. pmc Assessing neuronal metabolism in vivo by modeling imaging measures
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 30:15030-3. 2010
  9. ncbi request reprint Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London UK
    Brain 129:1859-71. 2006
  10. ncbi request reprint Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol 253:882-91. 2006

Detail Information

Publications36

  1. pmc T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosis
    B Bodini
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 82:72-7. 2011
    ..We aimed to determine whether spatial location of T2 and T1 brain lesions predicts clinical progression during a 10-year follow-up in PPMS...
  2. pmc Recovery after spinal cord relapse in multiple sclerosis is predicted by radial diffusivity
    Patrick Freund
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London, UK
    Mult Scler 16:1193-202. 2010
    ....
  3. pmc Combining tractography and cortical measures to test system-specific hypotheses in multiple sclerosis
    Nikos Gorgoraptis
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Mult Scler 16:555-65. 2010
    ..Combining tractography and cortical measures is a useful approach in testing hypotheses which are specific to clinically relevant functional systems in multiple sclerosis, and can be applied to other neurological diseases...
  4. doi request reprint Diffusion-based tractography in neurological disorders: concepts, applications, and future developments
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
    Lancet Neurol 7:715-27. 2008
    ..This Review will outline the limitations of tractography, describe its current clinical applications in the most common neurological diseases, and highlight future opportunities...
  5. pmc Spinal cord repair in MS: does mitochondrial metabolism play a role?
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neurology 74:721-7. 2010
    ....
  6. doi request reprint Investigation of white matter pathology in ALS and PLS using tract-based spatial statistics
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London
    Hum Brain Mapp 30:615-24. 2009
    ....
  7. ncbi request reprint Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis
    O Ciccarelli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
    Brain 130:2220-31. 2007
    ..These measures were found to correlate with acute disability. Our findings suggest that it would be worthwhile performing longitudinal studies and extending these novel techniques to other neurological diseases affecting the spinal cord...
  8. pmc Assessing neuronal metabolism in vivo by modeling imaging measures
    Olga Ciccarelli
    Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 30:15030-3. 2010
    ..Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage...
  9. ncbi request reprint Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London UK
    Brain 129:1859-71. 2006
    ..The development of such connectivity measures raises their potential as markers of disease progression in ALS, and provides guidance for their use in other neurological diseases...
  10. ncbi request reprint Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosis
    O Ciccarelli
    Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, London, UK
    J Neurol 253:882-91. 2006
    ..This may inform future treatment strategies...
  11. ncbi request reprint Identifying brain regions for integrative sensorimotor processing with ankle movements
    O Ciccarelli
    Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 166:31-42. 2005
    ..In future, similar fMRI studies using passive movements have potential to elucidate abnormalities of sensorimotor integration in central nervous system diseases that affect motor function...
  12. ncbi request reprint Diffusion tractography based group mapping of major white-matter pathways in the human brain
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 19:1545-55. 2003
    ..In the future, group mapping could investigate in vivo white matter differences between normal subjects and patients affected by neurological and psychiatric diseases...
  13. ncbi request reprint From diffusion tractography to quantitative white matter tract measures: a reproducibility study
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 18:348-59. 2003
    ..In conclusion, these findings underline the importance of assessing the reliability of diffusion tractography before investigating white matter pathology...
  14. ncbi request reprint Early pericalcarine atrophy in acute optic neuritis is associated with conversion to multiple sclerosis
    T M Jenkins
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:1017-21. 2011
    ....
  15. doi request reprint Lesion enhancement diminishes with time in primary progressive multiple sclerosis
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London WC1N 3BG, UK
    Mult Scler 16:317-24. 2010
    ..02). In conclusion, a proportion of patients with PPMS may undergo an early inflammatory phase, which has some impact on subsequent mobility...
  16. ncbi request reprint Localized grey matter damage in early primary progressive multiple sclerosis contributes to disability
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 37:253-61. 2007
    ..In conclusion, localized grey matter damage occurs in early PPMS, and MTR change is more widespread than atrophy. Damage demonstrated by reduced MTR is clinically eloquent...
  17. pmc The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up study
    D T Chard
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1, UK
    J Neurol Neurosurg Psychiatry 74:1551-4. 2003
    ..The temporal relation between these processes remains unclear...
  18. doi request reprint Complementary roles of grey matter MTR and T2 lesions in predicting progression in early PPMS
    C Tur
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 82:423-8. 2011
    ....
  19. pmc A comprehensive assessment of cerebellar damage in multiple sclerosis using diffusion tractography and volumetric analysis
