Aedin Cassidy

Summary

Affiliation: University of East Anglia
Country: UK

Publications

  1. ncbi request reprint Diet and menopausal health
    Aedin Cassidy
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich
    Nurs Stand 19:44-52; quiz 54-5. 2005
  2. pmc Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial
    PETER J CURTIS
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK
    Diabetes Care 35:226-32. 2012
  3. pmc Dietary flavonoids and risk of stroke in women
    Aedin Cassidy
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Stroke 43:946-51. 2012
  4. pmc Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: environmental Determinants in Young people)
    Esther M F van Sluijs
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    BMC Public Health 8:388. 2008
  5. ncbi request reprint Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 136:45-51. 2006
  6. ncbi request reprint Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
    Aedin Cassidy
    Centre for Metabolic Bone Disease, Hull Royal Infirmary, UK
    Proc Nutr Soc 65:76-92. 2006
  7. ncbi request reprint Phytoestrogens and cardiovascular disease
    Aedin Cassidy
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    J Br Menopause Soc 12:49-56. 2006
  8. doi request reprint Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in female twins
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 139:353-8. 2009
  9. ncbi request reprint Factors affecting the bioavailability of soy isoflavones in humans
    Aedin Cassidy
    University of East Anglia, School of Medicine, Norwich NR4 7TJ, United Kingdom
    J AOAC Int 89:1182-8. 2006
  10. doi request reprint Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro
    Lawrence N Barrera
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Eur J Nutr 52:1327-41. 2013

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Diet and menopausal health
    Aedin Cassidy
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich
    Nurs Stand 19:44-52; quiz 54-5. 2005
    ..This article outlines the evidence for exercise and dietary influences on many of the major disease risks for women around the menopause and after, including cardiovascular diseases, cancer and osteoporosis...
  2. pmc Chronic ingestion of flavan-3-ols and isoflavones improves insulin sensitivity and lipoprotein status and attenuates estimated 10-year CVD risk in medicated postmenopausal women with type 2 diabetes: a 1-year, double-blind, randomized, controlled trial
    PETER J CURTIS
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK
    Diabetes Care 35:226-32. 2012
    ..To assess the effect of dietary flavonoids on cardiovascular disease (CVD) risk in postmenopausal women with type 2 diabetes on established statin and hypoglycemic therapy...
  3. pmc Dietary flavonoids and risk of stroke in women
    Aedin Cassidy
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Stroke 43:946-51. 2012
    ..To date, few studies have examined associations between the wide range of flavonoid subclasses and risk of ischemic, hemorrhagic, and total stroke...
  4. pmc Physical activity and dietary behaviour in a population-based sample of British 10-year old children: the SPEEDY study (Sport, Physical activity and Eating behaviour: environmental Determinants in Young people)
    Esther M F van Sluijs
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrookes Hospital, Hills Road, Cambridge, CB2 0QQ, UK
    BMC Public Health 8:388. 2008
    ..We present here the analyses of the PA, dietary and anthropometry data...
  5. ncbi request reprint Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 136:45-51. 2006
    ..Only 30% of the subjects were equol producers and no differences in equol production with age or gender were observed...
  6. ncbi request reprint Critical review of health effects of soyabean phyto-oestrogens in post-menopausal women
    Aedin Cassidy
    Centre for Metabolic Bone Disease, Hull Royal Infirmary, UK
    Proc Nutr Soc 65:76-92. 2006
    ..Future studies should focus on high-risk post-menopausal women, especially in the areas of diabetes, CVD, breast cancer and bone health...
  7. ncbi request reprint Phytoestrogens and cardiovascular disease
    Aedin Cassidy
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    J Br Menopause Soc 12:49-56. 2006
    ..Most evidence relates to soy isoflavones, but there is some evidence for lignans. Further robust studies assessing the effects of whole soy foods on cardiovascular outcomes are needed...
  8. doi request reprint Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in female twins
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    J Nutr 139:353-8. 2009
    ..These data reinforce the importance of weight maintenance and increasing consumption of diets rich in plant-based foods to prevent CVD and type 2 diabetes...
  9. ncbi request reprint Factors affecting the bioavailability of soy isoflavones in humans
    Aedin Cassidy
    University of East Anglia, School of Medicine, Norwich NR4 7TJ, United Kingdom
    J AOAC Int 89:1182-8. 2006
    ..Available data suggest isoflavones are more bioavailable than other flavonoid subclasses. This review will focus on our current understanding of factors affecting isoflavone absorption and metabolism in humans...
