Affiliation: University of Oxford
Wu H, Carvalho P, Voeltz G. Here, there, and everywhere: The importance of ER membrane contact sites. Science. 2018;361: pubmed publisher
..We highlight how the dynamic ER network regulates a plethora of cellular processes through MCSs with various organelles and with the plasma membrane. ..
Wang S, Idrissi F, Hermansson M, Grippa A, Ejsing C, Carvalho P. Seipin and the membrane-shaping protein Pex30 cooperate in organelle budding from the endoplasmic reticulum. Nat Commun. 2018;9:2939 pubmed publisher
..We propose that seipin and Pex30 act in concert to organize membrane domains permissive for organelle budding, and that may have a lipid composition distinct from the bulk ER. ..
Teixeira V, Johnsen L, Martínez Montañés F, Grippa A, Búxo L, Idrissi F, et al
. Regulation of lipid droplets by metabolically controlled Ldo isoforms. J Cell Biol. 2018;217:127-138 pubmed publisher
..Our findings support a model in which Ldo proteins modulate the activity of the seipin complex, thereby affecting LD properties. Moreover, we identify ER-LD contacts as regulatory targets coupling energy storage to cellular metabolism. ..