John Carroll

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Ca2+ signalling and cortical re-organisation during the transition from meiosis to mitosis in mammalian oocytes
    John Carroll
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Obstet Gynecol Reprod Biol 115:S61-7. 2004
  2. ncbi request reprint Fertilization and InsP3-induced Ca2+ release stimulate a persistent increase in the rate of degradation of cyclin B1 specifically in mature mouse oocytes
    Petros Marangos
    Department of Physiology, University College London, WC1E 6BT, UK
    Dev Biol 272:26-38. 2004
  3. ncbi request reprint An increase in [Ca2+]i is sufficient but not necessary for driving mitosis in early mouse embryos
    Greg FitzHarris
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 118:4563-75. 2005
  4. ncbi request reprint The dynamics of cyclin B1 distribution during meiosis I in mouse oocytes
    Petros Marangos
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Reproduction 128:153-62. 2004
  5. ncbi request reprint Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production
    Remi Dumollard
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Development 131:3057-67. 2004
  6. ncbi request reprint The role of mitochondrial function in the oocyte and embryo
    Remi Dumollard
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    Curr Top Dev Biol 77:21-49. 2007
  7. pmc A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression
    Hayden Homer
    Oocyte and Embryo Research Laboratory, Department of Cell and Developmental Biology, Division of Biosciences and Institute for Women s Health, University College London, London, UK
    Science 326:991-4. 2009
  8. ncbi request reprint Changes in endoplasmic reticulum structure during mouse oocyte maturation are controlled by the cytoskeleton and cytoplasmic dynein
    Greg FitzHarris
    Department of Physiology, University College London, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 305:133-44. 2007
  9. doi request reprint Securin regulates entry into M-phase by modulating the stability of cyclin B
    Petros Marangos
    Department of Cell and Developmental Biology, Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Cell Biol 10:445-51. 2008
  10. ncbi request reprint Ca2+ oscillations at fertilization in mammals are regulated by the formation of pronuclei
    Petros Marangos
    Department of Physiology, UCL, Gower Street, London WC1E 6BT, UK
    Development 130:1461-72. 2003

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Ca2+ signalling and cortical re-organisation during the transition from meiosis to mitosis in mammalian oocytes
    John Carroll
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Obstet Gynecol Reprod Biol 115:S61-7. 2004
    ..These changes in organisation have implications for the inheritance of ER in meiotic and mitotic cell divisions and may reflect different roles and requirements for Ca(2+) in meiosis and mitosis...
  2. ncbi request reprint Fertilization and InsP3-induced Ca2+ release stimulate a persistent increase in the rate of degradation of cyclin B1 specifically in mature mouse oocytes
    Petros Marangos
    Department of Physiology, University College London, WC1E 6BT, UK
    Dev Biol 272:26-38. 2004
    ..Furthermore, this Ca2+ -induced increase in degradation of cyclin B1 requires factors specific to mature oocytes, and that to overcome arrest at MII, Ca2+ acts to release the CSF-mediated brake on cyclin B1 destruction...
  3. ncbi request reprint An increase in [Ca2+]i is sufficient but not necessary for driving mitosis in early mouse embryos
    Greg FitzHarris
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 118:4563-75. 2005
    ..Thus, although an induced [Ca2+]i increase can accelerate mitosis entry, neither cytosolic nor perinuclear [Ca2+] increases appear to be necessary for progression through mitosis in mouse embryos...
  4. ncbi request reprint The dynamics of cyclin B1 distribution during meiosis I in mouse oocytes
    Petros Marangos
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Reproduction 128:153-62. 2004
    ..These studies show that GVBD in mouse oocytes is sensitive to cyclin B1 abundance and that the changes in distribution of cyclin B1 contribute to progression through MI...
  5. ncbi request reprint Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production
    Remi Dumollard
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Development 131:3057-67. 2004
    ..As mitochondrial ATP generation is essential to sustain the [Ca2+] signals that are crucial to initiate development, mitochondrial integrity is clearly fundamental in sustaining fertility in mammalian eggs...
