James Wf Catto

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc Competing mortality in patients diagnosed with bladder cancer: evidence of undertreatment in the elderly and female patients
    A P Noon
    The Academic Urology Unit and Institute for Cancer Studies, G Floor, The Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2JF, UK
    Br J Cancer 108:1534-40. 2013
  2. pmc An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer
    S Miah
    Academic Urology Unit, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Br J Cancer 107:123-8. 2012
  3. pmc Integrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells
    Ewa Dudziec
    Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 7:e32750. 2012
  4. pmc Pancreatic debridement in a district general hospital--viable or vulnerable?
    J W F Catto
    Department of Surgery, York District Hospital, UK
    Ann R Coll Surg Engl 84:309-13. 2002
  5. ncbi request reprint Behavior of urothelial carcinoma with respect to anatomical location
    J W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 177:1715-20. 2007
  6. doi request reprint Neurofuzzy modeling to determine recurrence risk following radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
    James W F Catto
    Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK
    Clin Cancer Res 15:3150-5. 2009
  7. doi request reprint The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    Eur Urol 57:398-406. 2010
  8. ncbi request reprint Targeting chemotherapy to advanced bladder cancer patients most likely to benefit
    James Wf Catto
    Academic Urology Unit, K Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Future Oncol 6:193-6. 2010
  9. doi request reprint MicroRNA in prostate, bladder, and kidney cancer: a systematic review
    James W F Catto
    Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Sheffield, UK
    Eur Urol 59:671-81. 2011
  10. ncbi request reprint The changing face of prostate cancer: can gains in epigenetic knowledge translate into improvements in clinical care?
    James W F Catto
    Academic Urology Unit, K Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
    J Mol Med (Berl) 84:883-5. 2006

Detail Information

Publications32

  1. pmc Competing mortality in patients diagnosed with bladder cancer: evidence of undertreatment in the elderly and female patients
    A P Noon
    The Academic Urology Unit and Institute for Cancer Studies, G Floor, The Medical School, University of Sheffield, Beech Hill Road, Sheffield S10 2JF, UK
    Br J Cancer 108:1534-40. 2013
    ..Our aim was to determine the bladder cancer-specific mortality (CSM) rate and other-cause mortality (OCM) rate for patients with newly diagnosed BC...
  2. pmc An evaluation of urinary microRNA reveals a high sensitivity for bladder cancer
    S Miah
    Academic Urology Unit, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX, UK
    Br J Cancer 107:123-8. 2012
    ..We hypothesised that urinary miRs reflecting low- and high-grade pathways could detect bladder cancers and overcome differences in genetic events seen within the disease...
  3. pmc Integrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells
    Ewa Dudziec
    Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 7:e32750. 2012
    ..Hierarchical clustering revealed that this gene panel stratified samples according to the presence and phenotype of bladder cancer...
  4. pmc Pancreatic debridement in a district general hospital--viable or vulnerable?
    J W F Catto
    Department of Surgery, York District Hospital, UK
    Ann R Coll Surg Engl 84:309-13. 2002
    ..This is similar to other previously published rates and the rate from our local tertiary centre. It is concluded that acceptable results for pancreatic debridement are producible in the DGH at economically viable levels...
  5. ncbi request reprint Behavior of urothelial carcinoma with respect to anatomical location
    J W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 177:1715-20. 2007
    ..Observational studies conflict as to the significance of anatomical location on the behavior of urothelial carcinoma. We compared the biological outcome in a large series of urothelial carcinoma with respect to anatomical location...
  6. doi request reprint Neurofuzzy modeling to determine recurrence risk following radical cystectomy for nonmetastatic urothelial carcinoma of the bladder
    James W F Catto
    Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, UK
    Clin Cancer Res 15:3150-5. 2009
    ..We developed a neurofuzzy model (NFM) to predict disease recurrence following RC and PLND in patients who are not usually administered adjuvant chemotherapy...
  7. doi request reprint The application of artificial intelligence to microarray data: identification of a novel gene signature to identify bladder cancer progression
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    Eur Urol 57:398-406. 2010
    ..Gene expression microarrays can reveal insights into disease biology and identify novel biomarkers. However, these experiments produce large datasets that are difficult to interpret...
  8. ncbi request reprint Targeting chemotherapy to advanced bladder cancer patients most likely to benefit
    James Wf Catto
    Academic Urology Unit, K Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    Future Oncol 6:193-6. 2010
    ..006, without compromising recurrence. The authors conclude that a nomogram-derived 25% risk threshold produced better targeting of chemotherapy than the current standard criteria (mostly using pathological stage)...
