D Charlesworth

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc The birds and the bees and the flowers and the trees: lessons from genetic mapping of sex determination in plants and animals
    Deborah Charlesworth
    Department of Zoology, Edward Grey Institute, University of Oxford, Oxford OX1 3PS, United Kingdom
    Genetics 186:9-31. 2010
  2. pmc Self-incompatibility
    Deborah Charlesworth
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratory King s Buildings, West Mains Road, Edinburgh, EH9 3JT UK
    F1000 Biol Rep 2:68. 2010
  3. doi request reprint Plant sex chromosome evolution
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    J Exp Bot 64:405-20. 2013
  4. pmc A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plants
    Michael Nicolas
    Laboratoire de Reproduction et Développement des Plantes, ENS Lyon, France
    PLoS Biol 3:e4. 2005
  5. ncbi request reprint The genetics of inbreeding depression
    Deborah Charlesworth
    Institute for Evolutionary Biology, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Genet 10:783-96. 2009
  6. ncbi request reprint Breeding systems and genome evolution
    D Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Genet Dev 11:685-90. 2001
  7. ncbi request reprint Plant sex determination and sex chromosomes
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Heredity (Edinb) 88:94-101. 2002
  8. doi request reprint Evolutionary genetics: changed sex determination in honeybees
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Lab King s Buildings, W Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 18:R610-2. 2008
  9. ncbi request reprint Deborah Charlesworth
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Lab, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 17:R264-6. 2007
  10. pmc Effects of inbreeding on the genetic diversity of populations
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology ICAPB, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 358:1051-70. 2003

Detail Information

Publications79

  1. pmc The birds and the bees and the flowers and the trees: lessons from genetic mapping of sex determination in plants and animals
    Deborah Charlesworth
    Department of Zoology, Edward Grey Institute, University of Oxford, Oxford OX1 3PS, United Kingdom
    Genetics 186:9-31. 2010
    ....
  2. pmc Self-incompatibility
    Deborah Charlesworth
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratory King s Buildings, West Mains Road, Edinburgh, EH9 3JT UK
    F1000 Biol Rep 2:68. 2010
    ....
  3. doi request reprint Plant sex chromosome evolution
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, The King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    J Exp Bot 64:405-20. 2013
    ....
  4. pmc A gradual process of recombination restriction in the evolutionary history of the sex chromosomes in dioecious plants
    Michael Nicolas
    Laboratoire de Reproduction et Développement des Plantes, ENS Lyon, France
    PLoS Biol 3:e4. 2005
    ....
  5. ncbi request reprint The genetics of inbreeding depression
    Deborah Charlesworth
    Institute for Evolutionary Biology, Ashworth Laboratories, King s Buildings, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Nat Rev Genet 10:783-96. 2009
    ..Classical genetic studies and modern molecular evolutionary approaches now suggest that inbreeding depression and heterosis are predominantly caused by the presence of recessive deleterious mutations in populations...
  6. ncbi request reprint Breeding systems and genome evolution
    D Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Opin Genet Dev 11:685-90. 2001
    ..Theoretical models predict how such populations are expected to differ from outcrossed populations, and DNA sequence data are being collected and used to test the predictions...
  7. ncbi request reprint Plant sex determination and sex chromosomes
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Heredity (Edinb) 88:94-101. 2002
    ..Theories for Y chromosome degeneration are reviewed in the light of recent results from genes on plant sex chromosomes...
  8. doi request reprint Evolutionary genetics: changed sex determination in honeybees
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Lab King s Buildings, W Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 18:R610-2. 2008
    ..It now seems that this has also happened in honeybees, where the sex-determining gene has now been shown to be a duplicate of another Hymenopteran sex-determining gene...
  9. ncbi request reprint Deborah Charlesworth
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Lab, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 17:R264-6. 2007
  10. pmc Effects of inbreeding on the genetic diversity of populations
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology ICAPB, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 358:1051-70. 2003
    ..DNA sequence data are now starting to become available from suitable plant and animal populations, to measure and compare variability levels and test predictions...
