A Ceriello

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. doi request reprint Glucose "peak" and glucose "spike": Impact on endothelial function and oxidative stress
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Res Clin Pract 82:262-7. 2008
  2. pmc A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization
    Chandrashekhar D Kamat
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Cardiovasc Disord 7:4. 2007
  3. ncbi request reprint Thiazolidinediones as anti-inflammatory and anti-atherogenic agents
    Antonio Ceriello
    Warwick Medical School, Clinical Sciences Research Institute, University Hospital, Coventry, Warwickshire, UK
    Diabetes Metab Res Rev 24:14-26. 2008
  4. ncbi request reprint Postprandial hyperglycaemia and cardiovascular complications of diabetes: an update
    Antonio Ceriello
    Clinical Science Research Institute, Clinical Science Building, Warwick Medical School, University of Warwick, Coventry, UK
    Nutr Metab Cardiovasc Dis 16:453-6. 2006
  5. pmc International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations
    A Ceriello
    Clinical Science Research Institute, Warwick Medical School, Coventry, UK
    Diabet Med 25:1151-6. 2008
  6. doi request reprint Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1349-54. 2008
  7. doi request reprint Possible role of oxidative stress in the pathogenesis of hypertension
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 31:S181-4. 2008
  8. ncbi request reprint Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 30:649-54. 2007
  9. ncbi request reprint Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 30:1694-8. 2007
  10. ncbi request reprint Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes
    Antonio Ceriello
    Warwick Medical School, Clinical Science Research Institute, University Hospital Walsgrave Campus, University of Warwick, Clifford Bridge Road, Coventry CV2 2DX, UK
    Curr Opin Lipidol 17:510-8. 2006

Collaborators

Detail Information

Publications71

  1. doi request reprint Glucose "peak" and glucose "spike": Impact on endothelial function and oxidative stress
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Res Clin Pract 82:262-7. 2008
    ..Data suggest that 2h hyperglycaemia during an OGTT is less predictive for cardiovascular disease of the glucose "spike" (the difference between the baseline glucose level and the "peak" hyperglycaemia during the test)...
  2. pmc A long-term "memory" of HIF induction in response to chronic mild decreased oxygen after oxygen normalization
    Chandrashekhar D Kamat
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    BMC Cardiovasc Disord 7:4. 2007
    ..Hypoxia inducible factor (HIF) is a transcription factor complex shown to be the master regulator of the cellular response to decreased oxygen levels and many HIF target genes have been shown to be associated with ED...
  3. ncbi request reprint Thiazolidinediones as anti-inflammatory and anti-atherogenic agents
    Antonio Ceriello
    Warwick Medical School, Clinical Sciences Research Institute, University Hospital, Coventry, Warwickshire, UK
    Diabetes Metab Res Rev 24:14-26. 2008
    ..The data available up to the present time, in the context of the emerging cardiovascular outcome profiles of rosiglitazone and pioglitazone, will be discussed here...
  4. ncbi request reprint Postprandial hyperglycaemia and cardiovascular complications of diabetes: an update
    Antonio Ceriello
    Clinical Science Research Institute, Clinical Science Building, Warwick Medical School, University of Warwick, Coventry, UK
    Nutr Metab Cardiovasc Dis 16:453-6. 2006
    ..Therefore, in addition to HbA1c and FPG, physicians should consider monitoring and targeting PPG in patients with type 2 diabetes...
  5. pmc International Diabetes Federation guideline for management of postmeal glucose: a review of recommendations
    A Ceriello
    Clinical Science Research Institute, Warwick Medical School, Coventry, UK
    Diabet Med 25:1151-6. 2008
    ..The following review highlights the recommendations of the guideline, the supporting evidence provided and the major conclusions drawn. The full guideline is available for download at http://www.idf.org...
  6. doi request reprint Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes 57:1349-54. 2008
    ..To explore the possibility that oscillating glucose may outweigh A1C levels in determining the risk for cardiovascular diabetes complications...
  7. doi request reprint Possible role of oxidative stress in the pathogenesis of hypertension
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 31:S181-4. 2008
    ..In vitro and in human studies support this hypothesis. The supplementation of antioxidants, particularly in the form of fresh fruit and vegetables, reduces blood pressure, supporting a role for free radicals in hypertension...
