Christopher D Byrne

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease
    Christopher D Byrne
    From Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, United Kingdom C D B Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdom C D B and Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy G T
    Arterioscler Thromb Vasc Biol 34:1155-61. 2014
  2. pmc Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults
    Dong Sik Cho
    Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung Dong, Seoul, Jongro Ku 110 746, Republic of Korea
    Cardiovasc Diabetol 11:55. 2012
  3. doi request reprint Dorothy Hodgkin Lecture 2012: non-alcoholic fatty liver disease, insulin resistance and ectopic fat: a new problem in diabetes management
    C D Byrne
    Nutrition and Metabolism and NIHR Southampton Biomedical Research Centre, University Hospital Southampton and Faculty of Medicine, University of Southampton, Southampton, UK
    Diabet Med 29:1098-107. 2012
  4. ncbi request reprint Triglyceride-rich lipoproteins: are links with atherosclerosis mediated by a procoagulant and proinflammatory phenotype?
    C D Byrne
    University Department of Medicine, Southampton General Hospital, UK
    Atherosclerosis 145:1-15. 1999
  5. ncbi request reprint Should we routinely measure a proxy for insulin resistance as well as improve our modelling techniques to better predict the likelihood of coronary heart disease in people with type 2 diabetes
    Christopher D Byrne
    University of Southampton and Southampton University Hospitals Trust, Southampton, UK
    Diabetes Obes Metab 6:308-9. 2004
  6. pmc Fetal origins of adult disease: epidemiology and mechanisms
    C D Byrne
    University of Southampton, School of Medicine, Endocrine and Metabolism Unit, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    J Clin Pathol 53:822-8. 2000
  7. ncbi request reprint Cross-sectional but not longitudinal associations between non-esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 16:1007-15. 1999
  8. doi request reprint Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment
    Geraldine F Clough
    Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital MP 887, Southampton, UK
    Microcirculation 18:74-84. 2011
  9. pmc Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice
    Christopher Torrens
    Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 7:e50671. 2012
  10. ncbi request reprint Vascular disease in the metabolic syndrome: do we need to target the microcirculation to treat large vessel disease?
    Andrew J Krentz
    Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Vasc Res 46:515-26. 2009

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease
    Christopher D Byrne
    From Nutrition and Metabolism, Faculty of Medicine, University of Southampton, Southampton, United Kingdom C D B Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton, United Kingdom C D B and Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy G T
    Arterioscler Thromb Vasc Biol 34:1155-61. 2014
    ..Articles published in languages other than English were excluded...
  2. pmc Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults
    Dong Sik Cho
    Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung Dong, Seoul, Jongro Ku 110 746, Republic of Korea
    Cardiovasc Diabetol 11:55. 2012
    ..Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration...
  3. doi request reprint Dorothy Hodgkin Lecture 2012: non-alcoholic fatty liver disease, insulin resistance and ectopic fat: a new problem in diabetes management
    C D Byrne
    Nutrition and Metabolism and NIHR Southampton Biomedical Research Centre, University Hospital Southampton and Faculty of Medicine, University of Southampton, Southampton, UK
    Diabet Med 29:1098-107. 2012
    ....
  4. ncbi request reprint Triglyceride-rich lipoproteins: are links with atherosclerosis mediated by a procoagulant and proinflammatory phenotype?
    C D Byrne
    University Department of Medicine, Southampton General Hospital, UK
    Atherosclerosis 145:1-15. 1999
    ..All rights reserved...
  5. ncbi request reprint Should we routinely measure a proxy for insulin resistance as well as improve our modelling techniques to better predict the likelihood of coronary heart disease in people with type 2 diabetes
    Christopher D Byrne
    University of Southampton and Southampton University Hospitals Trust, Southampton, UK
    Diabetes Obes Metab 6:308-9. 2004
  6. pmc Fetal origins of adult disease: epidemiology and mechanisms
    C D Byrne
    University of Southampton, School of Medicine, Endocrine and Metabolism Unit, South Academic Block, Southampton General Hospital, Southampton SO16 6YD, UK
    J Clin Pathol 53:822-8. 2000
    ..The purpose of this review is to describe some of the relevant, important, and more recent epidemiological studies, and also to discuss potential mechanisms underpinning the associations...
