Imti Choonara

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. doi request reprint Epidemics of acute renal failure in children (diethylene glycol toxicity)
    Saad Alkahtani
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Arch Dis Child 95:1062-4. 2010
  2. doi request reprint WHO wants safer medicines for children
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Arch Dis Child 93:456-7. 2008
  3. pmc Pharmacovigilance in children in Camagüey Province, Cuba
    Z Bárzaga Arencibia
    Children s Hospital Eduardo Agramonte Piña, Camagüey Province, Cuba
    Eur J Clin Pharmacol 68:1079-84. 2012
  4. doi request reprint Educational Paper: Aspects of clinical pharmacology in children--pharmacovigilance and safety
    Imti Choonara
    Academic Division of Child Health, Derbyshire Children s Hospital, University of Nottingham, Derby, UK
    Eur J Pediatr 172:577-80. 2013
  5. pmc Improving children's medicines
    I Choonara
    University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Arch Dis Child 91:550-1. 2006
  6. doi request reprint Ethical and safety aspects of clinical trials in neonates
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
    Early Hum Dev 85:S19-20. 2009
  7. pmc Armed conflict and child health
    Michael Rieder
    University of Western Ontario, London, Canada
    Arch Dis Child 97:59-62. 2012
  8. doi request reprint Recent advances in medicines for children and neonates
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Expert Rev Clin Pharmacol 4:563-5. 2011
  9. pmc Training in paediatric clinical pharmacology in the UK
    Imti Choonara
    Working Group on Training in Paediatric Clinical Pharmacology and Therapeutics, Royal College of Paediatrics and Child Health, 50 Hallam Street, London, UK
    Br J Clin Pharmacol 58:217-8. 2004
  10. pmc Safety of herbal medicines in children
    I Choonara
    Academic Division in Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Arch Dis Child 88:1032-3. 2003

Collaborators

Detail Information

Publications48

  1. doi request reprint Epidemics of acute renal failure in children (diethylene glycol toxicity)
    Saad Alkahtani
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Arch Dis Child 95:1062-4. 2010
    ..Health professionals need to be aware of the clinical presentation of DEG poisoning as prompt action is likely to save lives by the removal of the contaminated/illegal medicine from pharmacies and shops in the affected area...
  2. doi request reprint WHO wants safer medicines for children
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Arch Dis Child 93:456-7. 2008
  3. pmc Pharmacovigilance in children in Camagüey Province, Cuba
    Z Bárzaga Arencibia
    Children s Hospital Eduardo Agramonte Piña, Camagüey Province, Cuba
    Eur J Clin Pharmacol 68:1079-84. 2012
    ..Our aim was to describe the adverse drug reactions (ADRs) detected following increased education about pharmacovigilance and drug toxicity in children in Camagüey Province, Cuba...
  4. doi request reprint Educational Paper: Aspects of clinical pharmacology in children--pharmacovigilance and safety
    Imti Choonara
    Academic Division of Child Health, Derbyshire Children s Hospital, University of Nottingham, Derby, UK
    Eur J Pediatr 172:577-80. 2013
    ..This information has been useful in developing guidelines to prevent further cases of drug toxicity. Greater awareness and understanding of drug toxicity in children should result in more rational prescribing...
  5. pmc Improving children's medicines
    I Choonara
    University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Arch Dis Child 91:550-1. 2006
  6. doi request reprint Ethical and safety aspects of clinical trials in neonates
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
    Early Hum Dev 85:S19-20. 2009
    ..It is essential that the clinical trials are performed safely and ethically and one therefore needs to be aware of predisposing factors for drug toxicity in the neonatal period...
  7. pmc Armed conflict and child health
    Michael Rieder
    University of Western Ontario, London, Canada
    Arch Dis Child 97:59-62. 2012
    ..Armed conflict is not inevitable but is an important health issue that should be prevented...
  8. doi request reprint Recent advances in medicines for children and neonates
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Expert Rev Clin Pharmacol 4:563-5. 2011
    ..The focus of the congress was recent advances in drug therapy in neonates and children. Alongside invited speakers, there were a host of presentations by young investigators which consisted of oral and poster presentations...
