Peter M A Calverley

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint COPD: early detection and intervention
    P M Calverley
    University Clinical Departments, University Hospital Aintree, Long Lane, Liverpool, United Kingdom
    Chest 117:365S-71S. 2000
  2. ncbi request reprint Chronic obstructive pulmonary disease
    P M A Calverley
    Department of Medicine, University of Liverpool, Liverpool, UK
    Lancet 362:1053-61. 2003
  3. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
  4. ncbi request reprint Dynamic hyperinflation: is it worth measuring?
    Peter M A Calverley
    School of Clinical Sciences, University Hospital Aintree, Liverpool, UK
    Proc Am Thorac Soc 3:239-44. 2006
  5. ncbi request reprint Respiratory failure in chronic obstructive pulmonary disease
    P M A Calverley
    Dept of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Eur Respir J Suppl 47:26s-30s. 2003
  6. doi request reprint Cardiovascular events in patients with COPD: TORCH study results
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Longmoor Lane, Liverpool, UK
    Thorax 65:719-25. 2010
  7. ncbi request reprint Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
    Peter M A Calverley
    School of Clinical Sciences, Liverpool, UK
    Lancet 374:685-94. 2009
  8. pmc Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol
    Peter M A Calverley
    Clinical Science Center, University Hospital Aintree, Liverpool, United Kingdom
    Int J Chron Obstruct Pulmon Dis 7:375-82. 2012
  9. pmc Chronic airflow limitation in a rural Indian population: etiology and relationship to body mass index
    Biswajit Chakrabarti
    Aintree Chest Centre, University Hospital Aintree, Liverpool, UK
    Int J Chron Obstruct Pulmon Dis 6:543-9. 2011
  10. ncbi request reprint Effect of corticosteroids on exacerbations of asthma and chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Clinical Sciences Centre, Longmoor Lane, Liverpool L9 7AL, UK
    Proc Am Thorac Soc 1:161-6. 2004

Detail Information

Publications36

  1. ncbi request reprint COPD: early detection and intervention
    P M Calverley
    University Clinical Departments, University Hospital Aintree, Long Lane, Liverpool, United Kingdom
    Chest 117:365S-71S. 2000
    ..In this article, some of the important concepts relevant to this process are considered, and some of the present techniques used to intervene in established COPD are reviewed...
  2. ncbi request reprint Chronic obstructive pulmonary disease
    P M A Calverley
    Department of Medicine, University of Liverpool, Liverpool, UK
    Lancet 362:1053-61. 2003
    ..Regular review of this guidance is important if future management advances are to be implemented effectively...
  3. pmc Efficacy of salmeterol/fluticasone propionate by GOLD stage of chronic obstructive pulmonary disease: analysis from the randomised, placebo-controlled TORCH study
    Christine R Jenkins
    Woolcock Institute of Medical Research, Sydney, Australia
    Respir Res 10:59. 2009
    ..However, there are only limited data about the influence of GOLD severity staging on the effectiveness of SFC, particularly in patients with milder disease...
  4. ncbi request reprint Dynamic hyperinflation: is it worth measuring?
    Peter M A Calverley
    School of Clinical Sciences, University Hospital Aintree, Liverpool, UK
    Proc Am Thorac Soc 3:239-44. 2006
    ....
  5. ncbi request reprint Respiratory failure in chronic obstructive pulmonary disease
    P M A Calverley
    Dept of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Eur Respir J Suppl 47:26s-30s. 2003
    ..More attention should be focused on the prevention of these episodes and identifying the factors which cause early relapse...
  6. doi request reprint Cardiovascular events in patients with COPD: TORCH study results
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Longmoor Lane, Liverpool, UK
    Thorax 65:719-25. 2010
    ....
  7. ncbi request reprint Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
    Peter M A Calverley
    School of Clinical Sciences, Liverpool, UK
    Lancet 374:685-94. 2009
    ..We therefore investigated whether roflumilast would reduce the frequency of exacerbations requiring corticosteroids in patients with COPD...
  8. pmc Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol
    Peter M A Calverley
    Clinical Science Center, University Hospital Aintree, Liverpool, United Kingdom
    Int J Chron Obstruct Pulmon Dis 7:375-82. 2012
    ..Roflumilast is approved to treat severe COPD in patients with chronic bronchitis--and a history of frequent exacerbations--as an add-on to bronchodilators...
  9. pmc Chronic airflow limitation in a rural Indian population: etiology and relationship to body mass index
    Biswajit Chakrabarti
    Aintree Chest Centre, University Hospital Aintree, Liverpool, UK
    Int J Chron Obstruct Pulmon Dis 6:543-9. 2011
    ..As such, this study aimed to explore factors associated with the development of airflow obstruction (AFO) in a rural Indian setting and, using spirometry, study whether underweight is linked to AFO...
