I L Chapple

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Glutathione in gingival crevicular fluid and its relation to local antioxidant capacity in periodontal health and disease
    I L C Chapple
    Unit of Periodontology, School of Dentistry, The University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK
    Mol Pathol 55:367-73. 2002
  2. ncbi request reprint Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth
    Helen J Wright
    Periodontal Research Group, Unit of Oral Biology and Pathology, School of Dentistry, University of Birmingham, St Chad s Queensway, Birmingham B4 6NN, UK
    Arch Oral Biol 49:421-5. 2004
  3. ncbi request reprint The role of reactive oxygen and antioxidant species in periodontal tissue destruction
    Iain L C Chapple
    Unit of Periodontology, The University of Birmingham School of Dentistry, Birmingham, UK
    Periodontol 2000 43:160-232. 2007
  4. ncbi request reprint Periodontitis associates with a type 1 IFN signature in peripheral blood neutrophils
    Helen J Wright
    Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
    J Immunol 181:5775-84. 2008
  5. pmc The natural history of, and risk factors for, progressive chronic kidney disease (CKD): the Renal Impairment in Secondary care (RIISC) study; rationale and protocol
    Stephanie Stringer
    Department of Nephrology, University Hospital Birmingham, Birmingham B15 2WB, UK
    BMC Nephrol 14:95. 2013
  6. doi request reprint Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
    Iain L C Chapple
    Periodontal Research Group and MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK
    J Periodontol 84:S106-12. 2013
  7. doi request reprint Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
    Iain L C Chapple
    Periodontal Research Group and MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK
    J Clin Periodontol 40:S106-12. 2013
  8. pmc Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT
    Iain L C Chapple
    Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, UK
    J Clin Periodontol 39:62-72. 2012
  9. ncbi request reprint Potential mechanisms underpinning the nutritional modulation of periodontal inflammation
    Iain L C Chapple
    School of Dentistry, College of Medical and Dental Sciences, The University of Birmingham, St Chads Queensway, Birmingham, England
    J Am Dent Assoc 140:178-84. 2009
  10. ncbi request reprint Management of periodontal diseases within the NHS three years on: are things any better?
    I L C Chapple
    Periodontal Research Group, The University of Birmingham School of Dentistry, Birmingham, UK
    Br Dent J 202:569-70. 2007

