Research Topics
| Imti ChoonaraSummaryAffiliation: University of Nottingham Country: UK Publications
| Collaborators
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Detail Information
Publications
Epidemics of acute renal failure in children (diethylene glycol toxicity)Saad Alkahtani
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
Arch Dis Child 95:1062-4. 2010..Health professionals need to be aware of the clinical presentation of DEG poisoning as prompt action is likely to save lives by the removal of the contaminated/illegal medicine from pharmacies and shops in the affected area...
Improving children's medicinesI Choonara
University of Nottingham, Derbyshire Children's Hospital, Derby, UK
Arch Dis Child 91:550-1. 2006- Training in paediatric clinical pharmacology in the UKImti Choonara
Working Group on Training in Paediatric Clinical Pharmacology and Therapeutics, Royal College of Paediatrics and Child Health, 50 Hallam Street, London, UK
Br J Clin Pharmacol 58:217-8. 2004..To produce a training programme in paediatric clinical pharmacology... - Drug misuse during pregnancy and fetal toxicityMark Anderson
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3DT, UK
Arch Dis Child Fetal Neonatal Ed 92:F332-3. 2007 
WHO wants safer medicines for childrenImti Choonara
Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3DT, UK
Arch Dis Child 93:456-7. 2008- Ethical and safety aspects of clinical trials in neonatesImti Choonara
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
Early Hum Dev 85:S19-20. 2009..It is essential that the clinical trials are performed safely and ethically and one therefore needs to be aware of predisposing factors for drug toxicity in the neonatal period... - Safety of herbal medicines in childrenI Choonara
Academic Division in Child Health, University of Nottingham, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3NE, UK
Arch Dis Child 88:1032-3. 2003 - Armed conflict and child healthMichael Rieder
University of Western Ontario, London, Canada
Arch Dis Child 97:59-62. 2012..Armed conflict is not inevitable but is an important health issue that should be prevented... - Unlicensed and off-label drug use in children: implications for safetyImti Choonara
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby, DE22 3NE, UK
Drug Saf 25:1-5. 2002..The risk of prescribing off-label and unlicensed drugs in children is not clear from the limited data available... - Recent advances in medicines for children and neonatesImti Choonara
Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
Expert Rev Clin Pharmacol 4:563-5. 2011..The focus of the congress was recent advances in drug therapy in neonates and children. Alongside invited speakers, there were a host of presentations by young investigators which consisted of oral and poster presentations... - Systematic review of safety in paediatric drug trials published in 2007Khairun Nain Bin Nor Aripin
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
Eur J Clin Pharmacol 68:189-94. 2012..Previous research shows that these children can suffer moderate and severe adverse drug reactions (ADRs) in clinical trials, yet very few of the trials designated a data safety monitoring board (DSMB) to oversee the trial... - Published pediatric randomized drug trials in developing countries, 1996-2002Khairun N B Nor Aripin
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
Paediatr Drugs 12:99-103. 2010..Children in developing countries deserve the same standard of medicines as those in developed countries, i.e. appropriate medications for the specific diseases that occur... - Parental assessment and management of children's postoperative pain: a randomized clinical trialVanessa Unsworth
Academic Division of Child Health, University of Nottingham, Derby, UK
J Child Health Care 11:186-94. 2007..26, Mann- Whitney U-test). It appears that a self-report pain scale does not improve the postoperative management of pain in children at home... - Validating the Derbyshire Children's Hospital Pain Tool: a pilot studyVanessa Peden
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
Paediatr Anaesth 13:109-13. 2003..The pain assessment chart encompasses pain assessment by utilizing facial expression, body movement and verbal expression. An exploratory study was performed to define its reliability and validity... - Case-control study of acute renal failure in patients with cystic fibrosis in the UKA Smyth
Division of Respiratory Medicine, Clinical Sciences Building, Nottingham City Hospital, Nottingham NG5 1PB, UK
Thorax 63:532-5. 2008..There has been a recent increase in the number of reported cases of acute renal failure (ARF) in cystic fibrosis (CF). A case-control study was conducted to determine the factors which are associated with an increased risk of ARF... - Safety in paediatric clinical trials--a 7-year reviewH M Sammons
Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3DT, UK
Acta Paediatr 97:474-7. 2008..The safety of clinical trials in children has not been previously studied. We aimed to identify how safety is monitored and the extent of adverse drug reactions (ADRs)... - British and Canadian views on the ethics of paediatric clinical trialsH M Sammons
Academic Division of Child Health, University of Nottingham, Medical School, Derbyshire Children s Hospital, Uttoxeter Road, Derby, DE22 3DT, UK
Eur J Clin Pharmacol 63:431-6. 2007..Ethical problems are quoted as a reason not to perform clinical trials in children. Little is known about the views of researchers regarding ethics... - Unlicensed and off label prescribing of drugs in general practiceJ McIntyre
Academic Division of Child Health University of Nottingham, Derbyshire Children s Hospital, Uttoxeter Road, Derby DE22 3NE, UK
Arch Dis Child 83:498-501. 2000..To determine the incidence and nature of unlicensed and off label prescribing of drugs for children in general practice... - Double checking the administration of medicines: what is the evidence? A systematic reviewZayed Alsulami
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, The Medical School, Clinical Sciences Wing, Uttoxeter Road, Derby, UK
Arch Dis Child 97:833-7. 2012..To evaluate the evidence for double checking the administration of medicines... - A systematic review of paediatric randomised controlled drug trials published in 2007Khairun N B Nor Aripin
Academic Division of Child Health, School of Graduate Entry Medicine and Health Sciences, University of Nottingham, Derby, UK
Arch Dis Child 95:469-73. 2010..To elucidate the current situation of randomised drug trials involving the paediatric population... - Randomized controlled trial of the intraligamental use of a local anaesthetic (lignocaine 2%) versus controls in paediatric tooth extractionHelen M Sammons
Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
Int J Paediatr Dent 17:297-303. 2007..Local anaesthetic has been shown to reduce this pain, but needs to be administered via a method that causes minimum injury or distress to the child... - A novel scheme for the reporting of adverse drug reactionsA Clarkson
Academic Division of Child Health (University of Nottingham, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3NE, UK
Arch Dis Child 84:337-9. 2001..This initiative will increase our knowledge about the safety of medicines used to treat children and so help protect public health... - Drug toxicity in the neonateJohn McIntyre
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, Derby, UK
Biol Neonate 86:218-21. 2004..This therefore predisposes to certain types of drug toxicity, which are described below. Medication errors are also a significant problem in the neonatal period due to the lack of appropriate formulations designed for neonates... - Surveillance for fatal suspected adverse drug reactions in the UKA Clarkson
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, Uttoxeter Road, Derby DE22 3NE, UK
Arch Dis Child 87:462-6. 2002..CONCLUSIONS: A wide range of suspected ADRs are associated with fatalities in children. Anticonvulsants were associated with the greatest number of reports of fatalities and hepatotoxicity in particular... 
What motivates British parents to consent for research? A questionnaire studyHelen M Sammons
Academic Division of Child Health, University of Nottingham, The Medical School, Derbyshire Children s Hospital, Uttoxeter Road Derby, DE22 3DT, UK
BMC Pediatr 7:12. 2007....- A systematic review of pharmacokinetics studies in children with protein-energy malnutritionKazeem A Oshikoya
Academic Division of Child Health, The Medical School in Derby, Royal Derby Hospital, University of Nottingham, Uttoxeter Road, Derby DE 22 3DT, UK
Eur J Clin Pharmacol 66:1025-35. 2010..Its association with a wide spectrum of infections necessitates multiple drug therapies. A systematic review was performed to determine the effects of PEM on drug pharmacokinetics... - Ciprofloxacin safety in paediatrics: a systematic reviewAbiodun Adefurin
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3DT, UK
Arch Dis Child 96:874-80. 2011..To determine the safety of ciprofloxacin in paediatric patients in relation to arthropathy, any other adverse events (AEs) and drug interactions... - Validating the Derbyshire Children's Hospital Pain Tool in children aged 6-12 yearsVanessa Peden
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby DE22 3NE, UK