  11. ncbi request reprint Haplotype structure of the stigmatic self-incompatibility gene in natural populations of Arabidopsis lyrata
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom
    Mol Biol Evol 20:1741-53. 2003
    ..Patterns of linkage disequilibrium in our SRK sequences do not support the conclusion that recombination occurs, which was suggested from previous analyses based on Brassica SLG sequences...
  12. pmc Diversity and linkage of genes in the self-incompatibility gene family in Arabidopsis lyrata
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Genetics 164:1519-35. 2003
    ..This suggests that the high polymorphism in these regions of incompatibility loci is due to balancing selection acting on sites within or near these regions, combined with low selective constraints...
  13. ncbi request reprint Evolution of plant breeding systems
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Lab King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 16:R726-35. 2006
    ..After discussing how the conclusions are affected by some of the many relevant ecological factors, I relate these theoretical ideas to empirical data from some of the many recent breeding system studies in plant populations...
  14. ncbi request reprint How and when did Arabidopsis thaliana become highly self-fertilising
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Bioessays 27:472-6. 2005
    ..thaliana. However, it is difficult to be sure of the time when the selfing habit evolved in the lineage that led to A. thaliana...
  15. ncbi request reprint Steps in the evolution of heteromorphic sex chromosomes
    D Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh, UK
    Heredity (Edinb) 95:118-28. 2005
    ..We discuss how selection during the period when a chromosome is adapting to its role as a Y chromosome might drive such a process...
  16. ncbi request reprint Plant self-incompatibility systems: a molecular evolutionary perspective
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratory, King s Buildings, Edinburgh EH9 3JT, UK
    New Phytol 168:61-9. 2005
    ....
  17. pmc Trans-specificity at loci near the self-incompatibility loci in Arabidopsis
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 172:2699-704. 2006
    ..This suggests maintenance of entire S-haplotypes for long evolutionary times and extreme recombination suppression in the region...
  18. pmc The male-sterility polymorphism of Silene vulgaris: analysis of genetic dat from two populations and comparison with Thymus vulgaris
    D Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, Edinburgh EH9 3JT, United Kingdom
    Genetics 150:1267-82. 1998
    ..The results from population 3 are quite similar, though there was no evidence in this population for an unrestored sterility cytoplasm. A similar joint nucleocytoplasmic model with multiple restorers fits data from Thymus vulgaris...
  19. doi request reprint Mimicry: the hunting of the supergene
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh EH9 3JT, UK
    Curr Biol 21:R846-8. 2011
    ..Genetic characterisation of a mimicry polymorphism in a butterfly reveals the expected suppression of recombination among its components, preventing the production of unfit character combinations...
  20. ncbi request reprint The evolution of the alcohol dehydrogenase gene family by loss of introns in plants of the genus Leavenworthia (Brassicaceae)
    D Charlesworth
    Department of Ecology and Evolution, University of Chicago, USA
    Mol Biol Evol 15:552-9. 1998
    ..The results therefore suggest that the Adh-3 locus may have arisen via an mRNA intermediate but, despite loss of the introns, is expressed...
  21. doi request reprint Evolutionary biology: the origins of two sexes
    Deborah Charlesworth
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Lab King s Buildings, W Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 20:R519-21. 2010
    ..Evidence is accumulating that in the green algae the evolution of female and male gametes differing in size--anisogamy--involves genes linked to the mating-type locus, as was predicted theoretically...
  22. pmc Balancing selection and its effects on sequences in nearby genome regions
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Genet 2:e64. 2006
    ....
  23. ncbi request reprint Flowering plant self-incompatibility: the molecular population genetics of Brassica S-loci
    D Charlesworth
    ICAPB, University of Edinburgh, Ashworth Laboratory, UK
    Heredity (Edinb) 81:1-9. 1998
    ....
