Kwok Leung Cheung

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for premenopausal advanced breast cancer
    D P Forward
    Professorial Unit of Surgery, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 90:590-4. 2004
  2. pmc Long-term clinical outcome of oestrogen receptor-positive operable primary breast cancer in older women: a large series from a single centre
    B M Syed
    Division of Breast Surgery, University of Nottingham, Nottingham NG5 1PB, UK
    Br J Cancer 104:1393-400. 2011
  3. pmc Long-term efficacy and safety of exemestane in the treatment of breast cancer
    Ga Walker
    Clinical Oncology, East Midlands Deanery, University of Nottingham, Nottingham, UK
    Patient Prefer Adherence 7:245-58. 2013
  4. pmc Biology of primary breast cancer in older women treated by surgery: with correlation with long-term clinical outcome and comparison with their younger counterparts
    B M Syed
    Division of Breast Surgery, University of Nottingham, Derby, UK
    Br J Cancer 108:1042-51. 2013
  5. doi request reprint Optimising the management of primary breast cancer in older women - a report of a multi-disciplinary study day
    K L Cheung
    Division of Breast Surgery, University of Nottingham, UK
    Breast 20:581-4. 2011
  6. pmc Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer
    Amit Agrawal
    Division of Breast Surgery, GEM School, University of Nottingham, Royal Derby Hospital, Derby DE22 3NE, UK
    World J Surg Oncol 9:101. 2011
  7. pmc The use of fulvestrant, a parenteral endocrine agent, in intestinal obstruction due to metastatic lobular breast carcinoma
    Jasmine Y M Tang
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 6:128. 2008
  8. pmc A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report
    Joanna P Wood
    Department of Medical Oncology, City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK
    World J Surg Oncol 6:132. 2008
  9. pmc Ruptured gallbladder as the first presentation of breast cancer
    M Jones
    Professorial Unit of Surgery, City Hospital, Nottingham, UK
    World J Surg Oncol 7:50. 2009
  10. pmc Serum epidermal growth factor receptor and HER2 expression in primary and metastatic breast cancer patients
    Kristjan S Asgeirsson
    Division of Breast Surgery, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Breast Cancer Res 9:R75. 2007

Collaborators

Detail Information

Publications43

  1. pmc Clinical and endocrine data for goserelin plus anastrozole as second-line endocrine therapy for premenopausal advanced breast cancer
    D P Forward
    Professorial Unit of Surgery, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 90:590-4. 2004
    ..Further studies involving more patients and longer follow-up are indicated...
  2. pmc Long-term clinical outcome of oestrogen receptor-positive operable primary breast cancer in older women: a large series from a single centre
    B M Syed
    Division of Breast Surgery, University of Nottingham, Nottingham NG5 1PB, UK
    Br J Cancer 104:1393-400. 2011
    ..We report outcome of a large series with ER-positive (ER+) early invasive primary breast cancer...
  3. pmc Long-term efficacy and safety of exemestane in the treatment of breast cancer
    Ga Walker
    Clinical Oncology, East Midlands Deanery, University of Nottingham, Nottingham, UK
    Patient Prefer Adherence 7:245-58. 2013
    ..How it compares with the nonsteroidal aromatase inhibitors remains to be established. Further studies are required on adherence to ensure that maximum benefit is obtained...
  4. pmc Biology of primary breast cancer in older women treated by surgery: with correlation with long-term clinical outcome and comparison with their younger counterparts
    B M Syed
    Division of Breast Surgery, University of Nottingham, Derby, UK
    Br J Cancer 108:1042-51. 2013
    ..As age advances breast cancer appears to change its biological characteristics, however, very limited data are available to define the precise differences between older and younger patients...
  5. doi request reprint Optimising the management of primary breast cancer in older women - a report of a multi-disciplinary study day
    K L Cheung
    Division of Breast Surgery, University of Nottingham, UK
    Breast 20:581-4. 2011
    ....
  6. pmc Clinical relevance of "withdrawal therapy" as a form of hormonal manipulation for breast cancer
    Amit Agrawal
    Division of Breast Surgery, GEM School, University of Nottingham, Royal Derby Hospital, Derby DE22 3NE, UK
    World J Surg Oncol 9:101. 2011
    ..However, evidence is scarce when this is extrapolated into clinical context. We report our experience to verify the clinical relevance of "withdrawal therapy"...