  7. ncbi request reprint Cross-sectional but not longitudinal associations between non-esterified fatty acid levels and glucose intolerance and other features of the metabolic syndrome
    C D Byrne
    University Department of Clinical Biochemistry, Addenbrooke s Hospital, Cambridge, UK
    Diabet Med 16:1007-15. 1999
    ..However, the direction of causality in these studies is uncertain. The aim of this study was to examine whether NEFA levels predicted the development of glucose intolerance in a prospective population-based cohort study...
  8. doi request reprint Functional dilator capacity is independently associated with insulin sensitivity and age in central obesity and is not improved by high dose statin treatment
    Geraldine F Clough
    Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital MP 887, Southampton, UK
    Microcirculation 18:74-84. 2011
    ....
  9. pmc Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice
    Christopher Torrens
    Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
    PLoS ONE 7:e50671. 2012
    ..To determine the impact of maternal and post-weaning consumption of a high fat diet on endothelium-dependent vasorelaxation and redox regulation in adult male mouse offspring...
  10. ncbi request reprint Vascular disease in the metabolic syndrome: do we need to target the microcirculation to treat large vessel disease?
    Andrew J Krentz
    Institute of Developmental Sciences, School of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Vasc Res 46:515-26. 2009
    ..The hypothesis that vascular events can be prevented, or at least deferred, through earlier therapeutic intervention in pre-diabetic subjects with glucose intolerance is amenable to testing in clinical trials...
  11. ncbi request reprint Association of nonalcoholic fatty liver disease with QTc interval in patients with type 2 diabetes
    Giovanni Targher
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy Electronic address
    Nutr Metab Cardiovasc Dis 24:663-9. 2014
    ..We therefore examined the relationship between NAFLD and QTc interval in patients with type 2 diabetes...
  12. ncbi request reprint Maternal dietary iron restriction modulates hepatic lipid metabolism in the fetuses
    Junlong Zhang
    Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Physiol Regul Integr Comp Physiol 288:R104-11. 2005
    ....
  13. ncbi request reprint High-unsaturated-fat, high-protein, and low-carbohydrate diet during pregnancy and lactation modulates hepatic lipid metabolism in female adult offspring
    Junlong Zhang
    Endocrinology and Metabolism Sub Division, Developmental Origins of Health and Disease Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Physiol Regul Integr Comp Physiol 288:R112-8. 2005
    ..57, P = 0.025) in these offspring. In conclusion, a maternal HFP diet during gestation and lactation reduces hepatic TG concentration in female offspring, which is linked with increased protein levels in fatty acid oxidation...
  14. doi request reprint Nonalcoholic fatty liver disease and vascular risk
    Lokpal S Bhatia
    National Institute of Health Research Biomedical Research Unit, Southampton University Hospitals NHS Trust, Southampton, UK
    Curr Opin Cardiol 27:420-8. 2012
    ..However, given the shared features between NAFLD, the metabolic syndrome and traditional cardiovascular risk factors, uncertainty exists as to whether NAFLD is an independent risk factor for increased cardiovascular disease...
  15. doi request reprint Fatty liver: role of inflammation and fatty acid nutrition
    Christopher D Byrne
    Institute for Developmental Sciences, University of Southampton and Southampton University Hospitals Trust, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 82:265-71. 2010
    ..The purpose of this review is to discuss the roles of inflammation, fatty acids and fatty acids in nutrition, in the pathogenesis and potential treatment of NAFLD...
