Research Topics
| Thomas Cavalier-SmithSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Ultrastructure of Allapsa vibrans and the body plan of Glissomonadida (Cercozoa)Thomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Protist 163:165-87. 2012..We discuss glissomonad radiation into families Sandonidae, Proleptomonadidae, Dujardinidae, Bodomorphidae and Allapsidae, establishing Aurigamonadidae fam. n. for the amoeboflagellate pansomonad Aurigamonas...
The zooflagellates Stephanopogon and Percolomonas are a clade (class Percolatea: Phylum Percolozoa)Thomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, United Kingdom
J Eukaryot Microbiol 55:501-9. 2008..We discuss evolution of the percolozoan cytoskeleton and different body forms...
Economy, speed and size matter: evolutionary forces driving nuclear genome miniaturization and expansionThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Ann Bot 95:147-75. 2005....
Origin of the cell nucleus, mitosis and sex: roles of intracellular coevolutionThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX13PS, UK
Biol Direct 5:7. 2010..Discussions on the origin of sex typically overlook its association with protozoan entry into dormant walled cysts and the likely simultaneous coevolutionary, not sequential, origin of mitosis and meiosis...
Phylogeny and megasystematics of phagotrophic heterokonts (kingdom Chromista)Thomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
J Mol Evol 62:388-420. 2006..Two GenBank 'opalinid' sequences are fungal; Pseudopirsonia is cercozoan; two previous GenBank 'Caecitellus' sequences are Adriamonas...
Introduction: How and when did microbes change the world?Thomas Cavalier-Smith
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
Philos Trans R Soc Lond B Biol Sci 361:845-50. 2006
The tiny enslaved genome of a rhizarian algaThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
Proc Natl Acad Sci U S A 103:9379-80. 2006
Origin of mitochondria by intracellular enslavement of a photosynthetic purple bacteriumThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Proc Biol Sci 273:1943-52. 2006..Massive gene transfer to the nucleus inevitably occurred by mutation pressure. Finally, pressure from harmful, non-selected gene transfer to the nucleus probably caused evolution of the presequence mechanism, and photosynthesis was lost...
Kingdoms Protozoa and Chromista and the eozoan root of the eukaryotic treeThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Biol Lett 6:342-5. 2010..Clarifying early eukaryote evolution requires intensive study of properties distinguishing Euglenozoa from neokaryotes and Eozoa from neozoa (eukaryotes except Eozoa; ancestrally defined by haem lyase)...
Deep phylogeny, ancestral groups and the four ages of lifeThomas Cavalier-Smith
Department of Zoology, University of Oxford, Oxford, UK
Philos Trans R Soc Lond B Biol Sci 365:111-32. 2010..Accidents and organizational constraints are as important as adaptiveness in body plan evolution...
Molecular phylogeny, scale evolution and taxonomy of centrohelid heliozoaThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Mol Phylogenet Evol 44:1186-203. 2007..Most clades are exclusively freshwater or exclusively marine; evolutionary transitions between these habitats have been rare...
Megaphylogeny, cell body plans, adaptive zones: causes and timing of eukaryote basal radiationsThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
J Eukaryot Microbiol 56:26-33. 2009..New subphyla are established for Choanozoa and Loukozoa; Amoebozoa are divided into three revised subphyla, with Variosea transferred into Conosa...
Helkesimastix marina n. sp. (Cercozoa: Sainouroidea superfam. n.) a gliding zooflagellate of novel ultrastructure and unusual ciliary behaviourThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 160:452-79. 2009..Bacteria are digested posteriorly in association with numerous mitochondria with flat cristae...
Planomonadida ord. nov. (Apusozoa): ultrastructural affinity with Micronuclearia podoventralis and deep divergences within Planomonas gen. novThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 159:535-62. 2008..micra, Micronuclearia, Amastigmonas marina. All were analysed phylogenetically; the Planomonas clade is ancient, diverse and robust: it sometimes groups weakly as sister to Micronuclearia...