  8. ncbi request reprint Simultaneous control of hyperglycemia and oxidative stress normalizes endothelial function in type 1 diabetes
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 30:649-54. 2007
    ..Moreover, oxidative stress has recently been demonstrated to be the mediator of hyperglycemia-induced endothelial dysfunction...
  9. ncbi request reprint Telmisartan shows an equivalent effect of vitamin C in further improving endothelial dysfunction after glycemia normalization in type 1 diabetes
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, UK
    Diabetes Care 30:1694-8. 2007
    ..Long-lasting hyperglycemia in type 1 diabetic patients induces permanent alterations of endothelial function by increased oxidative stress, even when glycemia is normalized...
  10. ncbi request reprint Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes
    Antonio Ceriello
    Warwick Medical School, Clinical Science Research Institute, University Hospital Walsgrave Campus, University of Warwick, Clifford Bridge Road, Coventry CV2 2DX, UK
    Curr Opin Lipidol 17:510-8. 2006
    ..In diabetes, oxidative stress plays a key role in the pathogenesis of vascular complications; therefore an antioxidant therapy would be of great interest in this disease...
  11. doi request reprint Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings
    Antonio Ceriello
    Warwick Medical School, Clinical Science Research Institute, University Hospital Coventry, CV2 2DX, UK
    Diab Vasc Dis Res 5:260-8. 2008
    ..In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented...
  12. doi request reprint Long-term glycemic control influences the long-lasting effect of hyperglycemia on endothelial function in type 1 diabetes
    Antonio Ceriello
    Warwick Medical School, Clinical Science Research Institute, Clinical Science Building, University Hospital, Walsgrave Campus, Clifford Bridge Road, Coventry, UK
    J Clin Endocrinol Metab 94:2751-6. 2009
    ..The objective of the study was to investigate the effect of different periods of hyperglycemia on the reversal of endothelial dysfunction by glucose normalization and antioxidant therapy...
  13. doi request reprint Lowering glucose to prevent adverse cardiovascular outcomes in a critical care setting
    Antonio Ceriello
    Centre of Excellence in Diabetes and Endocrinology, University Hospital of Coventry and Warwickshire, Warwick Medical School, University of Warwick, Coventry, United Kingdom
    J Am Coll Cardiol 53:S9-13. 2009
    ..The use of intensive insulin treatment has shown superior benefits in the treatment of hyperglycemia versus glucose-insulin-potassium infusion, particularly in critical care settings...
  14. doi request reprint Clinical review 2: The "metabolic memory": is more than just tight glucose control necessary to prevent diabetic complications?
    Antonio Ceriello
    Warwick Medical School, University of Warwick, Coventry CV2 2DX, United Kingdom
    J Clin Endocrinol Metab 94:410-5. 2009
    ..The concept of a "metabolic memory," that is of diabetic vascular stresses persisting after glucose normalization, has been supported both in the laboratory and in the clinic and in both type 1 and type 2 diabetes...
  15. ncbi request reprint Effects of macronutrient excess and composition on oxidative stress: relevance to diabetes and cardiovascular disease
    Antonio Ceriello
    Warwick Medical School, Clinical Science Research Institute, Clinical Science Building, University Hospital Walsgrave Campus, Clifford Bridge Road, Coventry CV2 2DX, United Kingdom
    Curr Atheroscler Rep 8:472-6. 2006
    ..All of these have intracellular antioxidant effects. Evidence on the efficacy of antioxidant interventions is accumulating, and oxidative stress may be a therapeutic target to prevent diabetes as well as cardiovascular complications...
  16. doi request reprint Administration of a new diabetes-specific enteral formula results in an improved 24h glucose profile in type 2 diabetic patients
    Antonio Ceriello
    Warwick Medical School, University of Warwick, UK
    Diabetes Res Clin Pract 84:259-66. 2009
    ..Study the effect of several boluses of a new diabetes-specific formula (DSF) during the day on 24h glucose profile...
  17. ncbi request reprint Pramlintide reduced markers of oxidative stress in the postprandial period in patients with type 2 diabetes
    Antonio Ceriello
    Warwick Medical School, Coventry, UK
    Diabetes Metab Res Rev 24:103-8. 2008
    ..The objective of this study was to examine the effects of pramlintide on plasma concentrations of glucose and several markers of oxidative stress in patients with type 2 diabetes following a standardized meal...
