- Cognitive change and the APOE epsilon 4 alleleIan J Deary
Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, UK
Nature 418:932. 2002..This effect of the APOE epsilon 4 allele on normal cognitive ageing may be mediated by a mechanism that is at least partly independent of its predisposing effect towards Alzheimer's disease...
- A polygenic basis for late-onset diseaseAlan Wright
MRC Human Genetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
Trends Genet 19:97-106. 2003..The origin and nature of this variation suggests that current strategies are poorly suited to identifying genes involved in many complex diseases...