Bmy Cheung

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. doi Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006
    Bernard M Y Cheung
    Department of Clinical Pharmacology, School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom
    Am J Med 122:443-53. 2009
  2. ncbi Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 68:730-7. 2008
  3. ncbi Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2)
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:17-22. 2008
  4. doi Statins for people with diabetes
    Bernard M Y Cheung
    Department of Clinical Pharmacology, Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Lancet 371:94-5. 2008
  5. doi Hypertension as part of the metabolic syndrome
    Bmy Cheung
    Department of Clinical Pharmacology, University of Birmingham, Birmingham, UK
    J Hum Hypertens 22:871-4. 2008
  6. pmc Association between raised blood pressure and dysglycemia in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 31:1889-91. 2008
  7. doi Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Int J Cardiol 135:156-61. 2009
  8. doi Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Chem Lab Med 46:523-7. 2008
  9. doi High density lipoprotein-cholesterol levels increase with age in American women but not in Hong Kong Chinese women
    Bernard M Y Cheung
    Department of Clinical Pharmacology, School of Clinical and Experimental Medicine, University of Birmingham, England
    Clin Endocrinol (Oxf) 70:561-8. 2009
  10. ncbi Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:1430-6. 2007

Collaborators

Detail Information

Publications43

  1. doi Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006
    Bernard M Y Cheung
    Department of Clinical Pharmacology, School of Clinical and Experimental Medicine, University of Birmingham, United Kingdom
    Am J Med 122:443-53. 2009
    ..Changes in the prevalence, treatment, and management of diabetes in the United States from 1999 to 2006 were studied using data from the National Health and Nutrition Examination Survey...
  2. ncbi Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Endocrinol (Oxf) 68:730-7. 2008
    ..To investigate which of the components of the metabolic syndrome best predict its development...
  3. ncbi Relationship between the metabolic syndrome and the development of hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS2)
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:17-22. 2008
    ..The metabolic syndrome is a predictor of diabetes and coronary events. We hypothesized that it also predicts hypertension...
  4. doi Statins for people with diabetes
    Bernard M Y Cheung
    Department of Clinical Pharmacology, Division of Medical Sciences, University of Birmingham, Birmingham B15 2TH, UK
    Lancet 371:94-5. 2008
  5. doi Hypertension as part of the metabolic syndrome
    Bmy Cheung
    Department of Clinical Pharmacology, University of Birmingham, Birmingham, UK
    J Hum Hypertens 22:871-4. 2008
    ..Measures to reduce obesity through lifestyle changes are therefore highly desirable, not because of reductions in blood pressure alone...
  6. pmc Association between raised blood pressure and dysglycemia in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 31:1889-91. 2008
    ..To investigate the association between raised blood pressure and dysglycemia...
  7. doi Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong SAR, China
    Int J Cardiol 135:156-61. 2009
    ..Alkaline phosphatase (ALP) is elevated in peripheral arterial disease (PAD). We therefore examined the relationship of PAD with ALP and other liver enzymes in the United States National Health and Nutrition Examination Survey 1999-2004...
  8. doi Association between plasma alkaline phosphatase and C-reactive protein in Hong Kong Chinese
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Clin Chem Lab Med 46:523-7. 2008
    ..In atherosclerotic plaques, ALP is expressed. Similar to C-reactive protein (CRP), it may be another marker of systemic inflammation. Therefore, we investigated their association in a Hong Kong Chinese population...
  9. doi High density lipoprotein-cholesterol levels increase with age in American women but not in Hong Kong Chinese women
    Bernard M Y Cheung
    Department of Clinical Pharmacology, School of Clinical and Experimental Medicine, University of Birmingham, England
    Clin Endocrinol (Oxf) 70:561-8. 2009
    ..High-density lipoprotein (HDL) cholesterol is a powerful cardiovascular risk factor. Important gender and ethnic differences in plasma HDL levels exist and warrant investigation...
  10. ncbi Development of diabetes in Chinese with the metabolic syndrome: a 6-year prospective study
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:1430-6. 2007
    ..We investigated the association of the metabolic syndrome with new-onset diabetes in the Hong Kong Cardiovascular Risk Factor Prevalence Study cohort...
  11. ncbi Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study
    G Neil Thomas
    Department of Community Medicine, The University of Hong Kong, Hong Kong, China
    Clin Endocrinol (Oxf) 66:666-71. 2007
    ..The metabolic syndrome has been associated with increased mortality in some Caucasian populations, but data in Asian populations are not available. We present data describing the association of the metabolic syndrome with mortality...
  12. ncbi Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study
    Aimin Xu
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, China
    Circulation 115:1537-43. 2007
    ..In the present study, we further evaluated the prospective association of A-FABP with the metabolic syndrome (MetS) as defined by the updated National Cholesterol Education Program criteria...
  13. ncbi Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study
    Wing Sun Chow