  9. pmc Training in paediatric clinical pharmacology in the UK
    Imti Choonara
    Working Group on Training in Paediatric Clinical Pharmacology and Therapeutics, Royal College of Paediatrics and Child Health, 50 Hallam Street, London, UK
    Br J Clin Pharmacol 58:217-8. 2004
    ..To produce a training programme in paediatric clinical pharmacology...
  10. pmc Safety of herbal medicines in children
    I Choonara
    Academic Division in Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Arch Dis Child 88:1032-3. 2003
  11. ncbi request reprint Unlicensed and off-label drug use in children: implications for safety
    Imti Choonara
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby, DE22 3NE, UK
    Drug Saf 25:1-5. 2002
    ..The risk of prescribing off-label and unlicensed drugs in children is not clear from the limited data available...
  12. pmc Drug misuse during pregnancy and fetal toxicity
    Mark Anderson
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Arch Dis Child Fetal Neonatal Ed 92:F332-3. 2007
  13. pmc Safety of fluconazole in paediatrics: a systematic review
    Oluwaseun Egunsola
    Academic Division of Child Health, Derbyshire Children s Hospital, University of Nottingham, Derby, DE22 3DT, UK
    Eur J Clin Pharmacol 69:1211-21. 2013
    ..To determine the safety of fluconazole in neonates and other paediatric age groups by identifying adverse events (AEs) and drug interactions associated with treatment...
  14. ncbi request reprint Parental assessment and management of children's postoperative pain: a randomized clinical trial
    Vanessa Unsworth
    Academic Division of Child Health, University of Nottingham, Derby, UK
    J Child Health Care 11:186-94. 2007
    ..26, Mann- Whitney U-test). It appears that a self-report pain scale does not improve the postoperative management of pain in children at home...
  15. pmc Systematic review of safety in paediatric drug trials published in 2007
    Khairun Nain Bin Nor Aripin
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Eur J Clin Pharmacol 68:189-94. 2012
    ..Previous research shows that these children can suffer moderate and severe adverse drug reactions (ADRs) in clinical trials, yet very few of the trials designated a data safety monitoring board (DSMB) to oversee the trial...
  16. doi request reprint Published pediatric randomized drug trials in developing countries, 1996-2002
    Khairun N B Nor Aripin
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
    Paediatr Drugs 12:99-103. 2010
    ..Children in developing countries deserve the same standard of medicines as those in developed countries, i.e. appropriate medications for the specific diseases that occur...
  17. ncbi request reprint Validating the Derbyshire Children's Hospital Pain Tool: a pilot study
    Vanessa Peden
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Paediatr Anaesth 13:109-13. 2003
    ..The pain assessment chart encompasses pain assessment by utilizing facial expression, body movement and verbal expression. An exploratory study was performed to define its reliability and validity...
  18. doi request reprint Safety in paediatric clinical trials--a 7-year review
    H M Sammons
    Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
    Acta Paediatr 97:474-7. 2008
    ..The safety of clinical trials in children has not been previously studied. We aimed to identify how safety is monitored and the extent of adverse drug reactions (ADRs)...
  19. ncbi request reprint British and Canadian views on the ethics of paediatric clinical trials
    H M Sammons
    Academic Division of Child Health, University of Nottingham, Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby, DE22 3DT, UK
    Eur J Clin Pharmacol 63:431-6. 2007
    ..Ethical problems are quoted as a reason not to perform clinical trials in children. Little is known about the views of researchers regarding ethics...
  20. pmc Unlicensed and off label prescribing of drugs in general practice
    J McIntyre
    Academic Division of Child Health University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Arch Dis Child 83:498-501. 2000
    ..To determine the incidence and nature of unlicensed and off label prescribing of drugs for children in general practice...
  21. doi request reprint Case-control study of acute renal failure in patients with cystic fibrosis in the UK
    A Smyth
    Division of Respiratory Medicine, Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 63:532-5. 2008
    ..There has been a recent increase in the number of reported cases of acute renal failure (ARF) in cystic fibrosis (CF). A case-control study was conducted to determine the factors which are associated with an increased risk of ARF...
