G J Burton

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta
    C Burdon
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Placenta 28:724-33. 2007
  2. pmc Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner
    Hong Wa Yung
    Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17894. 2011
  3. pmc Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling
    Tereza Cindrova-Davies
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Cardiovasc Res 89:671-9. 2011
  4. doi request reprint Optimising sample collection for placental research
    G J Burton
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK Electronic address
    Placenta 35:9-22. 2014
  5. pmc Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Am J Pathol 182:1448-58. 2013
  6. doi request reprint The Centre for Trophoblast Research: improving health through placental research
    Graham J Burton
    Department of Physiology, Development and Neuroscience, Cambridge, UK
    Reprod Biomed Online 25:2-4. 2012
  7. pmc Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude
    Hong Wa Yung
    Centre for Trophoblast Research, Physiology Laboratory, Downing St, Cambridge, CB2 3EG, UK
    FASEB J 26:1970-81. 2012
  8. ncbi request reprint Review: The placenta and developmental programming: balancing fetal nutrient demands with maternal resource allocation
    G J Burton
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, UK
    Placenta 33:S23-7. 2012
  9. pmc Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study
    Joanne Hempstock
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Reprod Biol Endocrinol 2:58. 2004
  10. pmc Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 30:473-82. 2009

Collaborators

Detail Information

Publications79

  1. pmc Oxidative stress and the induction of cyclooxygenase enzymes and apoptosis in the murine placenta
    C Burdon
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3DY, UK
    Placenta 28:724-33. 2007
    ..Generation of oxidative stress may also play a role in influencing the growth trajectory of the placenta, and its component cell types. The mouse may provide an experimental genetic model in which to investigate these phenomena...
  2. pmc Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner
    Hong Wa Yung
    Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e17894. 2011
    ..These findings provide one mechanistic explanation for how ER stress contributes to human pathologies demonstrating contrasting cell fates via modulation of AKT signalling...
  3. pmc Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling
    Tereza Cindrova-Davies
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Cardiovasc Res 89:671-9. 2011
    ..We tested this by manipulating VEGF receptor signalling and treating endothelial cells with low doses of tumour necrosis factor-α (TNF-α)...
  4. doi request reprint Optimising sample collection for placental research
    G J Burton
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK Electronic address
    Placenta 35:9-22. 2014
    ....
  5. pmc Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3EG, United Kingdom
    Am J Pathol 182:1448-58. 2013
    ..These results demonstrate that H2S is a powerful vasodilator of the placental vasculature and that expression of CSE is reduced in placentas associated with increased vascular resistance...
  6. doi request reprint The Centre for Trophoblast Research: improving health through placental research
    Graham J Burton
    Department of Physiology, Development and Neuroscience, Cambridge, UK
    Reprod Biomed Online 25:2-4. 2012
    ..Full details can be found at www.trophoblast.cam.ac.uk...
  7. pmc Evidence of endoplasmic reticulum stress and protein synthesis inhibition in the placenta of non-native women at high altitude
    Hong Wa Yung
    Centre for Trophoblast Research, Physiology Laboratory, Downing St, Cambridge, CB2 3EG, UK
    FASEB J 26:1970-81. 2012
    ..These effects may account for the reduced placental villous volume, and contribute to the low birth weight that typifies high-altitude populations...
  8. ncbi request reprint Review: The placenta and developmental programming: balancing fetal nutrient demands with maternal resource allocation
    G J Burton
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, UK
    Placenta 33:S23-7. 2012
    ..Hence, it ameliorates the effects of environmental cues that would otherwise lead to more extensive developmental programming. The P0 transcript of Igf2 appears to be a strong candidate as a mediator of these adaptations in the mouse...
  9. pmc Endometrial glands as a source of nutrients, growth factors and cytokines during the first trimester of human pregnancy: a morphological and immunohistochemical study
    Joanne Hempstock
    Department of Anatomy, University of Cambridge, Cambridge, UK
    Reprod Biol Endocrinol 2:58. 2004
    ..The aim was to determine the activity of the glands throughout the first trimester, and to identify components of the secretions...
  10. pmc Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 30:473-82. 2009
    ..Dilation has a surprisingly modest impact on total blood flow, and so we suggest the placental pathology associated with deficient conversion is dominated by rheological consequences rather than chronic hypoxia...
  11. doi request reprint Regulation of vascular growth and function in the human placenta
    G J Burton
    Centre for Trophoblast Research and Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Reproduction 138:895-902. 2009
    ..Suppression of placental angiogenesis results in impoverished development of the placenta, leading ultimately to fetal growth restriction...
