Graham J Burton

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Placental morphometry and Doppler flow velocimetry in cases of chronic human fetal hypoxia
    Irina Y Kuzmina
    Department of Obstetrics and Gynecology and Pathological Anatomy, Kharkhov State Medical University, St Vesnina, 7 A, ap 13, Kharkov 61023, Ukraine
    Eur J Obstet Gynecol Reprod Biol 120:139-45. 2005
  2. ncbi request reprint Placental oxidative stress: from miscarriage to preeclampsia
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge, United Kingdom
    J Soc Gynecol Investig 11:342-52. 2004
  3. pmc Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitam
    Tereza Cindrova-Davies
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Am J Pathol 170:1511-20. 2007
  4. doi request reprint Endothelin-1 induces endoplasmic reticulum stress by activating the PLC-IP(3) pathway: implications for placental pathophysiology in preeclampsia
    Arjun Jain
    Center for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Am J Pathol 180:2309-20. 2012
  5. pmc Oxygen, the Janus gas; its effects on human placental development and function
    Graham J Burton
    Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    J Anat 215:27-35. 2009
  6. pmc Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Am J Pathol 182:1448-58. 2013
  7. ncbi request reprint Working with oxygen and oxidative stress in vitro
    Graham J Burton
    Department of Anatomy, University of Cambridge, United Kingdom
    Methods Mol Med 122:413-25. 2006
  8. pmc Oxidative stress
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Best Pract Res Clin Obstet Gynaecol 25:287-99. 2011
  9. doi request reprint The influence of the intrauterine environment on human placental development
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Int J Dev Biol 54:303-12. 2010
  10. doi request reprint Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta
    Graham J Burton
    Department of Physiology, Centre for Trophoblast Research, University of Cambridge, UK
    Taiwan J Obstet Gynecol 48:28-37. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Placental morphometry and Doppler flow velocimetry in cases of chronic human fetal hypoxia
    Irina Y Kuzmina
    Department of Obstetrics and Gynecology and Pathological Anatomy, Kharkhov State Medical University, St Vesnina, 7 A, ap 13, Kharkov 61023, Ukraine
    Eur J Obstet Gynecol Reprod Biol 120:139-45. 2005
    ..To investigate the structural basis of abnormal Doppler waveforms in the utero-placental circulations in cases of chronic fetal hypoxia...
  2. ncbi request reprint Placental oxidative stress: from miscarriage to preeclampsia
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge, United Kingdom
    J Soc Gynecol Investig 11:342-52. 2004
    ..To review the role of oxidative stress in two common placental-related disorders of pregnancy, miscarriage and preeclampsia...
  3. pmc Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitam
    Tereza Cindrova-Davies
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Am J Pathol 170:1511-20. 2007
    ..Most of these effects are mediated through the p38 MAPK and nuclear factor-kappaB pathways and can be effectively blocked by vitamins C and E in vitro...
  4. doi request reprint Endothelin-1 induces endoplasmic reticulum stress by activating the PLC-IP(3) pathway: implications for placental pathophysiology in preeclampsia
    Arjun Jain
    Center for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Am J Pathol 180:2309-20. 2012
    ..Collectively, the data show that ET-1 induced ER stress in trophoblasts via the ETBR and initiation of signaling through the PLC-IP(3) pathway, with the potential for autocrine stimulation...
  5. pmc Oxygen, the Janus gas; its effects on human placental development and function
    Graham J Burton
    Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    J Anat 215:27-35. 2009
    ..Establishing an inviolable maternal blood supply for the second and third trimesters is therefore one of the most crucial aspects of human placentation...
  6. pmc Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Am J Pathol 182:1448-58. 2013
    ..These results demonstrate that H2S is a powerful vasodilator of the placental vasculature and that expression of CSE is reduced in placentas associated with increased vascular resistance...
  7. ncbi request reprint Working with oxygen and oxidative stress in vitro
    Graham J Burton
    Department of Anatomy, University of Cambridge, United Kingdom
    Methods Mol Med 122:413-25. 2006
    ..This chapter describes techniques by which the effects of oxygen and oxidative stress on placental tissues can be systematically investigated in vitro...
