Neil O Carragher

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src
    Neil O Carragher
    The Beatson Institute for Cancer Research, Cancer Research United Kingdom, Beatson Laboratories, Glasgow G61 1BD, Scotland, United Kingdom
    Curr Biol 13:1442-50. 2003
  2. ncbi request reprint Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion
    Neil O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK
    Trends Cell Biol 14:241-9. 2004
  3. pmc v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation
    N O Carragher
    The Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Glasgow, Scotland, United Kingdom
    Mol Cell Biol 22:257-69. 2002
  4. pmc Calpain activity is generally elevated during transformation but has oncogene-specific biological functions
    N O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, Scotland, UK
    Neoplasia 6:53-73. 2004
  5. ncbi request reprint Calpain: a role in cell transformation and migration
    Neil O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, G61 1BD Glasgow, Scotland, UK
    Int J Biochem Cell Biol 34:1539-43. 2002
  6. doi request reprint Dasatinib inhibits mammary tumour development in a genetically engineered mouse model
    Saadia A Karim
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    J Pathol 230:430-40. 2013
  7. ncbi request reprint v-Src's hold over actin and cell adhesions
    Margaret C Frame
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 3:233-45. 2002
  8. pmc AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins
    Heather J Spence
    Invasion and Metastasis Laboratory, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Cell Biol 26:1480-95. 2006
  9. ncbi request reprint The mechanism of cell cycle regulation by v-Src
    D Riley
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Oncogene 20:5941-50. 2001
  10. ncbi request reprint The role of focal-adhesion kinase in cancer - a new therapeutic opportunity
    Gordon W McLean
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Nat Rev Cancer 5:505-15. 2005

Detail Information

Publications18

  1. ncbi request reprint A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src
    Neil O Carragher
    The Beatson Institute for Cancer Research, Cancer Research United Kingdom, Beatson Laboratories, Glasgow G61 1BD, Scotland, United Kingdom
    Curr Biol 13:1442-50. 2003
    ..Furthermore, FAK is necessary for recruiting both Calpain 2 and p42ERK/MAPK to peripheral adhesion sites facilitating maximal Calpain activity...
  2. ncbi request reprint Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion
    Neil O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, UK
    Trends Cell Biol 14:241-9. 2004
    ..Dysregulation of these is associated with tumour cell invasion. In this article, we discuss established roles for these signalling pathways, as well as the functional interplay between them in controlling the migratory phenotype...
  3. pmc v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation
    N O Carragher
    The Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Glasgow, Scotland, United Kingdom
    Mol Cell Biol 22:257-69. 2002
    ..Thus, modulation of the calpain-calpastatin proteolytic system plays an important role in focal adhesion disassembly, morphological transformation, and cell cycle progression during v-Src-induced cell transformation...
  4. pmc Calpain activity is generally elevated during transformation but has oncogene-specific biological functions
    N O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, Scotland, UK
    Neoplasia 6:53-73. 2004
    ..Thus, targeting calpain activity may represent a useful general strategy for interfering with activated proto-oncogenes in cancer cells...
  5. ncbi request reprint Calpain: a role in cell transformation and migration
    Neil O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, G61 1BD Glasgow, Scotland, UK
    Int J Biochem Cell Biol 34:1539-43. 2002
    ..Thus, recent investigations suggest that the role of calpain in promoting cell transformation and cell migration may have important in vivo consequences in the context of cancer pathobiology...
  6. doi request reprint Dasatinib inhibits mammary tumour development in a genetically engineered mouse model
    Saadia A Karim
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    J Pathol 230:430-40. 2013
    ..Dasatinib also inhibited both the migration and the invasion of tumour-derived cell lines in vitro. Together these data support the argument that benefits of Src inhibitors may predominate in early or even pre-invasive disease...
  7. ncbi request reprint v-Src's hold over actin and cell adhesions
    Margaret C Frame
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 3:233-45. 2002
    ..Recent experiments have defined some of the key targets and effector pathways that mediate the pleiotropic oncogenic effects of v-Src...
  8. pmc AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins
    Heather J Spence
    Invasion and Metastasis Laboratory, Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Mol Cell Biol 26:1480-95. 2006
    ....
  9. ncbi request reprint The mechanism of cell cycle regulation by v-Src
    D Riley
    The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK
    Oncogene 20:5941-50. 2001
    ..However, the MEK inhibitor prevented p27 protein down regulation whereas the PI3-K inhibitor did not. This was because reduced PI3-K activity lead to proteolytic degradation of p27...
  10. ncbi request reprint The role of focal-adhesion kinase in cancer - a new therapeutic opportunity
    Gordon W McLean
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD, United Kingdom
    Nat Rev Cancer 5:505-15. 2005
    ..Mouse models have shown that FAK is involved in tumour formation and progression, and other studies showing that FAK expression is increased in human tumours make FAK a potentially important new therapeutic target...
  11. pmc SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling
    M A Westhoff
    The Beatson Institute for Cancer Research, Cancer Research UK, Glasgow G61 1BD, Scotland, United Kingdom
    Mol Cell Biol 24:8113-33. 2004
    ..This also highlights that dynamic regulation of actin and adhesions (which include the integrin matrix receptors) is critical to signaling output and biological responses...
  12. pmc Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53
    Paul Timpson
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, United Kingdom
    Cancer Res 71:747-57. 2011
    ....
  13. ncbi request reprint Calpain inhibition: a therapeutic strategy targeting multiple disease states
    N O Carragher
    The Beaston Insititue for Cancer Research, Cancer Research UK, Glasgow G61 1BD, Scotland, UK
    Curr Pharm Des 12:615-38. 2006
    ..The development of a new class of calpain inhibitors that interact with domains outside of the catalytic site of calpain may provide greater specificity and therapeutic potential...
  14. ncbi request reprint Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function
    N O Carragher
    The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Glasgow, UK
    Oncogene 25:5726-40. 2006
    ..Thus, the need for a major pathway that controls integrin adhesion turnover defines and distinguishes cancer cell invasion strategies...
  15. ncbi request reprint Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases
    N O Carragher
    The Beatson Institute for Cancer Research, Cancer Research Campaign Beatson Laboratories, Glasgow G61 1BD, United Kingdom
    J Biol Chem 276:4270-5. 2001
    ..Thus, calpain and caspase differentially regulate focal adhesion turnover during Src-regulated cell transformation, motility, and apoptosis...
  16. ncbi request reprint Inhibition of calpain stabilises podosomes and impairs dendritic cell motility
    Yolanda Calle
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, UK
    J Cell Sci 119:2375-85. 2006
    ..In summary, our results provide evidence that calpain regulates podosome composition and turnover and that this process is required for efficient migration of dendritic cells...
  17. ncbi request reprint Assaying calpain activity
    Neil O Carragher
    Cell Adhesion Linked Kinase Laboratory, Beatson Institute for Cancer Research, Bearsden, Glassgow, UK
    Methods Mol Biol 370:109-20. 2007
    ..The development of such second-generation assays may help to identify more effective calpain intervention strategies...
  18. pmc Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis
    Nicola Ferri
    Department of Pathology, University of Washington School of Medicine, Seattle, Washington, USA
    Am J Pathol 164:1575-85. 2004
    ..Taken together, these data provide evidence for the potential roles of DDR1 and DDR2 in the regulation of collagen turnover mediated by SMCs in obstructive diseases of blood vessels and the lung...