  24. ncbi request reprint Allozyme diversity in Leavenworthia populations with different inbreeding levels
    D Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Heredity (Edinb) 81:453-61. 1998
    ..The effect of inbreeding on allozyme diversity is consistently larger than has been estimated from comparisons of unrelated species...
  25. ncbi request reprint DNA diversity in sex-linked and autosomal genes of the plant species Silene latifolia and Silene dioica
    D A Filatov
    Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh, Scotland
    Mol Biol Evol 18:1442-54. 2001
    ..dioica, so it is not simple to test for selective sweeps. We also discuss the possibility that Y-linked diversity is reduced due to highly variable male reproductive success, and we conclude that this explanation is unlikely...
  26. ncbi request reprint Indirect evidence from DNA sequence diversity for genetic degeneration of the Y-chromosome in dioecious species of the plant Silene: the SlY4/SlX4 and DD44-X/DD44-Y gene pairs
    V Laporte
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 18:337-47. 2005
    ..Thus, all four Y-linked genes that have now been studied in these plants (the two studied here, and two previously studied genes, have low diversity). This supports other evidence for an ongoing degeneration process in these species...
  27. ncbi request reprint An X-linked gene with a degenerate Y-linked homologue in a dioecious plant
    D S Guttman
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Nature 393:263-6. 1998
    ..The homology between the active X-linked locus and the degenerate Y-linked locus supports a common ancestry for these two loci...
  28. pmc High DNA sequence diversity in pericentromeric genes of the plant Arabidopsis lyrata
    Akira Kawabe
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 179:985-95. 2008
    ..thaliana. Our data rule out balancing selection in the pericentromeric regions, suggesting that hitchhiking is more strongly reducing diversity in the chromosome arms than the pericentromere regions...
  29. ncbi request reprint Molecular variation at the self-incompatibility locus in natural populations of the genera Antirrhinum and Misopates
    C P Vieira
    Institute of Cell Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, W Mains Road, Edinburgh EH9 3JT, Scotland, UK
    Heredity (Edinb) 88:172-81. 2002
    ..Variability in these sequences follows the pattern of conserved and hypervariable regions seen in other S-RNases, but no regions have higher replacement than silent diversity, unlike the results in some other species...
  30. pmc Linkage disequilibrium and recombination rate estimates in the self-incompatibility region of Arabidopsis lyrata
    Esther Kamau
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, W Mains Road, Edinburgh, United Kingdom
    Genetics 176:2357-69. 2007
    ..Our estimates suggest that there is a small region of very low recombination surrounding the S-locus region...
  31. pmc Active miniature transposons from a plant genome and its nonrecombining Y chromosome
    R Bergero
    Institute of Evolutionary Biology, Ashworth Laboratories, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 178:1085-92. 2008
    ..In contrast, insertions on the Y chromosomes were present at high frequencies. Their potential contribution to Y degeneration is discussed...
  32. pmc Recombination and selection at Brassica self-incompatibility loci
    P Awadalla
    Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh, EH9 3JT, United Kingdom
    Genetics 152:413-25. 1999
    ..Finally, clusters of linkage disequilibrium within the SLG gene suggest that hypervariable regions are under balancing selection, and are not merely regions of relaxed selective constraint...
  33. ncbi request reprint Balancing selection and low recombination affect diversity near the self-incompatibility loci of the plant Arabidopsis lyrata
    Esther Kamau
    Institute of Evolutionary Biology, University of Edinburgh, UK
    Curr Biol 15:1773-8. 2005
    ..Our estimated recombination in this region, from fitting a model of the effects of S-allele polymorphism on linked neutral sites, supports the hypothesis of locally suppressed recombination around the S-locus...