Predation and eukaryote cell origins: a coevolutionary perspectiveT Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Int J Biochem Cell Biol 41:307-22. 2009....
Cell evolution and Earth history: stasis and revolutionThomas Cavalier-Smith
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
Philos Trans R Soc Lond B Biol Sci 361:969-1006. 2006..They yielded organisms that are a mosaic of extremely conservative and radically novel features, as characterized by De Beer's phrase 'mosaic evolution'. Evolution is not evenly paced and there are no real molecular clocks...
Only six kingdoms of lifeThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Proc Biol Sci 271:1251-62. 2004..However, immense lower-level diversity remains to be mapped, as does the root of the tree of life...
Phylogeny and evolution of apusomonadida (protozoa: apusozoa): new genera and speciesThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 161:549-76. 2010..oxoniensis, Multimonas, and Podomonas all branch deeply but unstably. Apusomonadida and Planomonas are weakly sister to opisthokonts...
Phylogeny of choanozoa, apusozoa, and other protozoa and early eukaryote megaevolutionThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, United Kingdom
J Mol Evol 56:540-63. 2003....
Molecular phylogeny of centrohelid heliozoa, a novel lineage of bikont eukaryotes that arose by ciliary lossThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
J Mol Evol 56:387-96. 2003..The centroplast that nucleates their axonemal microtubules is therefore almost certainly homologous with the centrosome of ciliated eukaryotes and should simply be called a centrosome...
Genomic reduction and evolution of novel genetic membranes and protein-targeting machinery in eukaryote-eukaryote chimaeras (meta-algae)T Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Philos Trans R Soc Lond B Biol Sci 358:109-33; discussion 133-4. 2003....
The neomuran origin of archaebacteria, the negibacterial root of the universal tree and bacterial megaclassificationT Cavalier-Smith
Department of Zoology, University of Oxford, UK
Int J Syst Evol Microbiol 52:7-76. 2002..The negibacterial outer membrane was lost once only in the history of life, when Posibacteria arose about 2800 My ago after their ancestors diverged from Cyanobacteria...
Phylogeny and classification of phylum Cercozoa (Protozoa)Thomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 154:341-58. 2003..g. Massisteria, Gymnophrys, a Dimorpha-like protozoan). Cercozoa, now with nine classes and 17 orders (four new), will probably include many, possibly most, other filose and reticulose amoebae and zooflagellates not yet assigned to phyla...
Chloroplast evolution: secondary symbiogenesis and multiple lossesT Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, OX1 3PS, Oxford, UK
Curr Biol 12:R62-4. 2002..Chloroplasts originated from cyanobacteria only once, but have been laterally transferred to other lineages by symbiogenetic cell mergers. Such secondary symbiogenesis is rarer and chloroplast losses commoner than often assumed...
Obcells as proto-organisms: membrane heredity, lithophosphorylation, and the origins of the genetic code, the first cells, and photosynthesisT Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, United Kingdom
J Mol Evol 53:555-95. 2001..Signal recognition particles, chaperones, compartmented proteases, and peptidoglycan arose prior to the last common ancestor of life, a complex autotrophic, anaerobic green bacterium...
Membrane heredity and early chloroplast evolutionT Cavalier-Smith
Dept of Zoology, University of Oxford, UK
Trends Plant Sci 5:174-82. 2000..Conservatism and innovation during early plastid diversification are discussed...
Origins of the machinery of recombination and sexT Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Heredity (Edinb) 88:125-41. 2002....
The phagotrophic origin of eukaryotes and phylogenetic classification of ProtozoaT Cavalier-Smith
Department of Zoology, University of Oxford, UK
Int J Syst Evol Microbiol 52:297-354. 2002....
Paracercomonas kinetid ultrastructure, origins of the body plan of Cercomonadida, and cytoskeleton evolution in CercozoaThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Protist 163:47-75. 2012....
