Neil O Carragher
Affiliation: University of Edinburgh
- Advancing cancer drug discovery towards more agile development of targeted combination therapiesNeil O Carragher
Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, UK
Future Med Chem 4:87-105. 2012....
- Combining imaging and pathway profiling: an alternative approach to cancer drug discoveryNeil O Carragher
Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, UK
Drug Discov Today 17:203-14. 2012..The implementation of such approaches at early stages of the drug discovery process enables more informed decisions on candidate drug selection and how to maximise and predict efficacy before clinical development...
- Development and bioorthogonal activation of palladium-labile prodrugs of gemcitabineJason T Weiss
Edinburgh Cancer Research UK Centre, and MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, U K
J Med Chem 57:5395-404. 2014..Zebrafish studies with allyl, propargyl, and benzyl carbamate-protected rhodamines confirmed N-Poc as the most suitable masking group for implementing in vivo bioorthogonal organometallic chemistry. ..
- Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approachJason T Weiss
Edinburgh Cancer Research UK Centre, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XR, UK
Nat Commun 5:3277. 2014..The in vitro efficacy shown by this masking/activation strategy underlines its potential to develop a bioorthogonally activated prodrug approach and supports further in vivo investigations. ..
- Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug developmentAlan Serrels
Edinburgh Cancer Research Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Res 69:2714-9. 2009..Furthermore, this work highlights critical differences in molecular dynamics in vitro and in vivo, which have important implications for the use of cultured disease models as surrogates for living tissue...