Research Topics
Species | M J CaslakeSummaryAffiliation: University of Glasgow Country: UK Publications
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Publications
Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and strokeMuriel J Caslake
Department of Vascular Biochemistry at Glasgow University, UK
Nat Clin Pract Cardiovasc Med 2:529-35. 2005....- Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery diseaseM J Caslake
Department of Pathological Biochemistry, 4th Floor QEB, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
Atherosclerosis 150:413-9. 2000..We propose, therefore, that plasma Lp-PLA(2) mass should be viewed as a potential novel risk factor for CAD that provides information related to but additional to traditional lipoprotein measurements... - Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemiaMuriel J Caslake
Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31 2ER, UK
Atherosclerosis 171:245-53. 2003..Rosuvastatin therefore, in addition to lowering LDL and apoB-concentrations, largely corrected the TG and LDL abnormalities in subjects who had the propensity to develop the atherogenic lipoprotein phenotype... - Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular diseaseMuriel J Caslake
Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
Curr Opin Lipidol 14:347-52. 2003..This review addresses the molecular properties of Lp-PLA(2), the controversy surrounding its role in atherosclerosis and the regulation of its plasma levels in humans... - Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study GroupC J Packard
Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
N Engl J Med 343:1148-55. 2000.... - Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal diseaseC J Deighan
Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle Street, Glasgow, G4 0SF, United Kingdom
J Am Soc Nephrol 12:341-8. 2001..Fenofibrate but not cerivastatin reduces remnant lipoproteins. The two treatments seem to reduce LDLIII by different mechanisms, suggesting a potential role for combination therapy to optimize lowering of LDLIII and RLP... - The atherogenic lipoprotein phenotype: small dense LDL and lipoprotein remnants in nephrotic range proteinuriaC J Deighan
Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle St, Glasgow, G4 0SF, UK
Atherosclerosis 157:211-20. 2001..Increases in LDLIII and RLP are closely related to plasma triglyceride. The association between excess RLP and LDLIII suggests that RLP contribute to the increased atherogenicity attributed to the atherogenic lipoprotein phenotype... - Atherogenic lipoprotein phenotype in end-stage renal failure: origin and extent of small dense low-density lipoprotein formationC J Deighan
Glasgow Royal Infirmary, UK
Am J Kidney Dis 35:852-62. 2000..Atherogenic levels of LDLIII are found in patients with triglyceride levels greater than 177 mg/dL. This is likely to represent a further cardiovascular risk factor in this population... - Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolismA Gaw
Institute of Biochemistry, Glasgow Royal Infirmary, UK
Arterioscler Thromb Vasc Biol 16:236-49. 1996..Compared with baseline, combined therapy generated falls in both IDL (35%, P = .01) and LDL (37%, P < .04) apoB pools due to enhanced clearance of IDL (214%, P < .03) and reduced total input of LDL (39%, P < .003)... - Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhageA D Kay
Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
Atherosclerosis 170:141-6. 2003..The remodelling of CSF Lps and selective reduction of apoE containing lipoproteins may reflect an important response of the human brain to injury... - Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemiaB de Roos
Department of Pathological Biochemistry, 4th Floor, Queen Elizabeth Building, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
Atherosclerosis 156:249-54. 2001..Therefore, the SMHL rabbit offers a valuable animal model in which to study the relation between hypertriglyceridaemia and insulin resistance... - Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese menF L Burton
Institute of Diet, Exercise and Lifestyle, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
Int J Obes (Lond) 32:481-9. 2008..The extent to which exercise-induced changes to postprandial metabolism are dependant on the associated energy deficit is not known... - Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restrictionV A Rodie
Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER, UK
Atherosclerosis 176:181-7. 2004..Our findings are potentially pertinent to understanding the future cardiovascular health of the offspring... - Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitusJeffrey W Stephens
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London WC1E 6JF, UK
Clin Chem 51:119-24. 2005..Apolipoprotein E (apoE) is found in association with triglyceride-rich lipoproteins and is the ligand for the removal of these particles from the plasma. Genetic variations in exon 4 lead to three common gene variants: E2, E3, and E4... - Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetesSiobhan Higgins
Division of Developmental Medicine, University of Glasgow, Glasgow, UK
Prev Med 40:145-51. 2005..In offspring, central adiposity and metabolic risk factors were influenced by habitual physical activity to a greater degree than in control subjects... - Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese menJason M R Gill
Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow G12 8QQ, Scotland, UK
J Am Coll Cardiol 44:2375-82. 2004..05). CONCLUSIONS: A session of prior exercise improves fasting and postprandial vascular function in middle-aged men. This may be one mechanism by which exercise influences cardiovascular risk... - Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbitBaukje de Roos
Department of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, Glasgow, UK
Atherosclerosis 181:63-8. 2005.... - Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemiaMartin Adiels
Department of Mathematical Sciences, Chalmers University of Technology, , Sweden
Arterioscler Thromb Vasc Biol 25:1697-703. 2005..We propose that hyperglycemia is the driving force that aggravates overproduction of VLDL1 in DM2... - A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitusTony Hayek
Lipid Research Unit, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
Atherosclerosis 184:404-12. 2006.... - Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged menJason M R Gill
Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