Phylogeny and classification of Cercomonadida (Protozoa, Cercozoa): Cercomonas, Eocercomonas, Paracercomonas, and Cavernomonas gen. novDavid Bass
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 160:483-521. 2009..We also describe Agitata tremulans gen. et sp. nov., previously misidentified as Cercobodo (=Dimastigamoeba) agilis Moroff...
Phylum-specific environmental DNA analysis reveals remarkably high global biodiversity of Cercozoa (Protozoa)David Bass
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Int J Syst Evol Microbiol 54:2393-404. 2004..Although Metromonas groups with weak to moderate support with Chlorarachnea, it is here placed in superclass Monadofilosa, to which it is morphologically more similar...
DNA evidence for global dispersal and probable endemicity of protozoaDavid Bass
Department of Zoology, The University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
BMC Evol Biol 7:162. 2007..However, morphology and most previously used evolutionary markers evolve too slowly to test this important hypothesis adequately...
Rooting the eukaryote tree by using a derived gene fusionAlexandra Stechmann
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Science 297:89-91. 2002..The root lies between bikonts and opisthokonts (animals, Fungi, Choanozoa). Amoebozoa either diverged even earlier or are sister of bikonts or (less likely) opisthokonts...
Phylogeny of novel naked Filose and Reticulose Cercozoa: Granofilosea cl. n. and Proteomyxidea revisedDavid Bass
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 160:75-109. 2009..Biomyxidae and Rhizoplasmidae fam. n. remain incertae sedis within Proteomyxidea. Gymnophrydium and Borkovia are revised. The reticulose Corallomyxa are unlike Filoreta and possibly Amoebozoa, not Cercozoa...
Polyubiquitin insertions and the phylogeny of Cercozoa and RhizariaDavid Bass
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 156:149-61. 2005..e. that the second insertion took place earlier, in the ancestral filosan, and was followed by three independent reversions to a single amino acid in Chlorarachnea, Metopion and Cercobodo...
Deep phylogeny and evolution of slime moulds (mycetozoa)Anna Maria Fiore-Donno
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, UK
Protist 161:55-70. 2010..Thus protostelids and Variosea are especially significant for understanding the evolutionary transition from solitary amoebae to macromycetozoa...
Invalidation of Hyperamoeba by transferring its species to other genera of MyxogastriaAnna Maria Fiore-Donno
Zoology Department, University of Oxford, South Parks Road, OX13PS Oxford, United Kingdom
J Eukaryot Microbiol 57:189-96. 2010..We discuss the implications for the ecology and evolution of Myxogastria, whose amoeboflagellates are more widespread than previous inventories supposed, being now found in freshwater and even marine environments...
Ribosomal RNA phylogeny of bodonid and diplonemid flagellates and the evolution of euglenozoaSophie von der Heyden
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
J Eukaryot Microbiol 51:402-16. 2004..Our analysis supports three phagotrophic euglenoid orders: Petalomonadida (holophyletic), Ploeotiida (probably holophyletic), Peranemida (paraphyletic)...
Morphology and phylogeny of Sainouron acronematica sp. n. and the ultrastructural unity of CercozoaThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 159:591-620. 2008..Ciliary transition region proximal hub-lattices (postulated to contain centrin) and distal nonagonal fibres are cercozoan synapomorphies, found with slight structural variation in all flagellate Cercozoa, but not in outgroups...
Myosin domain evolution and the primary divergence of eukaryotesThomas A Richards
Department of Zoology, The Natural History Museum, Cromwell Road, London SW7 5BD, UK
Nature 436:1113-8. 2005..We conclude that the eukaryotic cenancestor (last common ancestor) had a cilium, mitochondria, pseudopodia, and myosins with three contrasting domain combinations and putative functions...
Phylogeny, taxonomy, and astounding genetic diversity of glissomonadida ord. nov., the dominant gliding zooflagellates in soil (Protozoa: Cercozoa)Alexis T Howe
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 160:159-89. 2009....