  22. doi request reprint Double checking the administration of medicines: what is the evidence? A systematic review
    Zayed Alsulami
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, The Medical School, Clinical Sciences Wing, Uttoxeter Road, Derby, UK
    Arch Dis Child 97:833-7. 2012
    ..To evaluate the evidence for double checking the administration of medicines...
  23. doi request reprint A systematic review of paediatric randomised controlled drug trials published in 2007
    Khairun N B Nor Aripin
    Academic Division of Child Health, School of Graduate Entry Medicine and Health Sciences, University of Nottingham, Derby, UK
    Arch Dis Child 95:469-73. 2010
    ..To elucidate the current situation of randomised drug trials involving the paediatric population...
  24. ncbi request reprint Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extraction
    Helen M Sammons
    Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Int J Paediatr Dent 17:297-303. 2007
    ..Local anaesthetic has been shown to reduce this pain, but needs to be administered via a method that causes minimum injury or distress to the child...
  25. pmc A novel scheme for the reporting of adverse drug reactions
    A Clarkson
    Academic Division of Child Health (University of Nottingham, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Arch Dis Child 84:337-9. 2001
    ..This initiative will increase our knowledge about the safety of medicines used to treat children and so help protect public health...
  26. pmc Medication errors in the Middle East countries: a systematic review of the literature
    Zayed Alsulami
    Academic Division of Child Health, School of Graduate Entry Medicine and Health, University of Nottingham, Derbyshire Children s at the Royal Derby Hospital, Uttoxeter Road, Derby, DE22 3DT, UK
    Eur J Clin Pharmacol 69:995-1008. 2013
    ..The objectives of this systematic review were to review studies of the incidence and types of medication errors in Middle Eastern countries and to identify the main contributory factors involved...
  27. ncbi request reprint Drug toxicity in the neonate
    John McIntyre
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Biol Neonate 86:218-21. 2004
    ..This therefore predisposes to certain types of drug toxicity, which are described below. Medication errors are also a significant problem in the neonatal period due to the lack of appropriate formulations designed for neonates...
  28. pmc Surveillance for fatal suspected adverse drug reactions in the UK
    A Clarkson
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
    Arch Dis Child 87:462-6. 2002
    ..To determine the nature and number of suspected adverse drug reactions (ADRs) associated with fatal outcomes in children reported through the yellow card scheme...
  29. pmc What motivates British parents to consent for research? A questionnaire study
    Helen M Sammons
    Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road Derby, DE22 3DT, UK
    BMC Pediatr 7:12. 2007
    ....
  30. doi request reprint A systematic review of pharmacokinetics studies in children with protein-energy malnutrition
    Kazeem A Oshikoya
    Academic Division of Child Health, The Medical School in Derby, Royal Derby Hospital, University of Nottingham, Uttoxeter Road, Derby DE 22 3DT, UK
    Eur J Clin Pharmacol 66:1025-35. 2010
    ..Its association with a wide spectrum of infections necessitates multiple drug therapies. A systematic review was performed to determine the effects of PEM on drug pharmacokinetics...
  31. doi request reprint A systematic review of safety monitoring and drug toxicity in published randomised controlled trials of antiepileptic drugs in children over a 10-year period
    Mark Anderson
    University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Arch Dis Child 95:731-8. 2010
    ..To determine the extent of drug toxicity experienced by children and methods to detect it in randomised controlled trials (RCTs) of antiepileptic drugs (AEDs) published over a 10-year period...
  32. ncbi request reprint Validating the Derbyshire Children's Hospital Pain Tool in children aged 6-12 years
    Vanessa Peden
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3NE, UK
    J Child Health Care 9:59-71. 2005
    ..This study supports construct validity and inter-rater reliability of the DPC pain assessment tool for children aged 6-12 undergoing minor and intermediate surgery...
  33. pmc Ciprofloxacin safety in paediatrics: a systematic review
    Abiodun Adefurin
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
    Arch Dis Child 96:874-80. 2011
    ..To determine the safety of ciprofloxacin in paediatric patients in relation to arthropathy, any other adverse events (AEs) and drug interactions...
