M Caivano

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi request reprint Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages
    M Caivano
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, United Kingdom
    J Immunol 164:3018-25. 2000
  2. ncbi request reprint The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors
    M Caivano
    Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland
    J Biol Chem 276:48693-701. 2001
  3. ncbi request reprint The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts
    B Gorgoni
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 276:40769-77. 2001

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages
    M Caivano
    Medical Research Council Protein Phosphorylation Unit, Department of Biochemistry, University of Dundee, Dundee, United Kingdom
    J Immunol 164:3018-25. 2000
    ..They also suggest that MSK1 and MSK2 may play a role in these processes and hence are potential targets for the development of novel antiinflammatory drugs...
  2. ncbi request reprint The induction of cyclooxygenase-2 mRNA in macrophages is biphasic and requires both CCAAT enhancer-binding protein beta (C/EBP beta ) and C/EBP delta transcription factors
    M Caivano
    Medical Research Council Protein Phosphorylation Unit, University of Dundee, Dundee DD1 5EH, Scotland
    J Biol Chem 276:48693-701. 2001
    ..Taken together, these data identify CREB, NF-kappa B, and both C/EBP beta and -delta as key factors in coordinately orchestrating transcription from the COX-2 promoter in activated macrophages...
  3. ncbi request reprint The transcription factor C/EBPbeta is essential for inducible expression of the cox-2 gene in macrophages but not in fibroblasts
    B Gorgoni
    School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Biol Chem 276:40769-77. 2001
    ..In contrast, COX-2 induction was completely normal in C/EBPbeta-deficient fibroblasts, thus highlighting the diversity of cell-specific molecular mechanisms in determining inducible COX-2 expression and prostaglandins production...