  34. ncbi request reprint Comparative gene mapping in Arabidopsis lyrata chromosomes 1 and 2 and the corresponding A. thaliana chromosome 1: recombination rates, rearrangements and centromere location
    Bengt Hansson
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Res 87:75-85. 2006
    ..Given the two species' large DNA content difference, the similarity of map lengths, particularly for LG1, suggests that crossing-over is more frequent across comparable physical distances in the inbreeder, A. thaliana, as predicted...
  35. pmc Defining regions and rearrangements of the Silene latifolia Y chromosome
    R Bergero
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh EH9 3JT, United Kingdom
    Genetics 178:2045-53. 2008
    ..Future deletion mapping work should ensure that markers are studied in the parents of deletion mutants and should probably include additional deletions that were not ascertained by causing mutant sex phenotypes...
  36. pmc DNA polymorphism, haplotype structure and balancing selection in the Leavenworthia PgiC locus
    D A Filatov
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 153:1423-34. 1999
    ..The age of the haplotypes and the results of Kelly's Z(nS) and Wall's B and Q tests with recombination suggest that the haplotypes are maintained due to balancing selection at or near this locus...
  37. ncbi request reprint Low diversity and divergence in the fil1 gene family of Antirrhinum (Scrophulariaceae)
    C P Vieira
    Institute of Cell Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    J Mol Evol 52:171-81. 2001
    ..Using a sample of 52 genes, based on two measures of codon usage (ENC and GC3 content), we show that cyc and fil1 are among the least biased Antirrhinum genes, so that their low diversity is not due to extreme codon bias...
  38. ncbi request reprint The effects of local selection, balanced polymorphism and background selection on equilibrium patterns of genetic diversity in subdivided populations
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637, USA
    Genet Res 70:155-74. 1997
    ..We discuss how these theoretical results can be related to data on genetic diversity within and between local populations of a species...
  39. pmc A new plant sex-linked gene with high sequence diversity and possible introgression of the X copy
    V B Kaiser
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK
    Heredity (Edinb) 106:339-47. 2011
    ..However, SlX9 has higher diversity than other genes on the S. latifolia X chromosome. We evaluate the hypothesis of introgression from the closely related species S. dioica as an explanation for the high sequence diversity observed...
  40. ncbi request reprint The effect of recombination on background selection
    M Nordborg
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genet Res 67:159-74. 1996
    ..Large overall effects are less likely in species with higher levels of genetic recombination, such as mammals, although local reductions in regions of reduced recombination might be detectable...
  41. ncbi request reprint Low rates of silent substitution in nuclear genes of two distantly related Scrophulariaceae (Antirrhinum and Verbascum)
    C P Vieira
    Institute of Cell Animal and Population Biology, University of Edinburgh, Edinburgh, Scotland
    Mol Biol Evol 18:1940-51. 2001
    ..Repeated gene duplication and loss of elements in the Adh gene family is likely in these lineages, making it impossible to determine orthology of the Adh genes...
  42. ncbi request reprint Non-sex-linked, nuclear cleaved amplified polymorphic sequences in Silene latifolia
    V Laporte
    Institute of Cell, Animal, and Population Biology (ICAPB, University of Edinburgh, Ashworth Laboratory, King's Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    J Hered 92:357-9. 2001
    ....
  43. ncbi request reprint Comparative gene mapping in Arabidopsis lyrata chromosomes 6 and 7 and A. thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates
    Akira Kawabe
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Genet Res 88:45-56. 2006
    ..There were significantly fewer recombination events in the closer than the more distant region, supporting the above prediction, but showing that the low recombination region is very limited in size...
  44. pmc Linkage disequilibrium between incompatibility locus region genes in the plant Arabidopsis lyrata
    Jenny Hagenblad
    Institute of Evolutionary Biology, University of Edinburgh, UK
    Genetics 173:1057-73. 2006
    ..Overall, the results suggest that recombination rarely occurs in the interval between the S-loci and Aly8 and that linkage to the S-loci can probably account for the observed high Aly8 diversity...