  10. doi request reprint Colorectal cancer cells Caco-2 and HCT116 resist epigenetic effects of isothiocyanates and selenium in vitro
    Lawrence N Barrera
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Eur J Nutr 52:1327-41. 2013
    ..This study employed a combinatorial chemopreventive strategy to investigate the impact of selenium and/or isothiocyanates on DNA methylation processes in colorectal carcinoma cell lines...
  11. ncbi request reprint Higher anthocyanin intake is associated with lower arterial stiffness and central blood pressure in women
    Amy Jennings
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 96:781-8. 2012
    ..Although a high intake of some flavonoid subclasses may reduce cardiovascular disease mortality, data regarding the in vivo mechanisms of action are limited...
  12. doi request reprint Intakes of anthocyanins and flavones are associated with biomarkers of insulin resistance and inflammation in women
    Amy Jennings
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    J Nutr 144:202-8. 2014
    ..The observed reduction in insulin concentrations was similar to that reported previously for other lifestyle factors. Dose-response trials are needed to ascertain optimal intakes for the potential reduction of type 2 diabetes risk. ..
  13. pmc Habitual intake of flavonoid subclasses and incident hypertension in adults
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 93:338-47. 2011
    ..Dietary flavonoids have beneficial effects on blood pressure in intervention settings, but there is limited information on habitual intake and risk of hypertension in population-based studies...
  14. doi request reprint Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials
    Lee Hooper
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 95:740-51. 2012
    ..There is substantial interest in chocolate and flavan-3-ols for the prevention of cardiovascular disease (CVD)...
  15. pmc Breakfast consumption and daily physical activity in 9-10-year-old British children
    Pauline A J Vissers
    School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Public Health Nutr 16:1281-90. 2013
    ..To examine the association between breakfast consumption and physical activity in a well-characterised sample of English children...
  16. doi request reprint Vascular function and atherosclerosis progression after 1 y of flavonoid intake in statin-treated postmenopausal women with type 2 diabetes: a double-blind randomized controlled trial
    PETER J CURTIS
    Departments of Nutrition and Radiology Department, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom
    Am J Clin Nutr 97:936-42. 2013
    ....
  17. pmc Local food outlets, weight status, and dietary intake: associations in children aged 9-10 years
    Amy Jennings
    School of Medicine and School of Environmental Sciences, University of East Anglia, Norwich, United Kingdom
    Am J Prev Med 40:405-10. 2011
    ..Limited evidence suggests that there may be interactions between environmental factors at a neighborhood level and the development of obesity, with the availability and accessibility of food outlets being potentially important...
  18. pmc Food and drink consumption at school lunchtime: the impact of lunch type and contribution to overall intake in British 9-10-year-old children
    Flo Harrison
    School of Environmental Sciences, University of East Anglia, Norwich NR4 7JT, UK
    Public Health Nutr 16:1132-9. 2013
    ....
  19. doi request reprint Relative impact of flavonoid composition, dose and structure on vascular function: a systematic review of randomised controlled trials of flavonoid-rich food products
    Colin D Kay
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK
    Mol Nutr Food Res 56:1605-16. 2012
    ..The aim of the present study was to examine the relative impact of composition, flavonoid structure and dose...
  20. pmc High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women
    Aedin Cassidy
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Circulation 127:188-96. 2013
    ..Dietary flavonoids exert potential beneficial effects on endothelial function in short-term trials; however, the relationship between habitual intake and risk of MI in women is unknown...
  21. pmc Associations between eating frequency, adiposity, diet, and activity in 9-10 year old healthy-weight and centrally obese children
    Amy Jennings
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Obesity (Silver Spring) 20:1462-8. 2012
    ..Future obesity interventions should consider the mediating role of diet quality and activity in the relationship between EF and adiposity in children...
  22. doi request reprint Dietary fat and fatty acid profile are associated with indices of skeletal muscle mass in women aged 18-79 years
    Ailsa A Welch
    Norwich Medical School, University of East Anglia, Norwich, UK
    J Nutr 144:327-34. 2014
    ..These findings indicate that a dietary fat profile already associated with cardiovascular disease protection may also be beneficial for conservation of skeletal muscle mass. ..
