K J Campbell

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro
    Sonia Rocha
    School of Life Sciences, Division of Gene Regulation and Expression MSI WTB, Complex Dow Street University of Dundee Dundee, DD1 5EH, Scotland, United Kingdom
    BMC Mol Biol 4:9. 2003
  2. ncbi request reprint Post-translational modification of RelA(p65) NF-kappaB
    K J Campbell
    Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem Soc Trans 32:1087-9. 2004
  3. pmc Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB, CoMPLEX, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
    BMC Cancer 6:101. 2006
  4. ncbi request reprint Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Cell 13:853-65. 2004
  5. ncbi request reprint UV stimulation induces nuclear factor kappaB (NF-kappaB) DNA-binding activity but not transcriptional activation
    K J Campbell
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem Soc Trans 29:688-91. 2001
  6. ncbi request reprint Reprogramming RelA
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dundee, Scotland
    Cell Cycle 3:869-72. 2004
  7. ncbi request reprint Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    Cancer Res 66:929-35. 2006
  8. ncbi request reprint p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor
    Sonia Rocha
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
    Mol Cell 12:15-25. 2003
  9. pmc Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
    Sonia Rocha
    School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK
    EMBO J 24:1157-69. 2005

Detail Information

Publications9

  1. pmc The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro
    Sonia Rocha
    School of Life Sciences, Division of Gene Regulation and Expression MSI WTB, Complex Dow Street University of Dundee Dundee, DD1 5EH, Scotland, United Kingdom
    BMC Mol Biol 4:9. 2003
    ..In addition, pifithrin-alpha provides a useful tool in the laboratory to investigate the function of p53 in model systems...
  2. ncbi request reprint Post-translational modification of RelA(p65) NF-kappaB
    K J Campbell
    Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem Soc Trans 32:1087-9. 2004
    ..These observations suggest that diagnosis and new therapies based on reprogramming NF-kappaB activity could be more efficient than total NF-kappaB inhibition...
  3. pmc Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitors
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB, CoMPLEX, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
    BMC Cancer 6:101. 2006
    ....
  4. ncbi request reprint Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Mol Cell 13:853-65. 2004
    ..This has important implications for the role of NF-kappa B in tumorigenesis and the use of NF-kappa B inhibitors in cancer therapy...
  5. ncbi request reprint UV stimulation induces nuclear factor kappaB (NF-kappaB) DNA-binding activity but not transcriptional activation
    K J Campbell
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem Soc Trans 29:688-91. 2001
    ....
  6. ncbi request reprint Reprogramming RelA
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dundee, Scotland
    Cell Cycle 3:869-72. 2004
    ..The identification of these pathways not only allows a reinterpretation of NF-kappaB function in normal cells and during tumorigenesis but could also have implications for both traditional and NF-kappaB based cancer therapy...
  7. ncbi request reprint Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivation
    Kirsteen J Campbell
    School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
    Cancer Res 66:929-35. 2006
    ..Moreover, our data indicate that at least with respect to RelA, cisplatin functions as an ARF mimic. Other drugs capable of mimicking this aspect of ARF function might therefore have therapeutic potential...
  8. ncbi request reprint p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor
    Sonia Rocha
    School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
    Mol Cell 12:15-25. 2003
    ..Further, we show that the response of NF-kappa B to the oncogene Bcr-Abl is determined by the ARF status of the cell. These results reveal an important function of ARF that can regulate the NF-kappa B response to oncogene activation...
  9. pmc Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
    Sonia Rocha
    School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK
    EMBO J 24:1157-69. 2005
    ..Moreover, this pathway provides a mechanism through which ARF can remodel the cellular response to an oncogenic challenge and execute its function as a tumour suppressor...