  10. ncbi request reprint Effect of corticosteroids on exacerbations of asthma and chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Clinical Sciences Centre, Longmoor Lane, Liverpool L9 7AL, UK
    Proc Am Thorac Soc 1:161-6. 2004
    ..However, given the impact of exacerbations on overall quality of life in COPD, even this modest reduction is likely to be clinically important...
  11. ncbi request reprint Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease
    Peter M A Calverley
    University Hospital Aintree, Liverpool, United Kingdom
    N Engl J Med 356:775-89. 2007
    ..Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is unknown...
  12. ncbi request reprint Lung function changes following methacholine inhalation in COPD
    Paul P Walker
    Division of Infection and Immunity, School of Clinical Sciences, University of Liverpool, University Hospital Aintree, Liverpool, UK
    Respir Med 103:535-41. 2009
    ....
  13. ncbi request reprint The volumetric response to bronchodilators in stable chronic obstructive pulmonary disease
    Paul P Walker
    Division of Infection and Immunity, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    COPD 5:147-52. 2008
    ..We suggest that post-bronchodilator absolute change in FVC provides important additional physiological information when interpreting bronchodilator reversibility testing...
  14. ncbi request reprint Effect of 1-year treatment with roflumilast in severe chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, Clinical Sciences, University Hospital Aintree, Liverpool L97AL, UK
    Am J Respir Crit Care Med 176:154-61. 2007
    ..Whether treatment is effective in more severe COPD (GOLD [Global Initiative for Chronic Obstructive Lung Disease] stages III and IV) over a longer period is unknown...
  15. doi request reprint Reported pneumonia in patients with COPD: findings from the INSPIRE study
    Peter M A Calverley
    Clinical Science Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, England
    Chest 139:505-12. 2011
    ..We investigated patient characteristics and symptoms occurring before pneumonia reports in the Investigating New Standards for Prophylaxis in Reduction of Exacerbations (INSPIRE) study...
  16. ncbi request reprint Airway wall thickening and emphysema show independent familial aggregation in chronic obstructive pulmonary disease
    Bipen D Patel
    Department of Medicine, University of Cambridge, Cambridge, UK
    Am J Respir Crit Care Med 178:500-5. 2008
    ..It is unclear whether airway wall thickening and emphysema make independent contributions to airflow limitation in chronic obstructive pulmonary disease (COPD) and whether these phenotypes cluster within families...
  17. ncbi request reprint Reducing the frequency and severity of exacerbations of chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Clinical Sciences Centre, Longmoor Lane, Liverpool L9 7AL, UK
    Proc Am Thorac Soc 1:121-4. 2004
    ..Health status changes mirrored these effects. In summary, combination therapy can effectively prevent exacerbations in patients with more advanced COPD...
  18. ncbi request reprint Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease
    Nicola J Stevenson
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Am J Respir Crit Care Med 172:1510-6. 2005
    ..Exacerbation of chronic obstructive pulmonary disease commonly causes hospitalization. The change in lung mechanics during exacerbation and its relationship to symptoms in spontaneously breathing individuals has not been described...
  19. ncbi request reprint What have we learned from large drug treatment trials in COPD?
    Peter M A Calverley
    Division of Infection and Immunity, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Lancet 370:774-85. 2007
    ..Ensuring that these expensive studies are done objectively to the highest standard is an important goal for the next decade...
  20. pmc One-year treatment with mometasone furoate in chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Liverpool, UK
    Respir Res 9:73. 2008
    ..031). MF-DPI treatment was well tolerated.Once-daily MF-DPI improved lung function and health status in subjects with moderate-to-severe COPD and was comparable to BID MF-DPI...
  21. ncbi request reprint The role of corticosteroids in chronic obstructive pulmonary disease
    Peter M A Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool L9 7AL, United Kingdom
    Semin Respir Crit Care Med 26:235-45. 2005
    ..Inhaled corticosteroids are not suitable for monotherapy in COPD but can be helpfully combined with an inhaled bronchodilator in patients with symptomatic disease...
  22. ncbi request reprint Minimal clinically important difference--exacerbations of COPD
    Peter M A Calverley
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    COPD 2:143-8. 2005
    ..Existing methodologies for estimating clinically important differences are hard to apply with a binary outcome like this, and more work will be needed to develop a robust approach for dealing with this important clinical variable...
  23. ncbi request reprint Development of a population-based screening questionnaire for COPD
    Peter M A Calverley
    University of Liverpool, Liverpool, L9 7AL, UK
    COPD 2:225-32. 2005
    ..Dissemination of such tools should raise awareness among at-risk persons and help identify COPD patients in the primary care setting...