  7. pmc The use of fulvestrant, a parenteral endocrine agent, in intestinal obstruction due to metastatic lobular breast carcinoma
    Jasmine Y M Tang
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 6:128. 2008
    ..The role of fulvestrant in the management of intestinal obstruction associated with lobular carcinoma has not been specifically described...
  8. pmc A paraneoplastic manifestation of metastatic breast cancer responding to endocrine therapy: a case report
    Joanna P Wood
    Department of Medical Oncology, City Hospital, Nottingham University Hospitals NHS Trust, Nottingham, UK
    World J Surg Oncol 6:132. 2008
    ..These syndromes are usually treated by chemotherapy with or without immunosupression but they often respond poorly. There are no published reviews on response to endocrine treatment...
  9. pmc Ruptured gallbladder as the first presentation of breast cancer
    M Jones
    Professorial Unit of Surgery, City Hospital, Nottingham, UK
    World J Surg Oncol 7:50. 2009
    ..Perforation of the gall bladder as a first presentation of breast cancer has not been reported...
  10. pmc Serum epidermal growth factor receptor and HER2 expression in primary and metastatic breast cancer patients
    Kristjan S Asgeirsson
    Division of Breast Surgery, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Breast Cancer Res 9:R75. 2007
    ..The clinical relevance of this has not been fully established...
  11. ncbi request reprint Endocrine therapy for breast cancer: an overview
    K L Cheung
    Division of Breast Surgery, University of Nottingham, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Breast 16:327-43. 2007
    ..Ongoing and future studies will optimise treatment in established areas and will exploit its potential roles in preoperative use and chemoprevention...
  12. doi request reprint Pathological features of primary breast cancer in the elderly based on needle core biopsies--a large series from a single centre
    K L Cheung
    Division of Breast Surgery, University of Nottingham, UK
    Crit Rev Oncol Hematol 67:263-7. 2008
    ..We have clearly confirmed the high frequency of ER-positive tumours in elderly patients. Further work is underway to assess long-term outcome and clinical relevance...
  13. ncbi request reprint Endocrine response after prior treatment with fulvestrant in postmenopausal women with advanced breast cancer: experience from a single centre
    K L Cheung
    Division of Breast Surgery, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Endocr Relat Cancer 13:251-5. 2006
    ..It would thus appear that further endocrine response can be induced in a reasonable proportion of patients after failing fulvestrant...
  14. ncbi request reprint Approach to a lump in the breast: a regional perspective
    Kwok Leung Cheung
    Professorial Unit of Surgery, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, U K
    Asian J Surg 28:65-70. 2005
    ..This article discusses the clinical assessment and investigation of breast lumps and possible treatments from an Asia Pacific perspective...
  15. ncbi request reprint The use of blood tumour markers in the monitoring of metastatic breast cancer unassessable for response to systemic therapy
    K L Cheung
    Department of Surgery, City Hospital, Nottingham, United Kingdom
    Breast Cancer Res Treat 67:273-8. 2001
    ..5 months. Biochemical assessment by blood tumour markers is useful in patients with metastatic breast cancer unassessable for response to systemic therapy. These findings need to be confirmed in a larger patient series...
  16. pmc Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour marker
    Kwok Leung Cheung
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 8:38. 2010
    ..Serum concentrations of FA-2 appeared to be elevated in a number of disorders of bone metabolism. This paper is the first report of its role as a marker of bone metabolism in metastatic breast cancer...
  17. ncbi request reprint Objective measurement of remission and progression in metastatic breast cancer by the use of serum tumour markers
    K L Cheung
    Professorial Unit of Surgery, Nottingham City Hospital, UK
    Minerva Chir 58:297-303. 2003
    ..Future studies should aim at incorporating new markers (e.g. serum c-erbB2, markers of bone metabolism) to tailor different clinical situations, and at exploiting the use of serum markers to direct systemic therapy...
  18. ncbi request reprint Fulvestrant
    Kwok Leung Cheung
    Professorial Unit of Surgery, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Expert Opin Investig Drugs 11:303-8. 2002
    ..With the role of tamoxifen as the gold standard of first-line therapy being challenged by the third generation aromatase inhibitors, direct comparison of the latter with fulvestrant in the first-line setting may also be worthwhile...
  19. doi request reprint Suppression of ovarian function in combination with an aromatase inhibitor as treatment for advanced breast cancer in pre-menopausal women
    K L Cheung
    Division of Breast Surgery, University of Nottingham, UK
    Eur J Cancer 46:2936-42. 2010
    ..Within the limitations of being a non-randomised study, they should be considered in appropriate patients with hormone-sensitive ABC...
