Angus J M Cameron
Affiliation: University of Glasgow
- Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIbAngus J M Cameron
Department of Medicine and Therapeutics, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Immunol Lett 83:171-9. 2002..These data define a role for FcgammaRIIb in the modulation of immune complex mediated macrophage activation in a human model system...
- Fluvastatin inhibits raft dependent Fcgamma receptor signalling in human monocytesDianne Z Hillyard
Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Dumbarton Road, Glasgow G12 8QQ, UK
Atherosclerosis 172:219-28. 2004..Since many receptors utilise cholesterol rich rafts this mechanism may have broader significance given the pleiotropic effects of statins...
- Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular diseaseDianne Z Hillyard
Renal Research Group, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK
Atherosclerosis 175:305-13. 2004..NK cells have been implicated in the pathogenesis of atherosclerosis, so the effect of statin therapy on NK cell cytotoxicity may contribute to the benefits of statins in cardiovascular disease...
- Expression of Fc alpha/mu receptor by human mesangial cells: a candidate receptor for immune complex deposition in IgA nephropathyKenneth J McDonald
Renal Unit, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, Scotland, United Kingdom
Biochem Biophys Res Commun 290:438-42. 2002..These results suggest that Fcalpha/muR may be the receptor responsible for mesangial IgA deposition in IgA nephropathy...
- Statins inhibit NK cell cytotoxicity by membrane raft depletion rather than inhibition of isoprenylationDianne Z Hillyard
Renal Research Group, BHF Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, United Kingdom
Atherosclerosis 191:319-25. 2007..Moreover, there is likely to be a relationship between membrane cholesterol, membrane rafts and cell function that may be involved in the pathogenesis of cardiovascular and metabolic diseases...
- Inhibition of proliferation and signalling mechanisms in human lymphocytes by fluvastatinDianne Z Hillyard
Department of Medicine and Therapeutics, University of Glasgow, Western Infirmary, Glasgow, UK
Clin Exp Pharmacol Physiol 29:673-8. 2002..7. These data suggest that the potential immunosuppressive actions of statins involve inhibition of subcellular pathways dependent on isoprenylation of signal peptides, including Ras, Rho and related G-proteins...