- Glycosylation of PrPC determines timing of neuroinvasion and targeting in the brain following transmissible spongiform encephalopathy infection by a peripheral routeEnrico Cancellotti
The Roslin Institute and R D SVS University of Edinburgh, Roslin, Midlothian EH25 9PS, Scotland, United Kingdom
J Virol 84:3464-75. 2010..This demonstrates that targeting in the brain following peripheral inoculation is profoundly influenced by the glycosylation status of host PrP...
- Dramatic reduction of PrP C level and glycosylation in peripheral nerves following PrP knock-out from Schwann cells does not prevent transmissible spongiform encephalopathy neuroinvasionBarry M Bradford
The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9PS, United Kingdom
J Neurosci 29:15445-54. 2009..Thus, the myelinating glial cells within the PNS do not appear to play a significant role in TSE neuroinvasion...