M J Caslake

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke
    Muriel J Caslake
    Department of Vascular Biochemistry at Glasgow University, UK
    Nat Clin Pract Cardiovasc Med 2:529-35. 2005
  2. ncbi request reprint Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease
    M J Caslake
    Department of Pathological Biochemistry, 4th Floor QEB, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
    Atherosclerosis 150:413-9. 2000
  3. ncbi request reprint Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Atherosclerosis 171:245-53. 2003
  4. ncbi request reprint Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Curr Opin Lipidol 14:347-52. 2003
  5. ncbi request reprint Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
    N Engl J Med 343:1148-55. 2000
  6. ncbi request reprint Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease
    C J Deighan
    Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle Street, Glasgow, G4 0SF, United Kingdom
    J Am Soc Nephrol 12:341-8. 2001
  7. ncbi request reprint The atherogenic lipoprotein phenotype: small dense LDL and lipoprotein remnants in nephrotic range proteinuria
    C J Deighan
    Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle St, Glasgow, G4 0SF, UK
    Atherosclerosis 157:211-20. 2001
  8. ncbi request reprint Atherogenic lipoprotein phenotype in end-stage renal failure: origin and extent of small dense low-density lipoprotein formation
    C J Deighan
    Glasgow Royal Infirmary, UK
    Am J Kidney Dis 35:852-62. 2000
  9. ncbi request reprint Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism
    A Gaw
    Institute of Biochemistry, Glasgow Royal Infirmary, UK
    Arterioscler Thromb Vasc Biol 16:236-49. 1996
  10. ncbi request reprint Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhage
    A D Kay
    Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Atherosclerosis 170:141-6. 2003

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Lipoprotein-associated phospholipase A2 as a biomarker for coronary disease and stroke
    Muriel J Caslake
    Department of Vascular Biochemistry at Glasgow University, UK
    Nat Clin Pract Cardiovasc Med 2:529-35. 2005
    ....
  2. ncbi request reprint Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease
    M J Caslake
    Department of Pathological Biochemistry, 4th Floor QEB, Glasgow Royal Infirmary University NHS Trust, Glasgow, UK
    Atherosclerosis 150:413-9. 2000
    ..We propose, therefore, that plasma Lp-PLA(2) mass should be viewed as a potential novel risk factor for CAD that provides information related to but additional to traditional lipoprotein measurements...
  3. ncbi request reprint Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor Queen Elizabeth Building, 10 Alexandra Parade, Glasgow G31 2ER, UK
    Atherosclerosis 171:245-53. 2003
    ..Rosuvastatin therefore, in addition to lowering LDL and apoB-concentrations, largely corrected the TG and LDL abnormalities in subjects who had the propensity to develop the atherogenic lipoprotein phenotype...
  4. ncbi request reprint Lipoprotein-associated phospholipase A2 (platelet-activating factor acetylhydrolase) and cardiovascular disease
    Muriel J Caslake
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, UK
    Curr Opin Lipidol 14:347-52. 2003
    ..This review addresses the molecular properties of Lp-PLA(2), the controversy surrounding its role in atherosclerosis and the regulation of its plasma levels in humans...
  5. ncbi request reprint Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
    C J Packard
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Scotland
    N Engl J Med 343:1148-55. 2000
    ....
  6. ncbi request reprint Comparative effects of cerivastatin and fenofibrate on the atherogenic lipoprotein phenotype in proteinuric renal disease
    C J Deighan
    Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle Street, Glasgow, G4 0SF, United Kingdom
    J Am Soc Nephrol 12:341-8. 2001
    ..Fenofibrate but not cerivastatin reduces remnant lipoproteins. The two treatments seem to reduce LDLIII by different mechanisms, suggesting a potential role for combination therapy to optimize lowering of LDLIII and RLP...
  7. ncbi request reprint The atherogenic lipoprotein phenotype: small dense LDL and lipoprotein remnants in nephrotic range proteinuria
    C J Deighan
    Renal Unit, Walton Building, Glasgow Royal Infirmary, Castle St, Glasgow, G4 0SF, UK
    Atherosclerosis 157:211-20. 2001
    ..Increases in LDLIII and RLP are closely related to plasma triglyceride. The association between excess RLP and LDLIII suggests that RLP contribute to the increased atherogenicity attributed to the atherogenic lipoprotein phenotype...
