P Burton

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology
    Paul R Burton
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK
    Int J Epidemiol 38:263-73. 2009
  2. ncbi request reprint Comment on "Ascertainment adjustment in complex diseases"
    Paul R Burton
    Department of Epidemiology and Public Health, University of Leicester, Leicester, United Kingdom
    Genet Epidemiol 23:214-8. 2002
  3. ncbi request reprint Correcting for nonrandom ascertainment in generalized linear mixed models (GLMMs), fitted using Gibbs sampling
    Paul R Burton
    Department of Epidemiology and Public Health and Institute of Genetics, University of Leicester, Leicester, UK
    Genet Epidemiol 24:24-35. 2003
  4. ncbi request reprint Key concepts in genetic epidemiology
    Paul R Burton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Lancet 366:941-51. 2005
  5. pmc Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling
    Katrina J Scurrah
    Institute of Genetics and Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road, Leicester, LE1 6TP, United Kingdom
    BMC Genet 4:S25. 2003
  6. ncbi request reprint Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences, University of Leicester, Leicester, England
    Circulation 112:3423-9. 2005
  7. ncbi request reprint Covariance components models for longitudinal family data
    Paul R Burton
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, Institute of Genetics, University of Leicester, UK
    Int J Epidemiol 34:1063-77; discussion 1077-9. 2005
  8. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
  9. ncbi request reprint Beyond "misunderstanding": written information and decisions about taking part in a genetic epidemiology study
    Mary Dixon-Woods
    University of Leicester, Leicester, UK
    Soc Sci Med 65:2212-22. 2007
  10. doi request reprint Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children
    Martin D Tobin
    Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
    Hypertension 52:974-9. 2008