  20. pmc Successful management of elderly breast cancer patients treated without radiotherapy
    Kalliope Valassiadou
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 5:62. 2007
    ..The addition of RT to surgery might constitute an imposition to such patients due to age-related factors. The aim of this study was to assess the efficacy of BCS without adjuvant RT in this group of patients...
  21. doi request reprint Primary endocrine therapy in locally advanced breast cancers--the Nottingham experience
    J Mathew
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 113:403-7. 2009
    ..We report our experience of primary endocrine therapy in ER+ LAPC...
  22. pmc The reliability of assessment of oestrogen receptor expression on needle core biopsy specimens of invasive carcinomas of the breast
    Zsolt Hodi
    Departments of Histopathology and Surgery, Nottingham City Hospital, UK
    J Clin Pathol 60:299-302. 2007
    ..To assess the reliability of assessment of oestrogen receptor expression on needle core biopsy specimens of invasive carcinomas of the breast. Previous studies have mostly been small, with a range of agreement from 62% to 100%...
  23. pmc Bone metastases from breast carcinoma: histopathological - radiological correlations and prognostic features
    J J James
    Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 89:660-5. 2003
    ....
  24. doi request reprint Biological profile of oestrogen receptor positive primary breast cancers in the elderly and response to primary endocrine therapy
    G Okunade
    Division of Breast Surgery, Nottingham University Hospitals, City Hospital Campus, Nottingham, NG5 1PB, UK
    Crit Rev Oncol Hematol 72:76-82. 2009
    ..In this population, ERalpha+ breast cancer also appears to have a less aggressive biological profile favouring better hormone sensitivity...
  25. doi request reprint Strength of ER-positivity in relation to survival in ER-positive breast cancer treated by adjuvant tamoxifen as sole systemic therapy
    David A L Morgan
    Department of Clinical Oncology, Nottingham University Hospitals, City Campus, Nottingham, UK
    Breast 20:215-9. 2011
    ....
  26. doi request reprint Neoadjuvant endocrine treatment in primary breast cancer - review of literature
    J Mathew
    Division of Breast Surgery, Nottingham City Hospital, Nottingham, UK
    Breast 18:339-44. 2009
    ..Our review highlights the superiority of aromatase inhibitors over tamoxifen in the neoadjuvant setting and even challenges chemotherapy with regard to response in selected group of patients...
  27. ncbi request reprint Fulvestrant - a novel endocrine therapy for breast cancer
    S J Johnston
    University of Nottingham, Nottingham University Hospitals, Nottingham, UK
    Curr Med Chem 17:902-14. 2010
    ....
  28. doi request reprint Neoadjuvant chemotherapy for locally advanced breast cancer: a review of the literature and future directions
    J Mathew
    Professorial Unit of Surgery, Nottingham University Hospital, Nottingham, UK
    Eur J Surg Oncol 35:113-22. 2009
    ..Significant improvements in local disease control have been seen with recent advances in systemic chemotherapy regimens although thus far this has not shown in randomised trials to translate into overall survival benefits...
  29. ncbi request reprint Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia
    K L Cheung
    Department of Surgery, The University of Hong Kong, Queen Mary Hospital and Tung Wah Hospital
    Aust N Z J Surg 69:492-4. 1999
    ..In most Western countries gamolenic acid is the first-line treatment for women with cyclical mastalgia...
  30. ncbi request reprint The role of blood tumor marker measurement (using a biochemical index score and c-erbB2) in directing chemotherapy in metastatic breast cancer
    K L Cheung
    Department of Surgery, City Hospital, Nottingham, UK
    Int J Biol Markers 15:203-9. 2000
    ..003). Among the patients with positive tissue staining, sequential changes in serum c-erbB2 completely paralleled initial response...
  31. ncbi request reprint Selection of primary breast cancer patients for adjuvant endocrine therapy--is oestrogen receptor alone adequate?
    K L Cheung
    Professorial Unit of Surgery, City Hospital, Nottingham, UK
    Breast Cancer Res Treat 65:155-62. 2001
    ..Further studies to elucidate other possible factors are warranted to refine the use of endocrine therapy, especially in the adjuvant setting when no indication of response is available...