  8. ncbi request reprint Atherogenic lipoprotein phenotype in end-stage renal failure: origin and extent of small dense low-density lipoprotein formation
    C J Deighan
    Glasgow Royal Infirmary, UK
    Am J Kidney Dis 35:852-62. 2000
    ..Atherogenic levels of LDLIII are found in patients with triglyceride levels greater than 177 mg/dL. This is likely to represent a further cardiovascular risk factor in this population...
  9. ncbi request reprint Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism
    A Gaw
    Institute of Biochemistry, Glasgow Royal Infirmary, UK
    Arterioscler Thromb Vasc Biol 16:236-49. 1996
    ..Compared with baseline, combined therapy generated falls in both IDL (35%, P = .01) and LDL (37%, P < .04) apoB pools due to enhanced clearance of IDL (214%, P < .03) and reduced total input of LDL (39%, P < .003)...
  10. ncbi request reprint Remodelling of cerebrospinal fluid lipoproteins after subarachnoid hemorrhage
    A D Kay
    Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow G51 4TF, UK
    Atherosclerosis 170:141-6. 2003
    ..The remodelling of CSF Lps and selective reduction of apoE containing lipoproteins may reflect an important response of the human brain to injury...
  11. ncbi request reprint Insulin resistance in the St. Thomas' mixed hyperlipidaemic (SMHL) rabbit, a model for familial combined hyperlipidaemia
    B de Roos
    Department of Pathological Biochemistry, 4th Floor, Queen Elizabeth Building, Royal Infirmary, Glasgow G31 2ER, Scotland, UK
    Atherosclerosis 156:249-54. 2001
    ..Therefore, the SMHL rabbit offers a valuable animal model in which to study the relation between hypertriglyceridaemia and insulin resistance...
  12. ncbi request reprint Energy replacement attenuates the effects of prior moderate exercise on postprandial metabolism in overweight/obese men
    F L Burton
    Institute of Diet, Exercise and Lifestyle, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Int J Obes (Lond) 32:481-9. 2008
    ..The extent to which exercise-induced changes to postprandial metabolism are dependant on the associated energy deficit is not known...
  13. ncbi request reprint Fetal cord plasma lipoprotein status in uncomplicated human pregnancies and in pregnancies complicated by pre-eclampsia and intrauterine growth restriction
    V A Rodie
    Division of Developmental Medicine, University of Glasgow, Glasgow Royal Infirmary University NHS Trust, Glasgow G31 2ER, UK
    Atherosclerosis 176:181-7. 2004
    ..Our findings are potentially pertinent to understanding the future cardiovascular health of the offspring...
  14. ncbi request reprint Three novel mutations in the apolipoprotein E gene in a sample of individuals with type 2 diabetes mellitus
    Jeffrey W Stephens
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London WC1E 6JF, UK
    Clin Chem 51:119-24. 2005
    ..Apolipoprotein E (apoE) is found in association with triglyceride-rich lipoproteins and is the ligand for the removal of these particles from the plasma. Genetic variations in exon 4 lead to three common gene variants: E2, E3, and E4...
  15. ncbi request reprint Physical activity, dietary intake and metabolic risk factors in non-diabetic daughters of patients with type II diabetes
    Siobhan Higgins
    Division of Developmental Medicine, University of Glasgow, Glasgow, UK
    Prev Med 40:145-51. 2005
    ..This study aimed to investigate the impact of habitual physical activity and diet on metabolic risk factors in the daughters of patients with type II diabetes and control subjects...
  16. ncbi request reprint Effects of prior moderate exercise on postprandial metabolism and vascular function in lean and centrally obese men
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow G12 8QQ, Scotland, UK
    J Am Coll Cardiol 44:2375-82. 2004
    ..We investigated whether a session of prior exercise could ameliorate postprandial endothelial dysfunction...
  17. ncbi request reprint Characterisation of the lipoprotein structure in the St. Thomas' Mixed Hyperlipidaemic (SMHL) rabbit
    Baukje de Roos
    Department of Vascular Biochemistry, Division of Cardiovascular and Medical Sciences, Glasgow, UK
    Atherosclerosis 181:63-8. 2005
    ....
