Research Topics
Genomes and GenesSpecies | Angus J M CameronSummaryAffiliation: University of Glasgow Country: UK Publications
|
Detail Information
Publications
Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIbAngus J M Cameron
Department of Medicine and Therapeutics, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Immunol Lett 83:171-9. 2002..These data define a role for FcgammaRIIb in the modulation of immune complex mediated macrophage activation in a human model system...
Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytesDianne Z Hillyard
Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G12 8QQ, UK
Atherosclerosis 172:219-28. 2004..Since many receptors utilise cholesterol rich rafts this mechanism may have broader significance given the pleiotropic effects of statins...
Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular diseaseDianne Z Hillyard
Renal Research Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Atherosclerosis 175:305-13. 2004..NK cells have been implicated in the pathogenesis of atherosclerosis, so the effect of statin therapy on NK cell cytotoxicity may contribute to the benefits of statins in cardiovascular disease...
Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathyKenneth J McDonald
Renal Unit, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, United Kingdom
Biochem Biophys Res Commun 290:438-42. 2002..These results suggest that Fcalpha/muR may be the receptor responsible for mesangial IgA deposition in IgA nephropathy...
Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylationDianne Z Hillyard
Renal Research Group, BHF Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom
Atherosclerosis 191:319-25. 2007..Moreover, there is likely to be a relationship between membrane cholesterol, membrane rafts and cell function that may be involved in the pathogenesis of cardiovascular and metabolic diseases...
Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatinDianne Z Hillyard
Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, UK
Clin Exp Pharmacol Physiol 29:673-8. 2002..7. These data suggest that the potential immunosuppressive actions of statins involve inhibition of subcellular pathways dependent on isoprenylation of signal peptides, including Ras, Rho and related G-proteins...
