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Genomes and GenesSpecies | G J BurtonSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
The Centre for Trophoblast Research: improving health through placental researchGraham J Burton
Department of Physiology, Development and Neuroscience, Cambridge, UK
Reprod Biomed Online 25:2-4. 2012..Full details can be found at www.trophoblast.cam.ac.uk...
Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitudeHong Wa Yung
Centre for Trophoblast Research, Physiology Laboratory, Downing St, Cambridge, CB2 3EG, UK
FASEB J 26:1970-81. 2012..These effects may account for the reduced placental villous volume, and contribute to the low birth weight that typifies high-altitude populations...- Review: The placenta and developmental programming: balancing fetal nutrient demands with maternal resource allocationG J Burton
Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, UK
Placenta 33:S23-7. 2012..Hence, it ameliorates the effects of environmental cues that would otherwise lead to more extensive developmental programming. The P0 transcript of Igf2 appears to be a strong candidate as a mediator of these adaptations in the mouse... - Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical studyJoanne Hempstock
Department of Anatomy, University of Cambridge, Cambridge, UK
Reprod Biol Endocrinol 2:58. 2004..The aim was to determine the activity of the glands throughout the first trimester, and to identify components of the secretions... - Deportation of syncytial sprouts from the term human placentaG J Burton
Centre for Trophoblast Research, University of Cambridge, Physiological Laboratory, Downing Street, Cambridge CB2 3EG, UK
Placenta 32:96-8. 2011..In each case, sprouts containing euchromatic nuclei were observed in the intervillous space, clearly detached from neighbouring villi. Deportation of sprouts therefore continues until term... 
In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinasesS Campbell
Department of Renal Medicine, Kolling Institute of Medical Research, Sydney, Australia
Placenta 24:306-15. 2003..This study demonstrates the effectiveness of a bilayer co-culture model to study maternal-foetal cell interactions and provides evidence that maternal cells may contribute to the control of endovascular cytotrophoblast invasion...- Intralobular differences in antioxidant enzyme expression and activity reflect the pattern of maternal arterial bloodflow within the human placentaJ Hempstock
Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK
Placenta 24:517-23. 2003..5 per cent oxygen. We conclude that the activities of catalase and glutathione peroxidase reflect gradients established by the pattern of maternal intralobular bloodflow, and that oxygen tension is one regulatory factor in vitro... - Oxygen, the Janus gas; its effects on human placental development and functionGraham J Burton
Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
J Anat 215:27-35. 2009..Establishing an inviolable maternal blood supply for the second and third trimesters is therefore one of the most crucial aspects of human placentation... - The influence of the intrauterine environment on human placental developmentGraham J Burton
Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
Int J Dev Biol 54:303-12. 2010..Protein synthesis inhibition therefore appears to be a common mechanism for regulating placental development under different adverse conditions... - Oxidative stressGraham J Burton
Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
Best Pract Res Clin Obstet Gynaecol 25:287-99. 2011..We will then consider their involvement in normal placental development, and in complications ranging from miscarriage to pre-eclampsia and premature rupture of the membranes... - Oxygen, early embryonic metabolism and free radical-mediated embryopathiesGraham J Burton
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
Reprod Biomed Online 6:84-96. 2003..Administration of free radical scavengers, including vitamins C and E, can mitigate many of these effects, indicating the importance of a balanced maternal diet to successful reproduction... - Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsiaG J Burton
Department of Physiology, Development and Neuroscience, University of Cambridge, UK
Placenta 30:S43-8. 2009.... - Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placentaGraham J Burton
Department of Physiology, Centre for Trophoblast Research, University of Cambridge, UK
Taiwan J Obstet Gynecol 48:28-37. 2009..We recognize that apoptotic changes can occur in pathologic pregnancies, but consider the deportation of trophoblast that has been linked to preeclampsia to be most likely of necrotic origin following ischemic injury... - Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancyG J Burton
Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
Placenta 30:473-82. 2009..Dilation has a surprisingly modest impact on total blood flow, and so we suggest the placental pathology associated with deficient conversion is dominated by rheological consequences rather than chronic hypoxia... - Human early placental development: potential roles of the endometrial glandsG J Burton
Department of Physiology, Development and Neuroscience, Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Placenta 28:S64-9. 2007..There is circumstantial evidence, but as yet no conclusive proof, that deficient glandular activity is associated with pregnancy failure in the human... - Nutrition of the human fetus during the first trimester--a reviewG J Burton
Department of Anatomy, University of Cambridge, UK
Placenta 22:S70-7. 2001..Once this is complete, and fetal oxygen requirements rise, there is a transition to haemotrophic nutrition at the start of the second trimester, when the maternal placental circulation is fully established... - Maternal vascularisation of the human placenta: does the embryo develop in a hypoxic environment?G J Burton
Department of Anatomy, University of Cambridge, Department of Obstetrics and Gynaecology, Downing Street, Cambridge CB2 3DY, United Kingdom
