Research Topics
| Samuel R ChamberlainSummaryAffiliation: University of Cambridge Country: UK Publications
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Detail Information
Publications
Neurocognitive endophenotypes of obsessive-compulsive disorderLara Menzies
Brain Mapping Unit, University of Cambridge, Cambridge, UK
Brain 130:3223-36. 2007..In summary, structural variation in large-scale brain systems related to motor inhibitory control may mediate genetic risk for OCD, representing the first evidence for a neurocognitive endophenotype of OCD...- Cognition in mania and depression: psychological models and clinical implicationsSamuel R Chamberlain
Department of Psychiatry, University of Cambridge, School of Clinical Medicine, UK
Curr Psychiatry Rep 6:451-8. 2004..The clinical relevance of these developments is discussed... - Atomoxetine increases salivary cortisol in healthy volunteersSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
J Psychopharmacol 21:545-9. 2007..Furthermore, the effects of atomoxetine on HPA axis function may have clinical implications given the use of this agent in the treatment of ADHD... - The neuropsychiatry of impulsivitySamuel R Chamberlain
aDepartment of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Curr Opin Psychiatry 20:255-61. 2007..This article considers recent developments in the neuropsychological assessment of impulsivity with a focus on the ability to suppress motor responses (response inhibition)... - Lifting the veil on trichotillomaniaSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Box 189, Cambridge, CB2 2QQ UK
Am J Psychiatry 164:568-74. 2007 - Lack of deleterious effects of buspirone on cognition in healthy male volunteersSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK
J Psychopharmacol 21:210-5. 2007..Future research directions are discussed in relation to acute and chronic studies in neuropsychiatric populations... 
Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorderSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, CB2 2QQ UK
Am J Psychiatry 164:335-8. 2007..The aim was to assess inhibitory control processes in unaffected first-degree relatives of OCD patients for the first time with objective tests...- The neuropsychology of mood disordersSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Curr Psychiatry Rep 8:458-63. 2006..Results are discussed in the context of current conceptualizations of dysfunctional neural circuitry, and in relation to important clinical research implications... - Neuropharmacological modulation of cognitionSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, UK
Curr Opin Neurol 19:607-12. 2006..The purpose of this article is to review recent neuropharmacological manipulation studies in humans relating to these domains... - Strategy implementation in obsessive-compulsive disorder and trichotillomaniaSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Psychol Med 36:91-7. 2006.... - A neuropsychological comparison of obsessive-compulsive disorder and trichotillomaniaSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Neuropsychologia 45:654-62. 2007..However, the extent to which these disorders share a common cognitive phenotype has yet to be elucidated using patients without confounding co-morbidities... - Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomaniaSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge, UK
Am J Psychiatry 163:1282-4. 2006..The authors assessed and compared motor inhibition and cognitive flexibility in OCD and trichotillomania for the first time, to their knowledge... - Noradrenergic modulation of working memory and emotional memory in humansSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 188:397-407. 2006..NA dysfunction and abnormalities in arousal-dependent memory functions are evident in a variety of neuropsychiatric illnesses... - Neurochemical modulation of response inhibition and probabilistic learning in humansSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 189, Cambridge CB2 2QQ, UK
Science 311:861-3. 2006.... - The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markersS R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, P O Box 189, Cambridge CB2 2QQ, UK
Neurosci Biobehav Rev 29:399-419. 2005..This has direct implications not only for OCD but also for putative obsessive-compulsive spectrum conditions including attention deficit hyperactivity disorder, Tourette's syndrome, and trichotillomania (compulsive hair pulling)... - Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorderSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
Biol Psychiatry 62:977-84. 2007..Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential. Studies have yet to assess whether atomoxetine improves cognition following a single oral dose in ADHD... - Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging studySamuel R Chamberlain
Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
Br J Psychiatry 193:216-21. 2008..Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking... 
