Hong Cai

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Determination of the flavone tricin in human plasma by high-performance liquid chromatography
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Oncology, University of Leicester, Leicester LE2 7LX, UK
    Biomed Chromatogr 17:435-9. 2003
  2. doi request reprint Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Biomed Chromatogr 25:660-3. 2011
  3. ncbi request reprint Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
    Biomed Chromatogr 19:518-22. 2005
  4. doi request reprint Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE27LX, UK
    Biomed Chromatogr 23:335-9. 2009
  5. doi request reprint Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Eur J Cancer 46:811-7. 2010
  6. doi request reprint Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy
    Hong Cai
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, United Kingdom
    Cancer Prev Res (Phila) 2:743-50. 2009
  7. ncbi request reprint Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin
    Mohammad Al-Fayez
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, LE2 7LX, Leicester, UK
    Cancer Chemother Pharmacol 58:816-25. 2006
  8. doi request reprint Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone)
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, LRI, RKCSB, Leicester LE2 7LX, UK
    Cancer Chemother Pharmacol 67:255-63. 2011
  9. doi request reprint Pilot study of oral anthocyanins for colorectal cancer chemoprevention
    Sarah Thomasset
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    Cancer Prev Res (Phila) 2:625-33. 2009
  10. doi request reprint Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development
    Ankur Karmokar
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Mol Nutr Food Res 56:775-83. 2012

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Determination of the flavone tricin in human plasma by high-performance liquid chromatography
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Oncology, University of Leicester, Leicester LE2 7LX, UK
    Biomed Chromatogr 17:435-9. 2003
    ..6-102.8% (n = 6) with relative standard deviation below 10% for three concentrations of tricin, 5, 10 and 100 microg/mL. The lower limit of quantitation (relative standard deviation <20%) was 1 microg/mL...
  2. doi request reprint Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK
    Biomed Chromatogr 25:660-3. 2011
    ..This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption...
  3. ncbi request reprint Determination of the putative cancer chemopreventive flavone tricin in plasma and tissues of mice by HPLC with UV--visible detection
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK
    Biomed Chromatogr 19:518-22. 2005
    ..4%. Consumption of diet mixed with tricin at 0.05, 0.2 or 0.5% for one week furnished steady-state levels in plasma, liver and small intestine in the 1--3 x 10(-7), 4--22 x 10(-7) and 3--46 x 10(-5) m ranges, respectively...
  4. doi request reprint Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE27LX, UK
    Biomed Chromatogr 23:335-9. 2009
    ..08 nmol/mL, n = 11; 10th and 90th percentiles: 0.633 and 2.385 nmol/mL) and mucosa (108.5 nmol/g, n = 9; 10th and 90th percentiles: 38.9 and 164.4 nmol/g) in mice which had received PMF (0.2%, w/w) with their diet...
  5. doi request reprint Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Eur J Cancer 46:811-7. 2010
    ..Here the hypothesis was tested that oenocyanin added to the diet can interfere with intestinal adenoma development in the Apc(Min) mouse, a model of intestinal carcinogenesis linked to an Apc mutation...
  6. doi request reprint Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy
    Hong Cai
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester LE2 7LX, United Kingdom
    Cancer Prev Res (Phila) 2:743-50. 2009
    ....
  7. ncbi request reprint Differential modulation of cyclooxygenase-mediated prostaglandin production by the putative cancer chemopreventive flavonoids tricin, apigenin and quercetin
    Mohammad Al-Fayez
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, LE2 7LX, Leicester, UK
    Cancer Chemother Pharmacol 58:816-25. 2006
    ..Diet-derived flavonoids possess cancer chemopreventive properties in preclinical models. The knowledge of the pharmacology of most flavonoids is insufficient to warrant their advancement to clinical evaluation...
  8. doi request reprint Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone)
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, LRI, RKCSB, Leicester LE2 7LX, UK
    Cancer Chemother Pharmacol 67:255-63. 2011
    ..Here, the pharmacokinetic properties and metabolism of these flavones after oral administration were compared in mice...
  9. doi request reprint Pilot study of oral anthocyanins for colorectal cancer chemoprevention
    Sarah Thomasset
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, United Kingdom
    Cancer Prev Res (Phila) 2:625-33. 2009
    ..Studies of doses containing <0.5 gram bilberry anthocyanins are necessary to adjudge whether they may be appropriate for development as colorectal cancer chemopreventive agents...
  10. doi request reprint Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development
    Ankur Karmokar
    Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Mol Nutr Food Res 56:775-83. 2012
    ....
  11. ncbi request reprint Tissue distribution in mice and metabolism in murine and human liver of apigenin and tricin, flavones with putative cancer chemopreventive properties
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK
    Cancer Chemother Pharmacol 60:257-66. 2007
    ..Their pharmacology is only poorly understood. We compared their tissue levels in mice in vivo and their metabolism in liver fractions in vitro...
  12. doi request reprint Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?
    Sarah Thomasset
    Department of Cancer Studies and Molecular Medicine, Cancer Biomarkers and Prevention Group, RKCSB, LRI, University of Leicester, Leicester, UK
    Cancer Chemother Pharmacol 64:201-11. 2009
    ....
  13. ncbi request reprint The rice bran constituent tricin potently inhibits cyclooxygenase enzymes and interferes with intestinal carcinogenesis in ApcMin mice
    Hong Cai
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Robert Kilpatrick Clinical Sciences Building, UK
    Mol Cancer Ther 4:1287-92. 2005
    ..01) and 40% (P < 0.05), respectively, compared with control mice. The results suggest that tricin should be further evaluated as a putative colorectal cancer chemopreventive agent...
  14. ncbi request reprint A simple HPLC method for the determination of apigenin in mouse tissues
    Hong Cai
    Cancer Biomarkers and Prevention Research Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE2 7LX, UK hc47le ac uk
    Biomed Chromatogr 20:1038-42. 2006
    ..The lower limit of quantification for plasma was 25 ng/mL with a relative standard deviation of <15%. The method was used to measure the steady-phase apigenin levels in tissues of mice receiving apigenin in their diet...
  15. ncbi request reprint Preliminary safety evaluation of the putative cancer chemopreventive agent tricin, a naturally occurring flavone
    Richard D Verschoyle
    Department of Cancer Studies, LRI, RKCSB, University of Leicester, Leicester, LE2 7LX, UK
    Cancer Chemother Pharmacol 57:1-6. 2006
    ..Here, we explored safety aspects of the novel flavone tricin, a constituent of rice bran and other grass species, which has recently been found to interfere with murine gastrointestinal carcinogenesis...
  16. ncbi request reprint Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites
    Carmen S L Hoh
    Cancer Biomarkers and Chemoprevention Group, Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
    J Agric Food Chem 55:2532-5. 2007
    ..This method was utilized to detect silibinin in plasma of colorectal patients after 7 days of treatment with silipide (silibinin formulated with phosphatidyl choline)...
  17. ncbi request reprint [Discussion for clinical treatment in early stage of colorectal carcinoma with the invasion limited in the layer of muscularis mucosae]
    Hong Cai
    Department of Abdominal Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China
    Zhonghua Wai Ke Za Zhi 42:904-7. 2004
    ....
  18. ncbi request reprint A straightforward means of coupling preparative high-performance liquid chromatography and mass spectrometry
    Hong Cai
    ArQule Inc, 19 Presidential Way, Woburn, MA 01801, USA
    Rapid Commun Mass Spectrom 16:544-54. 2002
    ..We demonstrate that such optimization can reduce the volume of the collected fraction without compromising recovery, thus reducing the time spent in evaporating solvents to reclaim purified products...