  9. doi request reprint MicroRNA in prostate, bladder, and kidney cancer: a systematic review
    James W F Catto
    Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Sheffield, UK
    Eur Urol 59:671-81. 2011
    ..Their altered expression and function have been observed in most urologic cancers. MiRNAs represent potential disease biomarkers and novel therapeutic targets...
  10. ncbi request reprint The changing face of prostate cancer: can gains in epigenetic knowledge translate into improvements in clinical care?
    James W F Catto
    Academic Urology Unit, K Floor, Royal Hallamshire Hospital, Glossop Road, S10 2JF, Sheffield, UK
    J Mol Med (Berl) 84:883-5. 2006
  11. ncbi request reprint Multifocal urothelial cancers with the mutator phenotype are of monoclonal origin and require panurothelial treatment for tumor clearance
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 175:2323-30. 2006
    ..Tumors with high MSI have numerous DNA mutations, of which many provide no selection benefit. While these tumors represent an ideal model for studying UC clonality, their low frequency has prevented their previous investigation...
  12. ncbi request reprint Neuro-fuzzy modeling: an accurate and interpretable method for predicting bladder cancer progression
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    J Urol 175:474-9. 2006
    ..By defuzzification the NFM rule base becomes transparent to overcome the black box nature of ANN...
  13. ncbi request reprint Promoter hypermethylation is associated with tumor location, stage, and subsequent progression in transitional cell carcinoma
    James W F Catto
    Academic Urology Unit, K Floor, Royal Hallamshire Hospital, Glossop Rd, Sheffield, S10 2JF United Kingdom
    J Clin Oncol 23:2903-10. 2005
    ..Here we investigate the extent of promoter hypermethylation in TCC throughout the urinary tract...
  14. ncbi request reprint Simultaneous augmentation cystoplasty is associated with earlier rather than increased artificial urinary sphincter infection
    J W F Catto
    Princess Royal Spinal Injuries Unit, Northern General Hospital, Sheffield, United Kingdom
    J Urol 173:1237-41. 2005
    ..We reviewed the long-term infective complications of 195 sphincters to investigate for predisposing infective factors and review the role of augmentation cystoplasty...
  15. ncbi request reprint Distinct patterns of microsatellite instability are seen in tumours of the urinary tract
    James W F Catto
    The Institute for Cancer Studies, University of Sheffield, UK
    Oncogene 22:8699-706. 2003
    ..In addition, we have confirmed that MSI and EMAST are discrete forms of MSI, and that the presence of EMAST does not affect tumour phenotype...
  16. ncbi request reprint Differential expression of hMLH1 and hMSH2 is related to bladder cancer grade, stage and prognosis but not microsatellite instability
    James W F Catto
    Institute for Cancer Studies, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
    Int J Cancer 105:484-90. 2003
    ..Our findings indicate that reduced expression of the MMR proteins may have an important contribution in the development of a subset of TCCs and suggest a potential role for MMR expression as prognostic indicators...
  17. ncbi request reprint Promoter hypermethylation identifies progression risk in bladder cancer
    David R Yates
    Institute of Cancer Studies, Academic Urology Unit, Academic Pathology Unit, and Department of Automatic Control and Systems Engineering, The University of Sheffield, Sheffield, United Kingdom
    Clin Cancer Res 13:2046-53. 2007
    ..Here, we investigate a panel of methylated loci in a prospectively collected cohort of bladder tumors to determine whether hypermethylation has a useful role in the management of patients with bladder cancer...
  18. ncbi request reprint Human prostate cancer cells express neuroendocrine cell markers PGP 9.5 and chromogranin A
    Aaron Leiblich
    Section of Oncology, Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Prostate 67:1761-9. 2007
    ..To identify novel candidates associated with metastatic progression, we compared the proteomic profiles of LNCaP (lymph-node metastatic, androgen-dependant) and PC-3 (bone metastatic, androgen-independent), human prostate cancer cells...
  19. ncbi request reprint Dysregulated expression of S100A11 (calgizzarin) in prostate cancer and precursor lesions
    Ishtiaq Rehman
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, UK
    Hum Pathol 35:1385-91. 2004
    ..Our finding of frequent dysregulated expression of S100A11 in cancer and precursor lesions, together with an association with high histological stage, suggests that S100A11 may be involved in prostate cancer development and progression...
  20. ncbi request reprint Promoter hypermethylation in circulating blood cells identifies prostate cancer progression
    Morgan Roupret
    Institute for Cancer Studies, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
    Int J Cancer 122:952-6. 2008
    ..The extent of this hypermethylation increases during disease progression and can be used to identify the extent and duration of treatment response in prostate cancer...