  16. ncbi request reprint Metabolic disturbances in non-alcoholic fatty liver disease
    Christopher D Byrne
    Endocrinology and Metabolism Unit, Institute for Developmental Sciences, University of Southampton and Southampton University Hospitals Trust, Southampton General Hospital, Southampton SO16 6YD, UK
    Clin Sci (Lond) 116:539-64. 2009
    ....
  17. doi request reprint Ezetimibe as a potential treatment for non-alcoholic fatty liver disease: is the intestine a modulator of hepatic insulin sensitivity and hepatic fat accumulation?
    Mohamed H Ahmed
    Chemical Pathology Department, Southampton University Hospital NHS Trust, Southampton SO16 6YD, UK
    Drug Discov Today 15:590-5. 2010
    ..We suggest, therefore, that urgent studies are needed to assess the potential therapeutic benefit of ezetimibe in treating NAFLD...
  18. ncbi request reprint Effects of VLDL and remnant particles on platelets
    Rasaq Olufadi
    Department of Chemical Pathology MP 6, Southampton General Hospital, UK
    Pathophysiol Haemost Thromb 35:281-91. 2006
    ..The role of these lipoprotein classes in (1) platelet activation; (2) the intrinsic coagulation cascade, and (3) clot formation and fibrinolysis is discussed...
  19. doi request reprint Diagnosis and management of nonalcoholic fatty liver disease and its hemostatic/thrombotic and vascular complications
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Verona, Verona, Italy
    Semin Thromb Hemost 39:214-28. 2013
    ....
  20. ncbi request reprint Is there disparity between risk and incidence of cardiovascular disease after liver transplant?
    David A J Neal
    Department of Medicine, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Transplantation 77:93-9. 2004
    ....
  21. doi request reprint Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?
    Lokpal S Bhatia
    National Institute of Health Research Biomedical Research Unit, Southampton University Hospitals NHS Trust, Southampton General Hospital, Tremona Road, Southampton, UK
    Eur Heart J 33:1190-200. 2012
    ....
  22. doi request reprint Non-Alcoholic Fatty Liver Disease (NAFLD): new challenge for general practitioners and important burden for health authorities?
    Mohamed H Ahmed
    Chemical Pathology Department, Southampton University Hospital NHS Trust, Southampton, UK
    Prim Care Diabetes 4:129-37. 2010
    ....
  23. doi request reprint Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    Kimberley D Bruce
    Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Hepatology 50:1796-808. 2009
    ..In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring...
  24. doi request reprint Current treatment of non-alcoholic fatty liver disease
    Mohamed H Ahmed
    Chemical Pathology Department, Southampton University Hospitals NHS Trust, Southampton General Hospital, Southampton, UK
    Diabetes Obes Metab 11:188-95. 2009
    ..The potential benefit of bariatric surgery and the role of weight loss per se in treating NAFLD are also discussed...
  25. ncbi request reprint Ectopic fat, insulin resistance and non-alcoholic fatty liver disease
    Christopher D Byrne
    Endocrinology and Metabolism, Nutrition and Metabolism, Faculty of Medicine, University of Southampton, and Southampton National Institute for Health Research Biomedical Research Centre, University Hospital of Southampton, UK
    Proc Nutr Soc 72:412-9. 2013
    ..The review will also describe the relationships between NAFLD, type 2 diabetes and CVD...
  26. ncbi request reprint Nonalcoholic fatty liver disease and reduced serum vitamin D(3) levels
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    Metab Syndr Relat Disord 11:217-28. 2013
    ..Large placebo-controlled randomized clinical trials are urgently needed to determine whether vitamin D3 supplementation could have any potential benefit in reducing the development and progression of NAFLD...
  27. ncbi request reprint Hemodynamic effects of amlodipine, bisoprolol, and lisinopril in hypertensive patients after liver transplantation
    David A J Neal
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    Transplantation 77:748-50. 2004
    ..Hypertension is common after liver transplantation. There are few published data on optimum treatment. Augmentation index (AIx) is a measure of arterial wave reflection determined by pulse wave analysis...
