Research Topics
Species | Jonathan R ChubbSummaryAffiliation: University of Dundee Country: UK Publications
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Detail Information
Publications
Bursts and pulses: insights from single cell studies into transcriptional mechanismsJonathan R Chubb
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
Curr Opin Genet Dev 20:478-84. 2010..This review will highlight the evidence for these phenomena, the proposed mechanisms underlying discontinuity, and the biological implications of such behaviour...
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferaseJonathan R Chubb
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, The Bronx, NY 10461, USA
Dev Biol 292:519-32. 2006..Microarray analysis of the set1 mutants reveals genomic clustering of mis-expressed genes, suggesting a requirement for Set1 in the regulation of chromatin-mediated events at gene clusters...- Transcriptional pulsing of a developmental geneJonathan R Chubb
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, The Bronx, New York 10461, USA
Curr Biol 16:1018-25. 2006..This study represents the first direct visualization of transcriptional pulsing in eukaryotes. Discontinuity of transcription may allow greater flexibility in the gene-expression decisions of a cell... - Methylation of H3K4 Is required for inheritance of active transcriptional statesTetsuya Muramoto
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Curr Biol 20:397-406. 2010..However, the extent to which inheritance of active transcriptional states occurs from mother to daughter cells has not been directly addressed in unperturbed cell populations... 
Digital nature of the immediate-early transcriptional responseMichelle Stevense
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, UK
Development 137:579-84. 2010..Biased digital responses may be necessary for certain forms of developmental specification. Limiting bias in responsiveness is required to reduce noise in positional signalling...- The spatial order of transcription in mammalian cellsJeffrey M Levsky
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
J Cell Biochem 102:609-17. 2007..The approach has sufficient spatial resolution to be applied to the detection of chromosomal translocations or the identification of cancer cells... - Live imaging of nascent RNA dynamics reveals distinct types of transcriptional pulse regulationTetsuya Muramoto
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
Proc Natl Acad Sci U S A 109:7350-5. 2012.... - Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cellsIris Muller
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee, UK
PLoS ONE 5:e11560. 2010.... - Nuclear organization and transcriptional dynamics in DictyosteliumMichelle Stevense
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Dev Growth Differ 53:576-86. 2011..This review will bring together the available knowledge of the structure and dynamics of the Dictyostelium nucleus and discuss recent transcription imaging studies and their implications for stability and accuracy of cell decisions... - Live imaging of the Dictyostelium cell cycle reveals widespread S phase during development, a G2 bias in spore differentiation and a premitotic checkpointTetsuya Muramoto
Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Development 135:1647-57. 2008.... - Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryoteDuen Wei Hsu
Nuclear Signalling Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Nucleic Acids Res 40:7247-56. 2012..These studies confirm that dynamic acetylation targeted to H3K4me3 arose early in evolution and reveal a very high level of specificity of histone variant utilization in a simple multicellular eukaryote... - Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutantsJonathan R Chubb
School of Biosciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom
Cell Motil Cytoskeleton 53:150-62. 2002..The levels of F-actin in both mutant cell lines are significantly elevated with respect to the wild-type parental cells, suggesting a possible biochemical basis for these emphatic phenotypes... - Epigenetics in DictyosteliumMarkus Kaller
Abt. Genetik, Kassel University, Germany
Methods Mol Biol 346:491-505. 2006..The protocols in this chapter describe the more recent techniques established for other organisms, with an emphasis on special precautions for application in Dictyostelium... - Considering nuclear compartmentalization in the light of nuclear dynamicsJonathan R Chubb
MRC Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, United Kingdom
Cell 112:403-6. 2003..However, nuclear proteins have now been shown to be highly mobile. This review considers the formation and function of nuclear compartments in a situation in which proteins are rapidly moving through the nuclear volume... - Recruitment to the nuclear periphery can alter expression of genes in human cellsLee E Finlan
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
PLoS Genet 4:e1000039. 2008..This is compatible with the suggestion that re-localisation of genes relative to the peripheral zone of the nucleus could be used by metazoans to modulate the expression of selected genes during development and differentiation...