M A Caldwell

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells
    Joseph C Lim
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res 1159:67-76. 2007
  2. pmc Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage
    Padraig M Strappe
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Retrovirology 2:55. 2005
  3. ncbi request reprint 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro
    Maeve A Caldwell
    Centre for Brain Repair and Department of Clinical Neurosciences, Cambridge University Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Eur J Neurosci 22:2965-70. 2005
  4. ncbi request reprint Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells
    M A Caldwell
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, Robinson Way, Cambridge, CB2 2PY, England
    Exp Neurol 152:1-10. 1998
  5. ncbi request reprint Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF
    Maeve A Caldwell
    Centre for Brain Repair, Cambridge University Forvie Site, Robinson Way, CB2 2PY, UK
    Exp Neurol 188:408-20. 2004
  6. ncbi request reprint Growth factors regulate the survival and fate of cells derived from human neurospheres
    M A Caldwell
    MRC Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Nat Biotechnol 19:475-9. 2001
  7. ncbi request reprint Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease
    C N Svendsen
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, United Kingdom
    Exp Neurol 148:135-46. 1997
  8. ncbi request reprint Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
    T Ostenfeld
    MRC Centre for Brain Repair, University of Cambridge, United Kingdom
    Exp Neurol 164:215-26. 2000
  9. ncbi request reprint A new method for the rapid and long term growth of human neural precursor cells
    C N Svendsen
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, Robinson Way, UK
    J Neurosci Methods 85:141-52. 1998
  10. ncbi request reprint Human neural stem cells: isolation, expansion and transplantation
    C N Svendsen
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Pathol 9:499-513. 1999

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells
    Joseph C Lim
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res 1159:67-76. 2007
    ..Similar increases were observed in co-culture with astrocytes. These results suggest that undifferentiated NPCs produce factors that influence Pgp expression whereas their progeny also affect tight junction integrity...
  2. pmc Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage
    Padraig M Strappe
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Retrovirology 2:55. 2005
    ..Cross-packaged vectors expressing GFP were assessed for RNA packaging, viral vector titre and their ability to transduce rat primary glial cell cultures and human neural stem cells...
  3. ncbi request reprint 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro
    Maeve A Caldwell
    Centre for Brain Repair and Department of Clinical Neurosciences, Cambridge University Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Eur J Neurosci 22:2965-70. 2005
    ..Our results show that high levels of BrdU are selectively toxic to neurons through a mechanism that activates classical cell death pathways. This has implications for labelling studies both in vivo and in vitro...
  4. ncbi request reprint Heparin, but not other proteoglycans potentiates the mitogenic effects of FGF-2 on mesencephalic precursor cells
    M A Caldwell
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, Robinson Way, Cambridge, CB2 2PY, England
    Exp Neurol 152:1-10. 1998
    ..We conclude that heparin, but not other closely related proteoglycans, is vital for the growth of FGF-2-responsive mesencephalic neural precursors...
  5. ncbi request reprint Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF
    Maeve A Caldwell
    Centre for Brain Repair, Cambridge University Forvie Site, Robinson Way, CB2 2PY, UK
    Exp Neurol 188:408-20. 2004
    ....
  6. ncbi request reprint Growth factors regulate the survival and fate of cells derived from human neurospheres
    M A Caldwell
    MRC Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Nat Biotechnol 19:475-9. 2001
    ..These should be useful for both neuroactive drug screening in vitro and possibly cell therapy for neurodegenerative diseases...
  7. ncbi request reprint Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease
    C N Svendsen
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, United Kingdom
    Exp Neurol 148:135-46. 1997
    ..As such these cells may have potential for development as an alternative source of tissue for neural transplantation in degenerative diseases...
  8. ncbi request reprint Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantation
    T Ostenfeld
    MRC Centre for Brain Repair, University of Cambridge, United Kingdom
    Exp Neurol 164:215-26. 2000
    ....
  9. ncbi request reprint A new method for the rapid and long term growth of human neural precursor cells
    C N Svendsen
    MRC Cambridge Centre for Brain Repair, Cambridge University Forvie Site, Robinson Way, UK
    J Neurosci Methods 85:141-52. 1998
    ..This simple and novel culture method allows the rapid expansion of large numbers of non-transformed human neural precursor cells which may be of use in drug discovery, ex vivo gene therapy and clinical neural transplantation...
  10. ncbi request reprint Human neural stem cells: isolation, expansion and transplantation
    C N Svendsen
    MRC Cambridge Centre for Brain Repair, University of Cambridge, UK
    Brain Pathol 9:499-513. 1999
    ..This review summarises this fascinating and growing field of neurobiology, with a particular focus on human tissues...
  11. ncbi request reprint Astrocytes promote neurogenesis from oligodendrocyte precursor cells
    P M Gaughwin
    Department of Clinical Neurosciences and Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Eur J Neurosci 23:945-56. 2006
    ..The present findings show that hippocampal, astrocyte-derived signals can induce the neuronal differentiation of OPCs through a Noggin-independent mechanism...
  12. ncbi request reprint Improving the survival of human CNS precursor-derived neurons after transplantation
    J E Le Belle
    Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    J Neurosci Res 76:174-83. 2004
    ..Undifferentiated HNPCs migrated more widely in the brain after grafting than did the predifferentiated cells, which generally remained within the hippocampus...