  28. ncbi request reprint Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men
    Junlong Zhang
    Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, University of Southampton, Level F, Central Block, Mailpoint 113, Southampton General Hospital, Southampton, SO16 6YD, UK
    Diabetes Care 28:2058-60. 2005
  29. pmc Muscle microvascular dysfunction in central obesity is related to muscle insulin insensitivity but is not reversed by high-dose statin treatment
    Geraldine F Clough
    School of Medicine, University of Southampton, Southampton, UK
    Diabetes 58:1185-91. 2009
    ....
  30. doi request reprint Age and cigarette smoking are independently associated with the cutaneous vascular response to local warming
    Miriam R Avery
    School of Medicine, University of Southampton, Southampton, UK
    Microcirculation 16:725-34. 2009
    ..To investigate the relative impacts of age and cigarette smoking on cutaneous blood flow and flow motion...
  31. ncbi request reprint Percentage of body fat and plasma glucose predict plasma sialic acid concentration in type 2 diabetes mellitus
    Nicola A Englyst
    Endocrinology and Metabolism Unit, University of Southampton, Southampton SO16 6YD, UK
    Metabolism 55:1165-70. 2006
    ..In conclusion, this is the first study to show that percentage of body fat predicts plasma sialic acid concentration and contributes toward higher levels of sialic acid in type 2 diabetes mellitus...
  32. ncbi request reprint Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications
    Andrew J Krentz
    Department of Diabetes and Endocrinology, Southampton General Hospital, Southampton SO16 6YD, UK
    Diabetes Obes Metab 9:781-91. 2007
    ..Preferential use should be made of drug regimens that (i) maximize vascular protection, (ii) reduce the risk of iatrogenic vascular damage and (iii) minimize the increasing problem of polypharmacy...
  33. ncbi request reprint Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes
    Giovanni Targher
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy
    Diabetes Care 37:1729-36. 2014
    ..There is no information about the role of nonalcoholic fatty liver disease (NAFLD) in predicting the development of chronic kidney disease (CKD) in type 1 diabetes...
  34. doi request reprint Intensive glucose control and hypoglycaemia: a new cardiovascular risk factor?
    Omar A Rana
    Department of Cardiology, University of Southampton and Southampton University Hospitals NHS Foundation Trust, Southampton, Hampshire, UK
    Heart 100:21-7. 2014
    ....
  35. pmc Non-alcoholic fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes
    Giovanni Targher
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy
    PLoS ONE 8:e57183. 2013
    ..The relationship between non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) in type 2 diabetes is currently unknown. We examined the relationship between NAFLD and risk of incident AF in people with type 2 diabetes...
  36. pmc Daily energy expenditure, cardiorespiratory fitness and glycaemic control in people with type 1 diabetes
    John Joseph Valletta
    Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom Bioengineering Science, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom
    PLoS ONE 9:e97534. 2014
    ....
  37. doi request reprint Gaussian Process modelling of blood glucose response to free-living physical activity data in people with type 1 diabetes
    John Joseph Valletta
    School of Engineering Sciences, Computational Engineering and Design Group, University of Southampton, Southampton, United Kingdom
    Conf Proc IEEE Eng Med Biol Soc 2009:4913-6. 2009
    ..In this paper, Gaussian Processes are used to model the glucose excursions in response to physical activity data, to study its effect on glycaemic control...
  38. doi request reprint Hypoxia and non-alcoholic fatty liver disease
    Christopher D Byrne
    Department of Endocrinology and Metabolism, The Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, U K
    Clin Sci (Lond) 118:397-400. 2010
    ..The authors show that a short period (7 days) of exposure to hypoxia aggravates the NAFLD phenotype, causing changes in the liver that are in keeping with NASH with increased lipogenesis and inflammation...
