Amanda Jane Churchill

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. doi VEGF polymorphisms are associated with severity of diabetic retinopathy
    Amanda J Churchill
    Unit of Ophthalmology, Bristol Eye Hospital, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 49:3611-6. 2008
  2. pmc Clinical and experimental advances in congenital and paediatric cataracts
    Amanda Churchill
    University of Bristol and Bristol Eye Hospital, Bristol, UK
    Philos Trans R Soc Lond B Biol Sci 366:1234-49. 2011
  3. ncbi A compound heterozygous change found in Peters' anomaly
    Amanda Jane Churchill
    Department of Ophthalmology, University of Bristol, Bristol, United Kingdom
    Mol Vis 11:66-70. 2005
  4. ncbi VEGF polymorphisms are associated with neovascular age-related macular degeneration
    Amanda J Churchill
    Molecular Ophthalmology, University of Bristol, and West Midlands Regional Genetics Laboratory, Birmingham Womans Hospital NHS Trust, UK
    Hum Mol Genet 15:2955-61. 2006
  5. ncbi Cytokine gene polymorphism in sympathetic ophthalmia
    Denize Atan
    Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
    Invest Ophthalmol Vis Sci 46:4245-50. 2005
  6. doi Cytokine polymorphism in noninfectious uveitis
    Denize Atan
    Clinical Sciences at South Bristol, Bristol Eye Hospital, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4133-42. 2010
  7. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
  8. ncbi Polymorphisms in OPA1 are associated with normal tension glaucoma
    Brenda L Powell
    Division of Ophthalmology, University of Bristol, Bristol, United Kingdom
    Mol Vis 9:460-4. 2003
  9. pmc VEGF-A165b is cytoprotective and antiangiogenic in the retina
    Anette L Magnussen
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4273-81. 2010
  10. pmc Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    Jing Hua
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4282-8. 2010

Collaborators

Detail Information

Publications10

  1. doi VEGF polymorphisms are associated with severity of diabetic retinopathy
    Amanda J Churchill
    Unit of Ophthalmology, Bristol Eye Hospital, University of Bristol, Bristol, United Kingdom
    Invest Ophthalmol Vis Sci 49:3611-6. 2008
    ..To determine whether single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor (VEGF) gene are associated with severity of diabetic retinopathy...
  2. pmc Clinical and experimental advances in congenital and paediatric cataracts
    Amanda Churchill
    University of Bristol and Bristol Eye Hospital, Bristol, UK
    Philos Trans R Soc Lond B Biol Sci 366:1234-49. 2011
    ..There is increasing evidence for pleiotropic effects of these genes, and increasing consideration that cataracts may act as early and readily detectable biomarkers for a number of systemic syndromes...
  3. ncbi A compound heterozygous change found in Peters' anomaly
    Amanda Jane Churchill
    Department of Ophthalmology, University of Bristol, Bristol, United Kingdom
    Mol Vis 11:66-70. 2005
    ..To determine whether sequence variations in the congenital glaucoma gene, CYP1B1, are present in individuals with Peters' anomaly, a developmental eye anomaly frequently associated with glaucoma...
  4. ncbi VEGF polymorphisms are associated with neovascular age-related macular degeneration
    Amanda J Churchill
    Molecular Ophthalmology, University of Bristol, and West Midlands Regional Genetics Laboratory, Birmingham Womans Hospital NHS Trust, UK
    Hum Mol Genet 15:2955-61. 2006
    ..Identification of those at risk in the population would allow individual counselling with lifestyle advice to reduce the risks of blindness. (Genbank accession nos M63971 and AF437895)...
  5. ncbi Cytokine gene polymorphism in sympathetic ophthalmia
    Denize Atan
    Academic Unit of Ophthalmology, Clinical Sciences South Bristol, Bristol Eye Hospital, UK
    Invest Ophthalmol Vis Sci 46:4245-50. 2005
    ..The purpose of this study was to determine whether polymorphisms in the cytokine genes are important markers for disease severity and outcome in patients with SO...
  6. doi Cytokine polymorphism in noninfectious uveitis
    Denize Atan
    Clinical Sciences at South Bristol, Bristol Eye Hospital, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4133-42. 2010
    ..TNFA and IL10 are strong candidate genes, given the influence of these cytokines on inflammation, immune tolerance, and apoptosis...
  7. pmc Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
    Dawid G Nowak
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Southwell Street, Bristol BS2 8EJ, UK
    J Cell Sci 121:3487-95. 2008
    ....
  8. ncbi Polymorphisms in OPA1 are associated with normal tension glaucoma
    Brenda L Powell
    Division of Ophthalmology, University of Bristol, Bristol, United Kingdom
    Mol Vis 9:460-4. 2003
    ..corrected] To confirm whether specific polymorphisms in intron 8 (IVS8) of the OPA1 gene are found more commonly in patients with normal tension glaucoma (NTG) compared to normal controls...
  9. pmc VEGF-A165b is cytoprotective and antiangiogenic in the retina
    Anette L Magnussen
    Microvascular Research Laboratories, Bristol Heart Institute, Department of Physiology and Pharmacology, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4273-81. 2010
    ..Here the authors investigate the antiangiogenic activity of VEGF(165)b and its effect on retinal epithelial and endothelial cell survival...
  10. pmc Recombinant human VEGF165b inhibits experimental choroidal neovascularization
    Jing Hua
    Microvascular Research Laboratories, Department of Physiology and Pharmacology, Bristol Heart Institute, School of Veterinary Sciences, University of Bristol, Bristol, UK
    Invest Ophthalmol Vis Sci 51:4282-8. 2010
    ..It is the proangiogenic family that is responsible for the blood vessel growth seen in AMD...