  24. ncbi request reprint Is airway inflammation in chronic obstructive pulmonary disease (COPD) a risk factor for cardiovascular events?
    Peter M A Calverley
    Clinical Science Centre, University Hospital Aintree, Liverpool, UK
    COPD 3:233-42. 2006
    ..A large multicenter prospective randomized trial (Towards a Revolution in COPD Health [TORCH]) is now ongoing and will examine the effect of fluticasone propionate in combination with salmeterol on all-cause mortality...
  25. doi request reprint A study of patient attitudes in the United Kingdom toward ventilatory support in chronic obstructive pulmonary disease
    Biswajit Chakrabarti
    Clinical Sciences Centre, University of Liverpool, University Hospital Aintree, Liverpool, United Kingdom
    J Palliat Med 12:1029-35. 2009
    ....
  26. pmc Tuberculosis and its incidence, special nature, and relationship with chronic obstructive pulmonary disease
    Biswajit Chakrabarti
    Clinical Sciences Centre, University Hospital Aintree, Liverpool, UK
    Int J Chron Obstruct Pulmon Dis 2:263-72. 2007
    ..Patients diagnosed with TB may often have extensive co-morbidity such as COPD and the effect of an underlying diagnosis of COPD on outcomes in TB is also reviewed...
  27. ncbi request reprint Bronchodilator reversibility in chronic obstructive pulmonary disease: use and limitations
    Peter M A Calverley
    School of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK Aintree Chest Centre, University Hospital Aintree, Liverpool, UK Electronic address
    Lancet Respir Med 1:564-73. 2013
    ..In this Review we will discuss the insight that studies of bronchodilator reversibility have provided into the nature of the COPD, and how the abnormal physiology seen in patients with this disorder can be interpreted. ..
  28. ncbi request reprint Withdrawal from treatment as an outcome in the ISOLDE study of COPD
    Peter M A Calverley
    Department of Medicine, University Hospital Aintree, Liverpool, United Kingdom
    Chest 124:1350-6. 2003
    ..To investigate the determinants of patient withdrawal from our study, and the effect of these withdrawals on the outcome of treatment with inhaled corticosteroids in patients with COPD...
  29. doi request reprint Effect of pharmacotherapy on rate of decline of lung function in chronic obstructive pulmonary disease: results from the TORCH study
    Bartolome R Celli
    Tufts University School of Medicine, Pulmonary and Critical Care Division, Caritas St Elizabeth s Medical Center, Boston, MA 02135 2997, USA
    Am J Respir Crit Care Med 178:332-8. 2008
    ..Chronic obstructive pulmonary disease (COPD) is characterized by an accelerated decline in lung function. No drug has been shown conclusively to reduce this decline...
  30. ncbi request reprint The GOLD classification has advanced understanding of COPD
    Peter M A Calverley
    Am J Respir Crit Care Med 170:211-2; discussion 214. 2004
  31. ncbi request reprint Proposal for a multidimensional staging system for chronic obstructive pulmonary disease
    Bartolome R Celli
    Department of Pulmonary and Critical Care Medicine, Tufts University, Boston, MA 02135, USA
    Respir Med 99:1546-54. 2005
    ..Although the staging boundaries were based on existing literature, they have proven useful in predicting survival. We conclude that a multidimensional grading system is useful to assess the impact of COPD...
  32. ncbi request reprint The effect of bronchodilators and oxygen alone and in combination on self-paced exercise performance in stable COPD
    Alberto Cukier
    Pulmonary Division, Heart Institute InCor, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Respir Med 101:746-53. 2007
    ..Clinically relevant improvement is possible when therapies with a different mechanism of action are combined...
  33. ncbi request reprint The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, London, UK
    Am J Respir Crit Care Med 177:19-26. 2008
    ..Exacerbations are key drivers of morbidity and mortality in chronic obstructive pulmonary disease (COPD)...
  34. pmc Spirometry in chronic obstructive pulmonary disease
    Patrick J P Poels
    BMJ 333:870-1. 2006
  35. pmc Pathological networking: a new approach to understanding COPD
    Ian Sabroe
    Academic Unit of Respiratory Medicine, L Floor, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Thorax 62:733-8. 2007
    ....
  36. ncbi request reprint A 1-year prospective cost-effectiveness analysis of roflumilast for the treatment of patients with severe chronic obstructive pulmonary disease
    Maureen P M H Rutten-van Mölken
    Institute for Medical Technology Assessment, Erasmus MC, Rotterdam, The Netherlands
    Pharmacoeconomics 25:695-711. 2007
    ..This study investigated the cost effectiveness of roflumilast in patients with severe to very severe COPD from the perspective of the UK society and UK NHS...