  45. ncbi request reprint Analysis and evolution of two functional Y-linked loci in a plant sex chromosome system
    I Atanassov
    , , Lyon, France
    Mol Biol Evol 18:2162-8. 2001
    ..These results suggest that, as for human XY-linked genes, the sex-linked plant loci ceased recombining at different times and reveal distinct events in the evolutionary history of the sex chromosomes...
  46. ncbi request reprint High diversity due to balancing selection in the promoter region of the Medea gene in Arabidopsis lyrata
    Akira Kawabe
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories King s Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Curr Biol 17:1885-9. 2007
    ..lyrata endosperm but no evidence for adaptive evolution in the coding region, whereas the 5' flanking region displays high diversity, with distinct haplotypes, suggesting balancing selection in the promoter region...
  47. ncbi request reprint Self-incompatibility: how to stay incompatible
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, UK
    Curr Biol 12:R424-6. 2002
    ..Plant self-incompatibility is controlled by different genes for the recognition reactions of pollen and stigmas, yet correct association of the two genes have been maintained in two Brassica species...
  48. pmc Lack of degeneration of loci on the neo-Y chromosome of Drosophila americana americana
    B Charlesworth
    Department of Ecology and Evolution, University of Chicago, IL 60637 1573, USA
    Genetics 145:989-1002. 1997
    ..This is consistent with the recent origin of the neo-Y and neo-X chromosomes, and the slow rates at which the forces that cause Y chromosome degeneration are likely to work...
  49. ncbi request reprint Estimating the number, frequency, and dominance of S-alleles in a natural population of Arabidopsis lyrata(Brassicaceae) with sporophytic control of self-incompatibility
    B K Mable
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, Edinburgh EH9 3JT, UK
    Heredity (Edinb) 90:422-31. 2003
    ....
  50. ncbi request reprint The genetic basis of inbreeding depression
    B Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Genet Res 74:329-40. 1999
    ..Possible experimental approaches to resolving outstanding questions are discussed...
  51. pmc The degeneration of Y chromosomes
    B Charlesworth
    Institute for Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, UK
    Philos Trans R Soc Lond B Biol Sci 355:1563-72. 2000
    ..It is, however, currently unclear which of the various processes is most important; some directions for future work to help to resolve this question are discussed...
  52. ncbi request reprint Subdivision and haplotype structure in natural populations of Arabidopsis lyrata
    Stephen I Wright
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh, EH9 3JT, UK
    Mol Ecol 12:1247-63. 2003
    ..Complex population histories in both A. thaliana and A. lyrata complicate theoretical predictions and empirical tests of the effects of inbreeding on polymorphism and molecular evolution...
  53. ncbi request reprint Rates and patterns of molecular evolution in inbred and outbred Arabidopsis
    Stephen I Wright
    Institute of Cell, Animal, and Population Biology, Ashworth Laboratories, University of Edinburgh
    Mol Biol Evol 19:1407-20. 2002
    ..2-0.6 per generation...
  54. pmc Patterns of nucleotide polymorphism distinguish temperate and tropical wild isolates of Caenorhabditis briggsae
    Asher D Cutter
    Institute of Evolutionary Biology, University of Edinburgh, UK
    Genetics 173:2021-31. 2006
    ..briggsae into northern latitudes. We discuss these findings in relation to their implications for selection, demographic history, and the persistence of self-fertilization...
  55. doi request reprint Slcyt, a newly identified sex-linked gene, has recently moved onto the X chromosome in Silene latifolia (Caryophyllaceae)
    Vera B Kaiser
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, United Kingdom
    Mol Biol Evol 26:2343-51. 2009
    ..diclinis and S. latifolia/S. dioica. Diversity at Slcyt is extremely low (pi(syn) = 0.16%), and we find an excess of high frequency-derived variants and a negative Tajima's D, suggesting that the translocation was driven by selection...
  56. pmc Darwin and genetics
    Brian Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh EH9 3JT, United Kingdom
    Genetics 183:757-66. 2009
    ....
