Mar Carmena

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint Cytokinesis: the final stop for the chromosomal passengers
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Biochem Soc Trans 36:367-70. 2008
  2. pmc Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King s Buildings, Edinburgh, Scotland, UK
    Curr Opin Cell Biol 21:796-805. 2009
  3. pmc Flies stretch their cells to avoid a chromatin trap
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR Edinburgh, Scotland, UK
    J Cell Biol 199:719-21. 2012
  4. pmc The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, ICB Michael Swann Building, King s Buildings Mayfield Road, Edinburgh EH9 3JR Scotland, UK
    Nat Rev Mol Cell Biol 13:789-803. 2012
  5. pmc The chromosomal passenger complex activates Polo kinase at centromeres
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS Biol 10:e1001250. 2012
  6. ncbi request reprint The cellular geography of aurora kinases
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, Kings Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    Nat Rev Mol Cell Biol 4:842-54. 2003
  7. ncbi request reprint Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system
    Chih Jui Chang
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK
    J Cell Sci 119:1144-53. 2006
  8. ncbi request reprint RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate
    Chih Jui Chang
    Wellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, Kings Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Sci 116:4715-26. 2003
  9. ncbi request reprint The chromosomal passenger complex: one for all and all for one
    Sandrine Ruchaud
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
    Cell 131:230-1. 2007
  10. pmc Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis
    Nathalie Colombié
    Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK
    Development 135:3239-46. 2008

Collaborators

Detail Information

Publications18

  1. doi request reprint Cytokinesis: the final stop for the chromosomal passengers
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Biochem Soc Trans 36:367-70. 2008
    ..The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned since then about the role of the CPC in the late stages of mitosis and cytokinesis...
  2. pmc Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King s Buildings, Edinburgh, Scotland, UK
    Curr Opin Cell Biol 21:796-805. 2009
    ..This review will focus on how interacting proteins make this functional diversity possible by targeting the kinases to different subcellular locations and regulating their activity...
  3. pmc Flies stretch their cells to avoid a chromatin trap
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR Edinburgh, Scotland, UK
    J Cell Biol 199:719-21. 2012
    ..http://dx.doi.org/jcb.201208041) show that in Drosophila melanogaster, larval neuroblasts elongate to allow segregation of extra-long chromatids and clearance of the midzone, thereby avoiding cytokinesis failure and aneuploidy...
  4. pmc The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, ICB Michael Swann Building, King s Buildings Mayfield Road, Edinburgh EH9 3JR Scotland, UK
    Nat Rev Mol Cell Biol 13:789-803. 2012
    ..Our growing understanding of the CPC has seen it develop from a mere passenger riding on the chromosomes to one of the main controllers of mitosis...
  5. pmc The chromosomal passenger complex activates Polo kinase at centromeres
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, Scotland, United Kingdom
    PLoS Biol 10:e1001250. 2012
    ..This crosstalk may enable Polo and Aurora B to achieve a balance wherein microtubule mis-attachments are corrected, but proper attachments are stabilized allowing proper chromosome segregation...
  6. ncbi request reprint The cellular geography of aurora kinases
    Mar Carmena
    Wellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, Kings Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    Nat Rev Mol Cell Biol 4:842-54. 2003
  7. ncbi request reprint Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system
    Chih Jui Chang
    Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK
    J Cell Sci 119:1144-53. 2006
    ..In addition, the segregation of the cell-fate determinant Prospero in asymmetric neuroblast division is abnormal, suggesting a role for the chromosomal passenger complex in the regulation of this process...
  8. ncbi request reprint RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate
    Chih Jui Chang
    Wellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, Kings Buildings, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Sci 116:4715-26. 2003
    ..This is not kinetochore-based movement, as the centromere of the affected chromosome is located on the plate. This observation raises the possibility that further unexpected functions for Topo II may remain to be discovered...
  9. ncbi request reprint The chromosomal passenger complex: one for all and all for one
    Sandrine Ruchaud
    Wellcome Trust Centre for Cell Biology, Institute of Cell Biology, University of Edinburgh, Mayfield Road, Edinburgh EH9 3JR, UK
    Cell 131:230-1. 2007
    ..2007) report the crystal structure of the regulatory subunit complex and reveal how interactions between these proteins promote the targeting and function of the chromosomal passenger complex during mitosis...
  10. pmc Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis
    Nathalie Colombié
    Wellcome Trust Centre for Cell Biology, The University of Edinburgh, Edinburgh, UK
    Development 135:3239-46. 2008
    ..We propose that the two functions of Incenp are part of the mechanisms that compensate for the lack of centrosomes during meiotic spindle formation...
  11. ncbi request reprint Chromosomal passengers: conducting cell division
    Sandrine Ruchaud
    Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, Edinburgh, EH9 3JR, UK
    Nat Rev Mol Cell Biol 8:798-812. 2007
    ....
  12. ncbi request reprint Survivin is required for stable checkpoint activation in taxol-treated HeLa cells
    Ana Carvalho
    Chromosome Structure Group, Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, Scotland, UK
    J Cell Sci 116:2987-98. 2003
    ..However, Survivin is required for the maintenance of the checkpoint when it is activated by taxol, which is generally thought to cause a loss of spindle tension...
  13. pmc A perfect funeral with no corpse
    William C Earnshaw
    Wellcome Trust Centre for Cell Biology, Institute for Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    J Cell Biol 160:989-90. 2003
    ..quot; (Mazia, 1961)..
  14. pmc Abscission checkpoint control: stuck in the middle with Aurora B
    Mar Carmena
    The Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Open Biol 2:120095. 2012
    ..Recent work has started to shed some light on the molecular mechanism by which the CPC controls the timing of abscission...
  15. ncbi request reprint INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila
    Tamar D Resnick
    Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Dev Cell 11:57-68. 2006
    ..These results implicate the chromosomal passenger complex in directly regulating MEI-S332 localization and, therefore, the control of sister chromatid cohesion in meiosis...
  16. pmc MAST/Orbit has a role in microtubule-kinetochore attachment and is essential for chromosome alignment and maintenance of spindle bipolarity
    Helder Maiato
    Instituto de Ciencias Biomedicas de Abel Salazar, Instituto de Biologia Molecular e Celular, Universidade do Porto, 4150 180, Portugal
    J Cell Biol 157:749-60. 2002
    ..Together, these results strongly support the conclusion that MAST/Orbit is required for microtubules to form functional attachments to kinetochores and to maintain spindle bipolarity...
  17. ncbi request reprint INCENP at the kinase crossroads
    Mar Carmena
    Nat Cell Biol 8:110-1. 2006
  18. ncbi request reprint Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis
    María Teresa Parra
    Departamento de Biologia, Edificio de Biológicas, Universidad Autonoma de Madrid, E 28049 Madrid, Spain
    J Cell Sci 116:961-74. 2003
    ..We discuss the complex dynamic relocalization of the chromosomal passenger complex during prophase I. Additionally, we suggest that this complex may regulate sister-chromatid centromere cohesion during both meiotic divisions...