  23. ncbi request reprint Relation of birth weight, body mass index, and change in size from birth to adulthood to insulin resistance in a female twin cohort
    Paula M L Skidmore
    School of Medicine, Health Policy, and Practice, University of East Anglia, Norwich NR4 7JT, United Kingdom
    J Clin Endocrinol Metab 93:516-20. 2008
    ..The approach allows the influence of individual fetal nutrition on adult insulin resistance to be distinguished from effects that are mediated by confounding factors in the maternal environment...
  24. doi request reprint Human metabolism and elimination of the anthocyanin, cyanidin-3-glucoside: a (13)C-tracer study
    Charles Czank
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 97:995-1003. 2013
    ..Evidence suggests that the consumption of anthocyanin-rich foods beneficially affects cardiovascular health; however, the absorption, distribution, metabolism, and elimination (ADME) of anthocyanin-rich foods are relatively unknown...
  25. doi request reprint TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death
    Lawrence N Barrera
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Biochim Biophys Acta 1823:1914-24. 2012
    ....
  26. pmc The impact of rainfall and school break time policies on physical activity in 9-10 year old British children: a repeated measures study
    Flo Harrison
    School of Environmental Sciences, University of East Anglia, Norwich NR4 7JT, UK
    Int J Behav Nutr Phys Act 8:47. 2011
    ..This study aims to examine the association between PA and rainfall in 9-10 year old children, and how it may be modified by school policies...
  27. doi request reprint Cardiovascular disease risk biomarkers and liver and kidney function are not altered in postmenopausal women after ingesting an elderberry extract rich in anthocyanins for 12 weeks
    PETER J CURTIS
    School of Medicine, University of East Anglia, Norwich, Norfolk, UK
    J Nutr 139:2266-71. 2009
    ..02). In conclusion, these data suggest that chronic consumption of 500 mg/d of elderberry extract for 12 wk is apparently safe, but ineffective in altering biomarkers of CVD risk in healthy postmenopausal women...
  28. doi request reprint Habitual flavonoid intakes are positively associated with bone mineral density in women
    Ailsa Welch
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    J Bone Miner Res 27:1872-8. 2012
    ..In conclusion, total flavonoid intake was positively associated with BMD, with effects observed for anthocyanins and flavones at both the hip and spine, supporting a role for flavonoids present in plant-based foods on bone health. ...
  29. doi request reprint Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine
    Susan J Fairweather-Tait
    Norwich Medical School, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 94:1371-5. 2011
    ..The effect of diet on bone mineral density (BMD) remains controversial, mainly because of difficulties in isolating dietary factors from the confounding influences of age, lifestyle, and genetic factors...
  30. pmc Impact of neighbourhood food environment on food consumption in children aged 9-10 years in the UK SPEEDY (Sport, Physical Activity and Eating behaviour: Environmental Determinants in Young people) study
    Paula Skidmore
    School of Medicine, University of East Anglia, Norwich NR4 7JT, UK
    Public Health Nutr 13:1022-30. 2010
    ..Poor diet in childhood increases risk of obesity but the relationship between access to food and children's food choice is underexplored. We determined relationships between distance to and density of food outlets on children's food choice...
  31. ncbi request reprint Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 88:38-50. 2008
    ..The beneficial effects of flavonoid consumption on cardiovascular risk are supported by mechanistic and epidemiologic evidence...
  32. doi request reprint Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention
    Lawrence N Barrera
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
    Proc Nutr Soc 71:237-45. 2012
    ....
  33. doi request reprint The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
    Colin D Kay
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 53:S92-101. 2009
    ..Future efforts to establish the biological activities of anthocyanins should therefore include the investigation of phenolic acid and aldehyde products of degradation, along with their respective metabolites...
  34. pmc Potential role for plasma placental growth factor in predicting coronary heart disease risk in women
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, UK
    Arterioscler Thromb Vasc Biol 29:134-9. 2009
    ..The purpose of this study was to examine placental growth factor's (PlGF) predictive value in relation to coronary heart disease (CHD) risk in healthy women...
  35. pmc Associations between diet, lifestyle factors, and telomere length in women
    Aedin Cassidy
    School of Medicine, University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 91:1273-80. 2010
    ..Leukocyte telomere length is associated with diseases of aging, but there is limited knowledge of diet and lifestyle determinants...