  18. ncbi request reprint Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial
    Saverio Stranges
    State University of New York at Buffalo and Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA
    Ann Intern Med 147:217-23. 2007
    ..Findings from animal models suggest that selenium supplementation improves glucose metabolism...
  19. pmc Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin
    Naila Rabbani
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
    Diabetes 59:1038-45. 2010
    ..The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy...
  20. doi request reprint Guideline for management of postmeal glucose
    Antonio Ceriello
    Warwick Medical School, Clinical Science Research Institute, Clinical Science Building, University Hospital Walsgrave Campus, Clifford Bridge Road, Coventry CV2 2DX, UK
    Nutr Metab Cardiovasc Dis 18:S17-33. 2008
    ..This guideline reviews the evidence on the harmful effects of elevated postmeal glucose and makes recommendations on its treatment, assessment and targets...
  21. ncbi request reprint PROactive Study: (r)evolution in the therapy of diabetes?
    Antonio Ceriello
    Warwick Medical School, University of Warwick, Gibbett Hill, Coventry CV4 7AL, UK
    Diabet Med 22:1463-4. 2005
  22. doi request reprint Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells
    B Schisano
    Clinical Science Research Institute CSRI, Warwick Medical School, University of Warwick, University Hospital Walsgrave Campus, Coventry, CV2 2DX, UK
    Diabetologia 54:1219-26. 2011
    ....
  23. doi request reprint Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type 2 diabetes
    M V Chittari
    Diabetes Cardiology, University of Warwick, Coventry, UK
    Diabet Med 28:450-4. 2011
    ..Furthermore, an association between postprandial hyperglycaemia, retinopathy and cardiovascular disease has been observed...
  24. ncbi request reprint Advanced glycation end products and antioxidant status in type 2 diabetic patients with and without peripheral artery disease
    Annunziata Lapolla
    Department of Medical and Surgical Sciences, University of Padova, Via dei Colli 4, 35143 Padova, Italy
    Diabetes Care 30:670-6. 2007
    ..We investigated the relationship of AGEs, MDA, total reactive antioxidant potentials (TRAPs), and vitamin E in type 2 diabetic patients with and without peripheral artery disease (PAD)...
  25. ncbi request reprint Identifying patients with type 2 diabetes at high risk of microalbuminuria: results of the DEMAND (Developing Education on Microalbuminuria for Awareness of reNal and cardiovascular risk in Diabetes) Study
    Maria C E Rossi
    Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Via Nazionale, 66030 S Maria Imbaro CH, Italy
    Nephrol Dial Transplant 23:1278-84. 2008
    ..We evaluated to what extent the presence of risk factors and their interactions increased the likelihood of microalbuminuria (MAU) among individuals with type 2 diabetes...
  26. ncbi request reprint Oxidative stress in diabetes
    Ludovica Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Clin Chem Lab Med 41:1144-9. 2003
    ..Knowledge of the mechanisms of ROS damage of is the first step for development of new therapeutic molecules and for rationalizing the use of existing drugs...
  27. ncbi request reprint Addition of neutral protamine lispro insulin or insulin glargine to oral type 2 diabetes regimens for patients with suboptimal glycemic control: a randomized trial
    Katherine Esposito
    Second University of Naples and Azienda Sanitaria Locale Napoli 5, Naples, Italy
    Ann Intern Med 149:531-9. 2008
    ..Neutral protamine lispro (NPL) insulin has demonstrated better glycemic control and similar incidence of hypoglycemic events than that of neutral protamine Hagedorn insulin...
  28. doi request reprint Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism
    Prakash Deedwania
    Anesthesiology 109:14-24. 2008
    ..Although firm guidelines will need to await completion of these clinical trials, the present statement also provides consensus recommendations for hyperglycemia management in patients with ACS on the basis of the available data...
  29. ncbi request reprint High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects
    Scott Dickinson
    Boden Institute of Obesity, Nutrition and Exercise, University of Sydney, NSW, Australia
    Am J Clin Nutr 87:1188-93. 2008
    ..Postprandial glycemia within the normal range may promote oxidative stress and inflammatory processes underlying the development of disease...
  30. doi request reprint Post-meal glucose peaks at home associate with carotid intima-media thickness in type 2 diabetes
    Katherine Esposito
    Chair and Division of Metabolic Diseases, Second University of Naples, Piazza L Miraglia, 80138 Napoli, Italy
    J Clin Endocrinol Metab 93:1345-50. 2008
    ..Two-hour postprandial hyperglycemia is related to chronic complications of diabetes and is currently used in the international guidelines to drive the therapy...