  6. ncbi request reprint The role of mitochondrial function in the oocyte and embryo
    Remi Dumollard
    Department of Physiology, University College London, London WC1E 6BT, United Kingdom
    Curr Top Dev Biol 77:21-49. 2007
    ....
  7. pmc A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression
    Hayden Homer
    Oocyte and Embryo Research Laboratory, Department of Cell and Developmental Biology, Division of Biosciences and Institute for Women s Health, University College London, London, UK
    Science 326:991-4. 2009
    ..Both meiotic defects in BubR1-depleted oocytes are due to reduced activity of the master regulator known as the anaphase-promoting complex (APC), brought about through diminished levels of the APC coactivator Cdh1...
  8. ncbi request reprint Changes in endoplasmic reticulum structure during mouse oocyte maturation are controlled by the cytoskeleton and cytoplasmic dynein
    Greg FitzHarris
    Department of Physiology, University College London, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 305:133-44. 2007
    ....
  9. doi request reprint Securin regulates entry into M-phase by modulating the stability of cyclin B
    Petros Marangos
    Department of Cell and Developmental Biology, Division of Biosciences, University College London, Gower Street, London, WC1E 6BT, UK
    Nat Cell Biol 10:445-51. 2008
    ..These data reveal a role for securin at the G2-M transition and suggest a more general mechanism whereby physiological levels of co-competing APC substrates function in modulating the timing of cell-cycle transitions...
  10. ncbi request reprint Ca2+ oscillations at fertilization in mammals are regulated by the formation of pronuclei
    Petros Marangos
    Department of Physiology, UCL, Gower Street, London WC1E 6BT, UK
    Development 130:1461-72. 2003
    ..We conclude by suggesting a model where nuclear sequestration and release of a Ca(2+)-releasing activity contributes to the temporal organization of Ca(2+) transients in meiosis and mitosis in mice...
  11. pmc Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity
    Ibtissem Nabti
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 204:891-900. 2014
    ..These findings demonstrate new roles for MAPK in the regulation of meiosis in mammalian oocytes. ..
  12. pmc Conventional PKCs regulate the temporal pattern of Ca2+ oscillations at fertilization in mouse eggs
    Guillaume Halet
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, England, UK
    J Cell Biol 164:1033-44. 2004
    ..Finally, we present evidence that one physiological function of activated cPKCs in fertilized eggs is to sustain long-lasting Ca2+ oscillations, presumably via the regulation of store-operated Ca2+ entry...
  13. pmc Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1)
    Petros Marangos
    Department of Physiology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 176:65-75. 2007
    ..Finally, we show that Emi1-dependent effects on meiosis I require the presence of Cdh1. These observations reveal a novel mechanism for the control of entry into the first meiotic division: an Emi1-dependent inhibition of APC(Cdh1)...
  14. pmc Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte
    Caroline M Dalton
    Department of Cell and Developmental Biology, Division of Biosciences, University College London, Gower Street, London, WC1E 6BT
    J Cell Sci 126:2955-64. 2013
    ....
  15. doi request reprint Oocytes progress beyond prophase in the presence of DNA damage
    Petros Marangos
    Department of Cell and Developmental Biology, Division of Biosciences, University College London, Gower Street, London WC1E 6BT, UK
    Curr Biol 22:989-94. 2012
    ..We conclude that oocytes are the only nontransformed cells that fail to launch a robust G2 phase DNA damage checkpoint and that this renders them sensitive to genomic instability...
  16. ncbi request reprint Rac activity is polarized and regulates meiotic spindle stability and anchoring in mammalian oocytes
    Guillaume Halet
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 12:309-17. 2007
    ..These results demonstrate that Rac-GTP plays a major role in oocyte meiosis, via the regulation of spindle stability and anchoring to the cortex...