  36. pmc Effects of isoflavones on breast density in pre- and post-menopausal women: a systematic review and meta-analysis of randomized controlled trials
    Lee Hooper
    SRD Senior Lecturer in Research Synthesis and Nutrition, School of Medicine, University of East Anglia, Health Policy and Practice, Norwich NR4 7TJ, Norfolk, UK
    Hum Reprod Update 16:745-60. 2010
    ..The aim of this meta-analysis was to assess the effects of isoflavone-rich foods or supplements on a biomarker of breast cancer risk, women's mammographic density...
  37. pmc Environmental correlates of adiposity in 9-10 year old children: considering home and school neighbourhoods and routes to school
    Flo Harrison
    School of Environmental Sciences, University of East Anglia, Earlham Road, Norwich NR4 7JT, United Kingdom
    Soc Sci Med 72:1411-9. 2011
    ....
  38. pmc School level correlates with adiposity in 9-10 year old children
    Flo Harrison
    School of Environmental Sciences, University of East Anglia, Norwich, UK
    Health Place 17:710-6. 2011
    ..These data suggest that few school factors are associated with FMI, and provide limited pointers to inform potential future school-based interventions to reduce obesity...
  39. doi request reprint Effect of phytochemicals on phase II enzyme expression in infant human primary skin fibroblast cells
    Eliz Warwick
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
    Br J Nutr 108:2158-65. 2012
    ....
  40. ncbi request reprint Dietary patterns and heritability of food choice in a UK female twin cohort
    Birgit Teucher
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Twin Res Hum Genet 10:734-48. 2007
    ..The relatively high heritability of specific dietary components implicates taste perception as a possible target for future genetic studies...
  41. doi request reprint Positive effect of a targeted intervention to improve access and availability of fruit and vegetables in an area of deprivation
    Amy Jennings
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
    Health Place 18:1074-8. 2012
    ..The targeted model of improving access to fruit and vegetables was effective in increasing intake; however future controlled trials are required to objectively examine potential effects on fruit and vegetable intake and health outcomes...
  42. doi request reprint Diet quality is independently associated with weight status in children aged 9-10 years
    Amy Jennings
    Department of Nutrition, School of Medicine, University of East Anglia, Norwich, UK NR4 7TJ
    J Nutr 141:453-9. 2011
    ..These findings suggest that diet quality is independently associated with children's weight status. Future work should consider if diet quality scores could be key components of interventions designed to reduce obesity in children...
  43. ncbi request reprint Intrauterine, environmental, and genetic influences in the relationship between birth weight and lipids in a female twin cohort
    Paula M L Skidmore
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, NR4 7JT, UK
    Arterioscler Thromb Vasc Biol 26:2373-9. 2006
    ..To investigate the association between birth weight and lipid levels in a cohort of UK female twins...
  44. doi request reprint Phenolic metabolites of anthocyanins following a dietary intervention study in post-menopausal women
    Rachel M de Ferrars
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK
    Mol Nutr Food Res 58:490-502. 2014
    ..Numerous studies feeding anthocyanin-rich foods report limited bioavailability of the parent anthocyanins. The present study explores the identity and concentration of the phenolic metabolites of anthocyanins in humans...
  45. doi request reprint The potential for dietary factors to prevent or treat osteoarthritis
    Jonathan A Green
    School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Proc Nutr Soc 73:278-88. 2014
    ..In a chronic disease, with risk factors increasing in the population and with no pharmaceutical cure, an understanding of this will be crucial. ..
  46. doi request reprint Anthocyanin stability and recovery: implications for the analysis of clinical and experimental samples
    Gary Woodward
    School of Medicine, University of East Anglia, Norwich, United Kingdom
    J Agric Food Chem 57:5271-8. 2009
    ..Consequently, these compounds should be the target of future bioavailability and bioactivity studies to establish the true occurrence and impact of anthocyanins on human health...
  47. ncbi request reprint Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells
    Yujuan Shan
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ, UK
    Int J Oncol 34:1129-34. 2009
    ..Taken together, these data suggest that p38 is essential in sulforaphane-mediated COX-2 suppression and provide new insights into the molecular mechanisms of sulforaphane in the chemoprevention of bladder cancer...