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Rd, Hong Kong, People s Republic of China
    Hypertension 49:1455-61. 2007
    ..76; 95% CIs: 1.06 to 7.16; P=0.037 versus highest tertile). Our data suggest that hypoadiponectinaemia may be involved in the pathogenesis of hypertension in humans...
  14. ncbi Treatment and control of diabetes mellitus in the United States National Health and Nutrition Examination Survey, 1999-2002
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Ageing, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Cardiometab Syndr 1:301-7. 2006
    ..2%), while patients using diet treatment alone (65.9%) had the best glycemic control. There is a need to improve glycemic control. Better patient education, intensive lifestyle changes, and newer therapies need to be explored...
  15. doi Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension
    Kwok Leung Ong
    Department of Medicine, University of Hong Kong, Hong Kong
    Hypertension 51:1142-8. 2008
    ..Although there is room for improvement in blood pressure control, our study has highlighted the importance of addressing concomitant cardiovascular risk factors in women with hypertension...
  16. doi Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men
    K L Ong
    Department of Medicine, Faculty of Medicine, University of Hong Kong, Hong Kong
    Am J Hypertens 21:539-45. 2008
    ..The gene is located at 2p25.1, a susceptibility locus for hypertension. We studied the association of tagging single-nucleotide polymorphisms (SNPs) in the lipin 1 (LPIN1) gene with hypertension and blood pressure...
  17. ncbi Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004
    Kwok Leung Ong
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong
    Hypertension 49:69-75. 2007
    ..01). The improvement in blood pressure control is encouraging, although the prevalence of hypertension has not declined...
  18. ncbi Identification of factors differentially associated with isolated impaired fasting glucose and isolated post-load impaired glucose tolerance: the Hong Kong Cardiovascular Risk Factor Study
    G Neil Thomas
    Department of Community Medicine, and School of Public Health, The University of Hong Kong, Hong Kong
    Eur J Endocrinol 155:623-32. 2006
    ....
  19. ncbi The role of urotensin II in the metabolic syndrome
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Peptides 29:859-67. 2008
    ..These findings suggest a close relationship between urotensin II and at least some components of the metabolic syndrome, including hypertension, insulin resistance, hyperglycemia, and inflammation...
  20. ncbi Prevalence, awareness, treatment, and control of hypertension: United States National Health and Nutrition Examination Survey 2001-2002
    Bernard M Y Cheung
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Aging, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Clin Hypertens (Greenwich) 8:93-8. 2006
    ..In 2001-2002, significantly more people with hypertension and diabetes reached a blood pressure target of <130/85 mm Hg. Overall, the control rates were low, especially among middle-aged Mexican-American men (8%)...
  21. ncbi The cardiovascular continuum in Asia--a new paradigm for the metabolic syndrome
    Bernard M Y Cheung
    J Cardiovasc Pharmacol 46:125-9. 2005
    ..Strategies to combat cardiovascular disease should now focus on tackling the epidemic of obesity and developing innovative and effective lifestyle and pharmacological interventions...
  22. doi Prevalence, treatment, and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004
    Kwok Leung Ong
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Ageing, Faculty of Medicine, University of Hong Kong
    Ann Epidemiol 18:222-9. 2008
    ..This study aimed to examine the trends in prevalence, treatment, and control of diagnosed diabetes in United States adults 20 years of age or older...
  23. ncbi Traveler's thrombosis: a systematic review
    Mohammed T Ansari
    Clinical Trials Centre, Faculty of Medicine, The University of Hong Kong
    J Travel Med 12:142-54. 2005
    ..Anecdotal evidence suggests a possible link between travel and venous thromboembolism (VTE). We systematically evaluated the evidence from observational studies...
  24. ncbi Polymorphisms of the fibrinogen-beta gene are related to 2-hour glucose level after oral glucose tolerance test in Hong Kong Chinese
    Louisa Y F Wong
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Dis Markers 24:167-73. 2008
    ..002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance...
  25. pmc Queen Mary Utilization of Antihypertensive Drugs Study: use of antihypertensive drug classes in the hypertension clinic 1996-2004
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Br J Clin Pharmacol 60:90-7. 2005
    ..Utilization of antihypertensive drugs in the hypertension outpatient clinic is surveyed periodically in the Queen Mary Utilization of Antihypertensive Drugs Study (QUADS)...
  26. ncbi Urotensin II: its function in health and its role in disease
    Kwok Leung Ong
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Hong Kong
    Cardiovasc Drugs Ther 19:65-75. 2005
    ..U-II is also a neuropeptide and may play a role in tumour development. The development of UT receptor antagonists may provide a useful research tool as well as a novel treatment for cardiorenal diseases...
  27. ncbi Adrenomedullin is both proinflammatory and antiinflammatory: its effects on gene expression and secretion of cytokines and macrophage migration inhibitory factor in NR8383 macrophage cell line
    Louisa Y F Wong
    Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China
    Endocrinology 146:1321-7. 2005
    ..Our results suggest that ADM modulates MIF secretion and cytokine production and plays important roles in both the initiation and propagation of the inflammatory response...