  57. pmc Centromere locations and associated chromosome rearrangements in Arabidopsis lyrata and A. thaliana
    Akira Kawabe
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 173:1613-9. 2006
    ..thaliana chromosomes. However, we cannot tell whether genes were lost along with these centromeres, because such genes are absent from the A. thaliana genome, which is the sole source of markers for our mapping...
  58. pmc Nucleotide polymorphism and within-gene recombination in Daphnia magna and D. pulex, two cyclical parthenogens
    Christoph R Haag
    University of Edinburgh, Institute of Evolutionary Biology, Edinburgh, UK
    Genetics 182:313-23. 2009
    ....
  59. pmc Evolutionary strata on the X chromosomes of the dioecious plant Silene latifolia: evidence from new sex-linked genes
    Roberta Bergero
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Genetics 175:1945-54. 2007
    ..We can now conclude that the divergence value is saturated, confirming the cessation of X-Y recombination in the evolution of the sex chromosomes at approximately 10-20 MYA...
  60. ncbi request reprint Patterns of DNA variation among three centromere satellite families in Arabidopsis halleri and A. lyrata
    Akira Kawabe
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories King s Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    J Mol Evol 64:237-47. 2007
    ..halleri ssp. halleri. In A. lyrata ssp. lyrata there is some evidence for recent rapid spread of pAge2 variants, suggesting selection favoring these sequences...
  61. pmc Duplication of centromeric histone H3 (HTR12) gene in Arabidopsis halleri and A. lyrata, plant species with multiple centromeric satellite sequences
    Akira Kawabe
    Institute of Evolutionary Biology, Edinburgh University, UK
    Genetics 174:2021-32. 2006
    ..In contrast, HTR12A has low diversity, but many variants are amino acid replacements, possibly due to independent selective sweeps within populations of the species...
  62. ncbi request reprint Dynamics of inbreeding depression due to deleterious mutations in small populations: mutation parameters and inbreeding rate
    J Wang
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland, UK
    Genet Res 74:165-78. 1999
    ..The simulation results and their implications are discussed in the context of biological conservation and tests for purging...
  63. pmc The pattern of neutral molecular variation under the background selection model
    D Charlesworth
    Department of Ecology and Evolution, University of Chicago, Illinois 60637 1573, USA
    Genetics 141:1619-32. 1995
    ..It remains to be decided whether background selection is sufficient to explain the observed extent of reduction in diversity in regions of restricted recombination...
  64. ncbi request reprint Sex chromosomes: evolution of the weird and wonderful
    Deborah Charlesworth
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 15:R129-31. 2005
    ....
  65. pmc High nucleotide polymorphism and rapid decay of linkage disequilibrium in wild populations of Caenorhabditis remanei
    Asher D Cutter
    Institute of Evolutionary Biology, University of Edinburgh, United Kingdom
    Genetics 174:901-13. 2006
    ..This will be especially important if self-fertilization evolved recently in C. elegans history, because most of the evolutionary time separating C. elegans from its known relatives would have occurred in a state of obligate outcrossing...
  66. ncbi request reprint Plant evolution: modern sex chromosomes
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory King s Buildings, West Mains Roard, Edinburgh EH9 3JT, UK
    Curr Biol 14:R271-3. 2004
    ..This region is nevertheless a small part of the papaya genome compared with other male-specific genome regions, such as mammalian Y chromosomes...
  67. ncbi request reprint Evolution: an exception that proves the rule
    D Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, King's Buildings, W. Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 11:R13-5. 2001
    ..In some genera, polyploidy causes failure of self-incompatibility, and dioecy may then evolve...
  68. doi request reprint The evolution of restricted recombination in sex chromosomes
    Roberta Bergero
    University of Edinburgh, Edinburgh EH9 3JT, UK
    Trends Ecol Evol 24:94-102. 2009
    ....