  12. doi request reprint Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta
    Graham J Burton
    Department of Physiology, Centre for Trophoblast Research, University of Cambridge, UK
    Taiwan J Obstet Gynecol 48:28-37. 2009
    ..We recognize that apoptotic changes can occur in pathologic pregnancies, but consider the deportation of trophoblast that has been linked to preeclampsia to be most likely of necrotic origin following ischemic injury...
  13. pmc Oxygen, the Janus gas; its effects on human placental development and function
    Graham J Burton
    Centre for Trophoblast Research, Department of Physiology Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, UK
    J Anat 215:27-35. 2009
    ..Establishing an inviolable maternal blood supply for the second and third trimesters is therefore one of the most crucial aspects of human placentation...
  14. ncbi request reprint In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases
    S Campbell
    Department of Renal Medicine, Kolling Institute of Medical Research, Sydney, Australia
    Placenta 24:306-15. 2003
    ..This study demonstrates the effectiveness of a bilayer co-culture model to study maternal-foetal cell interactions and provides evidence that maternal cells may contribute to the control of endovascular cytotrophoblast invasion...
  15. pmc Placental endoplasmic reticulum stress and oxidative stress in the pathophysiology of unexplained intrauterine growth restriction and early onset preeclampsia
    G J Burton
    Department of Physiology, Development and Neuroscience, University of Cambridge, UK
    Placenta 30:S43-8. 2009
    ....
  16. pmc Human early placental development: potential roles of the endometrial glands
    G J Burton
    Department of Physiology, Development and Neuroscience, Physiological Laboratory, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Placenta 28:S64-9. 2007
    ..There is circumstantial evidence, but as yet no conclusive proof, that deficient glandular activity is associated with pregnancy failure in the human...
  17. ncbi request reprint The influence of the intrauterine environment on human placental development
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Int J Dev Biol 54:303-12. 2010
    ..Protein synthesis inhibition therefore appears to be a common mechanism for regulating placental development under different adverse conditions...
  18. ncbi request reprint Intralobular differences in antioxidant enzyme expression and activity reflect the pattern of maternal arterial bloodflow within the human placenta
    J Hempstock
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK
    Placenta 24:517-23. 2003
    ..5 per cent oxygen. We conclude that the activities of catalase and glutathione peroxidase reflect gradients established by the pattern of maternal intralobular bloodflow, and that oxygen tension is one regulatory factor in vitro...
  19. ncbi request reprint Uterine glands provide histiotrophic nutrition for the human fetus during the first trimester of pregnancy
    Graham J Burton
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    J Clin Endocrinol Metab 87:2954-9. 2002
    ..Our findings demonstrate that the uterine glands are an important source of nutrients during organogenesis, when metabolism is essentially anaerobic...
  20. doi request reprint Deportation of syncytial sprouts from the term human placenta
    G J Burton
    Centre for Trophoblast Research, University of Cambridge, Physiological Laboratory, Downing Street, Cambridge CB2 3EG, UK
    Placenta 32:96-8. 2011
    ..In each case, sprouts containing euchromatic nuclei were observed in the intervillous space, clearly detached from neighbouring villi. Deportation of sprouts therefore continues until term...
  21. pmc Oxidative stress
    Graham J Burton
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Best Pract Res Clin Obstet Gynaecol 25:287-99. 2011
    ..We will then consider their involvement in normal placental development, and in complications ranging from miscarriage to pre-eclampsia and premature rupture of the membranes...
  22. ncbi request reprint Oxygen, early embryonic metabolism and free radical-mediated embryopathies
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, UK
    Reprod Biomed Online 6:84-96. 2003
    ..Administration of free radical scavengers, including vitamins C and E, can mitigate many of these effects, indicating the importance of a balanced maternal diet to successful reproduction...
  23. ncbi request reprint Nutrition of the human fetus during the first trimester--a review
    G J Burton
    Department of Anatomy, University of Cambridge, UK
    Placenta 22:S70-7. 2001
    ..Once this is complete, and fetal oxygen requirements rise, there is a transition to haemotrophic nutrition at the start of the second trimester, when the maternal placental circulation is fully established...
  24. ncbi request reprint Maternal vascularisation of the human placenta: does the embryo develop in a hypoxic environment?
