M Bycroft

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease
    M Bycroft
    MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW
    EMBO J 18:297-305. 1999
  2. ncbi The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose
    S F Poget
    Cambridge Centre for Protein Engineering, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    J Mol Biol 290:867-79. 1999
  3. ncbi The ligand-binding loops in the tunicate C-type lectin TC14 are rigid
    S F Poget
    MRC Centre for Protein Engineering, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochemistry 40:10966-72. 2001
  4. ncbi The UBX domain: a widespread ubiquitin-like module
    A Buchberger
    MRC Centre for Protein Engineering, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 307:17-24. 2001
  5. ncbi The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold
    M Bycroft
    Department of Chemistry, University of Cambridge, United Kingdom
    Cell 88:235-42. 1997
  6. ncbi The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD)
    A Bateman
    The Sanger Centre, Welcome Trust Genome Campus, Cambridge, CB10 1SA, UK
    J Mol Biol 299:1113-9. 2000
  7. ncbi NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5
    M Bycroft
    Cambridge Centre for Protein Engineering, Department of Chemistry, University of Cambridge, UK
    EMBO J 14:3563-71. 1995
  8. ncbi Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
    O Perisic
    Medical Research Council Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, United Kingdom
    J Biol Chem 273:1596-604. 1998
  9. ncbi Assignment of the backbone 1H,15N,13C NMR resonances and secondary structure of a double-stranded RNA binding domain from the Drosophila protein staufen
    M Bycroft
    Cambridge Centre for Protein Engineering, Department of Chemistry, University of Cambridge, UK
    FEBS Lett 362:333-6. 1995
  10. ncbi Application of thermophilic enzymes in commercial biotransformation processes
    I N Taylor
    Dowpharma, Chirotech Technology Ltd, 321 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U K
    Biochem Soc Trans 32:290-2. 2004

Collaborators

Detail Information

Publications10

  1. ncbi The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease
    M Bycroft
    MRC Centre for Protein Engineering, Lensfield Road, Cambridge CB2 1EW
    EMBO J 18:297-305. 1999
    ..This structure will allow the likely effects of missense mutations in a large part of the PKD1 gene to be determined...
  2. ncbi The structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D -galactose
    S F Poget
    Cambridge Centre for Protein Engineering, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    J Mol Biol 290:867-79. 1999
    ..Possible biological functions can more easily be understood from the fact that TC14 is a dimer under physiological conditions...
  3. ncbi The ligand-binding loops in the tunicate C-type lectin TC14 are rigid
    S F Poget
    MRC Centre for Protein Engineering, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Biochemistry 40:10966-72. 2001
    ..Possible implications of these findings for the ligand binding in C-type lectin-like domains are discussed...
  4. ncbi The UBX domain: a widespread ubiquitin-like module
    A Buchberger
    MRC Centre for Protein Engineering, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    J Mol Biol 307:17-24. 2001
    ..A role of the UBX domain in ubiquitin-related processes is suggested...
  5. ncbi The solution structure of the S1 RNA binding domain: a member of an ancient nucleic acid-binding fold
    M Bycroft
    Department of Chemistry, University of Cambridge, United Kingdom
    Cell 88:235-42. 1997
    ..Enhanced sequence searches reveal hitherto unidentified S1 domains in RNase E, RNase II, NusA, EMB-5, and other proteins...
  6. ncbi The structure of a LysM domain from E. coli membrane-bound lytic murein transglycosylase D (MltD)
    A Bateman
    The Sanger Centre, Welcome Trust Genome Campus, Cambridge, CB10 1SA, UK
    J Mol Biol 299:1113-9. 2000
    ..The structure shows no similarity to other bacterial cell surface domains. A potential binding site in a shallow groove on surface of the protein has been identified...
  7. ncbi NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5
    M Bycroft
    Cambridge Centre for Protein Engineering, Department of Chemistry, University of Cambridge, UK
    EMBO J 14:3563-71. 1995
    ..Two residues that are essential for RNA binding, F32 and K50, are also conserved in the S5 protein family, suggesting that the two domains interact with RNA in a similar way...
  8. ncbi Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
    O Perisic
    Medical Research Council Laboratory of Molecular Biology, Medical Research Council Centre, Cambridge, United Kingdom
    J Biol Chem 273:1596-604. 1998
    ..Although hydrophobic interactions predominate for cPLA2, for other C2 domains such as in "conventional" protein kinase C and synaptotagmins, electrostatic forces prevail...
  9. ncbi Assignment of the backbone 1H,15N,13C NMR resonances and secondary structure of a double-stranded RNA binding domain from the Drosophila protein staufen
    M Bycroft
    Cambridge Centre for Protein Engineering, Department of Chemistry, University of Cambridge, UK
    FEBS Lett 362:333-6. 1995
    ..The domain has an alpha beta beta beta alpha arrangement of secondary structure, with the beta strands forming an antiparallel beta sheet. The secondary structure differs from that found in the RNP RNA binding domain...
  10. ncbi Application of thermophilic enzymes in commercial biotransformation processes
    I N Taylor
    Dowpharma, Chirotech Technology Ltd, 321 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, U K
    Biochem Soc Trans 32:290-2. 2004
    ..Several examples of commercial biotransformations will be discussed including a process that is successful by virtue of the enzyme's thermotolerance...