  13. ncbi request reprint Antioxidant strategy to counteract the side effects of antipsychotic therapy: an in vivo study in rats
    L Besret
    Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Eur J Pharmacol 408:35-9. 2000
    ..Moreover, the current study has shown the effect of the antioxidant vitamin C in protecting haloperidol effects on tyrosine hydroxylase-immunostaining...
  14. pmc Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation
    Haydn M Prosser
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Eur J Neurosci 26:3339-44. 2007
    ..Together, these findings suggest an important role for Prokr2 in OB neurogenesis...
  15. ncbi request reprint Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells
    Perrine Barraud
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    Eur J Neurosci 26:3345-57. 2007
    ..In contrast, EGF appears to be primarily a survival factor for both the olfactory stem and precursor cells...
  16. doi request reprint Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease
    Fiona E O'Keeffe
    Cambridge Center for Brain Repair and Department of Clinical Neurosciences, Forvie Site, Robinsons Way, Cambridge CB2 2PY, UK
    Brain 131:630-41. 2008
    ..This demonstrates that given the correct signals, NSCs can be induced to become dopaminergic neurons that can differentiate into the correct nigrastriatal phenotype required for the treatment of Parkinson's disease...
  17. pmc Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures
    Perrine Barraud
    Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK
    BMC Neurosci 9:24. 2008
    ..However, olfactory stem and progenitor cells expand very slowly when grown as free-floating spheres (olfactory-spheres) under growth factor stimulation in a neurosphere assay...
  18. ncbi request reprint Patterns of laminins and integrins in the embryonic ventricular zone of the CNS
    Justin D Lathia
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Comp Neurol 505:630-43. 2007
    ....
  19. ncbi request reprint Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease
    Lucy Anderson
    Centre for Brain Repair and Department of Clinical Neurosciences, University Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Neurobiol Dis 27:133-40. 2007
    ..This suggests that even in the absence of cell replacement strategies utilising immature progenitor cells could be of real therapeutic value...
  20. ncbi request reprint Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells
    Alexis J Joannides
    Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
    Brain 130:1263-75. 2007
    ..Controlled manipulation of environmental signals appropriate to the pathological specificity of the targeted disease will be necessary in the design of therapeutic stem cell-based strategies...
  21. ncbi request reprint Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo
    Lucy Anderson
    Centre for Brain Repair and Department of Clinical Neurosciences, University Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Exp Neurol 204:512-24. 2007
    ..Array analysis confirms that following extensive time in culture cells are entering growth arrest with fundamental expression changes in genes associated with cell cycle regulation, apoptosis and immune functions...
  22. ncbi request reprint Integrins are markers of human neural stem cells
    Peter E Hall
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, United Kingdom
    Stem Cells 24:2078-84. 2006
    ..Therefore, integrin subunits alpha6 and beta1 are highly expressed by human neural precursors and represent convenient markers for their prospective isolation...
  23. ncbi request reprint Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease
    Rowan M Burnstein
    Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK
    Int J Biochem Cell Biol 36:702-13. 2004
    ..There was no significant behavioural recovery or effect of transplanted HNPCs on the loss of dopaminergic cells from the host brain. In conclusion, HNPCs may provide a source of cells for use in the treatment of Parkinson's disease...
  24. ncbi request reprint Modern therapeutic approaches in Parkinson's disease
    Simon J G Lewis
    Cambridge Centre for Brain Repair, Forvie Site, Robinson Way, Cambridge, CB2 2PY, UK
    Expert Rev Mol Med 5:1-20. 2003
    ..In this review, we discuss the emerging new therapies in PD in terms of neuroprotective agents, drugs designed to control symptoms more effectively, and finally curative cell therapies...
  25. ncbi request reprint Gene expression in human neural stem cells: effects of leukemia inhibitory factor
    Lynda S Wright
    The Waisman Center Stem Cell Research Program and Department of Anatomy, University of Wisconsin, 53705, USA
    J Neurochem 86:179-95. 2003
    ..This study provides the first molecular profile of human ltNSCctx cultures capable of long-term self renewal, and reveals specific sets of genes that are directly or indirectly regulated by LIF...
  26. ncbi request reprint Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
    Sabine Bahn
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK
    Lancet 359:310-5. 2002
    ..We did a study to investigate abnormalities in gene expression in human neuronal stem cells and progenitor cells from Down's syndrome and control post-mortem human fetal tissue...
  27. pmc Laminin enhances the growth of human neural stem cells in defined culture media
    Peter E Hall
    Department of Pathology, University of Cambridge, Cambridge, UK
    BMC Neurosci 9:71. 2008
    ..A common feature of niches is the presence of the extracellular matrix molecule, laminin. Therefore, this study investigated the effect of exogenous laminin on hNSC growth...
  28. pmc Neurodegeneration and cell replacement
    Brandi K Ormerod
    Department of Neurosurgery, Stanford University, 300 Pasteur Drive, Boswell Building, A301, Stanford, CA 94305 5327, USA
    Philos Trans R Soc Lond B Biol Sci 363:153-70. 2008
    ....