    V M Anderson
    Department of Neuroinflammation, UCL Institute of Neurology, London, UK
    Mult Scler 17:1079-87. 2011
    ..White matter (WM) and grey matter (GM) brain damage in multiple sclerosis (MS) is widespread, but the extent of cerebellar involvement and impact on disability needs to be clarified...
  20. pmc Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosis
    Z Khaleeli
    Department of Brain Repair and Rehabilitation, Nuclear Magnetic Resonance Unit, Institute of Neurology, University College London, London, UK
    J Neurol Neurosurg Psychiatry 78:1076-82. 2007
    ..We investigated the predictive value of MTI and the longitudinal changes developing over 1 year in early PPMS...
  21. doi request reprint Grey matter damage and overall cognitive impairment in primary progressive multiple sclerosis
    C Tur
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
    Mult Scler 17:1324-32. 2011
    ..To identify associations between cognitive impairment and imaging measures in a cross-sectional study of patients with primary progressive multiple sclerosis (PPMS)...
  22. doi request reprint Linking white matter tracts to associated cortical grey matter: a tract extension methodology
    D J Tozer
    NMR Research Unit, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Neuroimage 59:3094-102. 2012
    ..The results show that the method can be used to produce anatomically plausible extensions of the WM tracts through the GM, and regions defined in this way yield reliable estimates of the MTR from the regions...
  23. ncbi request reprint Short-term adaptation to a simple motor task: a physiological process preserved in multiple sclerosis
    L Mancini
    Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
    Neuroimage 45:500-11. 2009
    ..These findings confirm that the short-term adaptation to a simple motor task is a physiological process which is preserved in MS...
  24. ncbi request reprint An automated approach to connectivity-based partitioning of brain structures
    P A Cook
    Centre for Medical Image Computing, Department of Computer Science, University College London, UK
    Med Image Comput Comput Assist Interv 8:164-71. 2005
    ..White-matter connectivities are inferred using a probabilistic tractography algorithm that models crossing pathways explicitly. The method is demonstrated with the partitioning of the corpus callosum of eight healthy subjects...
  25. doi request reprint Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: a pilot study with application to magnetisation transfer measurements
    M C Yiannakas
    NMR Research Unit, UCL Institute of Neurology, London, UK
    Neuroimage 63:1054-9. 2012
    ....
  26. doi request reprint Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosis
    C M Dalton
    NMR Research Unit, UCL Institute of Neurology, UCL, London, UK
    Mult Scler 18:322-8. 2012
    ....
  27. ncbi request reprint Diffusion tensor imaging in early relapsing-remitting multiple sclerosis
    C M Griffin
    NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
    Mult Scler 7:290-7. 2001
    ..transfer ratio (MTR) and N-Acetyl aspartate (NM) in this cohort of patients, and as such, DTI using a region of interest (ROI) approach may not be as sensitive as other MR techniques in detecting subtle changes in normal appearing brain..
  28. ncbi request reprint Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations
    O Ciccarelli
    NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
    Neurology 56:926-33. 2001
    ..Diffusion tensor imaging indices, in particular fractional anisotropy, appear sensitive to structural damage in NAWM that is associated with disability and progression in MS...
  29. pmc Tissue- and column-specific measurements from multi-parameter mapping of the human cervical spinal cord at 3 T
    R S Samson
    NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Queen Square, London, UK
    NMR Biomed 26:1823-30. 2013
    ..This technique has the potential to provide insight into the pathological processes occurring in the cervical cord affected by neurological disorders...
  30. doi request reprint Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration
    H Kearney
    Institute of Neurology, University College London, UK
    Mult Scler 20:72-80. 2014
    ..Understanding long-term disability in multiple sclerosis (MS) is a key goal of research; it is relevant to how we monitor and treat the disease...
  31. doi request reprint The current state-of-the-art of spinal cord imaging: applications
    C A Wheeler-Kingshott
    NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, England, UK Electronic address
    Neuroimage 84:1082-93. 2014
    ....
  32. pmc Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibition
    S C Manson
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
    Exp Brain Res 187:25-31. 2008
    ..The clinical significance of these deactivation changes is still uncertain, but the functional anatomy of the affected region suggests that they could contribute to impairments of motor control...
  33. doi request reprint Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI study
    C Wegner
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, UK
    Eur J Neurol 15:113-22. 2008
    ....
  34. ncbi request reprint Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
    T E J Behrens
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 6:750-7. 2003
    ..Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter...
  35. ncbi request reprint Diffusion MR imaging in multiple sclerosis: technical aspects and challenges
    E Pagani
    Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    AJNR Am J Neuroradiol 28:411-20. 2007
    ....
  36. ncbi request reprint Diffusion MRI in multiple sclerosis
    M Rovaris
    Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    Neurology 65:1526-32. 2005
    ..Postmortem studies correlating diffusion findings with histopathology of patients with MS are, therefore, also warranted...