  28. ncbi Plasma concentration of urotensin II is raised in hypertension
    Bernard M Y Cheung
    University Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    J Hypertens 22:1341-4. 2004
    ..Urotensin II is the most potent vasoconstrictor known. Its role in hypertension has not been investigated. Here, we studied the plasma levels in hypertensive and normotensive human subjects...
  29. pmc Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Clin Pharmacol 57:640-51. 2004
    ..The aim of the study was to estimate the effect of statins on major coronary events and strokes, all-cause mortality and noncardiovascular mortality, and in different subgroups...
  30. pmc Effectiveness of lipid lowering drugs in general practice: study had two major flaws
    Bernard M Y Cheung
    BMJ 327:51; author reply 51. 2003
  31. ncbi Advantages of blood pressure optimization
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Hong Kong
    Adv Ther 22:285-96. 2005
    ..Optimization of BP is feasible, safe, and well tolerated; however, a larger study of longer duration may be needed to demonstrate improvements in LVM and endothelial function with conventional versus optimal therapy...
  32. ncbi Differential induction of adrenomedullin, interleukins and tumour necrosis factor-alpha by lipopolysaccharide in rat tissues in vivo
    Yuk Yin Li
    Department of Physiology, The University of Hong Kong, Hong Kong, China
    Clin Exp Pharmacol Physiol 32:1110-8. 2005
    ..The present results suggest that the biosynthesis and secretion of AM may be differentially regulated in various tissues of rats injected with LPS and that AM may interact with cytokines during inflammation...
  33. ncbi Prevalence of the metabolic syndrome in the United States National Health and Nutrition Examination Survey 1999-2002 according to different defining criteria
    Bernard M Y Cheung
    Department of Medicine and the Research Centre of Heart, Brain, Hormone and Healthy Ageing, Faculty of Medicine, University of Hong Kong, Hong Kong, China
    J Clin Hypertens (Greenwich) 8:562-70. 2006
    ..Whether waist circumference is a prerequisite does not affect the diagnosis of the metabolic syndrome in the United States. The IDF definition identifies additional individuals at risk for cardiovascular disease...
  34. ncbi Identification and functional characterization of three novel human melanocortin-4 receptor gene variants in an obese Chinese population
    Rong Rong
    Department of Medicine, Li Ka Shing Medical Faculty, The University of Hong Kong, Pokfulam, Hong Kong, China
    Clin Endocrinol (Oxf) 65:198-205. 2006
    ..We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequences of the novel variants identified...
  35. ncbi Therapeutic potential of angiotensin receptor blockers in hypertension
    Bernard M Y Cheung
    University of Hong Kong, Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong
    Expert Opin Investig Drugs 15:625-35. 2006
    ..For patients in whom angiotensin-converting enzyme inhibitors are indicated but not tolerated, an ARB should be considered. Periodic monitoring of renal function and electrolytes is required in patients treated with an ARB...
  36. ncbi Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance
    Kwok Leung Ong
    Department of Medicine and Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Peptides 27:1659-67. 2006
    ..For UTS2R, the AC haplotype (-11640A and -8515C) was associated with higher 2 h plasma glucose after a 75 g oral glucose load. Therefore, U-II and its receptor may play a role in insulin resistance...
  37. ncbi A novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer's disease in Chinese
    Leung Wing Chu
    Department of Medicine, The University of Hong Kong, Hong Kong
    Am J Med Genet B Neuropsychiatr Genet 144:1007-13. 2007
    ..Further functional analysis of this polymorphism should be a high priority...
  38. ncbi Junctional adhesion molecule-1 may have a wider role in cardiovascular disease
    Bernard M Y Cheung
    Hypertension 50:e22; author reply e23. 2007
  39. ncbi The metabolic syndrome and vascular disease in Asia
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong
    Cardiovasc Hematol Disord Drug Targets 7:79-85. 2007
    ..To minimise further development of the obesity pandemic and subsequent vascular disease, innovative population-based preventative lifestyle and therapeutic strategies interventions need to be introduced...
  40. pmc The metabolic syndrome in China
    Bernard M Y Cheung
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong
    Br J Clin Pharmacol 62:260-3. 2006
  41. ncbi Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort
    Annette W K Tso
    Department of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes Care 30:2667-72. 2007
    ..Here we investigated whether serum A-FABP levels could predict the development of diabetes in a 10-year prospective study...
  42. ncbi Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias
    Tiago V Pereira
    Heart Institute InCor, Sao Paulo University Medical School, University of Sao Paulo, Brazil
    J Hypertens 25:1763-74. 2007
    ..To explore this hypothesis further, we performed a meta-analysis and re-evaluated the relationship between the three most widely studied NOS3 polymorphisms and hypertension status and blood pressure levels...
  43. ncbi Regression of left ventricular hypertrophy after treatment of hypertension: comparison of directed M-echocardiography with magnetic resonance imaging in quantification of serial mass changes
    Hung Fat Tse
    Department of Medicine, University of Hong Kong, China
    J Card Fail 9:122-7. 2003
    ..This study sought to validate the reliability of serial echocardiographic measurements in detecting left ventricular (LV) hypertrophy regression by using magnetic resonance imaging (MRI) as a reference standard...