J Child Health Care 9:59-71. 2005..This study supports construct validity and inter-rater reliability of the DPC pain assessment tool for children aged 6-12 undergoing minor and intermediate surgery... - A systematic review of safety monitoring and drug toxicity in published randomised controlled trials of antiepileptic drugs in children over a 10-year periodMark Anderson
University of Nottingham, Derbyshire Children s Hospital, Derby, UK
Arch Dis Child 95:731-8. 2010..To determine the extent of drug toxicity experienced by children and methods to detect it in randomised controlled trials (RCTs) of antiepileptic drugs (AEDs) published over a 10-year period... - Should paediatricians support the European Paediatric Clinical Trials Register?H M Sammons
Academic Division of Child Health, The Medical School, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
Arch Dis Child 90:559-60. 2005 - Research in general paediatricsH M Sammons
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, Derby, UK
Arch Dis Child 89:408-10. 2004 - Age and sex of drivers associated with child pedestrian injuriesRichard Thompson
Academic Division of Child Health, University of Nottingham, Derbyshire Children's Hospital, UK
J Child Health Care 7:184-90. 2003..Educational publicity campaigns to reduce driver speeds in urban areas need to be targeted at those drivers most likely to be involved in an RTC with a child... - Clinical trials: the viewpoint of children with a chronic illness compared with healthy childrenJ Cherrill
Academic Division of Child Health, The University of Nottingham, Derby, UK
Arch Dis Child 95:229-32. 2010..Young people should be given more opportunities to be involved in decision-making regarding clinical trials of medicines... - Clinical trials: the viewpoint of childrenJ Cherrill
Academic Division of Child Health, University of Nottingham, Derbyshire Children s Hospital, Derby, UK
Arch Dis Child 92:712-3. 2007..Nineteen children recognised that there were risks involved with taking part in clinical trials. Risks concerned with being paid were recognised by all children... - Incidence of adverse drug reactions in paediatric in/out-patients: a systematic review and meta-analysis of prospective studiesP Impicciatore
Academic Division of Child Health (Nottingham University) Derbyshire Children's Hospital, Derby, UK
Br J Clin Pharmacol 52:77-83. 2001..Further, methodologically sound drug surveillance studies are necessary for an effective promotion of a safer use of drugs in children... - Adverse drug reactions in children in Camagüey Province, CubaZ Bárzaga Arencibia
Department of Pharmacoepidemiology, Camaguey Children s Hospital, Camagüey Province, Cuba
Arch Dis Child 95:474-7. 2010..To determine the incidence of adverse drug reactions (ADRs) in children in Camagüey Province, Cuba... - Unlicensed and off-label drug use in children: implications for safetyImti Choonara
Expert Opin Drug Saf 3:81-3. 2004..Health professionals, however, usually have no alternative but to use unlicensed and off-label medicines. More clinical trials for medicines in children are required to provide the evidence base for safe and effective drug prescribing... - Regulation of drugs for children in EuropeImti Choonara
BMJ 335:1221-2. 2007 - [The first European registry for pediatric clinical trials: DEC-net]Maurizio Bonati
Istituto Mario Negn Milano
Assist Inferm Ric 23:91-2. 2004 - Publishing the evidence for children's medicinesImti Choonara
Arch Dis Child 93:815. 2008 - Sedation and neuromuscular blockade in paediatric intensive care: a review of current practice in the UKStephen D Playfor
Paediatric Intensive Care Unit, Royal Manchester Children s Hospital, Hospital Road, Pendlebury, Manchester M27 4HA, UK
Paediatr Anaesth 13:147-51. 2003..Our aim was to investigate the current practice of sedation and neuromuscular blockade in critically ill children in paediatric intensive care units (PICUs) in the UK... - The DEC-net European register of paediatric drug therapy trials: contents and contextChiara Pandolfini
Laboratory for Mother and Child Health, Mario Negri Pharmacological Research Institute, Via G La Masa 19, 20156 Milan, Italy
Eur J Clin Pharmacol 64:611-7. 2008..To describe the results and conclusions of DEC-net, an international, publicly available register of paediatric drug therapy clinical trials, and to assess which paediatric health areas are covered by research and by which trial types... - Direct reporting of suspected adverse drug reactions by patientsImti Choonara
J R Soc Med 97:316-7. 2004 - [A complete clinical trial register is already a reality in the paediatric field]Evelyne Jacqz-Aigrain
Hopital Robert Debre, Paris, France
Therapie 61:121-4. 2006..It will also allow for active monitoring of new or evolved knowledge of drug therapies...