  8. pmc Oxidative stress
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Best Pract Res Clin Obstet Gynaecol 25:287-99. 2011
    ..We will then consider their involvement in normal placental development, and in complications ranging from miscarriage to pre-eclampsia and premature rupture of the membranes...
  9. doi request reprint The influence of the intrauterine environment on human placental development
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Int J Dev Biol 54:303-12. 2010
    ..Protein synthesis inhibition therefore appears to be a common mechanism for regulating placental development under different adverse conditions...
  10. doi request reprint Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta
    Graham J Burton
    Department of Physiology, Centre for Trophoblast Research, University of Cambridge, UK
    Taiwan J Obstet Gynecol 48:28-37. 2009
    ..We recognize that apoptotic changes can occur in pathologic pregnancies, but consider the deportation of trophoblast that has been linked to preeclampsia to be most likely of necrotic origin following ischemic injury...
  11. ncbi request reprint Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
    ..Our findings demonstrate that the uterine glands are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic...
  12. doi request reprint Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth
    Emily Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    FASEB J 25:1737-45. 2011
    ..Our findings are indicative of fetal-placental signaling mechanisms that limit total demand for maternal nutrients...
  13. pmc Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition
    Francesca Colleoni
    Department of Physiology, Development and Neuroscience, and Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 8:e55194. 2013
    ..Our results demonstrate that mitochondrial function is altered in hypoxic human placentas, with specific suppression of complexes I and IV compromising energy metabolism and potentially contributing to impaired fetal growth...
  14. ncbi request reprint Developmental dynamics of the definitive mouse placenta assessed by stereology
    Philip M Coan
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Biol Reprod 70:1806-13. 2004
    ..39 microm by E18.5. The specific diffusion capacity for oxygen of the interhemal membrane is maximal by E16.5, which may be necessary to support rapid fetal growth until the end of gestation...
  15. ncbi request reprint Oxygen, early embryonic metabolism and free radical-mediated embryopathies
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
    Reprod Biomed Online 6:84-96. 2003
    ..Administration of free radical scavengers, including vitamins C and E, can mitigate many of these effects, indicating the importance of a balanced maternal diet to successful reproduction...
  16. pmc Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study
    Joanne Hempstock
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Reprod Biol Endocrinol 2:58. 2004
    ..The aim was to determine the activity of the glands throughout the first trimester, and to identify components of the secretions...
  17. doi request reprint Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage
    Norah M E Fogarty
    Centre for Trophoblast Research and the Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, United Kingdom
    Am J Pathol 183:144-52. 2013
    ..In vitro, we observed a negative correlation between transcriptional activity and oxidative damage. These findings demonstrate that true knots contain effete damaged nuclei and provide IHC markers for their identification...
  18. pmc Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner
    Hong Wa Yung
    Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17894. 2011
    ..These findings provide one mechanistic explanation for how ER stress contributes to human pathologies demonstrating contrasting cell fates via modulation of AKT signalling...
  19. ncbi request reprint Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial proliferation induced by 17beta-estradiol in the mouse uterus
    Julie M Hastings
    Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge, United Kingdom CB2 1QP
    Endocrinology 144:326-34. 2003
    ..These data suggest that sflt-1 could be a useful anti-VEGF-A agent and may be effective in modifying uterine biology...
  20. pmc Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Hum Reprod Update 12:747-55. 2006
    ..This would impair the placentation process leading to chronic oxidative stress in the placenta and finally to diffuse maternal endothelial cell dysfunction...
  21. ncbi request reprint Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia
    Tai Ho Hung
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan
    Taiwan J Obstet Gynecol 45:189-200. 2006
    ..Viewing the syndrome as a continuum of H/R insults provides new insight into the pathophysiology of pregnancy that will hope fully lead to improved clinical interventions...
  22. pmc Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
    Am J Pathol 162:115-25. 2003
    ..High oxygen concentrations in the periphery of normal early placentas may similarly induce local regression of the villi, leading to formation of the chorion laeve...