  18. ncbi request reprint Overproduction of VLDL1 driven by hyperglycemia is a dominant feature of diabetic dyslipidemia
    Martin Adiels
    Department of Mathematical Sciences, Chalmers University of Technology, Goteborg, Sweden
    Arterioscler Thromb Vasc Biol 25:1697-703. 2005
    ..We sought to compare the synthesis and metabolism of VLDL1 and VLDL2 in patients with type 2 diabetes mellitus (DM2) and nondiabetic subjects...
  19. ncbi request reprint A common variant in the glutathione S transferase gene is associated with elevated markers of inflammation and lipid peroxidation in subjects with diabetes mellitus
    Tony Hayek
    Lipid Research Unit, Rambam Medical Center, The Bruce Rappaport Faculty of Medicine, Haifa, Israel
    Atherosclerosis 184:404-12. 2006
    ....
  20. ncbi request reprint Effects of a moderate exercise session on postprandial lipoproteins, apolipoproteins and lipoprotein remnants in middle-aged men
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK
    Atherosclerosis 185:87-96. 2006
    ....
  21. ncbi request reprint Association between apolipoprotein E4 and cognitive decline in elderly adults
    Chris J Packard
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, Scotland
    J Am Geriatr Soc 55:1777-85. 2007
    ..To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women...
  22. ncbi request reprint Effect of prior moderate exercise on postprandial metabolism in men with type 2 diabetes: heterogeneity of responses
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, United Kingdom
    Atherosclerosis 194:134-43. 2007
    ....
  23. ncbi request reprint Fractionation of cholesteryl ester rich intermediate density lipoprotein subpopulations by chondroitin sulphate
    Barbara J Meyer
    School of Health Sciences, University of Wollongong, Northfields Ave, Wollongong, NSW 2522, Australia
    Atherosclerosis 195:e28-34. 2007
    ..It remains to be determined if these cholesterol rich IDL particles are potentially more atherogenic than the triglyceride rich IDL particles...
  24. ncbi request reprint Development of a novel method to determine very low density lipoprotein kinetics
    Iqbal A R Al-Shayji
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, United Kingdom
    J Lipid Res 48:2086-95. 2007
    ..05). The protocol is relatively quick, inexpensive, and transferable to nonspecialist laboratories...
  25. ncbi request reprint A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions
    Martin Adiels
    Mathematical Sciences, Chalmers University of Technology, 412 96 Goteborg, Sweden
    J Lipid Res 46:58-67. 2005
    ..These observations are consistent with a sequential assembly model of VLDL and suggest that the TG is added to a primordial apoB-containing particle in the liver...
  26. ncbi request reprint Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects
    Jason M R Gill
    Department of Vascular Biochemistry, University of Glasgow, Glasgow, UK
    Atherosclerosis 176:49-56. 2004
    ..These results suggest a role for insulin resistance in the determination of hepatic VLDL1 production and highlight the independent regulation of VLDL1 and VLDL2 metabolism...
  27. ncbi request reprint Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia
    Dairena Gaffney
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, North Glasgow Hospitals University NHS Trust, 4th Floor, Queen Elizabeth Building, Alexandra Parade, Glasgow G31 2ER, Scotland, UK
    Atherosclerosis 162:33-43. 2002
    ..We conclude that disturbances in IDL metabolism provide the basis for understanding why FDB is less severe than FH. Our findings suggest that an apoB-LDL receptor interaction is important in the IDL to LDL conversion...
  28. ncbi request reprint C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, UK
    Diabetes 51:1596-600. 2002
    ..They also add to the notion that low-grade inflammation is important in the pathogenesis of type 2 diabetes...
  29. ncbi request reprint Influence of atorvastatin and simvastatin on apolipoprotein B metabolism in moderate combined hyperlipidemic subjects with low VLDL and LDL fractional clearance rates
    Lorne F Forster
    Department of Pathological Biochemistry, Glasgow Royal Infirmary University NHS Trust, 4th Floor, Queen Elizabeth Building 10 Alexandra Parade, Glasgow, G31 2ER, Scotland, UK
    Atherosclerosis 164:129-45. 2002
    ..This leads to a substantial, and approximately equivalent, percentage reduction in plasma triglyceride and LDL cholesterol...
  30. ncbi request reprint Regulation of small dense LDL concentration in Korean and Scottish men and women
    Hong Keun Cho
    Department of Internal Medicine, Medical College, Ewha Women s University, Seoul, Republic of Korea
    Atherosclerosis 164:187-93. 2002
    ....