Gynecol Obstet Fertil 29:503-8. 2001..During the transition period there is a period of placental oxidative stress, and the response of the tissues to the changing oxygen concentration may play a pivotal role in determining the success or otherwise of the pregnancy... - Regulation of vascular growth and function in the human placentaG J Burton
Centre for Trophoblast Research and Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Reproduction 138:895-902. 2009..Suppression of placental angiogenesis results in impoverished development of the placenta, leading ultimately to fetal growth restriction... - Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancyGraham J Burton
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
J Clin Endocrinol Metab 87:2954-9. 2002..Our findings demonstrate that the uterine glands are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic... - Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in miceP M Coan
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 586:4567-76. 2008..Thus, this adaptability in placental phenotype provides a functional reserve capacity for maximizing fetal growth during late gestation when placental growth is compromised... - Adaptations in placental phenotype support fetal growth during undernutrition of pregnant miceP M Coan
Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 588:527-38. 2010..Consequently, placental phenotype is responsive to environmental conditions and may help predict the risk of adult disease programmed in utero... - Dietary composition programmes placental phenotype in miceP M Coan
Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 589:3659-70. 2011..This has important implications for the intrauterine programming of life expectancy... - Changes in concentration, localization and activity of catalase within the human placenta during early gestationA L Watson
Department of Anatomy, University of Cambridge, UK
Placenta 19:27-34. 1998..In this environment oxidative activity of the sort resulting in the generation of hydrogen peroxide would presumably be suppressed, thereby limiting the requirement for catalase until oxygen tension begins to rise... - Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouseP M Coan
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Physiol 586:5023-32. 2008..Thus, placental phenotype depends on the degree of Igf2 gene ablation and the interplay between placental and fetal Igf2 in the mouse... - Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in miceA N Sferruzzi-Perri
Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
Endocrinology 152:3202-12. 2011..Therefore, Igf2P0 plays important roles in adapting placental nutrient transfer capacity during UN, via actions directly on the placenta and/or indirectly through the mother... - Susceptibility of human placental syncytiotrophoblastic mitochondria to oxygen-mediated damage in relation to gestational ageA L Watson
Department of Anatomy, University of Cambridge, United Kingdom
J Clin Endocrinol Metab 83:1697-705. 1998..These results indicate an acute sensitivity of first trimester placenta syncytiotrophoblast to oxygen-mediated damage... - The placenta and intrauterine programmingA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Neuroendocrinol 20:439-50. 2008.... - Effects of maternal iron restriction on placental vascularization in the ratR M Lewis
Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
Placenta 22:534-9. 2001..These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters... - A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestationN M E Fogarty
Department Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
J Anat 219:601-10. 2011..9:1. These findings confirm that the majority of STB nuclei have intrinsic transcriptional activity, and that the STB is not dependent on CTB fusion for the provision of transcripts... - Origin and characteristics of glycogen cells in the developing murine placentaP M Coan
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
Dev Dyn 235:3280-94. 2006..Thus stereology and immunohistochemistry have provided useful insights into Jz development and function of the glycogen cells... - Ultrastructural changes in the interhaemal membrane and junctional zone of the murine chorioallantoic placenta across gestationP M Coan
Department of Anatomy, University of Cambridge, UK
J Anat 207:783-96. 2005..This is the first study to use both scanning and transmission electron microscopy in an ultrastructural description of murine placental development and is complementary to contemporary genetic investigations... - Imprinted genes and the epigenetic regulation of placental phenotypeA L Fowden
Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB23EG, United Kingdom
Prog Biophys Mol Biol 106:281-8. 2011..These genes, therefore, have a major role in the epigenetic regulation of placental phenotype with long term consequences for the developmental programming of adult health and disease... - An in vitro model for the study of wound healing in first trimester human placentaA L Watson
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Cell Tissue Res 286:431-8. 1996..Furthermore, we have noted that these indicators are suggestive of 'adult-type' rather than 'fetal-type' repair processes... - Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in ratsH G Richter
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
J Physiol 590:1377-87. 2012.... - Placental vessel adaptation during gestation and to high altitude: changes in diameter and perivascular cell coverageE G Zhang
Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge, CB2 2SW, UK
Placenta 23:751-62. 2002..The absence of perivascular cells may allow remodelling of capillaries and this is likely to be physiological important in the first trimester but also under physiological or pathological stress... - Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placentaC Burdon
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