Collaborators

Detail Information

Publications20

  1. pmc Glutathione in gingival crevicular fluid and its relation to local antioxidant capacity in periodontal health and disease
    I L C Chapple
    Unit of Periodontology, School of Dentistry, The University of Birmingham, St Chads Queensway, Birmingham B4 6NN, UK
    Mol Pathol 55:367-73. 2002
    ..To determine possible changes in gingival crevicular fluid (GCF) antioxidant defence in chronic adult periodontal disease and to investigate the nature of the local radical scavenging mechanisms, with particular reference to glutathione...
  2. ncbi request reprint Crevicular fluid levels of TGFbeta1 in drug-induced gingival overgrowth
    Helen J Wright
    Periodontal Research Group, Unit of Oral Biology and Pathology, School of Dentistry, University of Birmingham, St Chad s Queensway, Birmingham B4 6NN, UK
    Arch Oral Biol 49:421-5. 2004
    ..GCF levels of TGFbeta1 and alkaline phosphatase, a marker of inflammation, were determined by enhanced chemiluminescence ELISA and enzyme activity assays, respectively...
  3. ncbi request reprint The role of reactive oxygen and antioxidant species in periodontal tissue destruction
    Iain L C Chapple
    Unit of Periodontology, The University of Birmingham School of Dentistry, Birmingham, UK
    Periodontol 2000 43:160-232. 2007
  4. ncbi request reprint Periodontitis associates with a type 1 IFN signature in peripheral blood neutrophils
    Helen J Wright
    Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham, United Kingdom
    J Immunol 181:5775-84. 2008
    ..In conclusion, although chronic periodontitis is a complex disease, raised IFN-alpha may be one determinant of the distinct molecular phenotype and hyperresponsivity exhibited by patients' peripheral blood neutrophils...
  5. pmc The natural history of, and risk factors for, progressive chronic kidney disease (CKD): the Renal Impairment in Secondary care (RIISC) study; rationale and protocol
    Stephanie Stringer
    Department of Nephrology, University Hospital Birmingham, Birmingham B15 2WB, UK
    BMC Nephrol 14:95. 2013
    ..Accurate mapping of the bio-clinical determinants of this group will enable improved risk stratification and direct the development of better targeted management for people with CKD...
  6. doi request reprint Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
    Iain L C Chapple
    Periodontal Research Group and MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK
    J Periodontol 84:S106-12. 2013
    ..Guidelines: Given the current evidence, it is timely to provide guidelines for periodontal care in diabetes patients for medical and dental professionals and recommendations for patients/the public...
  7. doi request reprint Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
    Iain L C Chapple
    Periodontal Research Group and MRC Centre for Immune Regulation, University of Birmingham School of Dentistry, Birmingham, UK
    J Clin Periodontol 40:S106-12. 2013
    ....
  8. pmc Adjunctive daily supplementation with encapsulated fruit, vegetable and berry juice powder concentrates and clinical periodontal outcomes: a double-blind RCT
    Iain L C Chapple
    Periodontal Research Group, School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, UK
    J Clin Periodontol 39:62-72. 2012
    ..A double-blind randomized controlled trial to determine whether dietary supplementation with fruit/vegetable/berry juice powder concentrates, simultaneously with non-surgical periodontal therapy, improved 2-month treatment outcomes...
  9. ncbi request reprint Potential mechanisms underpinning the nutritional modulation of periodontal inflammation
    Iain L C Chapple
    School of Dentistry, College of Medical and Dental Sciences, The University of Birmingham, St Chads Queensway, Birmingham, England
    J Am Dent Assoc 140:178-84. 2009
    ..In this article, the author reviews the role of nutrition in the development and resolution of inflammation...
  10. ncbi request reprint Management of periodontal diseases within the NHS three years on: are things any better?
    I L C Chapple
    Periodontal Research Group, The University of Birmingham School of Dentistry, Birmingham, UK
    Br Dent J 202:569-70. 2007
    ..surrounding one-stage full mouth disinfection, and ask how strong the evidence is for benefit, before taking a look into the future of novel host-modulation therapies and demonstrating how we can control what our genes do by what we eat!..
  11. ncbi request reprint The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations
    Iain L C Chapple
    Periodontal Research Group, University of Birmingham, School of Dentistry, St Chads Queensway, Birmingham, B4 6NN, UK
    J Nutr 137:657-64. 2007
    ..38 (0.26,0.63, vitamin C) and 0.55 (0.33,0.93, TAOC). Increased serum antioxidant concentrations are associated with a reduced relative risk of periodontitis even in never-smokers...
  12. ncbi request reprint Prediction and diagnosis of attachment loss by enhanced chemiluminescent assay of crevicular fluid alkaline phosphatase levels
    I L Chapple
    Oral Diseases Research Group, School of Dentistry, University of Birmingham, UK
    J Clin Periodontol 26:190-8. 1999
    ..These results indicate that total GCF ALP levels may serve as a predictor of future or current disease activity...
  13. ncbi request reprint Compromised GCF total antioxidant capacity in periodontitis: cause or effect?
    I L C Chapple
    Periodontal Research Group, School of Dentistry, University of Birmingham, Birmingham B4 6NN, UK
    J Clin Periodontol 34:103-10. 2007
    ..The total antioxidant capacity (TAOC) of gingival crevicular fluid volume (GCF) and plasma appears compromised in periodontitis, but it is unclear whether this predisposes to, or results from the inflammatory process...
  14. ncbi request reprint Oxidative stress, nutrition and neutrogenomics in periodontal health and disease
    I L C Chapple
    Birmingham Dental School and Hospital, Birmingham, UK
    Int J Dent Hyg 4:15-21; discussion 50-2. 2006
  15. ncbi request reprint Management of chronic periodontal diseases within the NHS
    I L C Chapple
    University of Birmingham, Dental School, St Chad s Queensway, Birmingham B4 6NN
    Br Dent J 196:505. 2004
    ..However, when faced with the loss of an anterior tooth, they will contemplate immediate cessation and many succeed because the immediate consequences of not doing so are very tangible and personal...
  16. ncbi request reprint TGF-beta isoforms and TGF-beta receptors in drug-induced and hereditary gingival overgrowth
    H J Wright
    Unit of Oral Biology and Pathology, School of Dentistry, University of Birmingham, UK
    J Oral Pathol Med 30:281-9. 2001
    ..0001). These results indicate qualitative and quantitative differences in TGF-beta isoform and receptor expression by fibroblasts in gingival overgrowth that may contribute to disease pathogenesis...
  17. ncbi request reprint Dinucleotide repeat polymorphism in the interleukin-10 gene promoter (IL-10.G) and genetic susceptibility to early-onset periodontal disease
    B J Hennig
    Department of Oral Biology, Dental School, University of Newcastle upon Tyne, UK
    Genes Immun 1:402-4. 2000
    ..We conclude that this study provides no evidence for a role of IL-10.G alleles in genetic susceptibility to EOP...
  18. ncbi request reprint Efficacy of a prototype brush head for a powered toothbrush. A multicentre study
    G I McCracken
    Restorative Dentistry, Dental School, University of Newcastle upon Tyne, UK
    J Clin Periodontol 29:889-95. 2002
    ..To evaluate a multicentre clinical trial design for testing powered toothbrushes...
  19. pmc Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant
    Irundika H K Dias
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, United Kingdom
    Infect Immun 76:317-23. 2008
    ..During periodontitis, secreted gingipains may differentially affect neutrophil chemotaxis and activation in response to IL-8 according to the cellular source of the chemokine...
  20. ncbi request reprint Prediction of serum total antioxidant activity from the concentration of individual serum antioxidants
    Simon R Maxwell
    Clinical Pharmacology Unit, The University of Edinburgh, Queens Medical Research Institute, Edinburgh, Scotland, UK
    Clin Chim Acta 372:188-94. 2006
    ..Models therefore need developing to quantify contributions made by individual species to global antioxidant defence...