Detail Information

Publications35

  1. pmc Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology
    Paul R Burton
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK
    Int J Epidemiol 38:263-73. 2009
    ..This question has critical implications for governments, funding agencies, bioscientists and the tax-paying public. Difficult strategic decisions with imposing price tags and important opportunity costs must be taken...
  2. ncbi request reprint Comment on "Ascertainment adjustment in complex diseases"
    Paul R Burton
    Department of Epidemiology and Public Health, University of Leicester, Leicester, United Kingdom
    Genet Epidemiol 23:214-8. 2002
  3. ncbi request reprint Correcting for nonrandom ascertainment in generalized linear mixed models (GLMMs), fitted using Gibbs sampling
    Paul R Burton
    Department of Epidemiology and Public Health and Institute of Genetics, University of Leicester, Leicester, UK
    Genet Epidemiol 24:24-35. 2003
    ..The implications of this characteristic are investigated and discussed. This paper extends the utility of Gibbs sampling-based GLMMs to a variety of settings in which family data are ascertained nonrandomly...
  4. ncbi request reprint Key concepts in genetic epidemiology
    Paul R Burton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Lancet 366:941-51. 2005
    ..We anticipate that, depending on their professional background and specialist knowledge, some readers will wish to skip some of this article...
  5. pmc Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling
    Katrina J Scurrah
    Institute of Genetics and Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road, Leicester, LE1 6TP, United Kingdom
    BMC Genet 4:S25. 2003
    ..The first-stage analysis provided evidence for general genetic effects on both the baseline and slope of blood pressure, and the linkage analysis found evidence of several genes, again for both baseline and slope...
  6. ncbi request reprint Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences, University of Leicester, Leicester, England
    Circulation 112:3423-9. 2005
    ..Mutations in the WNK1 and WNK4 genes cause a rare monogenic hypertensive syndrome, pseudohypoaldosteronism type II. We investigated whether polymorphisms in these WNK genes influence BP in the general population...
  7. ncbi request reprint Covariance components models for longitudinal family data
    Paul R Burton
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, Institute of Genetics, University of Leicester, UK
    Int J Epidemiol 34:1063-77; discussion 1077-9. 2005
    ..We demonstrate the efficacy of our methods using a range of simulated data analyses, and illustrate its practical application to longitudinal blood pressure data measured in families from the Framingham Heart Study...
  8. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
    ....
  9. ncbi request reprint Beyond "misunderstanding": written information and decisions about taking part in a genetic epidemiology study
    Mary Dixon-Woods
    University of Leicester, Leicester, UK
    Soc Sci Med 65:2212-22. 2007
    ..These questions need to be addressed through engagement and dialogue between the research, research participants, social science, and ethics communities...
  10. doi request reprint Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children
    Martin D Tobin
    Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
    Hypertension 52:974-9. 2008
    ..Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age...
  11. doi request reprint The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    J Mol Med (Berl) 86:1233-41. 2008
    ..The findings support further investigation of the role of these genes in cholesterol metabolism and coronary risk...
  12. pmc Common variants near TERC are associated with mean telomere length
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Nat Genet 42:197-9. 2010
    ..Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition...
  13. doi request reprint Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences and Genetics, University of Leicester, UK
    Hypertension 51:1658-64. 2008
    ..Notably, variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention...
  14. ncbi request reprint How vague is vague? A simulation study of the impact of the use of vague prior distributions in MCMC using WinBUGS
    Paul C Lambert
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK
    Stat Med 24:2401-28. 2005
    ..The choice of 'vague' prior distribution can lead to a marked variation in results, particularly in small studies. Sensitivity to the choice of prior distribution should always be assessed...
  15. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  16. ncbi request reprint Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study
    Martin D Tobin
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Eur Heart J 25:459-67. 2004
    ..To identify polymorphisms and haplotypes in candidate genes that predispose to myocardial infarction (MI) using a multilocus approach...
  17. doi request reprint Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
    Martin D Tobin
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1132-41. 2008
    ..We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise...
  18. ncbi request reprint Commentary: development of Mendelian randomization: from hypothesis test to 'Mendelian deconfounding'
    Martin D Tobin
    University of Leicester, Department of Epidemiology and Public Health, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Int J Epidemiol 33:26-9. 2004
  19. ncbi request reprint Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure
    Martin D Tobin
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, U K
    Stat Med 24:2911-35. 2005
    ..Given that the more effective methods are straightforward to implement, there is no argument for undertaking a flawed analysis that wastes power and results in excessive bias...
  20. ncbi request reprint The analysis of peak expiratory flow data using a three-level hierarchical model
    Paul C Lambert
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Stat Med 23:3821-39. 2004
    ..In addition, the Bayesian models provide an intuitive and simple way to investigate the within-subject variance components...
  21. ncbi request reprint Associations between polymorphisms of the high-affinity immunoglobulin E receptor and late-onset airflow obstruction in older populations
    Charlotte E Ruse
    Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    J Am Geriatr Soc 51:1265-9. 2003
    ..To test the hypothesis that genetic polymorphisms in the beta subunit of the high-affinity immunoglobulin E (IgE) receptor are associated with late-onset airflow obstruction...
  22. doi request reprint The UK Biobank sample handling and storage protocol for the collection, processing and archiving of human blood and urine
    Paul Elliott
    Department of Epidemiology and Public Health, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Int J Epidemiol 37:234-44. 2008
    ..The biological samples that are collected and how they are processed and stored will have a major impact on the future scientific usefulness of the UK Biobank resource...
  23. doi request reprint Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses
    Tom M Palmer
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1161-8. 2008
    ..When the linearity assumption between the variables does not hold the IV estimates will be biased. The extent of this bias in the phenotype-disease log odds ratio of a Mendelian randomization study is investigated...
  24. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease...
  25. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  26. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  27. ncbi request reprint Comments on 'trying to be precise about vagueness' by Stephen Senn, Statistics in Medicine 2007; 26:1417-1430
    Paul C Lambert
    Stat Med 27:619-22, author reply 622-4. 2008
  28. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  29. doi request reprint Analysis, power and design of antimicrobial resistance surveillance studies, taking account of inter-centre variation and turnover
    Rosy Reynolds
    Department of Medical Microbiology, Southmead Hospital, Southmead Road, Bristol BS10 5NB, UK
    J Antimicrob Chemother 62:ii29-39. 2008
    ..We studied the impact of this problem and the ability of alternative methods to overcome it. We also investigated different study designs and estimated the statistical power of the BSAC Resistance Surveillance Programmes...
  30. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
    ..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data...
  31. ncbi request reprint Atopy, eczema and breast milk fatty acids in a high-risk cohort of children followed from birth to 5 yr
    Wendy H Oddy
    Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, Perth, WA, Australia
    Pediatr Allergy Immunol 17:4-10. 2006
    ....
  32. pmc Robust estimation of experimentwise P values applied to a genome scan of multiple asthma traits identifies a new region of significant linkage on chromosome 20q13
    Manuel A R Ferreira
    Queensland Institute of Medical Research, Brisbane, Australia
    Am J Hum Genet 77:1075-85. 2005
    ....
  33. ncbi request reprint Genetic epidemiology and public health: hope, hype, and future prospects
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Lancet 366:1484-98. 2005
    ....
  34. pmc Response to Epstein et al
    Paul R Burton
    Am J Hum Genet 71:441-2. 2002
  35. ncbi request reprint Using imprecise probabilities to address the questions of inference and decision in randomized clinical trials
    Lyle C Gurrin
    Women and Infants Research Foundation, King Edward Memorial Hospital, Subiaco, Perth, Australia
    J Eval Clin Pract 8:255-68. 2002
    ..Particular emphasis is placed on describing the type of medical conditions and treatment comparisons where the new methodology is expected to provide the greatest benefit...