    G J Burton
    Department of Anatomy, University of Cambridge, Department of Obstetrics and Gynaecology, Downing Street, Cambridge CB2 3DY, United Kingdom
    Gynecol Obstet Fertil 29:503-8. 2001
    ..During the transition period there is a period of placental oxidative stress, and the response of the tissues to the changing oxygen concentration may play a pivotal role in determining the success or otherwise of the pregnancy...
  25. pmc Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice
    P M Coan
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 586:4567-76. 2008
    ..Thus, this adaptability in placental phenotype provides a functional reserve capacity for maximizing fetal growth during late gestation when placental growth is compromised...
  26. pmc Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice
    P M Coan
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 588:527-38. 2010
    ..Consequently, placental phenotype is responsive to environmental conditions and may help predict the risk of adult disease programmed in utero...
  27. pmc Dietary composition programmes placental phenotype in mice
    P M Coan
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 589:3659-70. 2011
    ..This has important implications for the intrauterine programming of life expectancy...
  28. ncbi request reprint Changes in concentration, localization and activity of catalase within the human placenta during early gestation
    A L Watson
    Department of Anatomy, University of Cambridge, UK
    Placenta 19:27-34. 1998
    ..In this environment oxidative activity of the sort resulting in the generation of hydrogen peroxide would presumably be suppressed, thereby limiting the requirement for catalase until oxygen tension begins to rise...
  29. doi request reprint Placental-specific Igf2 deficiency alters developmental adaptations to undernutrition in mice
    A N Sferruzzi-Perri
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, United Kingdom
    Endocrinology 152:3202-12. 2011
    ..Therefore, Igf2P0 plays important roles in adapting placental nutrient transfer capacity during UN, via actions directly on the placenta and/or indirectly through the mother...
  30. pmc Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse
    P M Coan
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Physiol 586:5023-32. 2008
    ..Thus, placental phenotype depends on the degree of Igf2 gene ablation and the interplay between placental and fetal Igf2 in the mouse...
  31. ncbi request reprint Susceptibility of human placental syncytiotrophoblastic mitochondria to oxygen-mediated damage in relation to gestational age
    A L Watson
    Department of Anatomy, University of Cambridge, United Kingdom
    J Clin Endocrinol Metab 83:1697-705. 1998
    ..These results indicate an acute sensitivity of first trimester placenta syncytiotrophoblast to oxygen-mediated damage...
  32. pmc Ultrastructural changes in the interhaemal membrane and junctional zone of the murine chorioallantoic placenta across gestation
    P M Coan
    Department of Anatomy, University of Cambridge, UK
    J Anat 207:783-96. 2005
    ..This is the first study to use both scanning and transmission electron microscopy in an ultrastructural description of murine placental development and is complementary to contemporary genetic investigations...
  33. ncbi request reprint The placenta and intrauterine programming
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Neuroendocrinol 20:439-50. 2008
    ....
  34. pmc A quantitative analysis of transcriptionally active syncytiotrophoblast nuclei across human gestation
    N M E Fogarty
    Department Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    J Anat 219:601-10. 2011
    ..9:1. These findings confirm that the majority of STB nuclei have intrinsic transcriptional activity, and that the STB is not dependent on CTB fusion for the provision of transcripts...
  35. ncbi request reprint Effects of maternal iron restriction on placental vascularization in the rat
    R M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Placenta 22:534-9. 2001
    ..These changes in placental vascularization may contribute to the fetal growth retardation observed in iron-restricted litters...
  36. pmc Expression and immunolocalisation of the endocytic receptors megalin and cubilin in the human yolk sac and placenta across gestation
    K A Burke
    Centre for Trophoblast Research, University of Cambridge, Cambridge, UK
    Placenta 34:1105-9. 2013
    ..These results suggest megalin and cubilin may be important in human maternal-fetal transfer, and that they increase across gestation to facilitate this function. ..
  37. pmc Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats
    H G Richter
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    J Physiol 590:1377-87. 2012
    ....
  38. ncbi request reprint Origin and characteristics of glycogen cells in the developing murine placenta
    P M Coan
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing Street, Cambridge, United Kingdom
    Dev Dyn 235:3280-94. 2006
    ..Thus stereology and immunohistochemistry have provided useful insights into Jz development and function of the glycogen cells...
  39. ncbi request reprint Imprinted genes and the epigenetic regulation of placental phenotype
    A L Fowden
    Department of Physiology, Development and Neuroscience, Downing Street, Cambridge CB23EG, United Kingdom
    Prog Biophys Mol Biol 106:281-8. 2011
    ..These genes, therefore, have a major role in the epigenetic regulation of placental phenotype with long term consequences for the developmental programming of adult health and disease...