  34. pmc Should paediatricians support the European Paediatric Clinical Trials Register?
    H M Sammons
    Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Arch Dis Child 90:559-60. 2005
  35. pmc Research in general paediatrics
    H M Sammons
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Arch Dis Child 89:408-10. 2004
  36. ncbi request reprint Age and sex of drivers associated with child pedestrian injuries
    Richard Thompson
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, UK
    J Child Health Care 7:184-90. 2003
    ..Educational publicity campaigns to reduce driver speeds in urban areas need to be targeted at those drivers most likely to be involved in an RTC with a child...
  37. pmc Clinical trials: the viewpoint of children
    J Cherrill
    Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
    Arch Dis Child 92:712-3. 2007
    ..Nineteen children recognised that there were risks involved with taking part in clinical trials. Risks concerned with being paid were recognised by all children...
  38. pmc Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studies
    P Impicciatore
    Academic Division of Child Health (Nottingham University) Derbyshire Children's Hospital, Derby, UK
    Br J Clin Pharmacol 52:77-83. 2001
    ..Further, methodologically sound drug surveillance studies are necessary for an effective promotion of a safer use of drugs in children...
  39. doi request reprint Clinical trials: the viewpoint of children with a chronic illness compared with healthy children
    J Cherrill
    Academic Division of Child Health, The University of Nottingham, Derby, UK
    Arch Dis Child 95:229-32. 2010
    ..Young people should be given more opportunities to be involved in decision-making regarding clinical trials of medicines...
  40. doi request reprint Adverse drug reactions in children in Camagüey Province, Cuba
    Z Bárzaga Arencibia
    Department of Pharmacoepidemiology, Camaguey Children s Hospital, Camagüey Province, Cuba
    Arch Dis Child 95:474-7. 2010
    ..To determine the incidence of adverse drug reactions (ADRs) in children in Camagüey Province, Cuba...
  41. ncbi request reprint Unlicensed and off-label drug use in children: implications for safety
    Imti Choonara
    Expert Opin Drug Saf 3:81-3. 2004
    ..Health professionals, however, usually have no alternative but to use unlicensed and off-label medicines. More clinical trials for medicines in children are required to provide the evidence base for safe and effective drug prescribing...
  42. ncbi request reprint [The first European registry for pediatric clinical trials: DEC-net]
    Maurizio Bonati
    Istituto Mario Negn Milano
    Assist Inferm Ric 23:91-2. 2004
  43. pmc Regulation of drugs for children in Europe
    Imti Choonara
    BMJ 335:1221-2. 2007
  44. pmc Direct reporting of suspected adverse drug reactions by patients
    Imti Choonara
    J R Soc Med 97:316-7. 2004
  45. ncbi request reprint Sedation and neuromuscular blockade in paediatric intensive care: a review of current practice in the UK
    Stephen D Playfor
    Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK
    Paediatr Anaesth 13:147-51. 2003
    ..Our aim was to investigate the current practice of sedation and neuromuscular blockade in critically ill children in paediatric intensive care units (PICUs) in the UK...
  46. ncbi request reprint [A complete clinical trial register is already a reality in the paediatric field]
    Evelyne Jacqz-Aigrain
    Hopital Robert Debre, Paris, France
    Therapie 61:121-4. 2006
    ..It will also allow for active monitoring of new or evolved knowledge of drug therapies...
  47. doi request reprint Publishing the evidence for children's medicines
    Imti Choonara
    Arch Dis Child 93:815. 2008
  48. doi request reprint The DEC-net European register of paediatric drug therapy trials: contents and context
    Chiara Pandolfini
    Laboratory for Mother and Child Health, Mario Negri Pharmacological Research Institute, Via G La Masa 19, 20156 Milan, Italy
    Eur J Clin Pharmacol 64:611-7. 2008
    ..To describe the results and conclusions of DEC-net, an international, publicly available register of paediatric drug therapy clinical trials, and to assess which paediatric health areas are covered by research and by which trial types...