  23. ncbi request reprint Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment
    Eric Jauniaux
    Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 90:1171-5. 2005
    ..Polyols may also play important physiological roles in development of the human conceptus, possibly drawing water and solutes across the placenta and expanding the gestational sac...
  24. ncbi request reprint Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia
    Tai Ho Hung
    Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Circ Res 90:1274-81. 2002
    ..The quality of placental perfusion may therefore be a more important factor in the pathophysiology of preeclampsia than the absolute quantity...
  25. ncbi request reprint The contribution of placental oxidative stress to early pregnancy failure
    Joanne Hempstock
    Department of Anatomy, Cambridge University, UK
    Hum Pathol 34:1265-75. 2003
    ....
  26. ncbi request reprint Comparison of ultrasonographic and Doppler mapping of the intervillous circulation in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology Royal Free and University College London Medical School, London, United Kingdom
    Fertil Steril 79:100-6. 2003
    ..To assess the value of ultrasonography and Doppler imaging in characterizing the intervillous circulation in normal and abnormal early pregnancy...
  27. ncbi request reprint Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure
    Natalie Greenwold
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UCL Campus, London, United Kingdom
    Fertil Steril 79:1373-9. 2003
    ..To evaluate the relationship among maternal serum endocrinology, placental karyotype, and intervillous blood flow in missed miscarriage...
  28. ncbi request reprint Physiological implications of the materno-fetal oxygen gradient in human early pregnancy
    Eric Jauniaux
    Academic Department of Obstetrics, Royal Free and University College London Medical School, UCL Campus, London, UK
    Reprod Biomed Online 7:250-3. 2003
    ....
  29. pmc Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia
    Tai Ho Hung
    Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Pathol 164:1049-61. 2004
    ....
  30. pmc Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
    Hong Wa Yung
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Am J Pathol 173:451-62. 2008
    ..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development...
  31. ncbi request reprint Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Early Hum Dev 83:699-706. 2007
    ..In particular, smoking interferes strongly with the fetal brain and pancreas biological parameters and induces chromosomal instability, which is associated with an increase in the risk of cancer, especially childhood malignancies...
  32. pmc Oxidative stress, gene expression, and protein changes induced in the human placenta during labor
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing St, Cambridge CB2 3DY, UK
    Am J Pathol 171:1168-79. 2007
    ..Our findings are consistent with intermittent perfusion being the initiating cause. Placentas subjected to labor do not reflect the normal in vivo state at the molecular level...
  33. ncbi request reprint Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smoking
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, United Kingdom
    Am J Obstet Gynecol 197:58.e1-6. 2007
    ..The objective of the study was to investigate the transfer pathways of folic acid inside the first-trimester gestational sac and to evaluate the impact of maternal smoking...
  34. ncbi request reprint Distribution and transfer pathways of antioxidant molecules inside the first trimester human sestational sac
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 89:1452-8. 2004
    ..This finding indicates that the uterine glands and the secondary yolk sac play key roles in supplying this essential vitamin to the developing fetus before the placental circulations are established...
  35. ncbi request reprint Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes
    Petra L M Zusterzeel
    Department of Obstetrics and Gynaecology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Gynecol Obstet Invest 63:209-13. 2007
    ..We therefore studied the simultaneous occurrence of several genetic polymorphisms in biotransformation enzymes in women who had developed pre- eclampsia, either with or without the HELLP syndrome, in comparison with healthy controls...
  36. pmc Trophoblastic oxidative stress and the release of cell-free feto-placental DNA
    May Lee Tjoa
    Department of Pediatrics, Division of Genetics, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Pathol 169:400-4. 2006
    ....
  37. ncbi request reprint The importance of cysteine cathepsin proteases for placental development
    Aikaterini Varanou
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    J Mol Med (Berl) 84:305-17. 2006
    ..Overall, the distribution and abnormal expression levels in pre-eclamptic placentas indicate that cysteine cathepsins may play important roles during normal placentation and in the etiology of pre-eclampsia...