Apirat Chaikuad

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
    Apirat Chaikuad
    Department of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK
    BMC Struct Biol 9:42. 2009
  2. pmc Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family
    Apirat Chaikuad
    Structural Genomics Consortium, Old Road Research Campus Building, Oxford OX3 7DQ, UK
    BMC Struct Biol 12:14. 2012
  3. doi request reprint Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS
    Apirat Chaikuad
    Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK
    Biochem J 435:401-9. 2011
  4. pmc Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis
    Apirat Chaikuad
    Structural Genomics Consortium, Old Road Research Campus Building, Oxford, United Kingdom OX3 7DQ
    Proc Natl Acad Sci U S A 108:21028-33. 2011
  5. pmc Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
    Peter Canning
    Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Biol Chem 288:7803-14. 2013
  6. pmc Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
    Apirat Chaikuad
    Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Biol Chem 287:36990-8. 2012
  7. ncbi request reprint Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH
    Apirat Chaikuad
    Department of Biochemistry, University of Bristol, United Kingdom
    Biochemistry 44:16221-8. 2005

Collaborators

Detail Information

Publications7

  1. pmc Conservation of structure and activity in Plasmodium purine nucleoside phosphorylases
    Apirat Chaikuad
    Department of Biochemistry, University of Bristol, Bristol, BS8 1TD, UK
    BMC Struct Biol 9:42. 2009
    ..Whereas the PNP enzyme from Pf has previously been studied in detail, despite the prevalence of Pv little is known about many of the key metabolic enzymes from this parasite, including PvPNP...
  2. pmc Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family
    Apirat Chaikuad
    Structural Genomics Consortium, Old Road Research Campus Building, Oxford OX3 7DQ, UK
    BMC Struct Biol 12:14. 2012
    ..Despite previous enzyme and substrate characterization, structural details of DNPEP regarding ligand recognition and catalytic mechanism remain to be delineated...
  3. doi request reprint Structure and kinetic characterization of human sperm-specific glyceraldehyde-3-phosphate dehydrogenase, GAPDS
    Apirat Chaikuad
    Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, UK
    Biochem J 435:401-9. 2011
    ..Our data therefore elucidate structural and kinetic features of hGAPDS that might provide insightful information towards inhibitor development...
  4. pmc Conformational plasticity of glycogenin and its maltosaccharide substrate during glycogen biogenesis
    Apirat Chaikuad
    Structural Genomics Consortium, Old Road Research Campus Building, Oxford, United Kingdom OX3 7DQ
    Proc Natl Acad Sci U S A 108:21028-33. 2011
    ..Our data highlight the conformational plasticity of glycogenin and coexistence of two modes of glucosylation as integral to its catalytic mechanism...
  5. pmc Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
    Peter Canning
    Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Biol Chem 288:7803-14. 2013
    ..The presented data offer a model for the quaternary assembly of this E3 class that supports the bivalent capture of Nrf2 and reveals potential new sites for E3 inhibitor design...
  6. pmc Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva
    Apirat Chaikuad
    Structural Genomics Consortium, University of Oxford, Oxford OX3 7DQ, United Kingdom
    J Biol Chem 287:36990-8. 2012
    ..The presented ALK2 structure offers a valuable template for the further design of specific inhibitors of BMP signaling...
  7. ncbi request reprint Structure of lactate dehydrogenase from Plasmodium vivax: complexes with NADH and APADH
    Apirat Chaikuad
    Department of Biochemistry, University of Bristol, United Kingdom
    Biochemistry 44:16221-8. 2005
    ..The unusual cofactor binding site in these Plasmodium enzymes is found to readily accommodate both NADH and APADH, explaining why the Plasmodium enzymes retain enzymatic activity in the presence of this synthetic cofactor...