  32. ncbi request reprint Locally advanced primary breast cancer: medium-term results of a randomised trial of multimodal therapy versus initial hormone therapy
    S M Tan
    Department of Surgery, City Hospital, Nottingham, UK
    Eur J Cancer 37:2331-8. 2001
    ..Thus, initial hormone therapy may be a reasonable option for managing locally advanced primary breast cancer, especially for oestrogen receptor-positive tumours...
  33. doi request reprint Early primary breast cancer in the elderly - pattern of presentation and treatment
    S W Tang
    Division of Breast Surgery, City Hospital, Hucknall Road, University of Nottingham, Nottingham NG5 1PB, UK
    Surg Oncol 20:7-12. 2011
    ..This study aimed to identify a profile of characteristics in elderly women with operable primary breast cancer and investigate the dynamics influencing the treatment decision-making process...
  34. doi request reprint Bone turnover markers in postmenopausal breast cancer treated with fulvestrant--a pilot study
    A Agrawal
    University of Nottingham, Professorial Unit of Surgery, City Hospital Campus, Nottingham University Hospitals, Hucknall Road, Nottingham NG5 1PB, UK
    Breast 18:204-7. 2009
    ..Tamoxifen has a protective effect on bone metabolism in breast cancer; aromatase inhibitors deleterious and that of fulvestrant is unknown...
  35. ncbi request reprint Neoadjuvant chemotherapy in locally advanced primary breast cancers: the Nottingham experience
    J Mathew
    Professorial Unit of Surgery, Nottingham City Hospital, Hucknall Road, Nottingham, UK
    Eur J Surg Oncol 33:972-6. 2007
    ....
  36. ncbi request reprint Metastatic carcinoma of the breast with tubular features: differences compared with metastatic ductal carcinoma of no specific type
    L J Hamilton
    Nottingham Breast Institute, Nottingham City Hospital, Nottingham, UK
    Clin Oncol (R Coll Radiol) 16:119-24. 2004
    ....
  37. ncbi request reprint Brain metastases from breast cancer: identification of a high-risk group
    A J Evans
    Nottingham Breast Institute, City Hospital, Nottingham, UK
    Clin Oncol (R Coll Radiol) 16:345-9. 2004
    ....
  38. pmc Biological characteristics and clinical outcome of triple negative primary breast cancer in older women - comparison with their younger counterparts
    Binafsha M Syed
    School of Medicine, University of Nottingham, Nottingham, United Kingdom
    PLoS ONE 9:e100573. 2014
    ..This appears to be related to other biomarkers (in addition to ER/PgR/HER2) eg Ki67, bcl2 and cytokeratins which have different expression patterns influencing prognosis. ..
  39. pmc Comprehensive geriatric assessment for older women with early breast cancer - a systematic review of literature
    Ruth M Parks
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 10:88. 2012
    ..The Comprehensive Geriatric Assessment (CGA) is an analytical tool increasingly implemented in clinical practice. Breast cancer is primarily a disease of older people; however, most evidence-based research is aimed at younger patients...
  40. ncbi request reprint Concepts of seroma formation and prevention in breast cancer surgery
    Amit Agrawal
    Professorial Unit of Surgery, Nottingham City Hospital, Nottingham, UK
    ANZ J Surg 76:1088-95. 2006
    ..The aim of this paper is to review the concepts of pathophysiology of seroma formation following mastectomy and breast-conserving surgery for cancer. The various techniques in practice to reduce its incidence and treatment are outlined...
  41. ncbi request reprint Patterns of metastatic breast carcinoma: influence of tumour histological grade
    G J R Porter
    Helen Garrod Breast Unit, Nottingham City Hospitals NHS Trust, Nottingham, UK
    Clin Radiol 59:1094-8. 2004
    ..To assess if the pattern of metastatic spread of carcinoma of the breast varies according to tumour histological grade...
  42. ncbi request reprint Is surgery always indicated in older women with breast cancer?
    S W Tang
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    Minerva Chir 65:555-68. 2010
    ..A dedicated multidisciplinary-led clinic may provide a suitable platform for the assessment, review and management of this distinctive set of patients...
  43. ncbi request reprint Can computerised tomography replace bone scintigraphy in detecting bone metastases from breast cancer? A prospective study
    A R Bristow
    Division of Breast Surgery, University of Nottingham, UK
    Breast 17:98-103. 2008
    ..The aim of this study was to determine whether bone scans (BS) can be avoided if pelvis was included in CT thorax and abdomen to detect bony metastases from breast cancer...