Placenta 28:724-33. 2007..Generation of oxidative stress may also play a role in influencing the growth trajectory of the placenta, and its component cell types. The mouse may provide an experimental genetic model in which to investigate these phenomena... - Evidence for transcriptional activity in the syncytiotrophoblast of the human placentaP M Ellery
Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Placenta 30:329-34. 2009..Contrary to previous findings, these results confirm that a proportion of syncytiotrophoblast nuclei actively produce mRNA transcripts... - A reappraisal of the contrasting morphological appearances of villous cytotrophoblast cells during early human pregnancy; evidence for both apoptosis and primary necrosisG J Burton
Department of Anatomy, University of Cambridge, UK
Placenta 24:297-305. 2003..03),P< 0.05], confirming increased DNA fragmentation. We conclude that these cells are undergoing primary necrosis. The stimulus for both forms of cell death remains unknown, but may be associated with syncytiotrophoblastic stress... - Roles for genomic imprinting and the zygotic genome in placental developmentP Georgiades
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
Proc Natl Acad Sci U S A 98:4522-7. 2001..They provide insights into the function of imprinting in placental development and have evolutionary and clinical implications... - The contribution of placental oxidative stress to early pregnancy failureJoanne Hempstock
Department of Anatomy, Cambridge University, UK
Hum Pathol 34:1265-75. 2003.... - Imprinted genes in the placenta--a reviewP M Coan
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Placenta 26:S10-20. 2005..We review the current information on, and suggest possible functional roles for, imprinted genes in placental development... - Placental composition and surface area but not vascularization are altered by maternal protein restriction in the ratC B Doherty
Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke's Hospital, Hills Rd, UK
Placenta 24:34-8. 2003..This study found that maternal protein restriction is associated with an increase in placental size, and that this enlargement is accompanied by increases in some, but not all, structural correlates of function... - A microscopical study of wound repair in the human placentaA L Watson
Department of Anatomy, University of Cambridge, UK
Microsc Res Tech 42:351-68. 1998..Taken together these results clearly show that the human placenta is capable of a degree of self-maintenance by activating what appears to be an endogenous wound healing mechanism... - Placental efficiency and adaptation: endocrine regulationA L Fowden
Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
J Physiol 587:3459-72. 2009..This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes... - Placental oxidative stress: from miscarriage to preeclampsiaGraham J Burton
Department of Anatomy, University of Cambridge, Cambridge, United Kingdom
J Soc Gynecol Investig 11:342-52. 2004..To review the role of oxidative stress in two common placental-related disorders of pregnancy, miscarriage and preeclampsia... - Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowthEmily Angiolini
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
FASEB J 25:1737-45. 2011..Our findings are indicative of fetal-placental signaling mechanisms that limit total demand for maternal nutrients... - Developmental dynamics of the definitive mouse placenta assessed by stereologyPhilip M Coan
Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
Biol Reprod 70:1806-13. 2004..39 microm by E18.5. The specific diffusion capacity for oxygen of the interhemal membrane is maximal by E16.5, which may be necessary to support rapid fetal growth until the end of gestation... - Working with oxygen and oxidative stress in vitroGraham J Burton
Department of Anatomy, University of Cambridge, United Kingdom
Methods Mol Med 122:413-25. 2006..This chapter describes techniques by which the effects of oxygen and oxidative stress on placental tissues can be systematically investigated in vitro... - Cryopreservation of placental biopsies for mitochondrial respiratory analysisF Colleoni
Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Placenta 33:122-3. 2012..We found no impairments in respiration following cryopreservation in the delivery suite, with enhanced coupling, as indicated by higher respiratory control ratios, than in fresh placental samples transported to the laboratory on ice... - Comparative developmental anatomy of the murine and human definitive placentaeP Georgiades
Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
Placenta 23:3-19. 2002..This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work... - Endometrial secretions: creating a stimulatory microenvironment within the human early placenta and implications for the aetiopathogenesis of preeclampsiaG J Burton
Centre for Trophoblast Research, Department of Physiology, Neuroscience and Development, Physiological Laboratory, Downing Street, Cambridge CBE 3EG, United Kingdom
J Reprod Immunol 89:118-25. 2011..We also discuss whether a disconnect between the placental/fetal metabolic state and oxygen tension could lead to a preeclamptic-type syndrome via leakage of Warburg/IPG mediators into the maternal circulation... - Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restrictionHong Wa Yung
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
Am J Pathol 173:451-62. 2008..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development... - The importance of cysteine cathepsin proteases for placental developmentAikaterini Varanou
Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
J Mol Med 84:305-17. 2006..Overall, the distribution and abnormal expression levels in pre-eclamptic placentas indicate that cysteine cathepsins may play important roles during normal placentation and in the etiology of pre-eclampsia... - Oxidative stress, gene expression, and protein changes induced in the human placenta during laborTereza Cindrova Davies
Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing St, Cambridge CB2 3DY, UK
Am J Pathol 171:1168-79. 2007..Our findings are consistent with intermittent perfusion being the initiating cause. Placentas subjected to labor do not reflect the normal in vivo state at the molecular level... - Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitamTereza Cindrova Davies
Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
Am J Pathol 170:1511-20. 2007..Most of these effects are mediated through the p38 MAPK and nuclear factor-kappaB pathways and can be effectively blocked by vitamins C and E in vitro... - Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial proliferation induced by 17beta-estradiol in the mouse uterusJulie M Hastings
Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge, United Kingdom CB2 1QP
Endocrinology 144:326-34. 2003..These data suggest that sflt-1 could be a useful anti-VEGF-A agent and may be effective in modifying uterine biology... - Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnanciesEric Jauniaux
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
Am J Pathol 162:115-25. 2003..High oxygen concentrations in the periphery of normal early placentas may similarly induce local regression of the villi, leading to formation of the chorion laeve... - Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsiaTai-Ho Hung
Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taipei, Taiwan
Circ Res 90:1274-81. 2002..The quality of placental perfusion may therefore be a more important factor in the pathophysiology of preeclampsia than the absolute quantity... - Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failureNatalie Greenwold
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UCL Campus, London, United Kingdom
Fertil Steril 79:1373-9. 2003.... - Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsiaTai Ho Hung
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan
Taiwan J Obstet Gynecol 45:189-200. 2006..Viewing the syndrome as a continuum of H/R insults provides new insight into the pathophysiology of pregnancy that will hope fully lead to improved clinical interventions... - Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smokingEric Jauniaux
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, United Kingdom
Am J Obstet Gynecol 197:58.e1-6. 2007..The objective of the study was to investigate the transfer pathways of folic acid inside the first-trimester gestational sac and to evaluate the impact of maternal smoking... - Trophoblastic oxidative stress and the release of cell-free feto-placental DNAMay Lee Tjoa
Department of Pediatrics, Division of Genetics, Tufts-New England Medical Center, Boston, Massachusetts, USA
Am J Pathol 169:400-4. 2006.... - Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolutionEric Jauniaux
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
Hum Reprod Update 12:747-55. 2006..This would impair the placentation process leading to chronic oxidative stress in the placenta and finally to diffuse maternal endothelial cell dysfunction... - Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environmentEric Jauniaux
Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
J Clin Endocrinol Metab 90:1171-5. 2005..Polyols may also play important physiological roles in development of the human conceptus, possibly drawing water and solutes across the placenta and expanding the gestational sac... - Distribution and transfer pathways of antioxidant molecules inside the first trimester human sestational sacEric Jauniaux
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
J Clin Endocrinol Metab 89:1452-8. 2004..This finding indicates that the uterine glands and the secondary yolk sac play key roles in supplying this essential vitamin to the developing fetus before the placental circulations are established... - Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsiaTai-Ho Hung
Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taipei, Taiwan
Am J Pathol 164:1049-61. 2004.... - Comparison of ultrasonographic and Doppler mapping of the intervillous circulation in normal and abnormal early pregnanciesEric Jauniaux
Academic Department of Obstetrics and Gynaecology Royal Free and University College London Medical School, London, United Kingdom
Fertil Steril 79:100-6. 2003..To assess the value of ultrasonography and Doppler imaging in characterizing the intervillous circulation in normal and abnormal early pregnancy... - Placental morphometry and Doppler flow velocimetry in cases of chronic human fetal hypoxiaIrina Y Kuzmina
Department of Obstetrics and Gynecology and Pathological Anatomy, Kharkhov State Medical University, St Vesnina, 7 A, ap 13, Kharkov 61023, Ukraine
Eur J Obstet Gynecol Reprod Biol 120:139-45. 2005..To investigate the structural basis of abnormal Doppler waveforms in the utero-placental circulations in cases of chronic fetal hypoxia... - Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymesPetra L M Zusterzeel
Department of Obstetrics and Gynaecology, University Medical Center Nijmegen, Nijmegen, The Netherlands
Gynecol Obstet Invest 63:209-13. 2007..We therefore studied the simultaneous occurrence of several genetic polymorphisms in biotransformation enzymes in women who had developed pre- eclampsia, either with or without the HELLP syndrome, in comparison with healthy controls... - Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unitEric Jauniaux
Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
Early Hum Dev 83:699-706. 2007..In particular, smoking interferes strongly with the fetal brain and pancreas biological parameters and induces chromosomal instability, which is associated with an increase in the risk of cancer, especially childhood malignancies... - Physiological implications of the materno-fetal oxygen gradient in human early pregnancyEric Jauniaux
Academic Department of Obstetrics, Royal Free and University College London Medical School, UCL Campus, London, UK
Reprod Biomed Online 7:250-3. 2003....