Semimorula liquescens is a modified echinostelid myxomycete (Mycetozoa)Anna Maria Fiore-Donno
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, United Kingdom
Mycologia 101:773-6. 2009..Semimorula liquescens therefore might be a useful negative model to search for genes inducing stalk formation during sporulation...
Novel cultured protists identify deep-branching environmental DNA clades of cercozoa: New Genera Tremula, Micrometopion, Minimassisteria, Nudifila, PeregriniaAlexis T Howe
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Protist 162:332-72. 2011..Internal hollow silica skeletons evolved twice in Thecofilosea (Ebriida, Phaeodaria) or were multiply lost. Protaspa replaces preoccupied 'Protaspis'...
New genera, species, and improved phylogeny of Glissomonadida (Cercozoa)Alexis T Howe
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3PS, UK
Protist 162:710-22. 2011..We discuss the ecological and evolutionary significance of these new strains...
The novel marine gliding zooflagellate genus Mantamonas (Mantamonadida ord. n.: Apusozoa)Edvard Glücksman
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 162:207-21. 2011..On 28S rRNA and joint 18/28S rRNA phylogenies (including 11 other newly obtained apusozoan/amoebozoan 28S rRNA sequences) it consistently strongly groups with Apusomonadida (Apusozoa)...
Culturing and environmental DNA sequencing uncover hidden kinetoplastid biodiversity and a major marine clade within ancestrally freshwater Neobodo designisSophie von der Heyden
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Int J Syst Evol Microbiol 55:2605-21. 2005..The non-overlap between environmental DNA sequences and those from cultures suggests that there are hundreds, possibly thousands, of different rRNA gene sequences of free-living bodonids globally...
Evolutionary origins of Hsp90 chaperones and a deep paralogy in their bacterial ancestorsAlexandra Stechmann
University of Oxford, Department of Zoology, South Parks Road, Oxford OX1 3PS, United Kingdom
J Eukaryot Microbiol 51:364-73. 2004....
Oxnerella micra sp. n. (Oxnerellidae fam. n.), a tiny naked centrohelid, and the diversity and evolution of heliozoaThomas Cavalier-Smith
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Protist 163:574-601. 2012..ATCC50355; they must be from a centrohelid, probably misidentified as Pinaciophora, the rDNA sequence branching deeply within Pterocystida. We reclassify two Polyplacocystis, Luffisphaera, Phaeodaria and Rotosphaerida...
Phylogenetic analysis of eukaryotes using heat-shock protein Hsp90Alexandra Stechmann
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, United Kingdom
J Mol Evol 57:408-19. 2003..Although single-gene trees will probably never resolve these uncertainties, the congruence of Hsp90 trees with other data is greater than for most other molecules and further taxon sampling of this molecule is recommended...
Phylogeny and evolution of Planomonadida (Sulcozoa): eight new species and new genera Fabomonas and NutomonasEdvard Glücksman
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
Eur J Protistol 49:179-200. 2013..Ancyromonas indica, atlantica, and kenti are genetically more distinct from Ancyromonas sigmoides (=Planomonas mylnikovi). The first soil planomonad (new Nutomonas limna subspecies) was isolated...
Two-gene phylogeny of bright-spored myxomycetes (slime moulds, superorder lucisporidia)Anna Maria Fiore-Donno
Zoology Department, University of Oxford, Oxford, United Kingdom Institute of Botany and Landscape Ecology, University of Greifswald, Greifswald, Germany
PLoS ONE 8:e62586. 2013..Our study fills a gap in the phylogeny of Amoebozoa and provides an extensive SSU rRNA sequence reference database for environmental sampling and barcoding. We report a new group I intron insertion site for Myxomycetes in one Licea...