  31. doi request reprint The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose
    Ludovica Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    J Diabetes Complications 22:38-45. 2008
    ..The action of rosuvastatin on antioxidant pathways is related to the inhibition of the overexpression of components of NAD(P)H oxidase induced by the two conditions of high glucose...
  32. ncbi request reprint Glucose metabolism and hyperglycemia
    Dario Giugliano
    Department of Geriatrics and Metabolic Diseases, University of Naples SUN, Italy
    Am J Clin Nutr 87:217S-222S. 2008
    ..The goal of therapy should be to achieve glycemic status as near to normal as safely possible in all 3 components of glycemic control: HbA1c, fasting glucose, and postmeal glucose peak...
  33. ncbi request reprint Mealtime 50/50 basal + prandial insulin analogue mixture with a basal insulin analogue, both plus metformin, in the achievement of target HbA1c and pre- and postprandial blood glucose levels in patients with type 2 diabetes: a multinational, 24-week, rand
    David C Robbins
    Diabetes and Endocrine Platform Team, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Clin Ther 29:2349-64. 2007
    ..Using lispro mix (LM) 50/50 before meals may be a logical approach to achieving glycemic targets (glycosylated hemoglobin [HbA(lc)] and pre- and postprandial blood glucose [BG] concentrations) in these patients...
  34. ncbi request reprint Evaluation of gliclazide ability to attenuate the hyperglycaemic 'memory' induced by high glucose in isolated human endothelial cells
    Maddalena Corgnali
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Diabetes Metab Res Rev 24:301-9. 2008
    ....
  35. ncbi request reprint The effect of glucose variability on the risk of microvascular complications in type 1 diabetes
    Louis Monnier
    Diabetes Care 30:185-6; author reply 187-8. 2007
  36. ncbi request reprint Premeal insulin lispro plus bedtime NPH or twice-daily NPH in patients with type 2 diabetes: acute postprandial and chronic effects on glycemic control and cardiovascular risk factors
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    J Diabetes Complications 21:20-7. 2007
    ..Two insulin regimens were used to explore acute and chronic postprandial changes in glycemia, lipemia, and metabolic markers associated with increased risk of cardiovascular disease...
  37. ncbi request reprint Effect of atorvastatin and irbesartan, alone and in combination, on postprandial endothelial dysfunction, oxidative stress, and inflammation in type 2 diabetic patients
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, Chair of Internal Medicine, University of Udine, Udine, Italy
    Circulation 111:2518-24. 2005
    ..Statins and angiotensin type 1 receptor blockers have been shown to reduce oxidative stress and inflammation, improving endothelial function...
  38. ncbi request reprint Effects of pramlintide on postprandial glucose excursions and measures of oxidative stress in patients with type 1 diabetes
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Italy
    Diabetes Care 28:632-7. 2005
    ..The aim of this post hoc analysis was to assess the effects of pramlintide, an amylin analog shown to reduce postprandial glucose excursions in patients with diabetes, on markers of oxidative stress in the postprandial period...
  39. ncbi request reprint Comparison of effect of pioglitazone with metformin or sulfonylurea (monotherapy and combination therapy) on postload glycemia and composite insulin sensitivity index during an oral glucose tolerance test in patients with type 2 diabetes
    Antonio Ceriello
    Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Diabetes Care 28:266-72. 2005
    ..We compared the effects of these three drugs, used as monotherapy and in combination, on postload glycemia and composite insulin sensitivity index (CISI) in these patients...
  40. ncbi request reprint [Mechanism of action of ACE-inhibitors and angiotensin receptor antagonists in diabetic nephropathy. Recent insights]
    Lucia Martinelli
    Cattedra di Medicina Interna, Universita, Udine
    Recenti Prog Med 94:131-5. 2003
    ..The analysis of physiopathogenic mechanisms underlying diabetic nephropathy brings evidence that ACE-inhibitors and angiotensin II antagonists have a protective effect not limited to the blood pressure-lowering effect...
  41. ncbi request reprint Acute hyperglycaemia: a 'new' risk factor during myocardial infarction
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, P le S Maria della Misericordia, 33100 Udine, Italy
    Eur Heart J 26:328-31. 2005
    ..The possible usefulness of intensive insulin treatment is also discussed...