  39. ncbi request reprint Intrauterine growth, the vascular system, and the metabolic syndrome
    Richard I G Holt
    Endocrinology and Metabolism Sub Division, Fetal Origins of Adult Disease Division, School of Medicine, Southampton University, Southampton General Hospital, Southampton, England
    Semin Vasc Med 2:33-43. 2002
    ..We will also discuss mechanisms that might explain these associations...
  40. ncbi request reprint Modulation of sterol regulatory element binding proteins (SREBPs) as potential treatments for non-alcoholic fatty liver disease (NAFLD)
    Mohamed H Ahmed
    Chemical Pathology Department, Southampton General Hospital, Southampton, UK
    Drug Discov Today 12:740-7. 2007
    ..We suggest that further studies are urgently needed to evaluate modulation of SREBP activity as a potential new treatment for NAFLD...
  41. doi request reprint The housekeeping gene YWHAZ remains stable in a model of developmentally primed non-alcoholic fatty liver disease
    Kimberley D Bruce
    Human Development and Health, Institute of Developmental Sciences, University of Southampton Faculty of Medicine, Southampton, UK
    Liver Int 32:1315-21. 2012
    ..However, there is little existing data to show the effects of NAFLD on HKG expression...
  42. ncbi request reprint Long-chain n-3 fatty acid supplementation in men increases resistance to activated protein C
    Nicola A Englyst
    Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, Institute of Human Nutrition, University of Southampton, Southampton SO16 6YD, UK
    Metabolism 56:547-51. 2007
    ..These findings will need to be repeated in different disease states...
  43. doi request reprint Aspirin resistance is more common in lacunar strokes than embolic strokes and is related to stroke severity
    Nicola A Englyst
    Endocrinology and Metabolism Unit, Developmental Origins of Health and Disease Division, University of Southampton, Southampton, UK
    J Cereb Blood Flow Metab 28:1196-203. 2008
    ..765, P=0.005) as the outcome. In conclusion, aspirin resistance is related to stroke severity and aspirin resistance is more common in lacunar strokes than embolic strokes...
  44. ncbi request reprint A novel role for CD36 in VLDL-enhanced platelet activation
    Nicola A Englyst
    Endocrinology and Metabolism Unit, University of Southampton, Southhampton General Hospital, Tremona Road, Southampton SO16 6YD, U K
    Diabetes 52:1248-55. 2003
    ..These data suggest that platelet Cd36 has a key role in VLDL-induced collagen-mediated platelet aggregation, possibly contributing to atherothrombosis associated with increased VLDL levels...
  45. ncbi request reprint Human skeletal muscle PPARalpha expression correlates with fat metabolism gene expression but not BMI or insulin sensitivity
    Junlong Zhang
    Endocrinology and Metabolism Unit, Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Am J Physiol Endocrinol Metab 286:E168-75. 2004
    ....
  46. ncbi request reprint Glucose metabolism in adult survivors of severe acute malnutrition
    Patrice M Francis-Emmanuel
    Tropical Medicine Research Institute P M F E, D S T, A T B, T E F, M S B and Department of Surgery, Radiology, Anaesthesia, and Intensive Care A T B, The University of the West Indies, Mona, Kingston 7, Jamaica, West Indies Medical Research Council Lifecourse Epidemiology Unit C O, Institute of Developmental Sciences M A H and Nutrition and Metabolism Unit C D B, School of Medicine, University of Southampton, Southampton SO16 6YD, United Kingdom and Centre for Human Evolution, Adaptation, and Disease P D G, Liggins Institute, University of Auckland, Auckland 1142, New Zealand
    J Clin Endocrinol Metab 99:2233-40. 2014
    ..We hypothesized that resultant metabolic effects may persist into adulthood. We investigated whether marasmus survivors (MS) are more insulin resistant and glucose intolerant than kwashiorkor survivors (KS)...
