John C Cawley

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Hairy cell leukemia and the microenvironment
    John C Cawley
    Division of Haematology, University of Liverpool, Liverpool, UK
    Leuk Lymphoma 52:91-3. 2011
  2. ncbi request reprint Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways
    Aura S Kamiguti
    Department of Haematology, Royal Liverpool University Hospital, University of Liverpool, UK
    Oncogene 22:2272-84. 2003
  3. doi request reprint The biology of hairy-cell leukaemia
    John C Cawley
    Division of Haematology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Curr Opin Hematol 17:341-9. 2010
  4. pmc Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition
    Jianguo Zhuang
    Division of Hematology, School of Cancer Studies, University of Liverpool, 3 Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Haematologica 95:110-8. 2010
  5. doi request reprint Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine
    Kathleen J Till
    Division of Hematology, School of Cancer Studies, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    Cancer Res 68:8429-36. 2008
  6. ncbi request reprint c-Abl expression in chronic lymphocytic leukemia cells: clinical and therapeutic implications
    Ke Lin
    Department of Haematology, University of Liverpool, Daulby Street, Liverpool L69 3GA, United Kingdom
    Cancer Res 66:7801-9. 2006
  7. ncbi request reprint CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium
    Kathleen J Till
    Department of Haematology, University of Liverpool, United Kingdom
    Blood 105:4813-9. 2005
  8. ncbi request reprint Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion
    Peter K Baker
    Department of Haematology, University of Liverpool, United Kingdom
    Blood 100:647-53. 2002
  9. ncbi request reprint The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes
    Kathleen J Till
    Department of Haematology, University of Liverpool, Liverpool, United Kingdom
    Blood 99:2977-84. 2002
  10. ncbi request reprint The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL)
    Khalil A Aziz
    Department of Haematology, University of Liverpool, Liverpool, United Kingdom
    Blood 102:1051-6. 2003

Collaborators

Detail Information

Publications13

  1. doi request reprint Hairy cell leukemia and the microenvironment
    John C Cawley
    Division of Haematology, University of Liverpool, Liverpool, UK
    Leuk Lymphoma 52:91-3. 2011
    ..Two-way interactions between HCs and the microenvironment are especially prominent in HCL. Many of these interactions are now reasonably well understood and are summarised in this article...
  2. ncbi request reprint Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways
    Aura S Kamiguti
    Department of Haematology, Royal Liverpool University Hospital, University of Liverpool, UK
    Oncogene 22:2272-84. 2003
    ..These findings are relevant for the understanding of the prolonged cell survival of HCs and their selective sensitivity to some chemotherapeutic agents...
  3. doi request reprint The biology of hairy-cell leukaemia
    John C Cawley
    Division of Haematology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Curr Opin Hematol 17:341-9. 2010
    ..The biology of hairy-cell leukaemia is reviewed, focussing first on the hairy cell itself and then on its interactions with the microenvironment...
  4. pmc Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition
    Jianguo Zhuang
    Division of Hematology, School of Cancer Studies, University of Liverpool, 3 Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Haematologica 95:110-8. 2010
    ..The aims of the present study were to ascertain the activation status of Akt in the primary cells of chronic lymphocytic leukemia and to investigate the effects of specific Akt inhibition on chronic lymphocytic leukemia-cell survival...
  5. doi request reprint Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine
    Kathleen J Till
    Division of Hematology, School of Cancer Studies, School of Biological Sciences, University of Liverpool, Liverpool, United Kingdom
    Cancer Res 68:8429-36. 2008
    ..The present study not only clarifies the nature of the alphaLbeta2 defect of CLL cells but is the first to implicate activation of Rap1 in the pathophysiology of CLL...
  6. ncbi request reprint c-Abl expression in chronic lymphocytic leukemia cells: clinical and therapeutic implications
    Ke Lin
    Department of Haematology, University of Liverpool, Daulby Street, Liverpool L69 3GA, United Kingdom
    Cancer Res 66:7801-9. 2006
    ..We conclude that overexpression of c-Abl is likely to play a pathogenetic role in CLL and that STI-571 may be of potential use in the treatment of this disease...
  7. ncbi request reprint CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium
    Kathleen J Till
    Department of Haematology, University of Liverpool, United Kingdom
    Blood 105:4813-9. 2005
    ..Given the importance of cell motility for tissue invasion, the present results provide a rationale for a trial of VEGF and alpha(4) blockade in patients with CLL who have tissue disease...
  8. ncbi request reprint Response of hairy cells to IFN-alpha involves induction of apoptosis through autocrine TNF-alpha and protection by adhesion
    Peter K Baker
    Department of Haematology, University of Liverpool, United Kingdom
    Blood 100:647-53. 2002
    ....
  9. ncbi request reprint The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes
    Kathleen J Till
    Department of Haematology, University of Liverpool, Liverpool, United Kingdom
    Blood 99:2977-84. 2002
    ..The present studies are the first to shed light on the factors determining CLL cell entry into nodes and define the phenotype of circulating malignant cells likely to determine the pattern of lymph node enlargement in the disease...
  10. ncbi request reprint The role of autocrine FGF-2 in the distinctive bone marrow fibrosis of hairy-cell leukemia (HCL)
    Khalil A Aziz
    Department of Haematology, University of Liverpool, Liverpool, United Kingdom
    Blood 102:1051-6. 2003
    ....
  11. ncbi request reprint Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia
    Aura S Kamiguti
    Department of Hematology, Royal Liverpool Hospital, University of Liverpool, Liverpool, United Kingdom
    J Immunol 175:8424-30. 2005
    ..This allows the inactivation of SHP-1 by NOX5-generated ROS and contributes to the maintenance of the constitutive activation of HCs...
  12. ncbi request reprint Cytoprotective antioxidant activity of serum albumin and autocrine catalase in chronic lymphocytic leukaemia
    Elizabeth C Moran
    Department of Haematology, Royal Liverpool University Hospital, Liverpool, UK
    Br J Haematol 116:316-28. 2002
    ....
  13. ncbi request reprint The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia
    Aura S Kamiguti
    Department of Haematology, Royal Liverpool Hospital, University of Liverpool, Duncan Building 3rd Floor, Daulby Street, Liverpool L69 3GA, UK
    Br J Haematol 125:128-40. 2004
    ..Our data raise the possibility that MMP-9 modulation may have therapeutic potential in advanced CLL...