  40. ncbi request reprint An in vitro model for the study of wound healing in first trimester human placenta
    A L Watson
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Cell Tissue Res 286:431-8. 1996
    ..Furthermore, we have noted that these indicators are suggestive of 'adult-type' rather than 'fetal-type' repair processes...
  41. ncbi request reprint Placental vessel adaptation during gestation and to high altitude: changes in diameter and perivascular cell coverage
    E G Zhang
    Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge, CB2 2SW, UK
    Placenta 23:751-62. 2002
    ..The absence of perivascular cells may allow remodelling of capillaries and this is likely to be physiological important in the first trimester but also under physiological or pathological stress...
  42. pmc Evidence for transcriptional activity in the syncytiotrophoblast of the human placenta
    P M Ellery
    Centre for Trophoblast Research, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Placenta 30:329-34. 2009
    ..Contrary to previous findings, these results confirm that a proportion of syncytiotrophoblast nuclei actively produce mRNA transcripts...
  43. ncbi request reprint A reappraisal of the contrasting morphological appearances of villous cytotrophoblast cells during early human pregnancy; evidence for both apoptosis and primary necrosis
    G J Burton
    Department of Anatomy, University of Cambridge, UK
    Placenta 24:297-305. 2003
    ..03),P< 0.05], confirming increased DNA fragmentation. We conclude that these cells are undergoing primary necrosis. The stimulus for both forms of cell death remains unknown, but may be associated with syncytiotrophoblastic stress...
  44. pmc Roles for genomic imprinting and the zygotic genome in placental development
    P Georgiades
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, United Kingdom
    Proc Natl Acad Sci U S A 98:4522-7. 2001
    ..They provide insights into the function of imprinting in placental development and have evolutionary and clinical implications...
  45. ncbi request reprint The contribution of placental oxidative stress to early pregnancy failure
    Joanne Hempstock
    Department of Anatomy, Cambridge University, UK
    Hum Pathol 34:1265-75. 2003
    ....
  46. pmc Influence of speed of sample processing on placental energetics and signalling pathways: Implications for tissue collection
    H W Yung
    Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK Electronic address
    Placenta 35:103-8. 2014
    ..Therefore, this study aimed to elucidate the effects of ischaemia ex vivo as may occur during tissue collection on phosphorylation of placental proteins and kinases involved in growth and cell survival, and on mitochondrial complexes...
  47. ncbi request reprint Imprinted genes in the placenta--a review
    P M Coan
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Placenta 26:S10-20. 2005
    ..We review the current information on, and suggest possible functional roles for, imprinted genes in placental development...
  48. pmc Placental efficiency and adaptation: endocrine regulation
    A L Fowden
    Department of Physiology, Development and Neuroscience, University of Cambridge, Physiology Building, Downing Street, Cambridge CB2 3EG, UK
    J Physiol 587:3459-72. 2009
    ..This review examines placental efficiency as a means of altering fetal growth, the morphological and functional adaptations that influence placental efficiency and the endocrine regulation of these processes...
  49. ncbi request reprint A microscopical study of wound repair in the human placenta
    A L Watson
    Department of Anatomy, University of Cambridge, UK
    Microsc Res Tech 42:351-68. 1998
    ..Taken together these results clearly show that the human placenta is capable of a degree of self-maintenance by activating what appears to be an endogenous wound healing mechanism...
  50. ncbi request reprint Placental composition and surface area but not vascularization are altered by maternal protein restriction in the rat
    C B Doherty
    Department of Clinical Biochemistry, University of Cambridge, Box 232 Addenbrooke s Hospital, Hills Rd, UK
    Placenta 24:34-8. 2003
    ..This study found that maternal protein restriction is associated with an increase in placental size, and that this enlargement is accompanied by increases in some, but not all, structural correlates of function...
  51. ncbi request reprint Placental oxidative stress: from miscarriage to preeclampsia
    Graham J Burton
    Department of Anatomy, University of Cambridge, Cambridge, United Kingdom
    J Soc Gynecol Investig 11:342-52. 2004
    ..To review the role of oxidative stress in two common placental-related disorders of pregnancy, miscarriage and preeclampsia...
  52. doi request reprint Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth
    Emily Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    FASEB J 25:1737-45. 2011
    ..Our findings are indicative of fetal-placental signaling mechanisms that limit total demand for maternal nutrients...
