E D Carrol

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. pmc Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children
    Adam D Irwin
    Department of Women s and Children s Health, University of Liverpool, Liverpool, UK
    BMC Med Genomics 5:13. 2012
  2. pmc The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
    Limangeni A Mankhambo
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Crit Care 14:R91. 2010
  3. pmc Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease
    Antony Payton
    Centre for Integrated Genomic Medical Research, Stopford Building, The University of Manchester, Manchester, UK
    BMC Med Genet 10:28. 2009
  4. pmc PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia
    Enitan D Carrol
    Department of Women s and Children s Health, The University of Liverpool, Institute of Child Health, Alder Hey Children s NHS Foundation Trust, Liverpool, United Kingdom
    PLoS ONE 6:e21042. 2011
  5. pmc The diagnostic and prognostic accuracy of five markers of serious bacterial infection in Malawian children with signs of severe infection
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    PLoS ONE 4:e6621. 2009
  6. pmc Successful downstream application of the Paxgene Blood RNA system from small blood samples in paediatric patients for quantitative PCR analysis
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, PO Box 30096, Blantyre, Malawi, Africa
    BMC Immunol 8:20. 2007
  7. pmc Chemokine responses are increased in HIV-infected Malawian children with invasive pneumococcal disease
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    J Acquir Immune Defic Syndr 44:443-50. 2007
  8. pmc A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis
    Enitan D Carrol
    Wellcome Trust Research Laboratories, Blantyre 3, P O Box 30096, Chichiri, Malawi
    Intensive Care Med 31:1415-9. 2005
  9. ncbi request reprint The role of RANTES in meningococcal disease
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital, NHS Trust Alder Hey, Liverpool, L12 2AP, Liverpool, UK
    J Infect Dis 182:363-6. 2000
  10. ncbi request reprint New therapies and vaccines for meningococcal disease
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital, NHS Trust Alder Hey, Eaton Road, Liverpool, L12 2AP, Liverpool, UK
    Expert Opin Investig Drugs 10:1487-500. 2001