  42. ncbi request reprint Postprandial hyperglycemia and diabetes complications: is it time to treat?
    Antonio Ceriello
    Internal Medicine, University of Udine, P le S Maria della Misericordia, 33100 Udine, Italy
    Diabetes 54:1-7. 2005
    ..Correcting the postprandial hyperglycemia may form part of the strategy for the prevention and management of CVDs in diabetes...
  43. ncbi request reprint New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Italy
    Diabetes Care 26:1589-96. 2003
    ....
  44. ncbi request reprint Postprandial glucose regulation and diabetic complications
    Antonio Ceriello
    Department of Pathology and Medicine Experimental and Clinical, University of Udine, Udine, Italy
    Arch Intern Med 164:2090-5. 2004
    ..The present review examines the hypothesis that controlling postprandial glucose level is an important strategy in the prevention of cardiovascular complications associated with diabetes...
  45. ncbi request reprint Antioxidant therapy in diabetic complications: what is new?
    Roberto Da Ros
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine P le S Maria della Misericordia 33100 Udine, Italy
    Curr Vasc Pharmacol 2:335-41. 2004
    ..This preventive activity against oxidative stress generation can justify a large utilization and association of this compound for preventing complications in diabetic patients, where antioxidant defences have been shown to be defective...
  46. ncbi request reprint Impaired glucose tolerance and cardiovascular disease: the possible role of post-prandial hyperglycemia
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    Am Heart J 147:803-7. 2004
    ..Future studies may evaluate whether correcting the post-prandial hyperglycemia in the impaired glucose tolerance state can form part of the strategy for the prevention and management of cardiovascular diseases in these subjects...
  47. ncbi request reprint Molecular targets of diabetic vascular complications and potential new drugs
    Roberto Da Ros
    Department of Pathology and Medicine, Experimental and Clinical, Chair of Internal Medicine, University of Udine, Italy
    Curr Drug Targets 6:503-9. 2005
    ..This preventive activity against oxidative stress generation can justify a large utilization and association of this compounds for preventing complications in diabetic patients where antioxidant defences have been shown to be defective...
  48. ncbi request reprint Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: a systematic review and meta-analysis
    Marinos Elia
    Institute of Human Nutrition, University of Southampton, Southampton General Hospital, MP 113 F Level, Tremona Road, Southampton, SO16 6YD, UK
    Diabetes Care 28:2267-79. 2005
    ..The aim of this systematic review was to determine the benefits of nutritional support in patients with type 1 or type 2 diabetes...
  49. ncbi request reprint [Postprandial hyperglycemia and diabetic complications]
    Roberto Da Ros
    Cattedra di Medicina Interna, Universita di Udine
    Recenti Prog Med 96:436-44. 2005
    ..Correction of the postprandial hyperglycemia can be part of the strategy for the prevention and management of cardiovascular diseases in diabetes...
  50. ncbi request reprint Angiotensin-receptor blockers, type 2 diabetes, and renoprotection
    Antonio Ceriello
    N Engl J Med 346:705-7. 2002
  51. ncbi request reprint Effect of rosiglitazone on endothelial function and inflammatory markers in patients with the metabolic syndrome
    Katherine Esposito
    Division of Metabolic Diseases, University of Naples SUN, Naples, Italy
    Diabetes Care 29:1071-6. 2006
    ..The aim of this study was to assess the effect of rosiglitazone on endothelial function and inflammatory markers in patients with the metabolic syndrome...
  52. ncbi request reprint Effects of gliclazide beyond metabolic control
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, 33100 Udine, Italy
    Metabolism 55:S10-5. 2006
    ....
  53. ncbi request reprint Oxidative stress and diabetes-associated complications
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical and Chair of Internal Medicine, University of Udine, Italy
    Endocr Pract 12:60-2. 2006
    ..To review the role of oxidative stress in the development of complications of diabetes...
  54. ncbi request reprint Postprandial glucose regulation: new data and new implications
    Lawrence A Leiter
    St Michael s Hospital, University of Toronto, Toronto, Canada
    Clin Ther 27:S42-56. 2005
    ..However, physicians continue to rely on fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) to guide management...
  55. ncbi request reprint Role of hyperglycemia in nitrotyrosine postprandial generation
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    Diabetes Care 25:1439-43. 2002
    ..The aim of the present study was to evaluate whether postprandial hyperglycemia is accompanied by nitrotyrosine generation and, if so, to explore a possible direct role of hyperglycemia in such a phenomenon...