  53. ncbi request reprint Comparative developmental anatomy of the murine and human definitive placentae
    P Georgiades
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Placenta 23:3-19. 2002
    ..This could be of particular benefit to mouse developmental geneticists who study placental development and have an interest in the possible clinical implications of their work...
  54. ncbi request reprint Working with oxygen and oxidative stress in vitro
    Graham J Burton
    Department of Anatomy, University of Cambridge, United Kingdom
    Methods Mol Med 122:413-25. 2006
    ..This chapter describes techniques by which the effects of oxygen and oxidative stress on placental tissues can be systematically investigated in vitro...
  55. ncbi request reprint Developmental dynamics of the definitive mouse placenta assessed by stereology
    Philip M Coan
    Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom
    Biol Reprod 70:1806-13. 2004
    ..39 microm by E18.5. The specific diffusion capacity for oxygen of the interhemal membrane is maximal by E16.5, which may be necessary to support rapid fetal growth until the end of gestation...
  56. doi request reprint Cryopreservation of placental biopsies for mitochondrial respiratory analysis
    F Colleoni
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Placenta 33:122-3. 2012
    ..We found no impairments in respiration following cryopreservation in the delivery suite, with enhanced coupling, as indicated by higher respiratory control ratios, than in fresh placental samples transported to the laboratory on ice...
  57. doi request reprint Endometrial secretions: creating a stimulatory microenvironment within the human early placenta and implications for the aetiopathogenesis of preeclampsia
    G J Burton
    Centre for Trophoblast Research, Department of Physiology, Neuroscience and Development, Physiological Laboratory, Downing Street, Cambridge CBE 3EG, United Kingdom
    J Reprod Immunol 89:118-25. 2011
    ..We also discuss whether a disconnect between the placental/fetal metabolic state and oxygen tension could lead to a preeclamptic-type syndrome via leakage of Warburg/IPG mediators into the maternal circulation...
  58. pmc Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction
    Hong Wa Yung
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK
    Am J Pathol 173:451-62. 2008
    ..These findings may account for the increased microparticulate placental debris in the maternal circulation of these cases, leading to endothelial cell activation and impairing placental development...
  59. pmc Nuclear factor-kappa B, p38, and stress-activated protein kinase mitogen-activated protein kinase signaling pathways regulate proinflammatory cytokines and apoptosis in human placental explants in response to oxidative stress: effects of antioxidant vitam
    Tereza Cindrova-Davies
    Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK
    Am J Pathol 170:1511-20. 2007
    ..Most of these effects are mediated through the p38 MAPK and nuclear factor-kappaB pathways and can be effectively blocked by vitamins C and E in vitro...
  60. ncbi request reprint The importance of cysteine cathepsin proteases for placental development
    Aikaterini Varanou
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    J Mol Med (Berl) 84:305-17. 2006
    ..Overall, the distribution and abnormal expression levels in pre-eclamptic placentas indicate that cysteine cathepsins may play important roles during normal placentation and in the etiology of pre-eclampsia...
  61. pmc Oxidative stress, gene expression, and protein changes induced in the human placenta during labor
    Tereza Cindrova-Davies
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Downing St, Cambridge CB2 3DY, UK
    Am J Pathol 171:1168-79. 2007
    ..Our findings are consistent with intermittent perfusion being the initiating cause. Placentas subjected to labor do not reflect the normal in vivo state at the molecular level...
  62. ncbi request reprint Soluble vascular endothelial growth factor receptor 1 inhibits edema and epithelial proliferation induced by 17beta-estradiol in the mouse uterus
    Julie M Hastings
    Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge, United Kingdom CB2 1QP
    Endocrinology 144:326-34. 2003
    ..These data suggest that sflt-1 could be a useful anti-VEGF-A agent and may be effective in modifying uterine biology...
  63. pmc Trophoblastic oxidative stress and the release of cell-free feto-placental DNA
    May Lee Tjoa
    Department of Pediatrics, Division of Genetics, Tufts New England Medical Center, Boston, Massachusetts, USA
    Am J Pathol 169:400-4. 2006
    ....
  64. ncbi request reprint Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia
    Tai Ho Hung
    Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Circ Res 90:1274-81. 2002
    ..The quality of placental perfusion may therefore be a more important factor in the pathophysiology of preeclampsia than the absolute quantity...