Atherosclerosis 185:87-96. 2006.... - Association between apolipoprotein E4 and cognitive decline in elderly adultsChris J Packard
Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
J Am Geriatr Soc 55:1777-85. 2007..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women... - Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: heterogeneity of responsesJason M R Gill
Department of Vascular Biochemistry, University of Glasgow, United Kingdom
Atherosclerosis 194:134-43. 2007.... - Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphateBarbara J Meyer
School of Health Sciences, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia
Atherosclerosis 195:e28-34. 2007..It remains to be determined if these cholesterol rich IDL particles are potentially more atherogenic than the triglyceride rich IDL particles... - Development of a novel method to determine very low density lipoprotein kineticsIqbal A R Al Shayji
Department of Vascular Biochemistry, University of Glasgow, Glasgow, United Kingdom
J Lipid Res 48:2086-95. 2007..05). The protocol is relatively quick, inexpensive, and transferable to nonspecialist laboratories... - A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractionsMartin Adiels
Mathematical Sciences, Chalmers University of Technology, , Sweden
J Lipid Res 46:58-67. 2005..These observations are consistent with a sequential assembly model of VLDL and suggest that the TG is added to a primordial apoB-containing particle in the liver... - Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjectsJason M R Gill
Department of Vascular Biochemistry, University of Glasgow, Glasgow, UK
Atherosclerosis 176:49-56. 2004..These results suggest a role for insulin resistance in the determination of hepatic VLDL1 production and highlight the independent regulation of VLDL1 and VLDL2 metabolism... - Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemiaDairena Gaffney
Department of Pathological Biochemistry, Glasgow Royal Infirmary, North Glasgow Hospitals University NHS Trust, 4th Floor, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
Atherosclerosis 162:33-43. 2002..We conclude that disturbances in IDL metabolism provide the basis for understanding why FDB is less severe than FH. Our findings suggest that an apoB-LDL receptor interaction is important in the IDL to LDL conversion... - C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention StudyDilys J Freeman
Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
Diabetes 51:1596-600. 2002..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes... - Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance ratesLorne F Forster
Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor, Queen Elizabeth Building 10 Alexandra Parade, Glasgow, G31 2ER, Scotland, UK
Atherosclerosis 164:129-45. 2002..This leads to a substantial, and approximately equivalent, percentage reduction in plasma triglyceride and LDL cholesterol... - Regulation of small dense LDL concentration in Korean and Scottish men and womenHong Keun Cho
Department of Internal Medicine, Medical College, Ewha Women's University, Seoul, Republic of Korea
Atherosclerosis 164:187-93. 2002.... - Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDLJason M R Gill
Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom
Am J Clin Nutr 78:47-56. 2003..Replacing dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) lowers LDL cholesterol, but the underlying mechanisms remain unclear... - Measurement of plasma small-dense LDL concentration by a simplified ultracentrifugation procedure and immunoassay of apolipoprotein BValentine C Menys
Department of Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK
Clin Chim Acta 334:95-106. 2003..Existing methods for detecting small-dense low-density lipoprotein (SD-LDL) are either semiquantitative (e.g., gradient gel electrophoresis) or require specialised laboratory methods (e.g., density-gradient ultracentrifugation, DGU)... - Remodeling of cerebrospinal fluid lipoprotein particles after human traumatic brain injuryAndrew D Kay
Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
J Neurotrauma 20:717-23. 2003..Treatment strategies targeting CNS lipid transport, required for neuronal sprouting and synaptogenesis, may be applicable to traumatic brain injury... - Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. j.gill@bio.gla.ac.ukJason M R Gill
Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland G31 2ER, United Kingdom
J Clin Endocrinol Metab 88:4328-35. 2003..These results suggest that, although fat ingestion induces endothelial dysfunction, interventions that alter postprandial TG metabolism will not necessarily concomitantly influence endothelial function... - A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention StudyDilys J Freeman
Department of Biological Sciences, University of Durham, Durham, UK
Eur Heart J 24:1833-42. 2003..Gene-smoking and gene-treatment interactions were investigated... - Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunoassay of apolipoprotein BValentine C Menys
Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
Clin Chem Lab Med 42:30-6. 2004..237; p < 0.05) and dyslipidaemic men (r = -0.293; p < 0.005). Using a micro-method, we obtained results which establish that the Airfuge provides a more rapid and less expensive method for quantification of SD-LDL... - Phenotypes, genotypes and response to statin therapyMuriel J Caslake
Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, UK
Curr Opin Lipidol 15:387-92. 2004..The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to explain how plasma triglyceride influences the nature and magnitude of lipid lowering on statin therapy... - Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN StudyMuriel J Caslake
Department of Vascular Biochemistry, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
Am J Clin Nutr 88:618-29. 2008..The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits... - Lipolysis generates platelet dysfunction after in vivo heparin administrationElijah W Muriithi
Department of Cardiac Surgery, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
Clin Sci (Lond) 103:433-40. 2002..0001; n =8), suggesting that heparin-induced lipolysis inhibits platelet macroaggregation. Lipoprotein degradation products may cause this inhibition by interfering with eicosanoids and other lipid mediators of metabolism... - Effect of pravastatin on the development of diabetes and adiponectin productionToshiyuki Takagi
Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Atherosclerosis 196:114-21. 2008..47+/-0.33 microg/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment...