Celine Cano

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity
    Celine Cano
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom
    J Med Chem 56:6386-401. 2013
  2. doi request reprint Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK)
    Celine Cano
    Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, United KingdomNE1 7RU
    Org Biomol Chem 8:1922-8. 2010
  3. doi request reprint DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype
    Celine Cano
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, UK
    J Med Chem 53:8498-507. 2010
  4. doi request reprint Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives
    Kate M Clapham
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK
    Org Biomol Chem 10:6747-57. 2012
  5. doi request reprint Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors
    Sara L Payne
    Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK
    Bioorg Med Chem Lett 20:3649-53. 2010
  6. pmc Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K
    Joanne M Munck
    Medical School, Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Cancer Ther 11:1789-98. 2012
  7. doi request reprint Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure
    Sonsoles Rodriguez-Aristegui
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, United Kingdom NE1 7RU
    Org Biomol Chem 9:6066-74. 2011
  8. doi request reprint DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain
    Kate M Clapham
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, United Kingdom
    Bioorg Med Chem Lett 21:966-70. 2011
  9. doi request reprint Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors
    Francesco Marchetti
    Northern Institute for Cancer Research, Bedson Building, Newcastle University, Newcastle upon Tyne, UK NE1 7RU
    Org Biomol Chem 8:2397-407. 2010
  10. doi request reprint Trifluoroacetic Acid in 2,2,2-Trifluoroethanol Facilitates SN Ar Reactions of Heterocycles with Arylamines
    Benoit Carbain
    Newcastle Cancer Centre, Northern Institute for Cancer Research, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU UK
    Chemistry 20:2311-7. 2014

Collaborators

  • Ian R Hardcastle
  • Bernard T Golding
  • Nicola J Curtin
  • David R Newell
  • Keith A Menear
  • Yan Zhao
  • Francesco Marchetti
  • M Raymond V Finlay
  • Xiao ling Cockcroft
  • Roger J Griffin
  • Honorine Lebraud
  • Kate M Clapham
  • Benoit Carbain
  • Julia Bardos
  • Michele Tavecchio
  • Joanne M Munck
  • Sonsoles Rodriguez-Aristegui
  • Sara L Payne
  • Marine Desage-El Murr
  • Christopher J Matheson
  • David M Turner
  • Christopher R Coxon
  • Ross W Harrington
  • Pia Thommes
  • Attilla Ting
  • Tommy Rennison
  • Graeme C M Smith
  • Caroline Richardson
  • Elisa Meschini
  • Ulrich Baisch
  • Kristopher J Elliott
  • Christopher Wong
  • Amy R Roberts
  • Carlo M Bawn
  • Victoria S Archard
  • Liam Cornell
  • Helen Jenkins
  • Gavin Jones
  • Karen Haggerty
  • Jody Barbeau
  • Andrew Slade
  • Michael A Batey
  • Faye Craven
  • Niall M B Martin
  • Caroline J Richardson
  • Lauren Barrett
  • Gail L Young
  • Edward J Griffen
  • Paul Turner
  • Marcus Peacock
  • Nahida Parveen
  • Mark Frigerio
  • Marc Hummersome