  65. pmc Placental-related diseases of pregnancy: Involvement of oxidative stress and implications in human evolution
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Hum Reprod Update 12:747-55. 2006
    ..This would impair the placentation process leading to chronic oxidative stress in the placenta and finally to diffuse maternal endothelial cell dysfunction...
  66. ncbi request reprint Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smoking
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, United Kingdom
    Am J Obstet Gynecol 197:58.e1-6. 2007
    ..The objective of the study was to investigate the transfer pathways of folic acid inside the first-trimester gestational sac and to evaluate the impact of maternal smoking...
  67. ncbi request reprint Hypoxia and reoxygenation: a possible mechanism for placental oxidative stress in preeclampsia
    Tai Ho Hung
    Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan
    Taiwan J Obstet Gynecol 45:189-200. 2006
    ..Viewing the syndrome as a continuum of H/R insults provides new insight into the pathophysiology of pregnancy that will hope fully lead to improved clinical interventions...
  68. pmc Trophoblastic oxidative stress in relation to temporal and regional differences in maternal placental blood flow in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London
    Am J Pathol 162:115-25. 2003
    ..High oxygen concentrations in the periphery of normal early placentas may similarly induce local regression of the villi, leading to formation of the chorion laeve...
  69. pmc Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro: a potential mediator of the inflammatory response in preeclampsia
    Tai Ho Hung
    Department of Obstetrics and Gynaecology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Am J Pathol 164:1049-61. 2004
    ....
  70. ncbi request reprint Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment
    Eric Jauniaux
    Academic Department of Obstetrics and Gynecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 90:1171-5. 2005
    ..Polyols may also play important physiological roles in development of the human conceptus, possibly drawing water and solutes across the placenta and expanding the gestational sac...
  71. ncbi request reprint Relationship among maternal serum endocrinology, placental karyotype, and intervillous circulation in early pregnancy failure
    Natalie Greenwold
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, UCL Campus, London, United Kingdom
    Fertil Steril 79:1373-9. 2003
    ..To evaluate the relationship among maternal serum endocrinology, placental karyotype, and intervillous blood flow in missed miscarriage...
  72. ncbi request reprint Distribution and transfer pathways of antioxidant molecules inside the first trimester human gestational sac
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London WC1E 6HX, UK
    J Clin Endocrinol Metab 89:1452-8. 2004
    ..This finding indicates that the uterine glands and the secondary yolk sac play key roles in supplying this essential vitamin to the developing fetus before the placental circulations are established...
  73. ncbi request reprint Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes
    Petra L M Zusterzeel
    Department of Obstetrics and Gynaecology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Gynecol Obstet Invest 63:209-13. 2007
    ..We therefore studied the simultaneous occurrence of several genetic polymorphisms in biotransformation enzymes in women who had developed pre- eclampsia, either with or without the HELLP syndrome, in comparison with healthy controls...
  74. ncbi request reprint Comparison of ultrasonographic and Doppler mapping of the intervillous circulation in normal and abnormal early pregnancies
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology Royal Free and University College London Medical School, London, United Kingdom
    Fertil Steril 79:100-6. 2003
    ..To assess the value of ultrasonography and Doppler imaging in characterizing the intervillous circulation in normal and abnormal early pregnancy...
  75. ncbi request reprint Morphological and biological effects of maternal exposure to tobacco smoke on the feto-placental unit
    Eric Jauniaux
    Academic Department of Obstetrics and Gynaecology, Royal Free and University College London Medical School, London, UK
    Early Hum Dev 83:699-706. 2007
    ..In particular, smoking interferes strongly with the fetal brain and pancreas biological parameters and induces chromosomal instability, which is associated with an increase in the risk of cancer, especially childhood malignancies...
  76. ncbi request reprint Placental morphometry and Doppler flow velocimetry in cases of chronic human fetal hypoxia
    Irina Y Kuzmina
    Department of Obstetrics and Gynecology and Pathological Anatomy, Kharkhov State Medical University, St Vesnina, 7 A, ap 13, Kharkov 61023, Ukraine
    Eur J Obstet Gynecol Reprod Biol 120:139-45. 2005
    ..To investigate the structural basis of abnormal Doppler waveforms in the utero-placental circulations in cases of chronic fetal hypoxia...
  77. ncbi request reprint Physiological implications of the materno-fetal oxygen gradient in human early pregnancy
    Eric Jauniaux
    Academic Department of Obstetrics, Royal Free and University College London Medical School, UCL Campus, London, UK
    Reprod Biomed Online 7:250-3. 2003
    ....