  31. ncbi request reprint Effects of dietary monounsaturated fatty acids on lipoprotein concentrations, compositions, and subfraction distributions and on VLDL apolipoprotein B kinetics: dose-dependent effects on LDL
    Jason M R Gill
    Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom
    Am J Clin Nutr 78:47-56. 2003
    ..Replacing dietary saturated fatty acids (SFAs) with monounsaturated fatty acids (MUFAs) lowers LDL cholesterol, but the underlying mechanisms remain unclear...
  32. ncbi request reprint Measurement of plasma small-dense LDL concentration by a simplified ultracentrifugation procedure and immunoassay of apolipoprotein B
    Valentine C Menys
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, Manchester, UK
    Clin Chim Acta 334:95-106. 2003
    ..Existing methods for detecting small-dense low-density lipoprotein (SD-LDL) are either semiquantitative (e.g., gradient gel electrophoresis) or require specialised laboratory methods (e.g., density-gradient ultracentrifugation, DGU)...
  33. ncbi request reprint Remodeling of cerebrospinal fluid lipoprotein particles after human traumatic brain injury
    Andrew D Kay
    Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, United Kingdom
    J Neurotrauma 20:717-23. 2003
    ..Treatment strategies targeting CNS lipid transport, required for neuronal sprouting and synaptogenesis, may be applicable to traumatic brain injury...
  34. ncbi request reprint Effects of short-term detraining on postprandial metabolism, endothelial function, and inflammation in endurance-trained men: dissociation between changes in triglyceride metabolism and endothelial function. j.gill@bio.gla.ac.uk
    Jason M R Gill
    Department of Pathological Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland G31 2ER, United Kingdom
    J Clin Endocrinol Metab 88:4328-35. 2003
    ..These results suggest that, although fat ingestion induces endothelial dysfunction, interventions that alter postprandial TG metabolism will not necessarily concomitantly influence endothelial function...
  35. ncbi request reprint A polymorphism of the cholesteryl ester transfer protein gene predicts cardiovascular events in non-smokers in the West of Scotland Coronary Prevention Study
    Dilys J Freeman
    Department of Biological Sciences, University of Durham, Durham, UK
    Eur Heart J 24:1833-42. 2003
    ..Gene-smoking and gene-treatment interactions were investigated...
  36. ncbi request reprint Isolation of plasma small-dense low-density lipoprotein using a simple air-driven ultracentrifuge and quantification using immunoassay of apolipoprotein B
    Valentine C Menys
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Clin Chem Lab Med 42:30-6. 2004
    ..237; p < 0.05) and dyslipidaemic men (r = -0.293; p < 0.005). Using a micro-method, we obtained results which establish that the Airfuge provides a more rapid and less expensive method for quantification of SD-LDL...
  37. ncbi request reprint Phenotypes, genotypes and response to statin therapy
    Muriel J Caslake
    Department of Vascular Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, UK
    Curr Opin Lipidol 15:387-92. 2004
    ..The aim of this review is to describe what is known about factors that determine a patient's response, and to offer a mechanism to explain how plasma triglyceride influences the nature and magnitude of lipid lowering on statin therapy...
  38. ncbi request reprint Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study
    Muriel J Caslake
    Department of Vascular Biochemistry, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom
    Am J Clin Nutr 88:618-29. 2008
    ..The lipid-modulatory effects of high intakes of the fish-oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are well established and likely to contribute to cardioprotective benefits...
  39. ncbi request reprint Lipolysis generates platelet dysfunction after in vivo heparin administration
    Elijah W Muriithi
    Department of Cardiac Surgery, University of Glasgow, Royal Infirmary, Glasgow G31 2ER, UK
    Clin Sci (Lond) 103:433-40. 2002
    ..0001; n =8), suggesting that heparin-induced lipolysis inhibits platelet macroaggregation. Lipoprotein degradation products may cause this inhibition by interfering with eicosanoids and other lipid mediators of metabolism...
  40. ncbi request reprint Effect of pravastatin on the development of diabetes and adiponectin production
    Toshiyuki Takagi
    Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Atherosclerosis 196:114-21. 2008
    ..47+/-0.33 microg/ml, p=0.0003). Taken together, our findings suggest that pravastatin may have beneficial effects on adipose tissue, which may partly explain the reduction of the development of diabetes by pravastatin treatment...