18S ribosomal RNA gene sequences of Cochliopodium (Himatismenida) and the phylogeny of AmoebozoaAlexander Kudryavtsev
Department of Invertebrate Zoology, Faculty of Biology and Soil Science, Saint Petersburg State University, Saint Petersburg, 199034, Russia
Protist 156:215-24. 2005..cantabrigiensis and another divergent species is sister to Glaeseria, whilst Hartmannella vermiformis branches more deeply...
Multigene phylogeny of choanozoa and the origin of animalsKamran Shalchian-Tabrizi
Microbial Evolution Research Group, Department of Biology, University of Oslo, Oslo, Norway
PLoS ONE 3:e2098. 2008..Thus, several successive evolutionary innovations occurred among their unicellular closest relatives prior to the origin of the multicellular body-plan of animals...
Correct identification of species makes the amoebozoan rRNA tree congruent with morphology for the order Leptomyxida Page 1987; with description of Acramoeba dendroida n. g., n. sp., originally misidentified as 'Gephyramoeba sp.'Alexey V Smirnov
Faculty of Biology and Soil Sciences, Department of Invertebrate Zoology, St Petersburg State University, Universitetskaja nab 7 9, 199034 St Petersburg, Russia
Eur J Protistol 44:35-44. 2008..On morphological grounds we transfer Gephyramoebidae from Varipodida back to Leptomyxida and remove Flamella from Leptomyxida; sequences are needed to confirm these two revisions...
Evolution of dinoflagellate unigenic minicircles and the partially concerted divergence of their putative replicon originsZhaoduo Zhang
Department of Botany, University of British Columbia, 3529-6270 University Blvd, Vancouver, BC, Canada V6T 1Z4
Mol Biol Evol 19:489-500. 2002..The other postulates active transposition of putative replicon origins and formation of minicircles by homologous recombination between them...
Phylogeny, evolution, and taxonomy of vannellid amoebaeAlexey V Smirnov
Faculty of Biology and Soil Sciences, St Petersburg State University, Universitetskaja nab 7 9, 199034 St Petersburg, Russia
Protist 158:295-324. 2007..Species of the revised genus Vannella comprise four closely related, well-supported subclades: one marine and three freshwater. Here, we provide an illustrated checklist for all 40 known Vannellidae species...
The root of the eukaryote tree pinpointedAlexandra Stechmann
Curr Biol 13:R665-6. 2003
Analyses of RNA Polymerase II genes from free-living protists: phylogeny, long branch attraction, and the eukaryotic big bangJoel B Dacks
Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax
Mol Biol Evol 19:830-40. 2002..Additional RPB1 data, especially in combination with other genes, should provide further resolution of branching orders among protist groups within the apparently rapid early divergence of eukaryotes...
Concept of a bacterium still valid in prokaryote debateThomas Cavalier-Smith
Nature 446:257. 2007
Molecular phylogeny of Cercomonadidae and kinetid patterns of Cercomonas and Eocercomonas gen. nov. (Cercomonadida, Cercozoa)Serguei A Karpov
Department of Zoology, Herzen State Pedagogical University of Russia, Moika emb. 48, 191186 St. Petersburg, Russian Federation
Protist 157:125-58. 2006..n.). We establish Paracercomonas ekelundi sp. n. for culture SCCAP C1 and propose a Cercomonas longicauda neotype and Cercomonas (=Neocercomonas) jutlandica comb. n. and Paracercomonas (=Cercomonas) metabolica comb. n...
Global eukaryote phylogeny: Combined small- and large-subunit ribosomal DNA trees support monophyly of Rhizaria, Retaria and ExcavataDavid Moreira
Unité d Ecologie, Systematique et Evolution, UMR CNRS 8079, Universite Paris Sud, Orsay Cedex, France
Mol Phylogenet Evol 44:255-66. 2007..Nonetheless, our results suggest that combined SSU+LSU rDNA phylogenies can help to resolve several ambiguous regions of the eukaryotic tree and identify key taxa for subsequent multi-gene analyses...