  17. doi request reprint Developmentally acquired PKA localisation in mouse oocytes and embryos
    Rachel J Webb
    Department of Physiology, University College London, Gower Street, London, WC1E 6BT, UK
    Dev Biol 317:36-45. 2008
    ..RT-PCR and Western blotting revealed two candidate AKAPs that are known to be targeted to mitochondria, AKAP1 and D-AKAP2. In summary these data show a dynamic regulation of PKA localisation during oocyte and early embryo development...
  18. ncbi request reprint Calcium wave pacemakers in eggs
    Remi Dumollard
    Bio Mar Cell, Unité de Biologie du Développement UMR 7009 CNRS Paris VI, Observatoire, Station Zoologique, Villefranche sur Mer, 06230 France
    J Cell Sci 115:3557-64. 2002
    ....
  19. ncbi request reprint Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta
    Mark G Larman
    Department of Anatomy and Developmental Biology, University College London, WC1E 6BT, UK
    J Cell Sci 117:2513-21. 2004
    ..These data suggest a novel mechanism for regulating a PLC through nuclear sequestration and may explain the cell cycle-dependent regulation of Ca2+ oscillations following fertilisation...
  20. ncbi request reprint The dynamics of plasma membrane PtdIns(4,5)P(2) at fertilization of mouse eggs
    Guillaume Halet
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    J Cell Sci 115:2139-49. 2002
    ..These studies suggest that fertilization does not deplete plasma membrane PtdIns(4,5)P(2) and that one of the pathways for increasing PtdIns(4,5)P(2) at fertilization is invoked by exocytosis of cortical granules...
  21. ncbi request reprint Constitutive PtdIns(3,4,5)P3 synthesis promotes the development and survival of early mammalian embryos
    Guillaume Halet
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Development 135:425-9. 2008
    ..We show that constitutive PtdIns(3,4,5)P(3) synthesis is necessary for optimal development to blastocyst and to prevent large-scale apoptosis at the time of cavitation...
  22. doi request reprint Regulation of cytosolic and mitochondrial ATP levels in mouse eggs and zygotes
    Remi Dumollard
    Laboratoire de Biologie du Développement UMR 7009 CNRS Paris VI, Observatoire, Station Zoologique, Villefranche sur Mer, 06230, France
    Dev Biol 316:431-40. 2008
    ....
  23. pmc TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex
    Yu Tian
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Biol 27:6383-95. 2007
    ..These results establish a common role of TAZ across vertebrate species in a protein degradation pathway regulated by phosphorylation and implicate deficiencies in this pathway in the development of PKD...
  24. ncbi request reprint Regulation of redox metabolism in the mouse oocyte and embryo
    Remi Dumollard
    Laboratoire de Biologie du Développement UMR 7009 CNRS Paris VI, Observatoire, Station Zoologique, Villefranche sur Mer, France
    Development 134:455-65. 2007
    ..Remarkably, we also found that the oxidant action of pyruvate impairs development, demonstrating the fundamental importance of redox state on early development...
  25. pmc Cell cycle-dependent regulation of structure of endoplasmic reticulum and inositol 1,4,5-trisphosphate-induced Ca2+ release in mouse oocytes and embryos
    Greg FitzHarris
    Department of Obstetrics and Gynaecology and the Assisted Conception Unit, University College London, London, WC1E 6BT
    Mol Biol Cell 14:288-301. 2003
    ....
  26. ncbi request reprint The ability to develop an activity that transfers histones onto sperm chromatin is acquired with meiotic competence during oocyte growth
    David W McLay
    Department of Biology, McGill University, Montreal, Canada
    Dev Biol 241:195-206. 2002
    ....
  27. ncbi request reprint Follicle-stimulating hormone induces a gap junction-dependent dynamic change in [cAMP] and protein kinase a in mammalian oocytes
    Rachel J Webb
    Department of PhysiologyUniversity College London, Gower Street, London, WC1E 6BT, United Kingdom
    Dev Biol 246:441-54. 2002
    ..These experiments show that increases in cAMP in ovarian somatic cells are communicated via gap junctions to the oocyte, where it can lead to a redistribution of the catalytic subunit of PKA...