  47. doi request reprint Ferritin is independently associated with the presence of coronary artery calcium in 12,033 men
    Ki Chul Sung
    Division of Cardiology, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
    Arterioscler Thromb Vasc Biol 32:2525-30. 2012
    ....
  48. doi request reprint Bariatric surgery and renal function: a precarious balance between benefit and harm
    Mohamed H Ahmed
    Chemical Pathology Department, Southampton University Hospitals NHS Trust, Southampton, UK
    Nephrol Dial Transplant 25:3142-7. 2010
    ..The main risk factor for nephrolithiasis is increased excretion of urinary oxalate. In this review, we discuss the association between bariatric surgery, an increased risk of renal stone formation and oxalate nephropathy...
  49. doi request reprint Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase
    Malcolm C Richardson
    Developmental Origins of Health and Disease Research Division, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    J Clin Endocrinol Metab 94:670-7. 2009
    ..Production of 3-carbon units (as lactate) by granulosa cells (GCs) is important in follicular and oocyte development and may be modulated by metformin...
  50. ncbi request reprint Increased glucocorticoid receptor expression in human skeletal muscle cells may contribute to the pathogenesis of the metabolic syndrome
    Christopher B Whorwood
    Endocrine and Metabolism Unit, University Department of Medicine, University of Portsmouth, Portsmouth, UK
    Diabetes 51:1066-75. 2002
    ....
  51. pmc ABC of obesity. Risk factors for diabetes and coronary heart disease
    Sarah H Wild
    University of Edinburgh
    BMJ 333:1009-11. 2006
  52. ncbi request reprint Insulin and human chorionic gonadotropin cause a shift in the balance of sterol regulatory element-binding protein (SREBP) isoforms toward the SREBP-1c isoform in cultures of human granulosa cells
    Malcolm C Richardson
    Developmental Origins of Health and Disease Research Division, University of Southampton, Level F, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA, United Kingdom
    J Clin Endocrinol Metab 90:3738-46. 2005
    ..We suggest that high circulating insulin, associated with clinically defined insulin resistance, may up-regulate SREBP-1c expression in the ovary...
  53. ncbi request reprint Plasma adiponectin concentrations are independently predicted by fat insulin sensitivity in women and by muscle insulin sensitivity in men
    Junlong Zhang
    Diabetes Care 28:755-6. 2005
  54. ncbi request reprint Differences in cortisol concentrations in South Asian and European men living in the United Kingdom
    Rebecca M Reynolds
    University of Edinburgh, Endocrinology Unit, Centre for Cardiovascular Science, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Clin Endocrinol (Oxf) 64:530-4. 2006
    ..The aim of the study was to examine ethnic differences in cortisol levels and to compare the relationships between cortisol levels and cardiovascular risk factors in men from different ethnic groups...
  55. pmc A novel medium throughput quantitative competitive PCR technology to simultaneously measure mRNA levels from multiple genes
    Junlong Zhang
    Endocrinology and Metabolism Unit, Fetal Origins of Adult Diseases Division, University School of Medicine, South Academic Block, Level D, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Nucleic Acids Res 30:e20. 2002
    ..This quick, specific, sensitive, reproducible and yet inexpensive technique is ideal for simultaneously studying co-ordinate changes in mRNA levels from multiple genes...
  56. ncbi request reprint Low ankle-brachial pressure index predicts increased risk of cardiovascular disease independent of the metabolic syndrome and conventional cardiovascular risk factors in the Edinburgh Artery Study
    Sarah H Wild
    Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland
    Diabetes Care 29:637-42. 2006
    ..To investigate whether a low ankle-brachial pressure index (ABI) predicts increased risk of cardiovascular disease (CVD) independent of the metabolic syndrome and conventional cardiovascular risk factors...
  57. ncbi request reprint Time to rethink high-density lipoprotein?
    Sarah Wild
    Heart 94:692-4. 2008