Amanda Jayne Carr

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Development of human embryonic stem cell therapies for age-related macular degeneration
    Amanda Jayne F Carr
    The London Project to Cure Blindness, Division of Orbit, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Trends Neurosci 36:385-95. 2013
  2. pmc Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay
    Amanda Jayne Carr
    Institute of Ophthalmology, University College London, London, UK
    Mol Vis 15:283-95. 2009
  3. pmc Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat
    Amanda Jayne Carr
    Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 4:e8152. 2009
  4. pmc The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide
    Amanda Jayne Carr
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, UK
    Mol Vis 17:1701-15. 2011
  5. doi request reprint Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19
    Ahmad Ahmado
    Department of Ocular Biology and Therapeutics, University College London UCL, Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:7148-59. 2011
  6. doi request reprint Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation
    Anthony Vugler
    Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Exp Neurol 214:347-61. 2008
  7. doi request reprint Degeneration of cortical function in the Royal College of Surgeons rat
    Carlos Gias
    Institute of Ophthalmology, University College London, 11 43 Bath Street, EC1V 9EL London, UK
    Vision Res 51:2176-85. 2011

Detail Information

Publications7

  1. doi request reprint Development of human embryonic stem cell therapies for age-related macular degeneration
    Amanda Jayne F Carr
    The London Project to Cure Blindness, Division of Orbit, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Trends Neurosci 36:385-95. 2013
    ..We discuss the various methods used to differentiate and purify RPE from human embryonic stem cells (HESC), and describe the surgical approaches being used to transplant these cells in existing and forthcoming clinical trials. ..
  2. pmc Molecular characterization and functional analysis of phagocytosis by human embryonic stem cell-derived RPE cells using a novel human retinal assay
    Amanda Jayne Carr
    Institute of Ophthalmology, University College London, London, UK
    Mol Vis 15:283-95. 2009
    ....
  3. pmc Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat
    Amanda Jayne Carr
    Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, London, United Kingdom
    PLoS ONE 4:e8152. 2009
    ..These findings have identified an alternative source of replacement tissue for use in human retinal cellular therapies, and provide a new in vitro cellular model system in which to study RPE diseases affecting human patients...
  4. pmc The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide
    Amanda Jayne Carr
    Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, UK
    Mol Vis 17:1701-15. 2011
    ..Here we assess whether fenretinide can induce a neuroretinal cell phenotype in ARPE-19 cells, by examining retinal cell marker expression...
  5. doi request reprint Induction of differentiation by pyruvate and DMEM in the human retinal pigment epithelium cell line ARPE-19
    Ahmad Ahmado
    Department of Ocular Biology and Therapeutics, University College London UCL, Institute of Ophthalmology, London, United Kingdom
    Invest Ophthalmol Vis Sci 52:7148-59. 2011
    ..The purpose of this study was to examine how this sensitive phenotype of ARPE-19 can be modulated by growth media with or without the metabolite pyruvate to elucidate better RPE growth conditions...
  6. doi request reprint Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation
    Anthony Vugler
    Department of Ocular Biology and Therapeutics, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Exp Neurol 214:347-61. 2008
    ..The presence of rhodopsin-positive material within grafted HESC-RPE indicates that in the future, homogenous transplants of this cell type may be capable of supporting visual function following retinal dystrophy...
  7. doi request reprint Degeneration of cortical function in the Royal College of Surgeons rat
    Carlos Gias
    Institute of Ophthalmology, University College London, 11 43 Bath Street, EC1V 9EL London, UK
    Vision Res 51:2176-85. 2011
    ..These results show that degeneration in the cortical response of the RCS rat starts before development has been properly completed...