  69. ncbi request reprint Sex determination: balancing selection in the honey bee
    Deborah Charlesworth
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratory, King s Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Curr Biol 14:R568-9. 2004
    ....
  70. ncbi request reprint The transition to self-compatibility in Arabidopsis thaliana and evolution within S-haplotypes over 10 Myr
    Jesper S Bechsgaard
    Ecology and Genetics, Institute of Biological Sciences, University of Aarhus, Denmark
    Mol Biol Evol 23:1741-50. 2006
    ..thaliana, at least for some period after their split. In addition, the coalescence times of sequences of individual S-haplogroups are expected to be less than those of alleles at non-S-loci...
  71. pmc Early events in the evolution of the Silene latifolia Y chromosome: male specialization and recombination arrest
    Jitka Zluvova
    Department of Plant Developmental Genetics, Institute of Biophysics of the Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic
    Genetics 177:375-86. 2007
    ..Cytological analysis of meiotic X-Y pairing in one of the male-sterile mutants indicates that the Y carries sequences or functions specifically affecting sex chromosome pairing...
  72. ncbi request reprint The inter-specific hybrid Silene latifolia x S. viscosa reveals early events of sex chromosome evolution
    Jitka Zluvova
    Laboratory of Plant Developmental Genetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, CZ 612 65 Brno, Czech Republic
    Evol Dev 7:327-36. 2005
    ....
  73. ncbi request reprint Duplicative transfer of a MADS box gene to a plant Y chromosome
    Sachihiro Matsunaga
    Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Chiba, Japan
    Mol Biol Evol 20:1062-9. 2003
    ..Our results suggest that the acquisition of autosomal genes is an important event in the evolution of plant Y chromosomes...
  74. pmc Testing for effects of recombination rate on nucleotide diversity in natural populations of Arabidopsis lyrata
    Stephen I Wright
    Department of Biology, York University, Toronto, Ontario, Canada
    Genetics 174:1421-30. 2006
    ..lyrata populations is not related to recombination rate, including genic recombination hotspots, and low gene density in the low recombination rate region...
  75. doi request reprint Evidence for degeneration of the Y chromosome in the dioecious plant Silene latifolia
    Gabriel A B Marais
    Universite de Lyon, Universite Lyon 1, Centre National de la Recherche Scientifique, UMR 5558, Laboratoire de Biometrie et Biologie Evolutive, 69622 Villeurbanne Cedex, France
    Curr Biol 18:545-9. 2008
    ..We detect signs of degeneration in most of the Y-linked gene sequences analyzed, similar to those of animal Y-linked and neo-Y chromosome genes...
  76. pmc Impact of mating systems on patterns of sequence polymorphism in flowering plants
    Sylvain Glemin
    UMR 5171 Genome, Populations, Interactions, Adaptation, Universite Montpellier II, 34095 Montpellier, France
    Proc Biol Sci 273:3011-9. 2006
    ..We show that among various life-history traits, mating systems have the greatest influence on patterns of polymorphism...
  77. ncbi request reprint Substitution rates in the X- and Y-linked genes of the plants, Silene latifolia and S. dioica
    Dmitry A Filatov
    School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
    Mol Biol Evol 19:898-907. 2002
    ..It is thus probably caused by a difference in per-replication mutation rates between the sex chromosomes. This suggests that the local mutation rate can change in a relatively short evolutionary time...
  78. pmc Patterns of polymorphism and demographic history in natural populations of Arabidopsis lyrata
    Jeffrey Ross-Ibarra
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California, United States of America
    PLoS ONE 3:e2411. 2008
    ..Arabidopsis lyrata, a self-incompatible, perennial species with a circumpolar distribution, is an excellent model system in which to study the roles of demographic history and local adaptation in patterning genetic variation...
  79. ncbi request reprint Deborah Charlesworth
    Barbara Mable
    Genet Res (Camb) 90:1. 2008