Affiliation: University of Dundee
- Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophagesM Caivano
Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, United Kingdom
J Immunol 164:3018-25. 2000..They also suggest that MSK1 and MSK2 may play a role in these processes and hence are potential targets for the development of novel antiinflammatory drugs...
- The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factorsM Caivano
Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland
J Biol Chem 276:48693-701. 2001..Taken together, these data identify CREB, NF-kappa B, and both C/EBP beta and -delta as key factors in coordinately orchestrating transcription from the COX-2 promoter in activated macrophages...
- The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblastsB Gorgoni
School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
J Biol Chem 276:40769-77. 2001..In contrast, COX-2 induction was completely normal in C/EBPbeta-deficient fibroblasts, thus highlighting the diversity of cell-specific molecular mechanisms in determining inducible COX-2 expression and prostaglandins production...