Collaborators

Detail Information

Publications25

  1. pmc Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children
    Adam D Irwin
    Department of Women s and Children s Health, University of Liverpool, Liverpool, UK
    BMC Med Genomics 5:13. 2012
    ..Using transcriptomic analyses, we aimed to discover and to evaluate the clinical validity of a combination of reliable and functionally important biomarkers of serious bacterial infection (SBI)...
  2. pmc The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
    Limangeni A Mankhambo
    Malawi Liverpool Wellcome Trust Clinical Research Programme, College of Medicine, University of Malawi, Blantyre, Malawi
    Crit Care 14:R91. 2010
    ....
  3. pmc Nitric oxide synthase 2A (NOS2A) polymorphisms are not associated with invasive pneumococcal disease
    Antony Payton
    Centre for Integrated Genomic Medical Research, Stopford Building, The University of Manchester, Manchester, UK
    BMC Med Genet 10:28. 2009
    ..Nitric oxide is a modulator of apoptotic and inflammatory cascades and endothelial permeability. We hypothesised that genetic variants within this gene may predispose to disease risk and survival...
  4. pmc PCR improves diagnostic yield from lung aspiration in Malawian children with radiologically confirmed pneumonia
    Enitan D Carrol
    Department of Women s and Children s Health, The University of Liverpool, Institute of Child Health, Alder Hey Children s NHS Foundation Trust, Liverpool, United Kingdom
    PLoS ONE 6:e21042. 2011
    ..We aimed to determine if diagnostic yield could be increased further by polymerase chain reaction (PCR) detection of bacteria (Streptococcus pneumoniae and Haemophilus influenzae b) and viruses in lung aspirate fluid...
  5. pmc The diagnostic and prognostic accuracy of five markers of serious bacterial infection in Malawian children with signs of severe infection
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    PLoS ONE 4:e6621. 2009
    ....
  6. pmc Successful downstream application of the Paxgene Blood RNA system from small blood samples in paediatric patients for quantitative PCR analysis
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, PO Box 30096, Blantyre, Malawi, Africa
    BMC Immunol 8:20. 2007
    ..ICAM-1 and IL-6 gene expression were measured in 87 Malawian children with invasive pneumococcal disease...
  7. pmc Chemokine responses are increased in HIV-infected Malawian children with invasive pneumococcal disease
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    J Acquir Immune Defic Syndr 44:443-50. 2007
    ..The aims of this study were to investigate the chemokine response to invasive pneumococcal disease (IPD) and to examine the influence of HIV infection on the chemokine response, pneumococcal bacterial loads, and outcome...
  8. pmc A predominantly anti-inflammatory cytokine profile is associated with disease severity in meningococcal sepsis
    Enitan D Carrol
    Wellcome Trust Research Laboratories, Blantyre 3, P O Box 30096, Chichiri, Malawi
    Intensive Care Med 31:1415-9. 2005
    ..This study aimed to determine whether an anti-inflammatory profile in meningococcal disease is associated with an increased risk of severe disease or septic shock...
  9. ncbi request reprint The role of RANTES in meningococcal disease
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital, NHS Trust Alder Hey, Liverpool, L12 2AP, Liverpool, UK
    J Infect Dis 182:363-6. 2000
    ..001), in those with septic shock (P<.0005), and in nonsurvivors (P=.048; Mann-Whitney test). RANTES is a potential mediator in the pathophysiology of meningococcal disease...
  10. ncbi request reprint New therapies and vaccines for meningococcal disease
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital, NHS Trust Alder Hey, Eaton Road, Liverpool, L12 2AP, Liverpool, UK
    Expert Opin Investig Drugs 10:1487-500. 2001
    ..Whilst the development of effective therapies and vaccines are awaited, the priorities at present must be the prompt recognition and aggressive management of disease...
  11. ncbi request reprint Myositis in children with meningococcal disease: a role for tumour necrosis factor-alpha and interleukin-8?
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital, Alder Hey, Eaton Road, UK
    J Infect 44:17-21. 2002
    ..We aimed to demonstrate whether muscle damage mediated via TNF-alpha and other pro-inflammatory cytokines occurs in MCD, as estimated by creatine kinase skeletal muscle isoenzyme (CK-MM) and cardiac isoenzyme (CK-MB) concentrations...
  12. ncbi request reprint Procalcitonin as a marker of sepsis
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital NHS Trust, Alder Hey, Eaton Road, Liverpool L12 2AP, UK
    Int J Antimicrob Agents 20:1-9. 2002
    ..Together with good clinical judgement and judicious use of antimicrobial agents, PCT should serve as a valuable adjunct in the diagnosis and management of sepsis...
  13. pmc Procalcitonin as a diagnostic marker of meningococcal disease in children presenting with fever and a rash
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital NHS Trust, Alder Hey, Eaton Road, Liverpool L12 2AP, UK
    Arch Dis Child 86:282-5. 2002
    ..This comparison has never been reported in the differentiation of meningococcal disease (MCD) in children presenting with a fever and rash...
  14. pmc Performance characteristics of the polymerase chain reaction assay to confirm clinical meningococcal disease
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s Hospital, Alder Hey, Eaton Road, Liverpool L12 2AP, UK
    Arch Dis Child 83:271-3. 2000
    ..Rapid, reliable serogroup determination without the need to grow isolates could improve laboratory confirmation of MCD...
  15. pmc Improved case confirmation in meningococcal disease with whole blood Taqman PCR
    S J Hackett
    Institute of Child Health, Royal Liverpool Childrens NHS Trust Alder Hey, Eaton Road, Liverpool L12 2AP, UK
    Arch Dis Child 86:449-52. 2002
    ..A new whole blood DNA extraction method for Taqman (WB-Taqman) was introduced in September 1999...
  16. ncbi request reprint Increasing microbiological confirmation and changing epidemiology of meningococcal disease on Merseyside, England
    E D Carrol
    Institute of Child Health, Royal Liverpool Children s NHS Trust, Liverpool, UK
    Clin Microbiol Infect 6:259-62. 2000
    ..To determine, for the last 5 years in children on Merseyside with clinical meningococcal disease (MCD), the impact on diagnostic yield of newer bacteriologic methods; bacterial antigen detection (AD) and polymerase chain reaction (PCR)...
  17. doi request reprint Meeting report: A celebration of the work of Professor Tony Hart, Liverpool, United Kingdom, 7 March 2009
    Nigel A Cunliffe
    Division of Medical Microbiology, School of Infection and Host Defence, University of Liverpool, Liverpool, UK
    J Antimicrob Chemother 65:822-6. 2010
    ....
  18. pmc High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi
    Pediatr Infect Dis J 26:416-22. 2007
    ..Using real-time PCR, we aimed to determine pneumococcal DNA loads in blood and CSF, and their relationship to cytokine concentrations, clinical presentation and outcome...
  19. doi request reprint Susceptibility to invasive bacterial infections in children with sickle cell disease
    Anna J Battersby
    Institute of Child Health, University of Liverpool, Alder Hey Children s NHS Foundation Trust, Eaton Road, Liverpool, UK
    Pediatr Blood Cancer 55:401-6. 2010
    ..Early diagnosis of Hib and pneumococcal infections combined with antibiotic prophylaxis and immunization programs, could lead to significant improvements in mortality, especially in Africa...
  20. ncbi request reprint Prognostic value of procalcitonin in children with meningococcal sepsis
    Enitan D Carrol
    Institute of Child Health, Liverpool Children s Hospital NHS Trust, Alder Hey, Liverpool, UK
    Crit Care Med 33:224-5. 2005
    ..To compare procalcitonin, lactate, and C-reactive protein as prognostic markers in children with meningococcal septic shock...
  21. pmc Persistent visual loss as a complication of meningococcal meningitis
    Limangeni A Mankhambo
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    Pediatr Infect Dis J 25:566-7. 2006
    ....
  22. ncbi request reprint Recombinant tissue plasminogen activator in children with meningococcal purpura fulminans--role uncertain
    Paul Baines
    Crit Care Med 32:1806-7. 2004
  23. pmc Elevated cytokines in pneumococcal meningitis: Chicken or egg?
    Enitan D Carrol
    Crit Care Med 33:1153-4. 2005
  24. pmc Bacteremia is associated with a worse outcome in pneumococcal meningitis
    Enitan D Carrol
    J Infect Dis 198:626-7. 2008
  25. ncbi request reprint In meningococcal disease 4G bad, 5G good
    Paul B Baines
    Crit Care Med 31:2813-4. 2003