Translational approaches to frontostriatal dysfunction in attention-deficit/hyperactivity disorder using a computerized neuropsychological batterySamuel R Chamberlain
Department of Psychiatry and Medical Research Council Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, United Kingdom
Biol Psychiatry 69:1192-203. 2011..The findings suggest overlapping but also distinct early cognitive effects of ADHD medications and have important implications for understanding the pathophysiology of ADHD and for future trials...- White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relativesLara Menzies
Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB22QQ, UK
Am J Psychiatry 165:1308-15. 2008..They also explored whether such abnormalities occur in healthy first-degree relatives of patients, indicating they may be endophenotypes representing increased genetic risk for OCD... - Probing compulsive and impulsive behaviors, from animal models to endophenotypes: a narrative reviewNaomi A Fineberg
Department of Psychiatry, National OCDs Specialist Centre, Hertfordshire Partnership NHS Foundation Trust, Queen Elizabeth II Hospital, Welwyn Garden City, Hertfordshire, UK
Neuropsychopharmacology 35:591-604. 2010..Targeted application of neurocognitive tasks, receptor-specific neurochemical probes, and brain systems neuroimaging techniques have potential for future research in this field... - The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorderNatalia Del Campo
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
Biol Psychiatry 69:e145-57. 2011.... - Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging studySamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
Biol Psychiatry 65:550-5. 2009..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined... - Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relativesSamuel R Chamberlain
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
Science 321:421-2. 2008.... - Endophenotypes of obsessive-compulsive disorder: rationale, evidence and future potentialSamuel R Chamberlain
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
Expert Rev Neurother 9:1133-46. 2009.... - Cross-species models of OCD spectrum disordersVasileios Boulougouris
Department of Experimental Psychology and the Behavioural and Clinical Neuroscience Institute BCNI, University of Cambridge, Downing Street, CB2 3EB, Cambridge, UK
Psychiatry Res 170:15-21. 2009..We then survey animal models of OC spectrum conditions within this framework, focusing on (i) ethological models; (ii) genetic and pharmacological models; and (iii) behavioral models. Key future research directions are highlighted... - Cognitive dysfunction and anxious-impulsive personality traits are endophenotypes for drug dependenceKaren D Ersche
Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Am J Psychiatry 169:926-36. 2012.... - Effects of acute modafinil on cognition in trichotillomaniaSamuel R Chamberlain
Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 212:597-601. 2010..Individuals with trichotillomania often report significant difficulty resisting the urges and drive to pull hair... - The role of the right inferior frontal gyrus: inhibition and attentional controlAdam Hampshire
Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
Neuroimage 50:1313-9. 2010..Our results reveal that the RIFG is recruited when important cues are detected, regardless of whether that detection is followed by the inhibition of a motor response, the generation of a motor response, or no external response at all... - Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisitedLara Menzies
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
Neurosci Biobehav Rev 32:525-49. 2008.... - Differential cognitive deterioration in dementia: a two year longitudinal studySamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
J Alzheimers Dis 24:125-36. 2011..Follow-up studies in independent populations are needed to validate predictive algorithms identified... - Trichotillomania: neurobiology and treatmentSamuel R Chamberlain
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
Neurosci Biobehav Rev 33:831-42. 2009..Finally, we highlight important areas for future neurobiological and treatment research... - Neurocognitive mechanisms in depression: implications for treatmentLuke Clark
Behavioural and Clinical Neuroscience Institute BCNI, Department of Experimental Psychology, University of Cambridge, Cambridge CB23EB, United Kingdom
Annu Rev Neurosci 32:57-74. 2009.... - Effects of modafinil and prazosin on cognitive and physiological functions in healthy volunteersS E Winder-Rhodes
Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
J Psychopharmacol 24:1649-57. 2010..Our findings support the hypothesised involvement of α1-adrenoceptors in some of the cognitive-enhancing effects of modafinil and warrant further investigation... - Memantine reduces stealing behavior and impulsivity in kleptomania: a pilot studyJon E Grant
aDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois bDepartment of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA cDepartment of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark dDepartment of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neurosciences Institute, University of Cambridge, Cambridge, UK
Int Clin Psychopharmacol 28:106-11. 2013..Memantine was generally well tolerated. This study shows the effectiveness of memantine in reducing urges to shoplift and shoplifting behavior along with improving impulsivity, mood, anxiety, and psychosocial functioning... - The neurobiology of attention-deficit/hyperactivity disorderSamuel R Chamberlain
Biol Psychiatry 61:1317-9. 2007 - An A-B-C model of habit disorders: hair-pulling, skin-picking, and other stereotypic conditionsDan J Stein
Department of Mental Health and Psychiatry, University of Cape Town, South Africa
CNS Spectr 11:824-7. 2006..An affect regulation, behavioral addiction, and cognitive control (A-B-C) approach is outlined to conceptualizing and managing these conditions...