Research Topics
| O CiccarelliSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Investigation of white matter pathology in ALS and PLS using tract-based spatial statisticsOlga Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London
Hum Brain Mapp 30:615-24. 2009....
Probabilistic diffusion tractography: a potential tool to assess the rate of disease progression in amyotrophic lateral sclerosisO Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London UK
Brain 129:1859-71. 2006..The development of such connectivity measures raises their potential as markers of disease progression in ALS, and provides guidance for their use in other neurological diseases...- Functional response to active and passive ankle movements with clinical correlations in patients with primary progressive multiple sclerosisO Ciccarelli
Department of Headache, Brain Injury and Neurorehabilitation, Institute of Neurology, University College London, London, UK
J Neurol 253:882-91. 2006..This may inform future treatment strategies... 
Assessing neuronal metabolism in vivo by modeling imaging measuresOlga Ciccarelli
Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 30:15030-3. 2010..Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage...- Identifying brain regions for integrative sensorimotor processing with ankle movementsO Ciccarelli
Department of Headache, Brain Injury and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
Exp Brain Res 166:31-42. 2005..In future, similar fMRI studies using passive movements have potential to elucidate abnormalities of sensorimotor integration in central nervous system diseases that affect motor function... - Diffusion-based tractography in neurological disorders: concepts, applications, and future developmentsOlga Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London, UK
Lancet Neurol 7:715-27. 2008..This Review will outline the limitations of tractography, describe its current clinical applications in the most common neurological diseases, and highlight future opportunities... - Spinal cord repair in MS: does mitochondrial metabolism play a role?O Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neurology 74:721-7. 2010.... - Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosisO Ciccarelli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
Brain 130:2220-31. 2007..These measures were found to correlate with acute disability. Our findings suggest that it would be worthwhile performing longitudinal studies and extending these novel techniques to other neurological diseases affecting the spinal cord... - Diffusion tractography based group mapping of major white-matter pathways in the human brainO Ciccarelli
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 19:1545-55. 2003..In the future, group mapping could investigate in vivo white matter differences between normal subjects and patients affected by neurological and psychiatric diseases... - From diffusion tractography to quantitative white matter tract measures: a reproducibility studyO Ciccarelli
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 18:348-59. 2003..In conclusion, these findings underline the importance of assessing the reliability of diffusion tractography before investigating white matter pathology... - Early pericalcarine atrophy in acute optic neuritis is associated with conversion to multiple sclerosisT M Jenkins
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 82:1017-21. 2011.... - T2 lesion location really matters: a 10 year follow-up study in primary progressive multiple sclerosisB Bodini
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London, UK
J Neurol Neurosurg Psychiatry 82:72-7. 2011..We aimed to determine whether spatial location of T2 and T1 brain lesions predicts clinical progression during a 10-year follow-up in PPMS... - Lesion enhancement diminishes with time in primary progressive multiple sclerosisZ Khaleeli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, London WC1N 3BG, UK
Mult Scler 16:317-24. 2010..02). In conclusion, a proportion of patients with PPMS may undergo an early inflammatory phase, which has some impact on subsequent mobility... - A comprehensive assessment of cerebellar damage in multiple sclerosis using diffusion tractography and volumetric analysisV M Anderson
Department of Neuroinflammation, UCL Institute of Neurology, London, UK
Mult Scler 17:1079-87. 2011..White matter (WM) and grey matter (GM) brain damage in multiple sclerosis (MS) is widespread, but the extent of cerebellar involvement and impact on disability needs to be clarified... - Complementary roles of grey matter MTR and T2 lesions in predicting progression in early PPMSC Tur
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 82:423-8. 2011.... - Localized grey matter damage in early primary progressive multiple sclerosis contributes to disabilityZ Khaleeli
Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neuroimage 37:253-61. 2007..In conclusion, localized grey matter damage occurs in early PPMS, and MTR change is more widespread than atrophy. Damage demonstrated by reduced MTR is clinically eloquent... - Grey matter damage and overall cognitive impairment in primary progressive multiple sclerosisC Tur
Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, UK
Mult Scler 17:1324-32. 2011..To identify associations between cognitive impairment and imaging measures in a cross-sectional study of patients with primary progressive multiple sclerosis (PPMS)... - Linking white matter tracts to associated cortical grey matter: a tract extension methodologyD J Tozer
NMR Research Unit, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK
Neuroimage 59:3094-102. 2012..The results show that the method can be used to produce anatomically plausible extensions of the WM tracts through the GM, and regions defined in this way yield reliable estimates of the MTR from the regions... - The longitudinal relation between brain lesion load and atrophy in multiple sclerosis: a 14 year follow up studyD T Chard
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1, UK
J Neurol Neurosurg Psychiatry 74:1551-4. 2003.... - Brain lesion location and clinical status 20 years after a diagnosis of clinically isolated syndrome suggestive of multiple sclerosisC M Dalton
NMR Research Unit, UCL Institute of Neurology, UCL, London, UK
Mult Scler 18:322-8. 2012.... - Diffusion tensor imaging in early relapsing-remitting multiple sclerosisC M Griffin
NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK
Mult Scler 7:290-7. 2001..transfer ratio (MTR) and N-Acetyl aspartate (NM) in this cohort of patients, and as such, DTI using a region of interest (ROI) approach may not be as sensitive as other MR techniques in detecting subtle changes in normal appearing brain.. - Magnetisation transfer ratio in the normal appearing white matter predicts progression of disability over 1 year in early primary progressive multiple sclerosisZ Khaleeli
Department of Brain Repair and Rehabilitation, Nuclear Magnetic Resonance Unit, Institute of Neurology, University College London, London, UK
J Neurol Neurosurg Psychiatry 78:1076-82. 2007..We investigated the predictive value of MTI and the longitudinal changes developing over 1 year in early PPMS... - Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlationsO Ciccarelli
NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, United Kingdom
Neurology 56:926-33. 2001..Diffusion tensor imaging indices, in particular fractional anisotropy, appear sensitive to structural damage in NAWM that is associated with disability and progression in MS... - An automated approach to connectivity-based partitioning of brain structuresP A Cook
Centre for Medical Image Computing, Department of Computer Science, University College London, UK
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:164-71. 2005..White-matter connectivities are inferred using a probabilistic tractography algorithm that models crossing pathways explicitly. The method is demonstrated with the partitioning of the corpus callosum of eight healthy subjects... - Feasibility of grey matter and white matter segmentation of the upper cervical cord in vivo: A pilot study with application to magnetisation transfer measurementsM C Yiannakas
NMR Research Unit, UCL Institute of Neurology, London, UK Department of Neuroinflammation, UCL Institute of Neurology, London, UK Electronic address
Neuroimage 63:1054-9. 2012.... - Short-term adaptation to a simple motor task: a physiological process preserved in multiple sclerosisL Mancini
Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK
Neuroimage 45:500-11. 2009..These findings confirm that the short-term adaptation to a simple motor task is a physiological process which is preserved in MS... - Impairment of movement-associated brain deactivation in multiple sclerosis: further evidence for a functional pathology of interhemispheric neuronal inhibitionS C Manson
Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, UK
Exp Brain Res 187:25-31. 2008..The clinical significance of these deactivation changes is still uncertain, but the functional anatomy of the affected region suggests that they could contribute to impairments of motor control... - Relating functional changes during hand movement to clinical parameters in patients with multiple sclerosis in a multi-centre fMRI studyC Wegner
Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, UK
Eur J Neurol 15:113-22. 2008.... - Non-invasive mapping of connections between human thalamus and cortex using diffusion imagingT E J Behrens
Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Nat Neurosci 6:750-7. 2003..Our results provide the first quantitative demonstration of reliable inference of anatomical connectivity between human gray matter structures using diffusion data and the first connectivity-based segmentation of gray matter... - Diffusion MR imaging in multiple sclerosis: technical aspects and challengesE Pagani
Neuroimaging Research Unit, Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
AJNR Am J Neuroradiol 28:411-20. 2007.... - Diffusion MRI in multiple sclerosisM Rovaris
Department of Neurology, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 65:1526-32. 2005..Postmortem studies correlating diffusion findings with histopathology of patients with MS are, therefore, also warranted...