Andrew J Childs

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi LIN28 is selectively expressed by primordial and pre-meiotic germ cells in the human fetal ovary
    Andrew J Childs
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    Stem Cells Dev 21:2343-9. 2012
  2. ncbi Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e20249. 2011
  3. ncbi BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Stem Cells 28:1368-78. 2010
  4. ncbi Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development
    Andrew J Childs
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Dev Dyn 239:1211-9. 2010
  5. ncbi N- and E-cadherin expression in human ovarian and urogenital duct development
    Sarah R Smith
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, Scotland
    Fertil Steril 93:2348-53. 2010
  6. ncbi Activin A selectively represses expression of the membrane-bound isoform of Kit ligand in human fetal ovary
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Edinburgh, United Kingdom
    Fertil Steril 92:1416-9. 2009
  7. ncbi Prostaglandin E2 as a regulator of germ cells during ovarian development
    Rosemary A L Bayne
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 94:4053-60. 2009
  8. ncbi Experimental approaches to the study of human primordial germ cells
    Andrew J Childs
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Methods Mol Biol 825:199-210. 2012
  9. ncbi Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary
    Sharon L Eddie
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 18:88-95. 2012
  10. ncbi Immunohistochemical approaches to the study of human fetal ovarian development
    Jing He
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    Methods Mol Biol 957:59-75. 2013

Collaborators

Detail Information

Publications14

  1. ncbi LIN28 is selectively expressed by primordial and pre-meiotic germ cells in the human fetal ovary
    Andrew J Childs
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom
    Stem Cells Dev 21:2343-9. 2012
    ....
  2. ncbi Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e20249. 2011
    ....
  3. ncbi BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, Queen s Medical Research Institute, Edinburgh, United Kingdom
    Stem Cells 28:1368-78. 2010
    ....
  4. ncbi Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development
    Andrew J Childs
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    Dev Dyn 239:1211-9. 2010
    ..These data reveal that expression and regulation of the TrkB ligands are differentially controlled in the developing ovaries of humans and mice, and identify BDNF as a potential regulator of germ cell fate in the human fetal ovary...
  5. ncbi N- and E-cadherin expression in human ovarian and urogenital duct development
    Sarah R Smith
    Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, Edinburgh EH16 4TJ, Scotland
    Fertil Steril 93:2348-53. 2010
    ..To investigate expression of N- and E-cadherin in the developing human ovary...
  6. ncbi Activin A selectively represses expression of the membrane-bound isoform of Kit ligand in human fetal ovary
    Andrew J Childs
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh, Edinburgh, United Kingdom
    Fertil Steril 92:1416-9. 2009
    ....
  7. ncbi Prostaglandin E2 as a regulator of germ cells during ovarian development
    Rosemary A L Bayne
    Medical Research Council Human Reproductive Sciences Unit, University of Edinburgh Centre for Reproductive Biology, The Queen s Medical Research Institute, Edinburgh EH16 4TJ, United Kingdom
    J Clin Endocrinol Metab 94:4053-60. 2009
    ..The prostaglandins have pleiotrophic roles in reproduction, notably in ovulation and implantation, but there are no data regarding roles for prostaglandins in human fetal ovarian development...
  8. ncbi Experimental approaches to the study of human primordial germ cells
    Andrew J Childs
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh, UK
    Methods Mol Biol 825:199-210. 2012
    ....
  9. ncbi Developmentally regulated IL6-type cytokines signal to germ cells in the human fetal ovary
    Sharon L Eddie
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 18:88-95. 2012
    ..These data establish that IL6-type cytokines and their receptors are expressed in the human fetal ovary and may directly influence GC development at multiple stages of maturation...
  10. ncbi Immunohistochemical approaches to the study of human fetal ovarian development
    Jing He
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh, UK
    Methods Mol Biol 957:59-75. 2013
    ..In this chapter we describe the main methodologies used in immunohistochemistry, using both chromogen and fluorescence approaches, and both single and double antigen detection...
  11. ncbi Activin signals via SMAD2/3 between germ and somatic cells in the human fetal ovary and regulates kit ligand expression
    Shiona M Coutts
    MRC Human Reproductive Sciences Unit, The Queen s Medical Research Institute, University of Edinburgh, UK
    Dev Biol 314:189-99. 2008
    ..The effects of activin on germ cells are indirect and include mediation by the kit ligand/c-Kit pathway, rather than being an autocrine germ cell effect...
  12. ncbi Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation
    Rod T Mitchell
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Hum Reprod 25:2405-14. 2010
    ..Studies of human fetal testis development are hampered by the lack of appropriate model, and intervention systems. We hypothesized that human fetal testis xenografts can recapitulate normal development...
  13. ncbi Modelling germ cell development in vitro
    Andrew J Childs
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK
    Mol Hum Reprod 14:501-11. 2008
    ....
  14. ncbi Deletion of the pluripotency-associated Tex19.1 gene causes activation of endogenous retroviruses and defective spermatogenesis in mice
    Rupert Ollinger
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, United Kingdom
    PLoS Genet 4:e1000199. 2008
    ..Our results suggest that Tex19.1 is part of a specialised mechanism that operates in the germline to repress transposable genetic elements and maintain genomic stability through successive generations...