  21. ncbi request reprint Promoter hyper-methylation of calcium binding proteins S100A6 and S100A2 in human prostate cancer
    Ishtiaq Rehman
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, United Kingdom, and Service d Urologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Prostate 65:322-30. 2005
    ..S100A6 and S100A2 are members of the S100 family of calcium binding proteins, which are down regulated in prostate cancer, however the molecular mechanism(s) underlying their loss of expression is unknown...
  22. ncbi request reprint DNA methylation and immunohistochemical analysis of the S100A4 calcium binding protein in human prostate cancer
    Ishtiaq Rehman
    Academic Urology Unit, Division of Clinical Sciences South, University of Sheffield, Sheffield, UK
    Prostate 67:341-7. 2007
    ..The role of DNA methylation in the transcriptional regulation of S100A4 is unknown in human prostate cancer...
  23. ncbi request reprint Less is more: artificial intelligence and gene-expression arrays
    Freddie C Hamdy
    Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2 JF, UK
    Lancet 364:2003-4. 2004
  24. doi request reprint iTRAQ-facilitated proteomic analysis of human prostate cancer cells identifies proteins associated with progression
    Adam Glen
    Academic Urology Unit, Section of Oncology, University of Sheffield, Floor K, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK
    J Proteome Res 7:897-907. 2008
    ..0005, Mann-Whitney U). Our study is the first to report the application of iTRAQ technology and its potential for the global proteomic profiling of prostate cancer cells, including the identification of absent protein expression...
  25. ncbi request reprint Artificial intelligence in predicting bladder cancer outcome: a comparison of neuro-fuzzy modeling and artificial neural networks
    James W F Catto
    The Academic Urology Unit, Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield S10 2JF, United Kingdom
    Clin Cancer Res 9:4172-7. 2003
    ..We have compared the predictive accuracies of NFM, ANN, and traditional statistical methods, for the behavior of bladder cancer...
  26. doi request reprint A comparison of the performance of microsatellite and methylation urine analysis for predicting the recurrence of urothelial cell carcinoma, and definition of a set of markers by Bayesian network analysis
    Morgan Roupret
    Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, UK
    BJU Int 101:1448-53. 2008
    ....
  27. pmc Distinct microRNA alterations characterize high- and low-grade bladder cancer
    James W F Catto
    Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom
    Cancer Res 69:8472-81. 2009
    ..In conclusion, distinct microRNA alterations characterize UCC and target genes in a pathway-specific manner. These data reveal new insights into the disease biology and have implications regarding tumor diagnosis, prognosis and therapy...
  28. ncbi request reprint Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage
    Morgan Roupret
    Institute for Cancer Studies and Academic Urology Unit, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    Clin Cancer Res 13:1720-5. 2007
    ..Many patients require repeat prostate biopsies to diagnose the disease. We investigated whether aberrant promoter hypermethylation in prostatic fluid could reliably detect prostate cancer...
  29. pmc Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11
    Ross M Drayton
    Authors Affiliations Academic Unit of Molecular Oncology and Academic Urology Unit, University of Sheffield, Sheffield, United Kingdom Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom and Department of Pathology, University of Erlangen, Germany
    Clin Cancer Res 20:1990-2000. 2014
    ..We aimed to identify microRNAs (miRNA) that are dysregulated in cisplatin-resistant disease, ascertain how these contribute to a drug-resistant phenotype, and how this resistance might be overcome...
  30. ncbi request reprint Clinically localised prostate cancer is microsatellite stable
    Abdel Rahmene Azzouzi
    Service d Urologie, CHU d Angers, Centre de Recherche pour les Pathologies Protatiques, Universite Paris VII, Paris, France, and Department of Pathology, Royal Hallamshire Hospital, Sheffield, UK
    BJU Int 99:1031-5. 2007
    ..To determine the frequency of microsatellite instability (MSI) change with mono-, di- and tetranucleotide markers in clinically localized prostate cancer, and to correlate those markers with clinical and pathological variables...
  31. ncbi request reprint Application of artificial intelligence to the management of urological cancer
    Maysam F Abbod
    School of Engineering and Design, Brunel University, West London, United Kingdom
    J Urol 178:1150-6. 2007
    ..We reviewed the basic concepts behind artificial intelligence techniques and explored the applications of this new dynamic technology in various aspects of urological cancer management...
  32. ncbi request reprint More nomograms or better evidence of efficacy: what do we need in urologic oncology?
    James W F Catto
    Eur Urol 54:11-2. 2008