  56. ncbi request reprint The ubiquitin-proteasome system and inflammatory activity in diabetic atherosclerotic plaques: effects of rosiglitazone treatment
    Raffaele Marfella
    Department of Geriatrics and Metabolic Diseases, Second University Naples, Italy
    Diabetes 55:622-32. 2006
    ....
  57. ncbi request reprint Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation: effects of short- and long-term simvastatin treatment
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, Chair of Internal Medicine, University of Udine, Udine, Italy
    Circulation 106:1211-8. 2002
    ..Evidence suggests that postprandial hypertriglyceridemia and hyperglycemia induce endothelial dysfunction through oxidative stress; however, the distinct role of these two factors is a matter of debate...
  58. ncbi request reprint Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress
    Katherine Esposito
    Department of Geriatric and Metabolic Diseases, Second University of Naples, Italy
    Circulation 106:2067-72. 2002
    ..We assessed the role of glucose in the regulation of circulating levels of IL-6, TNF-alpha, and interleukin-18 (IL-18) in subjects with normal or impaired glucose tolerance (IGT), as well as the effect of the antioxidant glutathione...
  59. ncbi request reprint Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Italy
    Arterioscler Thromb Vasc Biol 24:816-23. 2004
    ....
  60. ncbi request reprint Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation
    Lisa Quagliaro
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Diabetes 52:2795-804. 2003
    ..Our data suggest that glucose fluctuations may also be involved in the development of vascular injury in diabetes...
  61. ncbi request reprint Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat
    Antonio Ceriello
    Department of Pathology and Medicine, Experimental and Clinical, University of Udine, Udine, Italy
    Diabetes 51:1076-82. 2002
    ....
  62. doi request reprint Exploring the gap between National Cholesterol Education Program guidelines and clinical practice in secondary care: results of a cross-sectional study involving over 10 000 patients followed in different specialty settings across Italy
    Claudio Rapezzi
    Institute of Cardiology, University of Bologna and Ospedale S Orsola Malpighi, Bologna, Italy
    J Cardiovasc Med (Hagerstown) 9:878-87. 2008
    ..To evaluate implementation of low-density lipoprotein cholesterol (LDL-C) control recommendations in secondary care and explore key points in the decisional workup...
  63. ncbi request reprint Insulin, glycemic control, and C-reactive protein during myocardial infarction
    Antonio Ceriello
    Diabetes Care 27:3017-8. 2004
  64. doi request reprint Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism
    Prakash Deedwania
    Circulation 117:1610-9. 2008
    ..Although firm guidelines will need to await completion of these clinical trials, the present statement also provides consensus recommendations for hyperglycemia management in patients with ACS on the basis of the available data...
  65. ncbi request reprint Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: the distinct role of protein kinase C and mitochondrial superoxide production
    Lisa Quagliaro
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Atherosclerosis 183:259-67. 2005
    ....
  66. ncbi request reprint Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction
    Ludovica Piconi
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Diabetes Metab Res Rev 22:198-203. 2006
    ..But the possible involvement of this pathway in the hyperglycemia-induced apoptosis of endothelial cells has not yet been reported...
  67. ncbi request reprint Pathogenetic loop between diabetes and cell senescence
    Roberto Testa
    Diabetes Care 30:2974-5. 2007
  68. ncbi request reprint Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC
    Lisa Quagliaro
    Morpurgo Hofman Research Laboratory on Aging, Udine, Italy
    Nutr Metab Cardiovasc Dis 17:257-67. 2007
    ..The aim of the study was to elucidate the chain of events leading to oxidative damage in endothelial cells exposed to high glucose...
  69. ncbi request reprint The effects of diet on inflammation: emphasis on the metabolic syndrome
    Dario Giugliano
    Division of Metabolic Diseases, Center of Excellence for Cardiovascular Diseases, University of Naples SUN, Italy
    J Am Coll Cardiol 48:677-85. 2006
    ..Western dietary patterns warm up inflammation, while prudent dietary patterns cool it down...
  70. doi request reprint Mediterranean diet inversely associated with the incidence of metabolic syndrome: the SUN Prospective Cohort: response to Tortosa et al
    Dario Giugliano
    Diabetes Care 31:e36; author reply e37. 2008