Detail Information

Publications14

  1. doi request reprint 1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity
    Celine Cano
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom
    J Med Chem 56:6386-401. 2013
    ..Counter-screening against other members of the phosphatidylinositol 3-kinase (PI-3K) related kinase (PIKK) family unexpectedly revealed that some of the compounds were potent mixed DNA-PK and PI-3K inhibitors...
  2. doi request reprint Atropisomeric 8-arylchromen-4-ones exhibit enantioselective inhibition of the DNA-dependent protein kinase (DNA-PK)
    Celine Cano
    Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, United KingdomNE1 7RU
    Org Biomol Chem 8:1922-8. 2010
    ..Biological evaluation against DNA-PK of the pairs of atropisomers showed a marked difference in potency, with only one enantiomer being biologically active...
  3. doi request reprint DNA-dependent protein kinase (DNA-PK) inhibitors. Synthesis and biological activity of quinolin-4-one and pyridopyrimidin-4-one surrogates for the chromen-4-one chemotype
    Celine Cano
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, UK
    J Med Chem 53:8498-507. 2010
    ....
  4. doi request reprint Potent enantioselective inhibition of DNA-dependent protein kinase (DNA-PK) by atropisomeric chromenone derivatives
    Kate M Clapham
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK
    Org Biomol Chem 10:6747-57. 2012
    ..Biological evaluation against DNA-PK of each pair of atropisomers showed a marked difference in potency, with biological activity residing exclusively in the laevorotatory enantiomer...
  5. doi request reprint Mapping the ATP-binding domain of DNA-dependent protein kinase (DNA-PK) with coumarin- and isocoumarin-derived inhibitors
    Sara L Payne
    Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, UK
    Bioorg Med Chem Lett 20:3649-53. 2010
    ..Structure-activity relationships for DNA-PK inhibition were broadly consistent, albeit with a reduction of potency compared with the parent chromenone...
  6. pmc Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K
    Joanne M Munck
    Medical School, Northern Institute for Cancer Research, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Mol Cancer Ther 11:1789-98. 2012
    ..5-fold, without exacerbating etoposide toxicity to unacceptable levels. The proof-of-principle in vitro and in vivo chemosensitization with KU-0060648 justifies further evaluation of dual DNA-PK and PI-3K inhibitors...
  7. doi request reprint Versatile synthesis of functionalised dibenzothiophenes via Suzuki coupling and microwave-assisted ring closure
    Sonsoles Rodriguez-Aristegui
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, United Kingdom NE1 7RU
    Org Biomol Chem 9:6066-74. 2011
    ..The data indicate permissive elaboration of hydroxyl at C-8 or C-9, enabling the possibility of improved pharmaceutical properties, whilst retaining potency against DNA-PK...
  8. doi request reprint DNA-dependent protein kinase (DNA-PK) inhibitors: structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain
    Kate M Clapham
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Newcastle University, Newcastle upon Tyne, United Kingdom
    Bioorg Med Chem Lett 21:966-70. 2011
    ....
  9. doi request reprint Synthesis and biological evaluation of 5-substituted O4-alkylpyrimidines as CDK2 inhibitors
    Francesco Marchetti
    Northern Institute for Cancer Research, Bedson Building, Newcastle University, Newcastle upon Tyne, UK NE1 7RU
    Org Biomol Chem 8:2397-407. 2010
    ..4 nM). The 5-formyl derivatives show selectivity for CDK2 over other CDK family members, and are growth inhibitory in tumour cells (e.g. 22j, GI(50) = 0.57 microM)...
  10. doi request reprint Trifluoroacetic Acid in 2,2,2-Trifluoroethanol Facilitates SN Ar Reactions of Heterocycles with Arylamines
    Benoit Carbain
    Newcastle Cancer Centre, Northern Institute for Cancer Research, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU UK
    Chemistry 20:2311-7. 2014
    ..Reactions can be performed with either conventional heating or microwave irradiation, with the latter often giving improved yields. ..
  11. doi request reprint Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
    Michele Tavecchio
    Northern Institute for Cancer Research, School of Medical Sciences, Newcastle University, Paul O Gorman Building, Framlington Place, NE2 4HH Newcastle upon Tyne, UK
    Cancer Chemother Pharmacol 69:155-64. 2012
    ..One promising target is DNA-PK, a pivotal kinase in double-strand break repair. The purpose of this study was to further characterise the activity of the DNA-PK inhibitor NU7441, giving some new insights into the biology of DNA-PK...
  12. doi request reprint 8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)
    Marine Desage-El Murr
    Northern Institute for Cancer Research, School of Natural Sciences Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne NE1 7RU, UK
    Bioorg Med Chem Lett 18:4885-90. 2008
    ....
  13. doi request reprint Trifluoroethanol solvent facilitates selective N-7 methylation of purines
    Honorine Lebraud
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom
    Org Biomol Chem 11:1874-8. 2013
    ..Subjecting the resulting cationic species to microwave irradiation releases an N(7)-methyl- or ethyl-purine. This one-pot procedure is an efficient regiospecific method applicable to diverse substrates...
  14. doi request reprint Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles
    Honorine Lebraud
    Newcastle Cancer Centre, Northern Institute for Cancer Research, School of Chemistry, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK
    Org Biomol Chem 12:141-8. 2014
    ..The results of this study indicate heterocyclic scaffolds that are likely to be more promising for inhibition of Nek2 and other kinases containing a reactive cysteine. ..