Ian Chambers


Affiliation: University of Edinburgh
Country: UK


  1. Chambers I, Tomlinson S. The transcriptional foundation of pluripotency. Development. 2009;136:2311-22 pubmed publisher
    ..Here we discuss how these observations advance our understanding of the transcription factor network that controls pluripotent identity and highlight unresolved issues that arise from these studies. ..
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    Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113:643-55 pubmed
    ..These findings establish a central role for Nanog in the transcription factor hierarchy that defines ES cell identity. ..
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    Chambers I, Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene. 2004;23:7150-60 pubmed
    ..Nanog function also requires Oct4. Here, we review recent progress in ES cell self-renewal, relate this to the biology of teratocarcinomas and offer testable hypotheses to expose the mechanics of ES cell self-renewal...
  4. Mistri T, Arindrarto W, Ng W, Wang C, Lim L, Sun L, et al. Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through Fgf4/Fgfr2 signaling in preimplantation mouse embryos. Biochem J. 2018;475:1075-1089 pubmed publisher
  5. Mistri T, Devasia A, Chu L, Ng W, Halbritter F, Colby D, et al. Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells. EMBO Rep. 2015;16:1177-91 pubmed publisher
    ..Thus, distinct interactions between Sox2 and POU-TF subclasses distinguish pluripotent ESCs from multipotent NSCs, providing molecular insight into how Oct4 alone can convert NSCs to pluripotency. ..
  6. Zhang J, Zhang M, Acampora D, Vojtek M, Yuan D, Simeone A, et al. OTX2 restricts entry to the mouse germline. Nature. 2018;562:595-599 pubmed publisher
  7. Mullin N, Gagliardi A, Khoa L, Colby D, Hall Ponsele E, Rowe A, et al. Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function. J Mol Biol. 2017;429:1544-1553 pubmed publisher
  8. Zhang M, Leitch H, Tang W, Festuccia N, Hall Ponsele E, Nichols J, et al. Esrrb Complementation Rescues Development of Nanog-Null Germ Cells. Cell Rep. 2018;22:332-339 pubmed publisher
    ..These effects are recapitulated in vivo: knockin of Esrrb to Nanog restores PGC numbers to wild-type levels and results in fertile adult mice. These findings demonstrate that Esrrb can replace Nanog function in germ cells. ..